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The map label for this gene is iscS [H]

Identifier: 161524319

GI number: 161524319

Start: 1261485

End: 1262708

Strand: Direct

Name: iscS [H]

Synonym: Bmul_1144

Alternate gene names: 161524319

Gene position: 1261485-1262708 (Clockwise)

Preceding gene: 161524318

Following gene: 161524320

Centisome position: 36.58

GC content: 63.97

Gene sequence:

>1224_bases
ATGACTCAACAGACCCTCCACCTGCCCATCTACATGGATTACAGCGCCACGACGCCCGTCGATCCGCGCGTGGTCGACAA
GATGGTGCCGTACCTGCGCGAACAGTTTGGCAACCCGGCGTCGCGCAGCCACGCGTACGGCTGGGATGCCGAGCGCGCGG
TCGAGGAGGCGCGCGAGCAGGTGGCCGCGCTCGTGAACGCGGATCCGCGCGAGATCATCTGGACGTCCGGCGCCACGGAA
TCGGACAACCTCGCGATCAAGGGCGCCGCGAACTTCTACAAGGGCAAGGGCAAGCACATCATCACGGTGAAGACCGAGCA
CAAGGCCGTGCTCGACACGTGCCGCGAGCTCGAGCGTGACGGCTTCGAAGTCACGTATCTCGACGTGAAGGAAAACGGGC
TGCTCGACCTCGACGTGTTCAAGGCCGCGCTGCGCCCCGACACGATTCTCGTCTCCGTGATGCACGTGAACAACGAGATC
GGCGTGATCCAGGACATCGAGACGATCGGCGAGATCTGCCGCGAGAAGGGCATCGTGTTCCACGTCGATGCCGCACAAGC
GACCGGCAAGGTCGAGATCGACCTCGCGAAGCTGAAGGTCGATCTGATGTCGTTCTCGGCGCACAAGACGTACGGCCCGA
AGGGCATCGGCGCGCTGTACGTGCGTCGCAAGCCGCGCGTGCGCATCGAAGCGCAGATGCACGGCGGCGGCCACGAGCGC
GGCATGCGTTCGGGCACGCTGCCGACGCACCAGATCGTCGGCATGGGCGAAGCGTTCCGCATCGCGCGCGAAGAAATGGC
GACCGAGAACGAGCGCATCCGCATGCTGCGCGACAAGCTGCTGCGCGGCCTGTCGCAGATCGAGGAAACGTACGTGAACG
GCGACATGGAGCACCGTATCCCGCACAACCTCAACATCAGTTTCAACTTCGTCGAAGGCGAGTCGCTGATCATGGCGATC
AAGGACGTCGCGGTATCGTCGGGTTCCGCGTGCACGTCGGCGTCGCTCGAGCCGTCGTACGTGCTGCGTGCGCTCGGCCG
CAACGACGAACTCGCGCACAGCTCGATCCGCTTCACGGTCGGCCGCTTCACGACGGAGCAGGAAGTCGACTACGTGATCG
AACTGCTGAACAGCAAGATCGCGAAGCTGCGCGAGCTGTCGCCGCTCTGGGAAATGCACCAGGAAGGCATCGATCTGTCG
ACGATCGAATGGGCCGCACACTGA

Upstream 100 bases:

>100_bases
CTCGGTCCCAATTCGGTGTTCAACATCGCGAGTTCGTGAGCGCGAACCGCGCCACACCCTATAACGCATATCGTCCCTGC
ACAGAATCCCGGAGCGACAG

Downstream 100 bases:

>100_bases
GCACCGCATATCGAACATACCCGCGGGCGGATTCGCGCACGCAGACGTAACGAGTCAAGGAGTCTGAGTCATGTCTTACA
GCAACAAGGTTCTGGATCAC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTQQTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQVAALVNADPREIIWTSGATE
SDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERDGFEVTYLDVKENGLLDLDVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQATGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLPTHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLSQIEETYVNGDMEHRIPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQEVDYVIELLNSKIAKLRELSPLWEMHQEGIDLS
TIEWAAH

Sequences:

>Translated_407_residues
MTQQTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQVAALVNADPREIIWTSGATE
SDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERDGFEVTYLDVKENGLLDLDVFKAALRPDTILVSVMHVNNEI
GVIQDIETIGEICREKGIVFHVDAAQATGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
GMRSGTLPTHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLSQIEETYVNGDMEHRIPHNLNISFNFVEGESLIMAI
KDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQEVDYVIELLNSKIAKLRELSPLWEMHQEGIDLS
TIEWAAH
>Mature_406_residues
TQQTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQVAALVNADPREIIWTSGATES
DNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERDGFEVTYLDVKENGLLDLDVFKAALRPDTILVSVMHVNNEIG
VIQDIETIGEICREKGIVFHVDAAQATGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLSQIEETYVNGDMEHRIPHNLNISFNFVEGESLIMAIK
DVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTVGRFTTEQEVDYVIELLNSKIAKLRELSPLWEMHQEGIDLST
IEWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=60, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=32.3671497584541, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI48994898, Length=404, Percent_Identity=74.009900990099, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI1789175, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787970, Length=218, Percent_Identity=28.4403669724771, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=60.8478802992519, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=33.0275229357798, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=58.6466165413534, Blast_Score=511, Evalue=1e-146,
Organism=Drosophila melanogaster, GI20129463, Length=406, Percent_Identity=57.8817733990148, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45567; Mature: 45435

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQ
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERD
HHHHHCCCCHHEEEECCCCCCCCEEEEECCHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
GFEVTYLDVKENGLLDLDVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIVF
CCEEEEEEECCCCEEEHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQATGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCEEEEEHHHEEEEHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLPTHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLSQIEETYVNGDMEHRI
CCCCCCCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PHNLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQEVDYVIELLNSKIAKLRELSPLWEMHQEGIDLSTIEWAAH
ECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
TQQTLHLPIYMDYSATTPVDPRVVDKMVPYLREQFGNPASRSHAYGWDAERAVEEAREQ
CCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VAALVNADPREIIWTSGATESDNLAIKGAANFYKGKGKHIITVKTEHKAVLDTCRELERD
HHHHHCCCCHHEEEECCCCCCCCEEEEECCHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
GFEVTYLDVKENGLLDLDVFKAALRPDTILVSVMHVNNEIGVIQDIETIGEICREKGIVF
CCEEEEEEECCCCEEEHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEE
HVDAAQATGKVEIDLAKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHER
EEECCCCCCEEEEEHHHEEEEHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHC
GMRSGTLPTHQIVGMGEAFRIAREEMATENERIRMLRDKLLRGLSQIEETYVNGDMEHRI
CCCCCCCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PHNLNISFNFVEGESLIMAIKDVAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTV
CCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEE
GRFTTEQEVDYVIELLNSKIAKLRELSPLWEMHQEGIDLSTIEWAAH
ECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA