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The map label for this gene is argM [C]

Identifier: 161524283

GI number: 161524283

Start: 1212041

End: 1213438

Strand: Direct

Name: argM [C]

Synonym: Bmul_1108

Alternate gene names: 161524283

Gene position: 1212041-1213438 (Clockwise)

Preceding gene: 161524282

Following gene: 161524286

Centisome position: 35.15

GC content: 66.31

Gene sequence:

>1398_bases
ATGAACGATCGTCACGACGCACGGCCGAGCGCGCGCTCCACCGCCGAATACCGCGCGCTCGACGCCGCGCACCACATCCA
TCCGTTCTCCGACATGGGCGCGCTGAACCGCGCGGGCAGCCGCGTGATCGTGAAGGCCGACGGCGTCTATCTGTGGGACT
CCGACGGCAACAAGATCATCGACGGCATGGCCGGGCTCTGGTGCGTGAACGTCGGCTACGGCCGCAAGGAGCTGCCCGAC
GCCGCCTATCGGCAACTGCAGGAGCTGCCGTTCTACAACACGTTCTTCAAGACCACGCACCCGCCCGTGATCGAACTCTC
GGCGATGCTCGCCGAAGTCACGCCGCCCGGCTTCAACCACTTCTTCTATTGCAACAGCGGCTCGGAAGGCAACGATACCG
TGCTGCGCGTCGTGCATCAGTACTGGCGCGTGCAGGGCAAGCCGCAGAAGAAGTACGTGATCTCGCGCAAGAACGGCTAT
CACGGCTCGACGATCGCGGGCGGCACGCTCGGCGGCATGGGCTACATGCACGAGCAGATGCCGTCGAAGGTCGAGCACAT
CGTCCATATCGACCAGCCGTATTTCTTCGGCGAAGCGCAGCCGGGCGAGACGCCCGAAGCGTTCGGCCTCGCGCGTGCGC
AGCAACTGGAAGCGAAGATTCTCGAGCTCGGCGCGGAGAACGTCGCGGCATTCATTGGCGAGCCGTTCCAGGGCGCGGGC
GGCGTGATCTTTCCGCCGTCGACGTACTGGCCGGAAATCCAGCGGATCTGCCGCAAGTACGACATTCTGCTCGTCGCCGA
CGAAGTGATCGGCGGCTTCGGCCGCACCGGCGAATGGTTCGCGCATCAGCACTTCGGCTTCGAACCGGATCTGATCACGA
TGGCCAAGGGGCTCACGTCGGGCTACGTGCCGATGGGCGCAGTCGGCATTCACGAGCGCGTCGCGCGGCCGATCATCGAC
AACGGCGAATTCAATCACGGGCTCACGTATTCGGGGCATCCCGTGGCCGCGGCGGTGGCGGTCGCGAACCTGAAGCTGCT
GCGCGACGAGGGCATCGTCGAGCGCGTGAAGCAGCATACGGGGCCGTACTTTCAGCGTCGGTTGCGCGAGGCGCTCGCCG
ATCATCCGATCGTCGGCGAGATCGCGGGCGCGGGGCTCGTCGCCGGCGTCCAGCTCGCCCGCGATCGAGAACAGCGCGTG
CGGTTCGACGCCGCGATCGACGTCGGCACGATCTGCCGCGACTTCTGCTTCAGCGGCAACCTGATCATGCGCGCGACGGG
CGACCGGATGCTGCTGTCGCCGCCGCTCGTGATTCGCGACGACGAGATCGATGCGCTCGTCGACAGCGCAAAGCGGGCAT
TCGATGCGACGGCGGAACGCGTGCGGCGGGGCGCGTGA

Upstream 100 bases:

>100_bases
GAAACCGAATACGAAGCGTTCTTCCGCGTGATCAGCTCGTGGGAGCGCCGCCATCTGCTGCTGCACGTATGAGCGTGCGG
CATCGTCATCCGGAGGCAAC

Downstream 100 bases:

