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The map label for this gene is pyrH

Identifier: 161524432

GI number: 161524432

Start: 1388603

End: 1389316

Strand: Direct

Name: pyrH

Synonym: Bmul_1259

Alternate gene names: 161524432

Gene position: 1388603-1389316 (Clockwise)

Preceding gene: 161524431

Following gene: 161524433

Centisome position: 40.27

GC content: 66.25

Gene sequence:

>714_bases
ATGTCCAATGCCTATAAACGCGTCCTCCTCAAACTCTCCGGCGAAGCGCTGATGGGCGACGATGCCTTCGGCATCAATCG
CGCGACGATCGAACGGATGGTGGCCGATATCGCCGAAGTCGTGCGTCTGGGCACGCAGCTCGCGGTCGTGATCGGCGGCG
GTAACATTTTCCGCGGTGTCGCGGGCGGCGCGGCGGGCATGGACCGCGCGACGGCCGACTACATGGGGATGCTCGCGACG
ATGATGAACGCGCTGGCGCTGCAGGATGCGATGCGTCACGCGGGCATCGAGGCGCGCGTGCAGTCCGCGCTGCGCATGGA
CCAGGTCGTCGAGCCGTACATCCGGCCGCGCGCGATCCGCCAGCTCGAGGAAGGCCGCGTCGTGATCTTCGCGGCCGGCA
CCGGCAACCCGTTCTTCACGACGGACACCGCCGCCGCGCTGCGCGGCTCGGAAGTGGGCGCCGAGGTCGTGCTGAAGGCG
ACCAAGGTCGATGGCGTATATTCTGCCGATCCGAAGAAGGATCCGTCGGCCACGCGCTATACGACGATCAGCTTCGACGA
GGCGATCAGCCGCAACCTGCAGGTGATGGACGCGACCGCGTTTGCGCTGTGCCGCGACCAGAAGCTGCCGATTCGCGTGT
TTTCGATCAACAAGCCGGGCGCGCTCAAGCGCATCGTGCTGGGCGAGGACGAGGGTACGCTCGTCCACGTGTAA

Upstream 100 bases:

>100_bases
CGGCGGCCGGGAAGCCCGGTCCGGCCGGCGGCGCTTGCCCGAATCAGTATTTCGCCCCTACAGTTCGTGGTTGTCATCCT
CTCGTCGCTCGGAAGCCCCT

Downstream 100 bases:

>100_bases
ACTCCCGCGGATGCGGGCAAGCGGCGTGGGCAACCGGCTGCGGCGCGCGCTGCGCGCGCCGGGCGGCCCGCGTTCTTTGA
AGGTTTGAAGGTTCGGAGGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLAT
MMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKA
TKVDGVYSADPKKDPSATRYTTISFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV

Sequences:

>Translated_237_residues
MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLAT
MMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKA
TKVDGVYSADPKKDPSATRYTTISFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
>Mature_236_residues
SNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKAT
KVDGVYSADPKKDPSATRYTTISFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=58.008658008658, Blast_Score=283, Evalue=8e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_BURCA (Q1BHI0)

Other databases:

- EMBL:   CP000380
- RefSeq:   YP_625898.1
- ProteinModelPortal:   Q1BHI0
- SMR:   Q1BHI0
- STRING:   Q1BHI0
- GeneID:   4097228
- GenomeReviews:   CP000380_GR
- KEGG:   bcn:Bcen_6060
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   BCEN331271:BCEN_6060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25391; Mature: 25260

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: BINDING 53-53 BINDING 54-54 BINDING 58-58 BINDING 73-73 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGV
CCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEHHC
AGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRY
HHHCCCEEEEEECCCCCCEECCHHHHHCCCCCCHHHEEEEECCCCEECCCCCCCCCCCEE
TTISFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
EEEEHHHHHHCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEC
>Mature Secondary Structure 
SNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGV
CHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEHHC
AGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRY
HHHCCCEEEEEECCCCCCEECCHHHHHCCCCCCHHHEEEEECCCCEECCCCCCCCCCCEE
TTISFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
EEEEHHHHHHCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA