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The map label for this gene is comA [H]

Identifier: 161524334

GI number: 161524334

Start: 1276747

End: 1279206

Strand: Direct

Name: comA [H]

Synonym: Bmul_1159

Alternate gene names: 161524334

Gene position: 1276747-1279206 (Clockwise)

Preceding gene: 161524333

Following gene: 161524335

Centisome position: 37.02

GC content: 74.55

Gene sequence:

>2460_bases
ATGGCGTTTGCGCTCGGCGTCGTTGTGCTGCAGCGGCAGGCGGCATTGCCCGGCGCGCGCATGTGGGCGGCCGGCGCGGC
GGTGCTGGCCGCCTGCGCGGCGCTGTACCTGGCACGTCGGCGCTGGCCGCGCTGCGCGAAGGGCGTGCCGGGATGGGCAC
TGTGTGCGGTCGCGGCGTGCGTGTCGGGGTTCGGCTACGCGGCCGCGCGCGCCGAATGGCGGCTGCGCGACGTGCTGCCG
GTCGAATGGGAGCGGCGCGACATCGTCGTGACGGGCGTGATCCGCGGGCTGCCGATCGTCGACGAAACGGGTGCGCGGCT
GCTGTTCGCGGTCGAGTCGAACGACGCGCGGCTCGCGCGGTTCCCGCCGCTGATCCGTCTGTCGTGGCGAAACGATCGCG
CGCCGGCCGCGCCCGCGGCGGTGCCCGACTTTCGCGCCGCGCAGCGCTGGCAGTTCGTCGTGCGCCTGAAGCGCCCGCAC
GCCGAGGCGAATCCCGGCGTGCGCGACACCGAGGCCGCGTGGCTCGCGGCCGGCATTCGCGCGATCGGCTACGTGAGCGC
GCCGTCGCGCGCGGTGCTGATCGATGCGCGCGCATCGGGCTGGCGTGCGTCCGTCGATCGGCTACGCGACATATTGCGTG
CACGCATCGCCGTGGCGCTCGGTGACGACGCGCGACATCGCGGCATCGTCGCCGCGCTCGCGATCGGCGATCAGTCGGCA
ATCGGCGACGACGACTGGCGCGTGCTGCGCGATACCGGCACGAGTCATCTGGTCGCGATCTCGGGGCTGCACGTCGGGCT
GGTCGGCGCATTGGCGGGCGCGCTCGCGTCGGCGGTGTGGCGTCGGTTCCACCGGCGCGGGCGGGCCGCCACGCTCGCGA
TGCCCGCGCCGTACGTCGCCGCGCTGGCGGCGCTTGCCGCGGCCGGCGGCTATGCGGCGCTGGCGGGTTTCAACGTGCCT
GCGCAACGCGCGTGGTGGATGATCGCCGCGGGCGGCGTCGCGTATCTGGCCGGCCGCAGCGTGCCGACGTCCGCGGTGCT
GTGCGCGGCGCTCGGCGGCGTGCTGCTCGCCGATCCGTGGGCCGTGCTGTCGGCCGGGTTCTGGCTGTCGTTCGGTGCGG
TCGCGGCGATCCTGCTGTCCGTGGCCGGCTGGCGCGCGGTACGCGAACACGAGGCCGACACCGATAGTGAACCGCCCGGC
GCGATGCAGCGGCTGCATGGGTGGGCGATGCGTGCGCTGCACCGCCTCGCCGACGCCGCGCGCGTGCAGTACGCGGTGAC
GATCGGCCTCGCGCCGCTGACGGCCGCATGGTTCGCGCAGATCTCGCTCTCGGGGCCGCTCGGCAATGCGTTCGCGATTC
CGTGGGTCAGTTTCGTCGTGACGCCGACCGTGCTTGCCGGCCTCGTGCTGCCCGCGCCGCTCGACGCGGCGATGCTGCGG
CTCGCGCATGCGTCGCTCGAACCGATGATGACGCTGCTGGCGCGGCTCGCCGCGTGGCCGGCCGGCGTGATGTGGCTGCG
CATGCCCGACGCGCCCGTGCTCGTGCTCGCGTGCGTCGGCGTCGTCTGGATGCTGATGCCGCGCGGCTGGCCGTTGCGCT
GGGCCGCGCCGCTCACGTGGCTGCCGCTCGTCGCGCCCGCGCCCGACGCACCGCCCGTCGGCGCGTTCCGGCTGACCGTG
CTCGACGTCGGGCAGGGCACGTCGGTGCTCGTCGAAACCGCGCGCCGCACGCTGCTGTTCGATGCGGGGCCGGGCGCCGA
ATCGACGCACGCGGGGCAGCGGATCGTCGCGCCGTCGCTGCGCGCGCGCGGCATCCGCACGCTCGATACGCTCGTGCTGA
GTCACGCGGACAGCGACCATACGGGCGGCGCGCCGGCCGTCTACGGCGCGGTCGACGTGCGGCAGCTGCTGGCCGGCATT
CCGGCCGGTCACGCGCGATGGCGCGATGCGCAGGCGGCCGGCGTGGCCGACCGCCTGCCGTGCGCGGCGGGGCAGCGCTG
GCGCTGGGACGGTGTCGATTTCACGGTGCTGTGGCCGCCGGGCGGCCCGCGTGCGGGGCCGTCGAACCGGCAGTCGTGCG
TGCTGCGCATCGACGCGGGCGCCACGTCGGCATTGCTGACCGGCGACATCGACGCGTACGCGGAGCGCCGGCTCGTCGAC
ACGATGCGCGACGCGCTGGCCGCGCAGATCCTCGTCGTTCCGCACCACGGCAGCCGGACGTCGTCGGTCGAGCCTTTCCT
CGACTCGGTCGGGCCGCGCGTCGCGGTATTTCCTGTAGGCTATCGAAACCATTTCGGGCACCCGCACCGCACGGTCGTCG
CGCGCTATGCGGCGCGCGGCATTCCGTTGCCGCGCACCGATCGCGACGGCGCGGTGCGCTTCGACGTCGGGCCGGCCGAG
CGCGGATTCGGATTCGCGCGCTACCGCGATGAGCGACGCCGGTACTGGATGGACCGCTGA

Upstream 100 bases:

>100_bases
CCTCGCGCTTTCGTCCGCATAATCGTTGCCGCAGGGCGCCGCTTGCACATGCGCAAGCGGGGCGCCGGTTCGGCAAGGAG
GCGGGATGCGCGGGTGGTGG

Downstream 100 bases:

>100_bases
CGCAGGCATGCGACGGCGCGGGGCGCGCGGCCGGCTGCGCGCGCGGCGACACAGGAGACAACGGCGTTTGAAGGACATTC
TGCATTTCTCGCATGCGAAC

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MAFALGVVVLQRQAALPGARMWAAGAAVLAACAALYLARRRWPRCAKGVPGWALCAVAACVSGFGYAAARAEWRLRDVLP
VEWERRDIVVTGVIRGLPIVDETGARLLFAVESNDARLARFPPLIRLSWRNDRAPAAPAAVPDFRAAQRWQFVVRLKRPH
AEANPGVRDTEAAWLAAGIRAIGYVSAPSRAVLIDARASGWRASVDRLRDILRARIAVALGDDARHRGIVAALAIGDQSA
IGDDDWRVLRDTGTSHLVAISGLHVGLVGALAGALASAVWRRFHRRGRAATLAMPAPYVAALAALAAAGGYAALAGFNVP
AQRAWWMIAAGGVAYLAGRSVPTSAVLCAALGGVLLADPWAVLSAGFWLSFGAVAAILLSVAGWRAVREHEADTDSEPPG
AMQRLHGWAMRALHRLADAARVQYAVTIGLAPLTAAWFAQISLSGPLGNAFAIPWVSFVVTPTVLAGLVLPAPLDAAMLR
LAHASLEPMMTLLARLAAWPAGVMWLRMPDAPVLVLACVGVVWMLMPRGWPLRWAAPLTWLPLVAPAPDAPPVGAFRLTV
LDVGQGTSVLVETARRTLLFDAGPGAESTHAGQRIVAPSLRARGIRTLDTLVLSHADSDHTGGAPAVYGAVDVRQLLAGI
PAGHARWRDAQAAGVADRLPCAAGQRWRWDGVDFTVLWPPGGPRAGPSNRQSCVLRIDAGATSALLTGDIDAYAERRLVD
TMRDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNHFGHPHRTVVARYAARGIPLPRTDRDGAVRFDVGPAE
RGFGFARYRDERRRYWMDR

Sequences:

>Translated_819_residues
MAFALGVVVLQRQAALPGARMWAAGAAVLAACAALYLARRRWPRCAKGVPGWALCAVAACVSGFGYAAARAEWRLRDVLP
VEWERRDIVVTGVIRGLPIVDETGARLLFAVESNDARLARFPPLIRLSWRNDRAPAAPAAVPDFRAAQRWQFVVRLKRPH
AEANPGVRDTEAAWLAAGIRAIGYVSAPSRAVLIDARASGWRASVDRLRDILRARIAVALGDDARHRGIVAALAIGDQSA
IGDDDWRVLRDTGTSHLVAISGLHVGLVGALAGALASAVWRRFHRRGRAATLAMPAPYVAALAALAAAGGYAALAGFNVP
AQRAWWMIAAGGVAYLAGRSVPTSAVLCAALGGVLLADPWAVLSAGFWLSFGAVAAILLSVAGWRAVREHEADTDSEPPG
AMQRLHGWAMRALHRLADAARVQYAVTIGLAPLTAAWFAQISLSGPLGNAFAIPWVSFVVTPTVLAGLVLPAPLDAAMLR
LAHASLEPMMTLLARLAAWPAGVMWLRMPDAPVLVLACVGVVWMLMPRGWPLRWAAPLTWLPLVAPAPDAPPVGAFRLTV
LDVGQGTSVLVETARRTLLFDAGPGAESTHAGQRIVAPSLRARGIRTLDTLVLSHADSDHTGGAPAVYGAVDVRQLLAGI
PAGHARWRDAQAAGVADRLPCAAGQRWRWDGVDFTVLWPPGGPRAGPSNRQSCVLRIDAGATSALLTGDIDAYAERRLVD
TMRDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNHFGHPHRTVVARYAARGIPLPRTDRDGAVRFDVGPAE
RGFGFARYRDERRRYWMDR
>Mature_818_residues
AFALGVVVLQRQAALPGARMWAAGAAVLAACAALYLARRRWPRCAKGVPGWALCAVAACVSGFGYAAARAEWRLRDVLPV
EWERRDIVVTGVIRGLPIVDETGARLLFAVESNDARLARFPPLIRLSWRNDRAPAAPAAVPDFRAAQRWQFVVRLKRPHA
EANPGVRDTEAAWLAAGIRAIGYVSAPSRAVLIDARASGWRASVDRLRDILRARIAVALGDDARHRGIVAALAIGDQSAI
GDDDWRVLRDTGTSHLVAISGLHVGLVGALAGALASAVWRRFHRRGRAATLAMPAPYVAALAALAAAGGYAALAGFNVPA
QRAWWMIAAGGVAYLAGRSVPTSAVLCAALGGVLLADPWAVLSAGFWLSFGAVAAILLSVAGWRAVREHEADTDSEPPGA
MQRLHGWAMRALHRLADAARVQYAVTIGLAPLTAAWFAQISLSGPLGNAFAIPWVSFVVTPTVLAGLVLPAPLDAAMLRL
AHASLEPMMTLLARLAAWPAGVMWLRMPDAPVLVLACVGVVWMLMPRGWPLRWAAPLTWLPLVAPAPDAPPVGAFRLTVL
DVGQGTSVLVETARRTLLFDAGPGAESTHAGQRIVAPSLRARGIRTLDTLVLSHADSDHTGGAPAVYGAVDVRQLLAGIP
AGHARWRDAQAAGVADRLPCAAGQRWRWDGVDFTVLWPPGGPRAGPSNRQSCVLRIDAGATSALLTGDIDAYAERRLVDT
MRDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNHFGHPHRTVVARYAARGIPLPRTDRDGAVRFDVGPAER
GFGFARYRDERRRYWMDR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=694, Percent_Identity=27.0893371757925, Blast_Score=199, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 87398; Mature: 87267

