Click here to switch to the map view.

The map label for this gene is pgi [H]

Identifier: 161524530

GI number: 161524530

Start: 1494265

End: 1495887

Strand: Reverse

Name: pgi [H]

Synonym: Bmul_1357

Alternate gene names: 161524530

Gene position: 1495887-1494265 (Counterclockwise)

Preceding gene: 161524531

Following gene: 161524528

Centisome position: 43.38

GC content: 67.34

Gene sequence:

>1623_bases
ATGACGCTGAATTCGCTCCCCGCCTGGACTGCCCTTCAATCCCACTTCGAACAGATCCGTCACGCGCGTCTGCGCGACTG
GTTTGCGCCGCAGAACGACCCCGCGCCGACGCGCGCCGAGCGCTTCACGTTCTCGGGCGGCGGTCTCGCGGCCGACTTCT
CGAAGAACCGCATCACCGACGAAACGCTGCGCCTGCTCGTGCAGCTCGCGCGCGAGGCGCGCGTCGAAGCGCGTCGCGAC
GCGATGTTCGCCGGCGAAATCGTGAACCCGACCGAAGGCCGCGCGGCGCTGCACACCGCGCTGCGCGCGACCGATCCGCA
CGCGCCGTTCCATGCGCAGGTGAGCGCCGAGCGCGCGAAGATGGCGACGTTCGCGCGCGCGGTGCGCAACGGCACGTGGA
CGGGCCACACGGGCAAGCGGATCCGCCATGTGATCAACATCGGCATCGGCGGCTCCGACCTCGGGCCGAAGATGGTCACG
CACGCGCTGCGCCACGTCGCGACGCGCGACATCTCGATGCATTTCGTGTCGAACGTCGACGGCGCCGATCTCGCGCGCGT
GCTCGAGCAGGTCGATCCGGAAGAAACGCTCGCGATCGTCGTGTCGAAGACGTTCACGACGCTCGAGACGATGACGAACG
CACGCTCGCTGCGCGACTGGTTCGTCGCGAAGGGCTGCCCCGAGGATGCGCTCGCGAAGCACTTCGTCGGCGTTTCGGCG
AATCCGGCCGAGGTCGTGAAATTCGGCATTGCCGCCGACAACGTGTTCGAAATGTGGGACTGGGTCGGCGGCCGCTACTC
GCTGTGGTCGGCGGTCGGCCTGTCGATCATGATCGCGATCGGGCCCGAGCAGTTCGACGAACTGCTCGCCGGCGCGAACG
ACATGGACCGCCATTTCCGCGAAGCGCCGCTCGAACGCAACCTGCCGGTGCTGCTCGGCTTGATCGGCATCTGGTATCGG
AACTTCTTCGGCTCGCAGAGCTATCTCGTCGCGCCGTATTCCGAAGCGCTGCACTATCTGCCGTCGTATCTGCAGCAGCT
CGAGATGGAAAGCAACGGCAAGTCGGCGCGCCTCGACGGCCGCTTCGTCGACTATCCGACCGCCGCCGTCACGTGGGGCG
AACCGGGCACGAACGGTCAGCACGCGTTCTTCCAGATGCTGCATCAGGGGCCGACGATCGTACCGATCGACTTCATCGCG
GTGCTGACGCCCGAGCATCCGCTCGCGAGCCATCATCCGAAGCTGCTCGCGAACTGCTTCGCGCAGAGCGAGGCGCTGAT
GCTCGGCCGCACGCTCGAGGAAGCGCGCAAGGTCGCCGGCCCCGGCAAGGAAGATCTCGCGCCGCACCTGACCTTCCCCG
GCAACCGCCCGACGACGACGCTGCTCGTCGACGCGCTGACGCCGCGCTCGCTCGGCGCGCTGATCGCGCTCTACGAACAC
AAGGTGCTCGTGCAGGCGACCGTGTGGGACATCAATCCGTTCGATCAGTGGGGCGTCGAGCTCGGCAAGATTCTCGGCAA
GGTCGTCGAGGCCGATCTGGCGGCCGACGCGCTCGATACGGCGAAGCACGATTCGTCGACGACCGCGCTGATCGCGCGCG
CACGCGCGGCGCTCAAGCGCTGA

Upstream 100 bases:

>100_bases
ACTGACTGCCCCGCCGCACGGCGGGCCCTCGTCCGCCGGCCGTCCGATCCCGACGCGCCGGCGCGGCATTCCTCCCGATT
CACGCTTCACACGAACCGCC

Downstream 100 bases:

>100_bases
CGCGCGCCGCACCGGCCGCGTGCGGACGCTGTCGCACGCGGCCGGGCGATCGAGCCGTCGCGCGCGGCGCCGCGTCATGC
GGCGCCATGCGGCGTGATGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTLNSLPAWTALQSHFEQIRHARLRDWFAPQNDPAPTRAERFTFSGGGLAADFSKNRITDETLRLLVQLAREARVEARRD
AMFAGEIVNPTEGRAALHTALRATDPHAPFHAQVSAERAKMATFARAVRNGTWTGHTGKRIRHVINIGIGGSDLGPKMVT
HALRHVATRDISMHFVSNVDGADLARVLEQVDPEETLAIVVSKTFTTLETMTNARSLRDWFVAKGCPEDALAKHFVGVSA
NPAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFREAPLERNLPVLLGLIGIWYR
NFFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDGRFVDYPTAAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIA
VLTPEHPLASHHPKLLANCFAQSEALMLGRTLEEARKVAGPGKEDLAPHLTFPGNRPTTTLLVDALTPRSLGALIALYEH
KVLVQATVWDINPFDQWGVELGKILGKVVEADLAADALDTAKHDSSTTALIARARAALKR

