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The map label for this gene is lpxB [H]

Identifier: 161611305

GI number: 161611305

Start: 1568475

End: 1569644

Strand: Direct

Name: lpxB [H]

Synonym: pc1312

Alternate gene names: 161611305

Gene position: 1568475-1569644 (Clockwise)

Preceding gene: 46446945

Following gene: 46446947

Centisome position: 64.96

GC content: 36.67

Gene sequence:

>1170_bases
ATGAAAAATTGTTTTATTTTTGCCGGGGAAGCAAGCGGTGATTTGCATGGTAGTCGCTTGATGCGTGCCTTGAAAGAGCA
ATTCGTTTTTTCCTCTTTAAATGGGGTTGGAGGCCCTCTTATGCGCCTCGAAGGTCTTGAAGTTCTTTACCCCATGGAAG
AATTTCAAGTCATGGGTTTCACAGATGTATTAAAAGCTTTTCCAAAGCTCTACAAACTATTTTATGCTATTCGAAAACAT
ATCCTTAAAACAAATCCTTCCTGTGTGATTCTTATCGATTACCCGGGATTTAACTTGCGACTCACTAAATCTCTACGCAA
AGTTGGATACAAAGGAAAGATTATTCAATTTATCTGTCCTACTGTTTGGGCTCATGGCAAAAAACGTATCGATACGATGG
TTAAACATTTGGATTTACTTTTAACCATTTATCCATTCGAAGCTGCATTTTTTTCCCATACCCCTTTAAAAGTACGTTAT
GTGGGTAACCCGCTAGTTGAAACTGTCAGCAATTATCCCTATAAAGAAAATTGGAAATCTATTTGCGGAATCCCTCACAA
TCAAAAATTATTAGCCATTTTTCCAGGAAGCCGAATCGGTGAAATCCAAAGGCATCTTCCTCAGCAATTAGAAGTTGCTC
AATTATTAATAAAAAATCATCCTTCAATTCATTTCGCTATTTCCTGCTCAGACGACCGCCTTCTCTCTTTTATAAAAACC
CACATTCATAACACTTCTCTACAAATGGGTCTAAACATTCATTTAGTTCCTCGCTTTTTTAGCTATGAACTAATGAAAGA
TTGTCATTGTAGTTTAGCCAAATCAGGCACGGTTACCTTAGAACTCGCTCTCCATCAAAAACCGACTGTTGTGCTTTACA
CCCTAACGCAATTAAATTATTTATTAGCCAAGTATTGGATGCATTTAAATCTTCCTCATTATTGCATTGTCAATATTTTA
CTAGAACGAACTGTATACCCTGAATTTATTGGAAAAAAACTCGATATTTATCAAATCTTTAAGCAAATCGAAAAGTTATT
CATTAATCAAGACCACTATGACAGCGTTATCGGAGATTGTGCCATTTTACGCCAGCAATTGGGAGATGGTATAGCTTCCA
GCCTTGCAAGTCGAGAGATCCAGGAGCTATTAAATGCTAAAAAAACTTAA

Upstream 100 bases:

>100_bases
ATATTCAAGATAGCGTCAATTTAATTGGCCCTTTAATCGGAATGGTTCCTTATATTCGAAATTTAATGCTATTGAAAAAC
GCTAAAATAGCGGCTGCAAA

Downstream 100 bases:

>100_bases
ACAAGGGTGGAAAAATTTCTCTTATCGATGCTTTGCTTTTCTTATTGCGACAATAGGTAAAGCCTTAATTCGTATTTTGT
TAGCCACATGTCGTTCAAAA

Product: putative lipid A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKNCFIFAGEASGDLHGSRLMRALKEQFVFSSLNGVGGPLMRLEGLEVLYPMEEFQVMGFTDVLKAFPKLYKLFYAIRKH
ILKTNPSCVILIDYPGFNLRLTKSLRKVGYKGKIIQFICPTVWAHGKKRIDTMVKHLDLLLTIYPFEAAFFSHTPLKVRY
VGNPLVETVSNYPYKENWKSICGIPHNQKLLAIFPGSRIGEIQRHLPQQLEVAQLLIKNHPSIHFAISCSDDRLLSFIKT
HIHNTSLQMGLNIHLVPRFFSYELMKDCHCSLAKSGTVTLELALHQKPTVVLYTLTQLNYLLAKYWMHLNLPHYCIVNIL
LERTVYPEFIGKKLDIYQIFKQIEKLFINQDHYDSVIGDCAILRQQLGDGIASSLASREIQELLNAKKT

Sequences:

>Translated_389_residues
MKNCFIFAGEASGDLHGSRLMRALKEQFVFSSLNGVGGPLMRLEGLEVLYPMEEFQVMGFTDVLKAFPKLYKLFYAIRKH
ILKTNPSCVILIDYPGFNLRLTKSLRKVGYKGKIIQFICPTVWAHGKKRIDTMVKHLDLLLTIYPFEAAFFSHTPLKVRY
VGNPLVETVSNYPYKENWKSICGIPHNQKLLAIFPGSRIGEIQRHLPQQLEVAQLLIKNHPSIHFAISCSDDRLLSFIKT
HIHNTSLQMGLNIHLVPRFFSYELMKDCHCSLAKSGTVTLELALHQKPTVVLYTLTQLNYLLAKYWMHLNLPHYCIVNIL
LERTVYPEFIGKKLDIYQIFKQIEKLFINQDHYDSVIGDCAILRQQLGDGIASSLASREIQELLNAKKT
>Mature_389_residues
MKNCFIFAGEASGDLHGSRLMRALKEQFVFSSLNGVGGPLMRLEGLEVLYPMEEFQVMGFTDVLKAFPKLYKLFYAIRKH
ILKTNPSCVILIDYPGFNLRLTKSLRKVGYKGKIIQFICPTVWAHGKKRIDTMVKHLDLLLTIYPFEAAFFSHTPLKVRY
VGNPLVETVSNYPYKENWKSICGIPHNQKLLAIFPGSRIGEIQRHLPQQLEVAQLLIKNHPSIHFAISCSDDRLLSFIKT
HIHNTSLQMGLNIHLVPRFFSYELMKDCHCSLAKSGTVTLELALHQKPTVVLYTLTQLNYLLAKYWMHLNLPHYCIVNIL
LERTVYPEFIGKKLDIYQIFKQIEKLFINQDHYDSVIGDCAILRQQLGDGIASSLASREIQELLNAKKT

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=331, Percent_Identity=31.4199395770393, Blast_Score=167, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835
- InterPro:   IPR011499
- ProDom:   PD339292 [H]

Pfam domain/function: PF07578 LAB_N; PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44625; Mature: 44625

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNCFIFAGEASGDLHGSRLMRALKEQFVFSSLNGVGGPLMRLEGLEVLYPMEEFQVMGF
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCHHHHHCCCH
TDVLKAFPKLYKLFYAIRKHILKTNPSCVILIDYPGFNLRLTKSLRKVGYKGKIIQFICP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHCCCCCCHHHHHHH
TVWAHGKKRIDTMVKHLDLLLTIYPFEAAFFSHTPLKVRYVGNPLVETVSNYPYKENWKS
HHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHCHHH
ICGIPHNQKLLAIFPGSRIGEIQRHLPQQLEVAQLLIKNHPSIHFAISCSDDRLLSFIKT
HCCCCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
HIHNTSLQMGLNIHLVPRFFSYELMKDCHCSLAKSGTVTLELALHQKPTVVLYTLTQLNY
HHCCCCEEECCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHHH
LLAKYWMHLNLPHYCIVNILLERTVYPEFIGKKLDIYQIFKQIEKLFINQDHYDSVIGDC
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AILRQQLGDGIASSLASREIQELLNAKKT
HHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNCFIFAGEASGDLHGSRLMRALKEQFVFSSLNGVGGPLMRLEGLEVLYPMEEFQVMGF
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCHHHHHCCCH
TDVLKAFPKLYKLFYAIRKHILKTNPSCVILIDYPGFNLRLTKSLRKVGYKGKIIQFICP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHCCCCCCHHHHHHH
TVWAHGKKRIDTMVKHLDLLLTIYPFEAAFFSHTPLKVRYVGNPLVETVSNYPYKENWKS
HHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHCCCCHHCHHH
ICGIPHNQKLLAIFPGSRIGEIQRHLPQQLEVAQLLIKNHPSIHFAISCSDDRLLSFIKT
HCCCCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
HIHNTSLQMGLNIHLVPRFFSYELMKDCHCSLAKSGTVTLELALHQKPTVVLYTLTQLNY
HHCCCCEEECCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHHH
LLAKYWMHLNLPHYCIVNILLERTVYPEFIGKKLDIYQIFKQIEKLFINQDHYDSVIGDC
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AILRQQLGDGIASSLASREIQELLNAKKT
HHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]