>100_bases
GCGTTGCGTCGGCGCCGTTACGCGCGCGCGAAACGCTGTTCCTCGAACGCGATGATGCGGGCGACGGAATCGGTGACGGT
CAGCGCGCCGGTTTCGATCA

Product: putative aminotransferase

Products: L-glutamate; N2-succinylglutamic-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNDRHDARPSARSTAEYRALDAAHHIHPFSDMGALNRAGSRVIVKADGVYLWDSDGNKIIDGMAGLWCVNVGYGRKELPD
AAYRQLQELPFYNTFFKTTHPPVIELSAMLAEVTPPGFNHFFYCNSGSEGNDTVLRVVHQYWRVQGKPQKKYVISRKNGY
HGSTIAGGTLGGMGYMHEQMPSKVEHIVHIDQPYFFGEAQPGETPEAFGLARAQQLEAKILELGAENVAAFIGEPFQGAG
GVIFPPSTYWPEIQRICRKYDILLVADEVIGGFGRTGEWFAHQHFGFEPDLITMAKGLTSGYVPMGAVGIHERVARPIID
NGEFNHGLTYSGHPVAAAVAVANLKLLRDEGIVERVKQHTGPYFQRRLREALADHPIVGEIAGAGLVAGVQLARDREQRV
RFDAAIDVGTICRDFCFSGNLIMRATGDRMLLSPPLVIRDDEIDALVDSAKRAFDATAERVRRGA

Sequences:

>Translated_465_residues
MNDRHDARPSARSTAEYRALDAAHHIHPFSDMGALNRAGSRVIVKADGVYLWDSDGNKIIDGMAGLWCVNVGYGRKELPD
AAYRQLQELPFYNTFFKTTHPPVIELSAMLAEVTPPGFNHFFYCNSGSEGNDTVLRVVHQYWRVQGKPQKKYVISRKNGY
HGSTIAGGTLGGMGYMHEQMPSKVEHIVHIDQPYFFGEAQPGETPEAFGLARAQQLEAKILELGAENVAAFIGEPFQGAG
GVIFPPSTYWPEIQRICRKYDILLVADEVIGGFGRTGEWFAHQHFGFEPDLITMAKGLTSGYVPMGAVGIHERVARPIID
NGEFNHGLTYSGHPVAAAVAVANLKLLRDEGIVERVKQHTGPYFQRRLREALADHPIVGEIAGAGLVAGVQLARDREQRV
RFDAAIDVGTICRDFCFSGNLIMRATGDRMLLSPPLVIRDDEIDALVDSAKRAFDATAERVRRGA
>Mature_465_residues
MNDRHDARPSARSTAEYRALDAAHHIHPFSDMGALNRAGSRVIVKADGVYLWDSDGNKIIDGMAGLWCVNVGYGRKELPD
AAYRQLQELPFYNTFFKTTHPPVIELSAMLAEVTPPGFNHFFYCNSGSEGNDTVLRVVHQYWRVQGKPQKKYVISRKNGY
HGSTIAGGTLGGMGYMHEQMPSKVEHIVHIDQPYFFGEAQPGETPEAFGLARAQQLEAKILELGAENVAAFIGEPFQGAG
GVIFPPSTYWPEIQRICRKYDILLVADEVIGGFGRTGEWFAHQHFGFEPDLITMAKGLTSGYVPMGAVGIHERVARPIID
NGEFNHGLTYSGHPVAAAVAVANLKLLRDEGIVERVKQHTGPYFQRRLREALADHPIVGEIAGAGLVAGVQLARDREQRV
RFDAAIDVGTICRDFCFSGNLIMRATGDRMLLSPPLVIRDDEIDALVDSAKRAFDATAERVRRGA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=451, Percent_Identity=27.0509977827051, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24119277, Length=428, Percent_Identity=28.0373831775701, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557809, Length=440, Percent_Identity=26.3636363636364, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI226442705, Length=448, Percent_Identity=27.2321428571429, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=26.4976958525346, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI226442709, Length=407, Percent_Identity=26.2899262899263, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=27.8996865203762, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI188536080, Length=431, Percent_Identity=23.6658932714617, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38679950, Length=431, Percent_Identity=23.6658932714617, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38679946, Length=431, Percent_Identity=23.6658932714617, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788044, Length=426, Percent_Identity=28.4037558685446, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=27.5184275184275, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786991, Length=448, Percent_Identity=29.2410714285714, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=27.4074074074074, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=25.1173708920188, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787560, Length=415, Percent_Identity=29.1566265060241, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=25, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992977, Length=418, Percent_Identity=27.7511961722488, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=27.1186440677966, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=30.1149425287356, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=253, Percent_Identity=32.0158102766798, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=436, Percent_Identity=25.4587155963303, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=458, Percent_Identity=26.6375545851528, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324432, Length=430, Percent_Identity=26.2790697674419, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324386, Length=367, Percent_Identity=29.1553133514986, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=28.7703016241299, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574759, Length=434, Percent_Identity=29.0322580645161, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21357415, Length=442, Percent_Identity=26.9230769230769, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21356575, Length=372, Percent_Identity=28.2258064516129, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI281366494, Length=290, Percent_Identity=25.8620689655172, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667139, Length=290, Percent_Identity=25.8620689655172, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667143, Length=290, Percent_Identity=25.8620689655172, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 51271; Mature: 51271

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDRHDARPSARSTAEYRALDAAHHIHPFSDMGALNRAGSRVIVKADGVYLWDSDGNKII
CCCCCCCCCCHHCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCEEEECCCCCCHH
DGMAGLWCVNVGYGRKELPDAAYRQLQELPFYNTFFKTTHPPVIELSAMLAEVTPPGFNH
HCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCE
FFYCNSGSEGNDTVLRVVHQYWRVQGKPQKKYVISRKNGYHGSTIAGGTLGGMGYMHEQM
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH
PSKVEHIVHIDQPYFFGEAQPGETPEAFGLARAQQLEAKILELGAENVAAFIGEPFQGAG
HHHHHHHEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
GVIFPPSTYWPEIQRICRKYDILLVADEVIGGFGRTGEWFAHQHFGFEPDLITMAKGLTS
CEEECCCCCCHHHHHHHHHHCEEEEEHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHCCC
GYVPMGAVGIHERVARPIIDNGEFNHGLTYSGHPVAAAVAVANLKLLRDEGIVERVKQHT
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GPYFQRRLREALADHPIVGEIAGAGLVAGVQLARDREQRVRFDAAIDVGTICRDFCFSGN
CHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
LIMRATGDRMLLSPPLVIRDDEIDALVDSAKRAFDATAERVRRGA
EEEEECCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNDRHDARPSARSTAEYRALDAAHHIHPFSDMGALNRAGSRVIVKADGVYLWDSDGNKII
CCCCCCCCCCHHCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCEEEECCCCCCHH
DGMAGLWCVNVGYGRKELPDAAYRQLQELPFYNTFFKTTHPPVIELSAMLAEVTPPGFNH
HCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCE
FFYCNSGSEGNDTVLRVVHQYWRVQGKPQKKYVISRKNGYHGSTIAGGTLGGMGYMHEQM
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH
PSKVEHIVHIDQPYFFGEAQPGETPEAFGLARAQQLEAKILELGAENVAAFIGEPFQGAG
HHHHHHHEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
GVIFPPSTYWPEIQRICRKYDILLVADEVIGGFGRTGEWFAHQHFGFEPDLITMAKGLTS
CEEECCCCCCHHHHHHHHHHCEEEEEHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHCCC
GYVPMGAVGIHERVARPIIDNGEFNHGLTYSGHPVAAAVAVANLKLLRDEGIVERVKQHT
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GPYFQRRLREALADHPIVGEIAGAGLVAGVQLARDREQRVRFDAAIDVGTICRDFCFSGN
CHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
LIMRATGDRMLLSPPLVIRDDEIDALVDSAKRAFDATAERVRRGA
EEEEECCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-alpha-acetylornithine; 2-oxoglutarate [C]

Specific reaction: N-alpha-acetylornithine + 2-oxoglutarate = N-acetylglutamate semialdehyde + L-glutamate N2-succinylornithine + 2-oxoglutarate = N2-succinylglutamic-semialdehyde + L-glutamate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]