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The map label for this gene is cobB [H]

Identifier: 161525622

GI number: 161525622

Start: 2666661

End: 2667533

Strand: Reverse

Name: cobB [H]

Synonym: Bmul_2452

Alternate gene names: 161525622

Gene position: 2667533-2666661 (Counterclockwise)

Preceding gene: 161525625

Following gene: 161525621

Centisome position: 77.35

GC content: 71.48

Gene sequence:

>873_bases
ATGTCCGCTTCCGATTCGACCGATTCCGCCGATGCCTCCGGCGCCGCGCCGCTGTCCGCCGATCTCGTCGCAGCCGCCGT
GGCGGCGCTGTCGCGCGCCGACGCATTGCTCGTGACGGCCGGCGCCGGCATCGGCGTCGACTCGGGGCTGCCCGACTTTC
GCGGCACCGACGGCTTCTGGCGCGCGTATCCGGCGCTGCGCCACGAGCGCTTCGAATTCCACGAGATCGCGTCGCCGCAG
GCGTTCCGCGCGCGGCCGCAGCTCGCCTGGGGCTTCTATGGCCATCGTCTCGCGCTGTACCGGTCGACGGTCCCGCACGC
GGGCTTCGCGATCCTGCGCCGCTGGATCGACGCGATGCCGAACGGCGGCTTCGTGCTGACGAGCAACGTCGACGGACAGT
TTCAGAAGGCCGGCTTCGATCCGGCGCGCATCGTCGAGATTCACGGGTCGATCCATGCGCTGCAGTGTCTGCGGCCGTGC
TCGGACGACACATGGGACGCCGCGCCTTTCATCCCGACCGTCGACGAAGCCGCATGCCGGCTCGTCGGCGAGCCCCCGCG
CTGCCCGCATTGCGGCGGCCTCGCGCGGCCGAACATCCTGATGTTCGGCGACGCGGGCTGGCTCGGTGCACGCTACGCCG
AGCAGGAGCGTGCGCTGCAGCAATGGATCGCGCAGGCGGGGCGCGTCGCCGTCGTCGAGATCGGCGCGGGCACCGCGATT
CCGACGGTGCGCATGCTGAGCGAGCAACTCGGCGCCGACGTGATCCGCATCAATGCGCGCGAAGCGCATGCGCGGCGCGC
GGACGTGATCGGCCTGAAAGGCGGCGCGCTCGCGACGCTGAACGCGCTCGACGCGGCGTGGCAGCACGCATAG

Upstream 100 bases:

>100_bases
CGGCATACGCGTCATCGTGCGTCGCGGCGTCCGAACCGGCGTATGATCGCGACGCCGCTCGCGCAACGTCCTTCGTTCGT
CCACCGCTTCATTCATCATC

Downstream 100 bases:

>100_bases
GCACGATCGCCGATCGCCGATCGCCGGTTGCTGCCACGCGACGAATCCGCCTACAGTGCTGGCAATGCCGCGGATGCGCG
CGCCGCGCGGATCCGTGCCG

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSASDSTDSADASGAAPLSADLVAAAVAALSRADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPQ
AFRARPQLAWGFYGHRLALYRSTVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHALQCLRPC
SDDTWDAAPFIPTVDEAACRLVGEPPRCPHCGGLARPNILMFGDAGWLGARYAEQERALQQWIAQAGRVAVVEIGAGTAI
PTVRMLSEQLGADVIRINAREAHARRADVIGLKGGALATLNALDAAWQHA

Sequences:

>Translated_290_residues
MSASDSTDSADASGAAPLSADLVAAAVAALSRADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPQ
AFRARPQLAWGFYGHRLALYRSTVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHALQCLRPC
SDDTWDAAPFIPTVDEAACRLVGEPPRCPHCGGLARPNILMFGDAGWLGARYAEQERALQQWIAQAGRVAVVEIGAGTAI
PTVRMLSEQLGADVIRINAREAHARRADVIGLKGGALATLNALDAAWQHA
>Mature_289_residues
SASDSTDSADASGAAPLSADLVAAAVAALSRADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPQA
FRARPQLAWGFYGHRLALYRSTVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHALQCLRPCS
DDTWDAAPFIPTVDEAACRLVGEPPRCPHCGGLARPNILMFGDAGWLGARYAEQERALQQWIAQAGRVAVVEIGAGTAIP
TVRMLSEQLGADVIRINAREAHARRADVIGLKGGALATLNALDAAWQHA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=178, Percent_Identity=29.7752808988764, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI13787215, Length=189, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI6912664, Length=189, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI308199517, Length=173, Percent_Identity=27.1676300578035, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30868; Mature: 30737

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDSTDSADASGAAPLSADLVAAAVAALSRADALLVTAGAGIGVDSGLPDFRGTDGFW
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHH
RAYPALRHERFEFHEIASPQAFRARPQLAWGFYGHRLALYRSTVPHAGFAILRRWIDAMP
HHHHHHHHHCCHHHHCCCCHHHHCCCCEEECHHHHEEEEHHCCCCHHHHHHHHHHHHHCC
NGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHALQCLRPCSDDTWDAAPFIPTVDEAACR
CCCEEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
LVGEPPRCPHCGGLARPNILMFGDAGWLGARYAEQERALQQWIAQAGRVAVVEIGAGTAI
HCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCH
PTVRMLSEQLGADVIRINAREAHARRADVIGLKGGALATLNALDAAWQHA
HHHHHHHHHHCCCEEEEECHHHHHHHHCEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SASDSTDSADASGAAPLSADLVAAAVAALSRADALLVTAGAGIGVDSGLPDFRGTDGFW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHH
RAYPALRHERFEFHEIASPQAFRARPQLAWGFYGHRLALYRSTVPHAGFAILRRWIDAMP
HHHHHHHHHCCHHHHCCCCHHHHCCCCEEECHHHHEEEEHHCCCCHHHHHHHHHHHHHCC
NGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHALQCLRPCSDDTWDAAPFIPTVDEAACR
CCCEEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
LVGEPPRCPHCGGLARPNILMFGDAGWLGARYAEQERALQQWIAQAGRVAVVEIGAGTAI
HCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCH
PTVRMLSEQLGADVIRINAREAHARRADVIGLKGGALATLNALDAAWQHA
HHHHHHHHHHCCCEEEEECHHHHHHHHCEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]