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The map label for this gene is ubiE

Identifier: 161611201

GI number: 161611201

Start: 4516044

End: 4516736

Strand: Direct

Name: ubiE

Synonym: MAP4055

Alternate gene names: 161611201

Gene position: 4516044-4516736 (Clockwise)

Preceding gene: 41410152

Following gene: 41410156

Centisome position: 93.5

GC content: 72.58

Gene sequence:

>693_bases
GTGAGCCGCGCGGAGTTGGACAAGAATCCCCGGGACGTCGCGTCGATGTTCGACGGCGTGGCCCGCCGGTACGACCTGAC
CAACACCGTGCTGTCGCTGGGCCAGGACCGGTACTGGCGCAAGGCCACCCGGTCGGCGCTGGGCATCGGACCCGGCCAGA
AGGTGCTCGACCTGGCCGCGGGCACCGCGGTGTCCACCGTCGAGCTGAACAAATCCGGGGCGTGGTGCGTGGCCGCCGAC
TTCTCGGTCGGCATGCTGGCGGCCGGTGCCGCCCGCCGGGTGCCCAAGGTCGCCGGTGACGCCACCAGGCTGCCGTTCGC
CGACGACGTATTCGACGCCGTCACAATCAGTTTCGGGCTGCGCAACGTGGTCGACACGCAGGCGGCGCTGCGCGAGATGG
CCCGGGTCACCCGGCCCGGCGGGCGGCTGGTGGTGTGCGAGTTCTCCACCCCCAGCAACGCGCTGTTCGCCACCGTCTAC
AAGGAGTACCTGATGCGGGCGCTGCCGCGGGTGGCGCGGGCGGTGTCCAGCAACCCCGACGCCTACGTGTACCTCGCCGA
GTCGATCCGAGCCTGGCCGGATCAGGCGGCGCTGGCCGACCAGATCGCCGGGGCCGGCTGGGCGGGGGTGCGCTGGCGCA
ATCTGACCGGCGGCATCGTCGCGCTACACGCCGCCCACCGGCCGCCGCGCTGA

Upstream 100 bases:

>100_bases
GACCAGCGTGACATGCACACCGAACGGCGCGATCTCTAGCCACGCAGAGGTGCAACGCTGGCGTCGCCGCGGCATTCCCG
CACCGGGTAGCGTCAAGCGG

Downstream 100 bases:

>100_bases
GCGGTGCTTACCGGCCGGCCGCCTGGACGACGTCGATGTGCTCGGGGCAGTAGTGGTCCACCGCCGCGCCGAGGAACTGC
AGCGACTGGCCCTCGGAGGT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSRAELDKNPRDVASMFDGVARRYDLTNTVLSLGQDRYWRKATRSALGIGPGQKVLDLAAGTAVSTVELNKSGAWCVAAD
FSVGMLAAGAARRVPKVAGDATRLPFADDVFDAVTISFGLRNVVDTQAALREMARVTRPGGRLVVCEFSTPSNALFATVY
KEYLMRALPRVARAVSSNPDAYVYLAESIRAWPDQAALADQIAGAGWAGVRWRNLTGGIVALHAAHRPPR

Sequences:

>Translated_230_residues
MSRAELDKNPRDVASMFDGVARRYDLTNTVLSLGQDRYWRKATRSALGIGPGQKVLDLAAGTAVSTVELNKSGAWCVAAD
FSVGMLAAGAARRVPKVAGDATRLPFADDVFDAVTISFGLRNVVDTQAALREMARVTRPGGRLVVCEFSTPSNALFATVY
KEYLMRALPRVARAVSSNPDAYVYLAESIRAWPDQAALADQIAGAGWAGVRWRNLTGGIVALHAAHRPPR
>Mature_229_residues
SRAELDKNPRDVASMFDGVARRYDLTNTVLSLGQDRYWRKATRSALGIGPGQKVLDLAAGTAVSTVELNKSGAWCVAADF
SVGMLAAGAARRVPKVAGDATRLPFADDVFDAVTISFGLRNVVDTQAALREMARVTRPGGRLVVCEFSTPSNALFATVYK
EYLMRALPRVARAVSSNPDAYVYLAESIRAWPDQAALADQIAGAGWAGVRWRNLTGGIVALHAAHRPPR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=259, Percent_Identity=32.4324324324324, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=42.0353982300885, Blast_Score=175, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17557039, Length=230, Percent_Identity=32.1739130434783, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323526, Length=237, Percent_Identity=30.8016877637131, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641702, Length=244, Percent_Identity=31.9672131147541, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_MYCPA (Q73SL8)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962989.2
- ProteinModelPortal:   Q73SL8
- SMR:   Q73SL8
- EnsemblBacteria:   EBMYCT00000038397
- GeneID:   2718963
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP4055
- NMPDR:   fig|262316.1.peg.4055
- GeneTree:   EBGT00050000014588
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 24718; Mature: 24587

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAELDKNPRDVASMFDGVARRYDLTNTVLSLGQDRYWRKATRSALGIGPGQKVLDLAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHC
GTAVSTVELNKSGAWCVAADFSVGMLAAGAARRVPKVAGDATRLPFADDVFDAVTISFGL
CCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHH
RNVVDTQAALREMARVTRPGGRLVVCEFSTPSNALFATVYKEYLMRALPRVARAVSSNPD
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AYVYLAESIRAWPDQAALADQIAGAGWAGVRWRNLTGGIVALHAAHRPPR
EEEEEHHHHHCCCCHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SRAELDKNPRDVASMFDGVARRYDLTNTVLSLGQDRYWRKATRSALGIGPGQKVLDLAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHC
GTAVSTVELNKSGAWCVAADFSVGMLAAGAARRVPKVAGDATRLPFADDVFDAVTISFGL
CCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHH
RNVVDTQAALREMARVTRPGGRLVVCEFSTPSNALFATVYKEYLMRALPRVARAVSSNPD
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AYVYLAESIRAWPDQAALADQIAGAGWAGVRWRNLTGGIVALHAAHRPPR
EEEEEHHHHHCCCCHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA