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The map label for this gene is pepP [H]

Identifier: 161525858

GI number: 161525858

Start: 2936671

End: 2938056

Strand: Direct

Name: pepP [H]

Synonym: Bmul_2689

Alternate gene names: 161525858

Gene position: 2936671-2938056 (Clockwise)

Preceding gene: 161525856

Following gene: 161525859

Centisome position: 85.16

GC content: 71.07

Gene sequence:

>1386_bases
ATGAATCCGCCCCTCGATACCGCCATTGCCGTCGACGTCTACCGCCAGCGCCGCGAACGCGTGCTTGCCGCACTGCGCGC
CGCGGGCGGCGGCGTCGCCATCGTGCCCACCGCGCCGGAAGTGCTGCGCAACCGCGATACGGGCTATCCGTACCGGCACG
ACAGCTACTTCTATTACCTGACCGGCTTCACCGAGCCCGACGCGGTGCTCGTGCTGAACGCGGCCGCGCCGCACGGCGCG
CCCGAGTCGATCCTGTTCTGCCGCGCGAAGAACGCCGATCGCGAGATCTGGGAAGGGTTCCACTACGGGCCCGAGGCCGC
GCGCGACACGTTCGGCTTCGACGCCGCGTACGCGACCGACGTGCTCGATACCGAGATCCCGCGCCTGCTCGCCGACGCGG
GCACCGTCCACTACCGGTTCGGCGCGTCGGCCGAGTTCGACCGGCAGCTCGCGCGCTGGCTCGATGCGGTGCGCGGGCAG
GCGCGCTCGGGCGTCGCCGCGCCGGACGCGATGCGCGACCTCACGCCGCTGCTCGACGACATGCGGCTCGTGAAGGACGA
ACACGAGCTCGCGATCATGACGCGCGCCGCGCACATCTCGGCGCTCGCGCATCGGCGTGCGATGCAGGCATGCAAGCCCG
GCATCCGCGAATACGAACTCGAGGCCGAGCTGCTGTATACGTTCCGCTTGCACGGCGCGCAGGCGCCCGCCTATGGATCG
ATCGTCGCGGCCGGCGCAAACGCGTGCGTGCTGCACTACCCGGCCGGCAACGCGGTCGCGCAGGACGGCGATCTGATCCT
GATCGACGCCGCGTGCGAACTCGACGGCTACGCCTCCGACATCACGCGCACGTTCCCCGCGAACGGGCGCTTCTCGCCCG
CACAACGCACGCTGTACGACATCGTGCTCGCCGCGCAGCAGGCCGCGATCGACGCGACGCGCGCGGGCGTGCCGTTCGAG
GCGCCGCACGATGCGGCCGTGCGCGTGCTCGCGCAGGGCCTGCTCGACACCGGCATCATCGCGAAGACGCGCTTCTCGAA
CGTCGACGACGTGATCGCCGAGCGCGCGTACACGCGTTTCTACATGCACCGCACGGGCCACTGGCTCGGGATGGACGTGC
ACGACTGCGGCGACTACCGCGAACGGCACGCCGAGCGCGACGCCAACGGCGCGCTGCCGTGGCGCACGCTCAAGCCCGGC
ATGGCGCTGACGGTCGAACCGGGCCTCTACGTGCGCGCGGCCGACGACGTGCCGTCCGAGTACTGGAACATCGGCATCCG
CATCGAGGACGACGCGATCGTGCGCGAGCACGGCTGCGAGCTGATCACGCGCGACGTGCCCGTCGCGGCGGCCGACATCG
AGGCGCTGATGCGTGCGCGCGCGTAA

Upstream 100 bases:

>100_bases
CCGGCCTGTGGATGGTTTGCAACAATCGGCCGGCGGGCCCGGCTGCGCGGCGCTCGCGCGCACTTTCGCGCGCCGCGGCC
GGCGGCGCTACAATCGCACG

Downstream 100 bases:

>100_bases
GCCGCACGCGGGCTGCCGACCGTTATTTCCGTTTCACGAATTCCGATGACCCACGCTTCCTCCCCGCTTCCGACCGACTA
CGACCTCGCGATCGTCGGCG

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNPPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVLRNRDTGYPYRHDSYFYYLTGFTEPDAVLVLNAAAPHGA
PESILFCRAKNADREIWEGFHYGPEAARDTFGFDAAYATDVLDTEIPRLLADAGTVHYRFGASAEFDRQLARWLDAVRGQ
ARSGVAAPDAMRDLTPLLDDMRLVKDEHELAIMTRAAHISALAHRRAMQACKPGIREYELEAELLYTFRLHGAQAPAYGS
IVAAGANACVLHYPAGNAVAQDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIAKTRFSNVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERHAERDANGALPWRTLKPG
MALTVEPGLYVRAADDVPSEYWNIGIRIEDDAIVREHGCELITRDVPVAAADIEALMRARA

Sequences:

