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The map label for this gene is hemN [H]

Identifier: 161525646

GI number: 161525646

Start: 2691908

End: 2693356

Strand: Direct

Name: hemN [H]

Synonym: Bmul_2477

Alternate gene names: 161525646

Gene position: 2691908-2693356 (Clockwise)

Preceding gene: 161525642

Following gene: 161525647

Centisome position: 78.06

GC content: 67.08

Gene sequence:

>1449_bases
ATGCAGCCCAATCGCGCGTTTATATACTCGAAAGCATCTAAAAAGCGCGAGACCGCCATGACTTCCGGTTCTGCCGACAC
GCTGTTCCGTCCCGACCTGCTCGCGAAATACGGCGCGAACGGGCCGCGCTACACGTCCTACCCCACCGCGCTGCAATTCC
GCGACGATTTCCCGCATAGCGACTACGTGCGCGCGGCGAGCGATCCGGGCGCGTCGTCGAGCGAGCTGTCGCTGTACTTC
CACATCCCGTTCTGCAACACGGCGTGCTTCTACTGCGGCTGCAACCGGATCGCGACGAACAACCATCGCCGCGCGCGCCC
GTATCTCGATCAGCTGAAACGTGAAATCGCGCTGCAGGCGACGCTGTTCGATCGGTCGCGCGCGGTCACGCAACTGCATT
GGGGCGGCGGCACGCCGACGTTCCTGTCAGACGACGAAACGGCCGAGCTGATGGCCGCGACGCGCGAGCACTTCCTGCTC
GCGCCCGATGCGGATGCCGAATACTCGATCGAAATCGACCCGCGCACGGTCACGCCGGCCACGCTCGTCCATCTGCGCAC
GATCGGCTTCAACCGGCTGAGCCTCGGCGTGCAGGATTTCGATCCGGAAGTGCAGTGCGCGATCAATCGTATCCAGCCGC
TCGCGCAGACGGCCGATCTGCTGCGCGCCGCGCGCACGACGGGCTTCCACTCGACCAGCGTCGACCTGATCTACGGGCTG
CCGCACCAGACGGTCGCCACGTTCGCGCGCACGCTCGAGACGATCATCGAGCTCGCGCCCGACCGCCTGTCGGTGTTCGG
CTACGCGCACATGCCGCACCTGTTCAAGATGCAGCGCCGGATCGACGATGCGACGCTGCCGCCGCCCGAAACGCGCATCG
CGCTGCTCGGTCTCGCGATCGACATGCTGACGTCGGCGGGCTACGTCTACATCGGGATGGACCACTTCGCACGGCCCTCG
GACGAACTCGTGCGCGCGCAGCGCAACGGCACGCTGCAGCGCAATTTCCAGGGCTACAGTACGCGCGCCGATACGGACCT
GATCGGGATCGGCGTGTCGTCGATCGGCAAGGTCGGCGACGTCTACGCGCAGAACGCGAAGGATCTGCCGGCCTACGGCG
CGGCGCTCGACGCCGGACGCCTGCCGATCGCGCGCGGCGTGCGCCTGACCGCCGACGACCGCCTGCGCCGCGACGTGATC
GCTCAGCTGATGTGCAATCTCGAGCTGCCGTTCTCGCCGATCGAAGCCGCGCACGGCATCCGCTTCGCCGATCGTTTCGC
GCGCGAGCTCGACGCACTGCGCCCGTTCGAGCGCGACGGGCTGCTGACGATCGCCGCCGATCGGCTGACGATCCATTCGC
CGGGCCGGATGGTCGTGCGCAACATCGCGATGGCATTCGACGCGTATCTCGGCCGCACGCCGGCGCAGCGCTACTCGCGC
ACGGTCTGA

Upstream 100 bases:

>100_bases
GGCTCTCCGGCAAACAACAAAAAAATCGGTGCGGCAACCGGACGCGTCGTCCGATCGTGCAGCCCGCATTGTGCCACCGC
CGCTGCGACGTTATTACACA

Downstream 100 bases:

>100_bases
GCGGCCGCGCACTACAGGCAGCCGGCGCGCGGGCGGCCGGTTTGATAAAGTACGGAGCTTACGCCCCGCCAGACTCCGCA
CGATGCGCACCACCAAAGCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MQPNRAFIYSKASKKRETAMTSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFPHSDYVRAASDPGASSSELSLYF
HIPFCNTACFYCGCNRIATNNHRRARPYLDQLKREIALQATLFDRSRAVTQLHWGGGTPTFLSDDETAELMAATREHFLL
APDADAEYSIEIDPRTVTPATLVHLRTIGFNRLSLGVQDFDPEVQCAINRIQPLAQTADLLRAARTTGFHSTSVDLIYGL
PHQTVATFARTLETIIELAPDRLSVFGYAHMPHLFKMQRRIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPS
DELVRAQRNGTLQRNFQGYSTRADTDLIGIGVSSIGKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTADDRLRRDVI
AQLMCNLELPFSPIEAAHGIRFADRFARELDALRPFERDGLLTIAADRLTIHSPGRMVVRNIAMAFDAYLGRTPAQRYSR
TV