Theoretical pI: Translated: 11.30; Mature: 11.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFALGVVVLQRQAALPGARMWAAGAAVLAACAALYLARRRWPRCAKGVPGWALCAVAAC
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHH
VSGFGYAAARAEWRLRDVLPVEWERRDIVVTGVIRGLPIVDETGARLLFAVESNDARLAR
HHCCCHHHHHHCHHHHCCCCCCCCCCCEEEEEHHCCCCCEECCCCEEEEEEECCCCEEEC
FPPLIRLSWRNDRAPAAPAAVPDFRAAQRWQFVVRLKRPHAEANPGVRDTEAAWLAAGIR
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHH
AIGYVSAPSRAVLIDARASGWRASVDRLRDILRARIAVALGDDARHRGIVAALAIGDQSA
HHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCC
IGDDDWRVLRDTGTSHLVAISGLHVGLVGALAGALASAVWRRFHRRGRAATLAMPAPYVA
CCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHH
ALAALAAAGGYAALAGFNVPAQRAWWMIAAGGVAYLAGRSVPTSAVLCAALGGVLLADPW
HHHHHHHCCCHHEEECCCCCHHHEEEEEEECCCCEECCCCCCHHHHHHHHHCCHHHCCCH
AVLSAGFWLSFGAVAAILLSVAGWRAVREHEADTDSEPPGAMQRLHGWAMRALHRLADAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RVQYAVTIGLAPLTAAWFAQISLSGPLGNAFAIPWVSFVVTPTVLAGLVLPAPLDAAMLR
HEEEEEEECCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LAHASLEPMMTLLARLAAWPAGVMWLRMPDAPVLVLACVGVVWMLMPRGWPLRWAAPLTW
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
LPLVAPAPDAPPVGAFRLTVLDVGQGTSVLVETARRTLLFDAGPGAESTHAGQRIVAPSL
CCEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHEEEEECCCCCCCCCCCCEEECCCH
RARGIRTLDTLVLSHADSDHTGGAPAVYGAVDVRQLLAGIPAGHARWRDAQAAGVADRLP
HHCCCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHCC
CAAGQRWRWDGVDFTVLWPPGGPRAGPSNRQSCVLRIDAGATSALLTGDIDAYAERRLVD
CCCCCCEEECCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHH
TMRDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNHFGHPHRTVVARYAARG
HHHHHHHEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHCCCCCHHHHHHHHHHCC
IPLPRTDRDGAVRFDVGPAERGFGFARYRDERRRYWMDR
CCCCCCCCCCEEEEECCCCHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AFALGVVVLQRQAALPGARMWAAGAAVLAACAALYLARRRWPRCAKGVPGWALCAVAAC
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHH
VSGFGYAAARAEWRLRDVLPVEWERRDIVVTGVIRGLPIVDETGARLLFAVESNDARLAR
HHCCCHHHHHHCHHHHCCCCCCCCCCCEEEEEHHCCCCCEECCCCEEEEEEECCCCEEEC
FPPLIRLSWRNDRAPAAPAAVPDFRAAQRWQFVVRLKRPHAEANPGVRDTEAAWLAAGIR
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHH
AIGYVSAPSRAVLIDARASGWRASVDRLRDILRARIAVALGDDARHRGIVAALAIGDQSA
HHEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCC
IGDDDWRVLRDTGTSHLVAISGLHVGLVGALAGALASAVWRRFHRRGRAATLAMPAPYVA
CCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHH
ALAALAAAGGYAALAGFNVPAQRAWWMIAAGGVAYLAGRSVPTSAVLCAALGGVLLADPW
HHHHHHHCCCHHEEECCCCCHHHEEEEEEECCCCEECCCCCCHHHHHHHHHCCHHHCCCH
AVLSAGFWLSFGAVAAILLSVAGWRAVREHEADTDSEPPGAMQRLHGWAMRALHRLADAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RVQYAVTIGLAPLTAAWFAQISLSGPLGNAFAIPWVSFVVTPTVLAGLVLPAPLDAAMLR
HEEEEEEECCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LAHASLEPMMTLLARLAAWPAGVMWLRMPDAPVLVLACVGVVWMLMPRGWPLRWAAPLTW
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
LPLVAPAPDAPPVGAFRLTVLDVGQGTSVLVETARRTLLFDAGPGAESTHAGQRIVAPSL
CCEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHEEEEECCCCCCCCCCCCEEECCCH
RARGIRTLDTLVLSHADSDHTGGAPAVYGAVDVRQLLAGIPAGHARWRDAQAAGVADRLP
HHCCCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHCC
CAAGQRWRWDGVDFTVLWPPGGPRAGPSNRQSCVLRIDAGATSALLTGDIDAYAERRLVD
CCCCCCEEECCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHH
TMRDALAAQILVVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNHFGHPHRTVVARYAARG
HHHHHHHEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHCCCCCHHHHHHHHHHCC
IPLPRTDRDGAVRFDVGPAERGFGFARYRDERRRYWMDR
CCCCCCCCCCEEEEECCCCHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]