>Translated_461_residues
MNPPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVLRNRDTGYPYRHDSYFYYLTGFTEPDAVLVLNAAAPHGA
PESILFCRAKNADREIWEGFHYGPEAARDTFGFDAAYATDVLDTEIPRLLADAGTVHYRFGASAEFDRQLARWLDAVRGQ
ARSGVAAPDAMRDLTPLLDDMRLVKDEHELAIMTRAAHISALAHRRAMQACKPGIREYELEAELLYTFRLHGAQAPAYGS
IVAAGANACVLHYPAGNAVAQDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIAKTRFSNVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERHAERDANGALPWRTLKPG
MALTVEPGLYVRAADDVPSEYWNIGIRIEDDAIVREHGCELITRDVPVAAADIEALMRARA
>Mature_461_residues
MNPPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVLRNRDTGYPYRHDSYFYYLTGFTEPDAVLVLNAAAPHGA
PESILFCRAKNADREIWEGFHYGPEAARDTFGFDAAYATDVLDTEIPRLLADAGTVHYRFGASAEFDRQLARWLDAVRGQ
ARSGVAAPDAMRDLTPLLDDMRLVKDEHELAIMTRAAHISALAHRRAMQACKPGIREYELEAELLYTFRLHGAQAPAYGS
IVAAGANACVLHYPAGNAVAQDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIAKTRFSNVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERHAERDANGALPWRTLKPG
MALTVEPGLYVRAADDVPSEYWNIGIRIEDDAIVREHGCELITRDVPVAAADIEALMRARA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=454, Percent_Identity=30.3964757709251, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI149589008, Length=484, Percent_Identity=30.1652892561983, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI260593665, Length=309, Percent_Identity=35.9223300970874, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI260593663, Length=478, Percent_Identity=27.4058577405858, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789275, Length=453, Percent_Identity=41.0596026490066, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1788728, Length=336, Percent_Identity=32.7380952380952, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790282, Length=292, Percent_Identity=31.5068493150685, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17508215, Length=488, Percent_Identity=30.1229508196721, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=378, Percent_Identity=27.2486772486773, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320922, Length=421, Percent_Identity=28.978622327791, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6321118, Length=420, Percent_Identity=28.5714285714286, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19920384, Length=402, Percent_Identity=36.0696517412935, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21357079, Length=502, Percent_Identity=29.4820717131474, Blast_Score=191, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50614; Mature: 50614

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVLRNRDTGYPYRHDSYFYYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCEECCCEEEEE
TGFTEPDAVLVLNAAAPHGAPESILFCRAKNADREIWEGFHYGPEAARDTFGFDAAYATD
ECCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHCCCCCCHHHHHHCCCCCHHHHHH
VLDTEIPRLLADAGTVHYRFGASAEFDRQLARWLDAVRGQARSGVAAPDAMRDLTPLLDD
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHH
MRLVKDEHELAIMTRAAHISALAHRRAMQACKPGIREYELEAELLYTFRLHGAQAPAYGS
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHEECHHEEEEEEEECCCCCCCCCC
IVAAGANACVLHYPAGNAVAQDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYD
EEECCCCEEEEECCCCCCEECCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
IVLAAQQAAIDATRAGVPFEAPHDAAVRVLAQGLLDTGIIAKTRFSNVDDVIAERAYTRF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHH
YMHRTGHWLGMDVHDCGDYRERHAERDANGALPWRTLKPGMALTVEPGLYVRAADDVPSE
HHHHCCCEEECCHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEECCCEEEEECCCCCCC
YWNIGIRIEDDAIVREHGCELITRDVPVAAADIEALMRARA
HHEEEEEECCCHHHHHCCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNPPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEVLRNRDTGYPYRHDSYFYYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCEECCCEEEEE
TGFTEPDAVLVLNAAAPHGAPESILFCRAKNADREIWEGFHYGPEAARDTFGFDAAYATD
ECCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHCCCCCCHHHHHHCCCCCHHHHHH
VLDTEIPRLLADAGTVHYRFGASAEFDRQLARWLDAVRGQARSGVAAPDAMRDLTPLLDD
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHH
MRLVKDEHELAIMTRAAHISALAHRRAMQACKPGIREYELEAELLYTFRLHGAQAPAYGS
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHEECHHEEEEEEEECCCCCCCCCC
IVAAGANACVLHYPAGNAVAQDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYD
EEECCCCEEEEECCCCCCEECCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
IVLAAQQAAIDATRAGVPFEAPHDAAVRVLAQGLLDTGIIAKTRFSNVDDVIAERAYTRF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHH
YMHRTGHWLGMDVHDCGDYRERHAERDANGALPWRTLKPGMALTVEPGLYVRAADDVPSE
HHHHCCCEEECCHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEECCCEEEEECCCCCCC
YWNIGIRIEDDAIVREHGCELITRDVPVAAADIEALMRARA
HHEEEEEECCCHHHHHCCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]