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The map label for this gene is trpE [H]

Identifier: 161526029

GI number: 161526029

Start: 3124481

End: 3125974

Strand: Direct

Name: trpE [H]

Synonym: Bmul_2860

Alternate gene names: 161526029

Gene position: 3124481-3125974 (Clockwise)

Preceding gene: 161526028

Following gene: 161526030

Centisome position: 90.6

GC content: 66.6

Gene sequence:

>1494_bases
ATGACCGAACTCGAATTCCAATCGCTCGCGAACGAAGGCTATAACCGCATCCCGCTGATCGCCGAAGCGCTCGCCGATCT
CGAAACGCCGCTGTCGCTCTACCTGAAGCTCGCGCAGCCCGAACGCGCCGGCGCGAACTCCTTCCTGCTCGAATCGGTGG
TCGGCGGCGAACGCTTCGGCCGCTACTCGTTCATCGGGCTGCCGGCACGCACGCTCGTGCGCACCCGCAACGGCGTCTCC
GAAGTCGTGCGCGACGGCGCGGTCGTCGAGACGCACGACGGCGATCCGTTCGAGTTCATCGCGTCGTTCCAGGCGCGCTT
CAAGGTCGCGCAGCGCCCCGGTCTGCCGCGCTTCTGCGGCGGTCTGGCCGGCTATTTCGGCTACGACGCGGTGCGCTACA
TCGAGAAGAAGCTCGCACACACCGCGCCGCGCGACGATCTCGGCCTGCCCGACATCCAGCTGCTGCTCACCGAGGAAGTC
GCGGTGATCGACAACCTCGCCGGCAAGCTGTATCTGATCATCTACGCGGATCCGGGCCAGCCCGAGGCGTACGCGAAGGC
GAAGCAGCGCCTGCGCGAGCTCAAGCAGCGGCTGCGCGCGACCGTGCAGCCGCCCGTCACGTCGGCGAGCGTGCGCACCG
AGACGTTCCGCGAATTCAAGAAGGACGACTATCTGGCCGCCGTGCGTCAGGCGAAGGAATACATCGCGGCCGGCGAGCTG
ATGCAGATCCAGGTCGGACAGCGCCTGACGAAGCCCTATCGCGACAATCCGCTGTCGCTGTATCGCGCGCTGCGCTCGCT
GAATCCGTCGCCGTACATGTACTACTACAACTTCGGCGAGTTCCACGTGGTCGGCGCGTCGCCGGAAATCCTCGTGCGCC
AGGAAAAGCGCGGCGACGACCAGATCGTCACGATCCGCCCGCTCGCCGGCACACGCCCGCGCGGCAACACGCCCGAGCGC
GACGCGGAACTCGCGACCGAGCTGCTGAACGATCCGAAGGAAATCGCCGAGCACGTGATGCTGATTGACCTCGCGCGCAA
CGACGTCGGCCGCATCGCCGACATCGGCTCGGTGCAGGTGACCGACAAGATGGTGATCGAGAAGTACTCGCACGTGCAGC
ACATCGTCAGCTCGGTCGAAGGCAAGCTCAAGCCCGGCATGACGAACTTCGACGTGCTGCGCGCGACGTTCCCGGCCGGC
ACGCTGTCCGGCGCGCCGAAGGTGCGCGCGATGGAGCTGATCGACGAGCTCGAGCCCGTCAAGCGCGGGCTCTACGGCGG
CGCCGTCGGCTATCTGTCGTTCTCGGGCGAGATGGATCTCGCGATCGCGATCCGCACGGGCCTGATCCACAACGGCAACC
TGTATGTGCAAGCGGCGGCCGGCGTCGTCGCGGATTCGGTGCCCGAATCCGAATGGCAAGAGACCGAGAACAAGGCGCGC
GCGGTGCTGCGCGCGGCCGAACAGGTCCAGGACGGCCTCGATAGCGACTTCTGA

Upstream 100 bases:

>100_bases
CCAGGCACTTCAGGATCGACCGCCCTTTCGCCGACGGCCACCCGCGCAGCGTCAAACGATCCCTGGCGCACGCGCCGCTC
GTCCCGAACAGGACCGGAAC

Downstream 100 bases:

>100_bases
CCGGAGACTGACCATGCTGCTCATGATCGACAACTACGACTCGTTCACCTACAACCTGGTCCAGTACTTCGGCGAACTGG
GCGAGGACGTGCGCACCTAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVS
EVVRDGAVVETHDGDPFEFIASFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLLLTEEV
AVIDNLAGKLYLIIYADPGQPEAYAKAKQRLRELKQRLRATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRPRGNTPER
DAELATELLNDPKEIAEHVMLIDLARNDVGRIADIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF

Sequences:

>Translated_497_residues
MTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVS
EVVRDGAVVETHDGDPFEFIASFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLLLTEEV
AVIDNLAGKLYLIIYADPGQPEAYAKAKQRLRELKQRLRATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRPRGNTPER
DAELATELLNDPKEIAEHVMLIDLARNDVGRIADIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDSDF
>Mature_496_residues
TELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVSE
VVRDGAVVETHDGDPFEFIASFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLLLTEEVA
VIDNLAGKLYLIIYADPGQPEAYAKAKQRLRELKQRLRATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGELM
QIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRPRGNTPERD
AELATELLNDPKEIAEHVMLIDLARNDVGRIADIGSVQVTDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAGT
LSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKARA
VLRAAEQVQDGLDSDF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=378, Percent_Identity=41.005291005291, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788114, Length=445, Percent_Identity=31.9101123595506, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082077, Length=275, Percent_Identity=28.7272727272727, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=29.7777777777778, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=465, Percent_Identity=40.8602150537634, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=27.0471464019851, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55030; Mature: 54899

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFG
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHEEECCCCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLVRTRNGVSEVVRDGAVVETHDGDPFEFIASFQARFKVAQRPGLPRFCG
CEEEECCCHHHHHHHHCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIIYADPGQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCC
PEAYAKAKQRLRELKQRLRATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGDD
EEEHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCEEEEECCCCCC
QIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIADIGSVQV
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHCCCCEEH
TDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDSDF
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERAGANSFLLESVVGGERFG
CCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHEEECCCCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLVRTRNGVSEVVRDGAVVETHDGDPFEFIASFQARFKVAQRPGLPRFCG
CEEEECCCHHHHHHHHCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIIYADPGQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCC
PEAYAKAKQRLRELKQRLRATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
MQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGDD
EEEHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCEEEEECCCCCC
QIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIADIGSVQV
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHCCCCEEH
TDKMVIEKYSHVQHIVSSVEGKLKPGMTNFDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDSDF
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]