Sequences:

>Translated_482_residues
MQPNRAFIYSKASKKRETAMTSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFPHSDYVRAASDPGASSSELSLYF
HIPFCNTACFYCGCNRIATNNHRRARPYLDQLKREIALQATLFDRSRAVTQLHWGGGTPTFLSDDETAELMAATREHFLL
APDADAEYSIEIDPRTVTPATLVHLRTIGFNRLSLGVQDFDPEVQCAINRIQPLAQTADLLRAARTTGFHSTSVDLIYGL
PHQTVATFARTLETIIELAPDRLSVFGYAHMPHLFKMQRRIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPS
DELVRAQRNGTLQRNFQGYSTRADTDLIGIGVSSIGKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTADDRLRRDVI
AQLMCNLELPFSPIEAAHGIRFADRFARELDALRPFERDGLLTIAADRLTIHSPGRMVVRNIAMAFDAYLGRTPAQRYSR
TV
>Mature_482_residues
MQPNRAFIYSKASKKRETAMTSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFPHSDYVRAASDPGASSSELSLYF
HIPFCNTACFYCGCNRIATNNHRRARPYLDQLKREIALQATLFDRSRAVTQLHWGGGTPTFLSDDETAELMAATREHFLL
APDADAEYSIEIDPRTVTPATLVHLRTIGFNRLSLGVQDFDPEVQCAINRIQPLAQTADLLRAARTTGFHSTSVDLIYGL
PHQTVATFARTLETIIELAPDRLSVFGYAHMPHLFKMQRRIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPS
DELVRAQRNGTLQRNFQGYSTRADTDLIGIGVSSIGKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTADDRLRRDVI
AQLMCNLELPFSPIEAAHGIRFADRFARELDALRPFERDGLLTIAADRLTIHSPGRMVVRNIAMAFDAYLGRTPAQRYSR
TV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=24.9056603773585, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082341, Length=451, Percent_Identity=50.3325942350333, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1789325, Length=283, Percent_Identity=30.3886925795053, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 53561; Mature: 53561

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPNRAFIYSKASKKRETAMTSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFPHS
CCCCCEEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCCCC
DYVRAASDPGASSSELSLYFHIPFCNTACFYCGCNRIATNNHRRARPYLDQLKREIALQA
CCEECCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TLFDRSRAVTQLHWGGGTPTFLSDDETAELMAATREHFLLAPDADAEYSIEIDPRTVTPA
HHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHH
TLVHLRTIGFNRLSLGVQDFDPEVQCAINRIQPLAQTADLLRAARTTGFHSTSVDLIYGL
HHHHHHHCCCCCEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
PHQTVATFARTLETIIELAPDRLSVFGYAHMPHLFKMQRRIDDATLPPPETRIALLGLAI
CHHHHHHHHHHHHHHHHHCCCHHEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
DMLTSAGYVYIGMDHFARPSDELVRAQRNGTLQRNFQGYSTRADTDLIGIGVSSIGKVGD
HHHHCCCEEEEEHHHHCCCHHHHHHHHHCCCEEECCCCCCCCCCCCEEEECHHHHHHHHH
VYAQNAKDLPAYGAALDAGRLPIARGVRLTADDRLRRDVIAQLMCNLELPFSPIEAAHGI
HHHCCCCCCCCCCCCCCCCCCCHHCCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
RFADRFARELDALRPFERDGLLTIAADRLTIHSPGRMVVRNIAMAFDAYLGRTPAQRYSR
HHHHHHHHHHHHHCCCCCCCEEEEEECEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHCC
TV
CC
>Mature Secondary Structure
MQPNRAFIYSKASKKRETAMTSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFPHS
CCCCCEEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCCCC
DYVRAASDPGASSSELSLYFHIPFCNTACFYCGCNRIATNNHRRARPYLDQLKREIALQA
CCEECCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TLFDRSRAVTQLHWGGGTPTFLSDDETAELMAATREHFLLAPDADAEYSIEIDPRTVTPA
HHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHH
TLVHLRTIGFNRLSLGVQDFDPEVQCAINRIQPLAQTADLLRAARTTGFHSTSVDLIYGL
HHHHHHHCCCCCEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
PHQTVATFARTLETIIELAPDRLSVFGYAHMPHLFKMQRRIDDATLPPPETRIALLGLAI
CHHHHHHHHHHHHHHHHHCCCHHEEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
DMLTSAGYVYIGMDHFARPSDELVRAQRNGTLQRNFQGYSTRADTDLIGIGVSSIGKVGD
HHHHCCCEEEEEHHHHCCCHHHHHHHHHCCCEEECCCCCCCCCCCCEEEECHHHHHHHHH
VYAQNAKDLPAYGAALDAGRLPIARGVRLTADDRLRRDVIAQLMCNLELPFSPIEAAHGI
HHHCCCCCCCCCCCCCCCCCCCHHCCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
RFADRFARELDALRPFERDGLLTIAADRLTIHSPGRMVVRNIAMAFDAYLGRTPAQRYSR
HHHHHHHHHHHHHCCCCCCCEEEEEECEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHCC
TV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]