Sequences:

>Translated_540_residues
MTLNSLPAWTALQSHFEQIRHARLRDWFAPQNDPAPTRAERFTFSGGGLAADFSKNRITDETLRLLVQLAREARVEARRD
AMFAGEIVNPTEGRAALHTALRATDPHAPFHAQVSAERAKMATFARAVRNGTWTGHTGKRIRHVINIGIGGSDLGPKMVT
HALRHVATRDISMHFVSNVDGADLARVLEQVDPEETLAIVVSKTFTTLETMTNARSLRDWFVAKGCPEDALAKHFVGVSA
NPAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFREAPLERNLPVLLGLIGIWYR
NFFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDGRFVDYPTAAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIA
VLTPEHPLASHHPKLLANCFAQSEALMLGRTLEEARKVAGPGKEDLAPHLTFPGNRPTTTLLVDALTPRSLGALIALYEH
KVLVQATVWDINPFDQWGVELGKILGKVVEADLAADALDTAKHDSSTTALIARARAALKR
>Mature_539_residues
TLNSLPAWTALQSHFEQIRHARLRDWFAPQNDPAPTRAERFTFSGGGLAADFSKNRITDETLRLLVQLAREARVEARRDA
MFAGEIVNPTEGRAALHTALRATDPHAPFHAQVSAERAKMATFARAVRNGTWTGHTGKRIRHVINIGIGGSDLGPKMVTH
ALRHVATRDISMHFVSNVDGADLARVLEQVDPEETLAIVVSKTFTTLETMTNARSLRDWFVAKGCPEDALAKHFVGVSAN
PAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFREAPLERNLPVLLGLIGIWYRN
FFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDGRFVDYPTAAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIAV
LTPEHPLASHHPKLLANCFAQSEALMLGRTLEEARKVAGPGKEDLAPHLTFPGNRPTTTLLVDALTPRSLGALIALYEHK
VLVQATVWDINPFDQWGVELGKILGKVVEADLAADALDTAKHDSSTTALIARARAALKR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=541, Percent_Identity=48.6136783733826, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI296080693, Length=541, Percent_Identity=44.916820702403, Blast_Score=457, Evalue=1e-129,
Organism=Escherichia coli, GI1790457, Length=544, Percent_Identity=50.9191176470588, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71996708, Length=551, Percent_Identity=48.0943738656987, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71996703, Length=551, Percent_Identity=48.0943738656987, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319673, Length=542, Percent_Identity=46.8634686346863, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24651916, Length=553, Percent_Identity=48.6437613019892, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651914, Length=553, Percent_Identity=48.6437613019892, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17737445, Length=553, Percent_Identity=48.6437613019892, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 59399; Mature: 59268

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNSLPAWTALQSHFEQIRHARLRDWFAPQNDPAPTRAERFTFSGGGLAADFSKNRITD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEECCCCEEECCCCCCCCH
ETLRLLVQLAREARVEARRDAMFAGEIVNPTEGRAALHTALRATDPHAPFHAQVSAERAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHH
MATFARAVRNGTWTGHTGKRIRHVINIGIGGSDLGPKMVTHALRHVATRDISMHFVSNVD
HHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GADLARVLEQVDPEETLAIVVSKTFTTLETMTNARSLRDWFVAKGCPEDALAKHFVGVSA
HHHHHHHHHHCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
NPAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFR
CHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHH
EAPLERNLPVLLGLIGIWYRNFFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDG
HCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEECC
RFVDYPTAAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIAVLTPEHPLASHHPKLLANCF
EEEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHH
AQSEALMLGRTLEEARKVAGPGKEDLAPHLTFPGNRPTTTLLVDALTPRSLGALIALYEH
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHC
KVLVQATVWDINPFDQWGVELGKILGKVVEADLAADALDTAKHDSSTTALIARARAALKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLNSLPAWTALQSHFEQIRHARLRDWFAPQNDPAPTRAERFTFSGGGLAADFSKNRITD
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEECCCCEEECCCCCCCCH
ETLRLLVQLAREARVEARRDAMFAGEIVNPTEGRAALHTALRATDPHAPFHAQVSAERAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHH
MATFARAVRNGTWTGHTGKRIRHVINIGIGGSDLGPKMVTHALRHVATRDISMHFVSNVD
HHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GADLARVLEQVDPEETLAIVVSKTFTTLETMTNARSLRDWFVAKGCPEDALAKHFVGVSA
HHHHHHHHHHCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
NPAEVVKFGIAADNVFEMWDWVGGRYSLWSAVGLSIMIAIGPEQFDELLAGANDMDRHFR
CHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHH
EAPLERNLPVLLGLIGIWYRNFFGSQSYLVAPYSEALHYLPSYLQQLEMESNGKSARLDG
HCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEECC
RFVDYPTAAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFIAVLTPEHPLASHHPKLLANCF
EEEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHH
AQSEALMLGRTLEEARKVAGPGKEDLAPHLTFPGNRPTTTLLVDALTPRSLGALIALYEH
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHC
KVLVQATVWDINPFDQWGVELGKILGKVVEADLAADALDTAKHDSSTTALIARARAALKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA