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The map label for this gene is 161525731

Identifier: 161525731

GI number: 161525731

Start: 2789435

End: 2790739

Strand: Reverse

Name: 161525731

Synonym: Bmul_2562

Alternate gene names: NA

Gene position: 2790739-2789435 (Counterclockwise)

Preceding gene: 161525732

Following gene: 161525725

Centisome position: 80.93

GC content: 67.66

Gene sequence:

>1305_bases
ATGAGCGATACCCAAGACTGGCGCGCGACGCTCGACCCGGCCCGCAAGAGCTGGGTCGAGACGGCGAACGATCCCGCCTG
CGATTTTCCGATCCAGAACCTGCCGTTCGGGATCTTCAGCGATGCGAAGCAGCCCGCGCGTCGTGCGGGCGTCGCGCTCG
GCGACCAGATCGTCGATCTCGCGGCGCTCGCGCGCGCGGGCCTGCTGACGCTGCCGGGCGGCGCGGACGTGTTCGCCGCA
TCGACGCTGAACGCCTTCATCGCGCTCGGTCGCGATGCGTGGCGCAGCGTGCGCGTGCAGCTGTCCGAGCTGTTCTCGCG
CGACAACGCGCGGCTGCGCGACGATGCGGCGCTACGCGCGCAGGTGCTGGTGGCGCAGCGCGACGCGACGCTGCATCTGC
CCGTCGACATTCCCGGCTACACCGATTTCTATTCGTCGAAGGAGCATGCGACGAACGTCGGCTCGATGTTCCGCGATCCG
AAGAATGCGCTGCTGCCGAACTGGTCGGAGATGCCGATCGGCTACAACGGGCGCGCGTCGTCGGTGGTCGTCAGCGGGAC
GCCGGTGCGGCGCCCGAACGGGCAGCTGAAGCTGCCCGATCTCGAGCGCCCGGTGTTCGGCGCGTGCCGCAAGCTCGACA
TCGAGCTCGAGACGGGCTTCATCGTCGGCAAGGGCAATGCGCTCGGCGAGCCGATCGCATGCGAGGACGCGGAAGCGCAC
ATCTTCGGCATGGTGCTGCTGAACGACTGGAGCGCGCGCGACATCCAGCAATGGGAATACGTGCCGCTCGGCCCGTTCAA
CTCGAAGTCGTTCGCGACGACGATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAGCCGTTCCGCACGGCGCAGCCGG
AGCAGACGCCGCCGCCGCTCGCGTATCTGCAGCATGCGGGCCGGCACGCATTCGACATCGCGCTCGAAGTGACGCTGCGC
GCGCAGGACGCGGCCGAAGCGACGACGATCTCCCGTACCAACTTCAAGTACATGTACTGGTCGATGGCGCAGCAGCTCGC
GCATCACACGGTGTCGGGCTGCAATACGCGGGTCGGCGACCTGATGGGTTCGGGCACGATCAGCGGGCCGACGAAGGATT
CGTTCGGCAGCTTGCTCGAGCTCACGTGGAACGGCAAGGAGCCCGTTGCACTGAACGGCGGCGGCACGCGTACGTTCATC
GAGGACGGCGACGAGCTGACGCTCGCCGGCTGGTGCCAGGGCGACGGCTATCGTGTCGGCTTCGGCACTTGCGTCGGCAA
GATCCTGCCTGCATTGCAAGCGTGA

Upstream 100 bases:

>100_bases
TGATCCGGCCGACGCGCTACGCGCTCGACACCGCGCAGCTGCAGGCCAACTACTTCGAATGCTGGCAAGGCATCAGGAAA
CACTTCAATCCGGAGCAACG

Downstream 100 bases:

