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The map label for this gene is ubiH [H]

Identifier: 161525859

GI number: 161525859

Start: 2938102

End: 2939289

Strand: Direct

Name: ubiH [H]

Synonym: Bmul_2690

Alternate gene names: 161525859

Gene position: 2938102-2939289 (Clockwise)

Preceding gene: 161525858

Following gene: 161525860

Centisome position: 85.2

GC content: 73.48

Gene sequence:

>1188_bases
ATGACCCACGCTTCCTCCCCGCTTCCGACCGACTACGACCTCGCGATCGTCGGCGCGGGCCCGGTCGGGCTCGCGCTCGC
CGGCTGGCTCGCGCGGCGCAGCGCGACGCAGCACGCGTCGATCGCGCTGATCGATGCGCGCGAGCCGTCCGCGAGCGCGA
ACGATCCGCGCGCGATCGCGGTGTCGCACGGCAGCCGCGTGCTGCTCGATACGCTCGCGTGGCCGGCCGACGCGACGCCG
ATCGAACACATTCACGTGTCGCAGCGCGGCCATTTCGGGCGCACGCTGATCGAGCGCGACGAGCACGATCTCGCGGCGCT
CGGCTACGTCGTGCGCTACGGCTCGCTCGTCCAGGCGCTCGCCGGCGCCGTGCGCGGCAGCCGCGTCGACTGGCTCACGT
CGACCACCGCGCGCGCACCGCTGCAGGACGCCGACGGCGTCGCGCTGACGCTCGACGGGCCGCACGGCGAACGCGTACTG
CGCGCGCGCATCGTCGTGAATGCGGAAGGCGGGCTGTTCCACGAGCAGCAGGCAGACGCCGGCAAGCATCGACGCGACTA
CGGCCAGACCGCGATCGTCGGCACCGTGACGGTGTCGTCGCCGCGGCCGAACGTCGCGTGGGAGCGCTTCACGCACGAAG
GCCCGCTCGCGCTGCTGCCGCTCGGCGGCCCGCGGCAGGCCGACTATGCGCTCGTCTGGTGCTGCGCACCGGACGAGGCG
GCACGCCGCGCGGCGCTGCCCGACGACGCCTTCCTGCGCGAACTCGGGACCGCATTCGGCGAGCGCATGGGCAGCTTCGT
CGCGATCGCGGGCCGCGCGTCGTTCCCGCTCGGGCTGAACGCCGCGCAGACGCTCGTCAAGGGCCGCATCGCGATCGTCG
GCAATGCCGCGCAGACGCTGCACCCGGTCGCGGGCCAAGGACTGAACCTCGGGCTGCGCGACGCGCACACGCTCGTCGAC
GTGCTGTCGACGCAGGGTTTCGACGCGACCGCGCTCGCGACCTTCAATGCGCGCCGCGCGCTCGACCGGCGGCTCACGAT
CGGCGCGACCGACACGCTCGCGCGGCTGTTTACGATCGATGCCGGCCCGCTGCCGCTGCTGCGCGGCGCGGCGCTCACCG
CGCTCGAATTCGTGCCGCCGCTGAAGAAGGCGATCGCGCGGCAGATGATGTTCGGCCAGCGCGGCTGA

Upstream 100 bases:

>100_bases
CGACGTGCCCGTCGCGGCGGCCGACATCGAGGCGCTGATGCGTGCGCGCGCGTAAGCCGCACGCGGGCTGCCGACCGTTA
TTTCCGTTTCACGAATTCCG

Downstream 100 bases:

>100_bases
CGCGCGCGGCGCGCACAGCACGCCGGCGTGCGCCGGTGTGCGCCCGCACAAACCGGGTCAAATCGGCGGGGGTTGGGAAT
ACGGTAAAATGCGCGTTTTC

Product: hypothetical protein

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTHASSPLPTDYDLAIVGAGPVGLALAGWLARRSATQHASIALIDAREPSASANDPRAIAVSHGSRVLLDTLAWPADATP
IEHIHVSQRGHFGRTLIERDEHDLAALGYVVRYGSLVQALAGAVRGSRVDWLTSTTARAPLQDADGVALTLDGPHGERVL
RARIVVNAEGGLFHEQQADAGKHRRDYGQTAIVGTVTVSSPRPNVAWERFTHEGPLALLPLGGPRQADYALVWCCAPDEA
ARRAALPDDAFLRELGTAFGERMGSFVAIAGRASFPLGLNAAQTLVKGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLVD
VLSTQGFDATALATFNARRALDRRLTIGATDTLARLFTIDAGPLPLLRGAALTALEFVPPLKKAIARQMMFGQRG

Sequences:

>Translated_395_residues
MTHASSPLPTDYDLAIVGAGPVGLALAGWLARRSATQHASIALIDAREPSASANDPRAIAVSHGSRVLLDTLAWPADATP
IEHIHVSQRGHFGRTLIERDEHDLAALGYVVRYGSLVQALAGAVRGSRVDWLTSTTARAPLQDADGVALTLDGPHGERVL
RARIVVNAEGGLFHEQQADAGKHRRDYGQTAIVGTVTVSSPRPNVAWERFTHEGPLALLPLGGPRQADYALVWCCAPDEA
ARRAALPDDAFLRELGTAFGERMGSFVAIAGRASFPLGLNAAQTLVKGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLVD
VLSTQGFDATALATFNARRALDRRLTIGATDTLARLFTIDAGPLPLLRGAALTALEFVPPLKKAIARQMMFGQRG
>Mature_394_residues
THASSPLPTDYDLAIVGAGPVGLALAGWLARRSATQHASIALIDAREPSASANDPRAIAVSHGSRVLLDTLAWPADATPI
EHIHVSQRGHFGRTLIERDEHDLAALGYVVRYGSLVQALAGAVRGSRVDWLTSTTARAPLQDADGVALTLDGPHGERVLR
ARIVVNAEGGLFHEQQADAGKHRRDYGQTAIVGTVTVSSPRPNVAWERFTHEGPLALLPLGGPRQADYALVWCCAPDEAA
RRAALPDDAFLRELGTAFGERMGSFVAIAGRASFPLGLNAAQTLVKGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLVDV
LSTQGFDATALATFNARRALDRRLTIGATDTLARLFTIDAGPLPLLRGAALTALEFVPPLKKAIARQMMFGQRG

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=400, Percent_Identity=29.25, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI32967307, Length=351, Percent_Identity=29.9145299145299, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1789274, Length=399, Percent_Identity=34.5864661654135, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789273, Length=396, Percent_Identity=31.0606060606061, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1786883, Length=396, Percent_Identity=31.8181818181818, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321694, Length=148, Percent_Identity=34.4594594594595, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920760, Length=436, Percent_Identity=25.4587155963303, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 41798; Mature: 41667

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHASSPLPTDYDLAIVGAGPVGLALAGWLARRSATQHASIALIDAREPSASANDPRAIA
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEE
VSHGSRVLLDTLAWPADATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVVRYGSLVQAL
EECCCEEEEHHHCCCCCCCCHHEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
AGAVRGSRVDWLTSTTARAPLQDADGVALTLDGPHGERVLRARIVVNAEGGLFHEQQADA
HHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHC
GKHRRDYGQTAIVGTVTVSSPRPNVAWERFTHEGPLALLPLGGPRQADYALVWCCAPDEA
HHHHHHCCCEEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCHH
ARRAALPDDAFLRELGTAFGERMGSFVAIAGRASFPLGLNAAQTLVKGRIAIVGNAAQTL
HHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCEEEEECCHHHH
HPVAGQGLNLGLRDAHTLVDVLSTQGFDATALATFNARRALDRRLTIGATDTLARLFTID
CHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCEEEECCHHHHHHHEEEC
AGPLPLLRGAALTALEFVPPLKKAIARQMMFGQRG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THASSPLPTDYDLAIVGAGPVGLALAGWLARRSATQHASIALIDAREPSASANDPRAIA
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEE
VSHGSRVLLDTLAWPADATPIEHIHVSQRGHFGRTLIERDEHDLAALGYVVRYGSLVQAL
EECCCEEEEHHHCCCCCCCCHHEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
AGAVRGSRVDWLTSTTARAPLQDADGVALTLDGPHGERVLRARIVVNAEGGLFHEQQADA
HHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHC
GKHRRDYGQTAIVGTVTVSSPRPNVAWERFTHEGPLALLPLGGPRQADYALVWCCAPDEA
HHHHHHCCCEEEEEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCHH
ARRAALPDDAFLRELGTAFGERMGSFVAIAGRASFPLGLNAAQTLVKGRIAIVGNAAQTL
HHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCEEEEECCHHHH
HPVAGQGLNLGLRDAHTLVDVLSTQGFDATALATFNARRALDRRLTIGATDTLARLFTID
CHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCEEEECCHHHHHHHEEEC
AGPLPLLRGAALTALEFVPPLKKAIARQMMFGQRG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]