>100_bases
CGCATCGCGCGTGACGCGCCGGTTCCGGACGGCCCGCTTCGCGCGGGCCGTCGTCGTTTCGGCCGTGCCACGCGTGCCAT
GTGAGCGCGGACCTCAGACG

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSDTQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQPARRAGVALGDQIVDLAALARAGLLTLPGGADVFAA
STLNAFIALGRDAWRSVRVQLSELFSRDNARLRDDAALRAQVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDLERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNSKSFATTISPWIVTLDALEPFRTAQPEQTPPPLAYLQHAGRHAFDIALEVTLR
AQDAAEATTISRTNFKYMYWSMAQQLAHHTVSGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGTRTFI
EDGDELTLAGWCQGDGYRVGFGTCVGKILPALQA

Sequences:

>Translated_434_residues
MSDTQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQPARRAGVALGDQIVDLAALARAGLLTLPGGADVFAA
STLNAFIALGRDAWRSVRVQLSELFSRDNARLRDDAALRAQVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDLERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNSKSFATTISPWIVTLDALEPFRTAQPEQTPPPLAYLQHAGRHAFDIALEVTLR
AQDAAEATTISRTNFKYMYWSMAQQLAHHTVSGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGTRTFI
EDGDELTLAGWCQGDGYRVGFGTCVGKILPALQA
>Mature_433_residues
SDTQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQPARRAGVALGDQIVDLAALARAGLLTLPGGADVFAAS
TLNAFIALGRDAWRSVRVQLSELFSRDNARLRDDAALRAQVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPK
NALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDLERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAHI
FGMVLLNDWSARDIQQWEYVPLGPFNSKSFATTISPWIVTLDALEPFRTAQPEQTPPPLAYLQHAGRHAFDIALEVTLRA
QDAAEATTISRTNFKYMYWSMAQQLAHHTVSGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGTRTFIE
DGDELTLAGWCQGDGYRVGFGTCVGKILPALQA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=419, Percent_Identity=58.2338902147971, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17568863, Length=418, Percent_Identity=54.5454545454545, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24657182, Length=406, Percent_Identity=52.4630541871921, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47119; Mature: 46987

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQPARRAGVALGDQIVDL
CCCCCCHHHHCCHHHHHHHHCCCCCCCCCCHHHCCCCHHHCCHHHHHHHCCHHHHHHHHH
AALARAGLLTLPGGADVFAASTLNAFIALGRDAWRSVRVQLSELFSRDNARLRDDAALRA
HHHHHCCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHE
QVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
SVVVSGTPVRRPNGQLKLPDLERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHHHEEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNSKSFATTISPWIVTLDALEPFRTAQPEQTPPPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCHHCCCCCCCCCCH
AYLQHAGRHAFDIALEVTLRAQDAAEATTISRTNFKYMYWSMAQQLAHHTVSGCNTRVGD
HHHHHCCCCEEEEEEEEEEECCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGTRTFIEDGDELTLAGWCQGDGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCEEEECCCCEEEEEEEECCCCEEEE
FGTCVGKILPALQA
HHHHHHHHHHHHCC
>Mature Secondary Structure 
SDTQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQPARRAGVALGDQIVDL
CCCCCHHHHCCHHHHHHHHCCCCCCCCCCHHHCCCCHHHCCHHHHHHHCCHHHHHHHHH
AALARAGLLTLPGGADVFAASTLNAFIALGRDAWRSVRVQLSELFSRDNARLRDDAALRA
HHHHHCCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHE
QVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
SVVVSGTPVRRPNGQLKLPDLERPVFGACRKLDIELETGFIVGKGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHHHEEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNSKSFATTISPWIVTLDALEPFRTAQPEQTPPPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCHHCCCCCCCCCCH
AYLQHAGRHAFDIALEVTLRAQDAAEATTISRTNFKYMYWSMAQQLAHHTVSGCNTRVGD
HHHHHCCCCEEEEEEEEEEECCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGTRTFIEDGDELTLAGWCQGDGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCEEEECCCCEEEEEEEECCCCEEEE
FGTCVGKILPALQA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA