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The map label for this gene is hutU [H]

Identifier: 161524275

GI number: 161524275

Start: 1203278

End: 1204966

Strand: Direct

Name: hutU [H]

Synonym: Bmul_1100

Alternate gene names: 161524275

Gene position: 1203278-1204966 (Clockwise)

Preceding gene: 161524274

Following gene: 161524276

Centisome position: 34.89

GC content: 66.67

Gene sequence:

>1689_bases
ATGAACCATCCGAAACACATCGATCCCCGTCTCGATCCGACGCGCACGATCCGCGCCCCGCGCGGCAGCGAGAAGACCTG
CAAGACCTGGCTCGCCGAAGCGGCGTACCGGATGATCCAGAACAACCTCGATCCGGAAGTCGCCGAGCATCCGCATGCGC
TCGTCGTGTACGGCGGCATCGGTCGCGCGGCGCGCAACTGGGAGTGCTACGACCAGATCCTCGCGTCGCTGAAGGATCTC
GAGGAAAACGAAACGCTGCTGATCCAGTCGGGCAAGCCGGTCGGTGTGTTCCGCACGCACAAGGACGCGCCGCGCGTGCT
GCTCGCGAACTCGAACCTCGTCCCGCACTGGGCGAACTGGGATCACTTCAACGAGCTCGATCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCCGGCAGCTGGATCTACATCGGCAGCCAGGGCATCGTGCAAGGCACGTACGAGACGTTCTTCTCG
GTCGCGAACCAGCACTTCAACGGTGATCCGTCGGGCCGCTGGATCCTGACGGGCGGCCTCGGCGGCATGGGCGGCGCGCA
GCCGCTCGCCGCGACGATGGCCGGCTTCTCGATGATCGCGGTCGAATGCGACGAGACGCGCATCGACTTCCGCCTGAAGA
CGCGCTACGTCGACAAGAAGGCGACGACGCTCGACGAAGCGCTCGGCATGATCGAGGAAGCGAAGCGCAGCGGCAAGCCG
GTGTCGGTCGGCCTGCTCGGCAACGCGGCCGACGTGTTCACCGAACTCGTCGAGCGCGGCATCACGCCGGACTGCGTGAC
CGACCAGACGAGCGCGCACGATCCGATCAACGGCTACCTGCCGCAGGGCTGGACCGTCGCGCAATGGCGCGAGGCGCAGA
AGGTCGATCCGCAGAGCATCGTGAAGGTCGCGAAGCAGTCGATGGCCGTGCAGGTGCGCGCGATGCTGACGCTGCAGCAA
CGTGGTGCCGCGACGCTCGACTACGGCAACAACATTCGCCAGATGGCGCTCGAGATGGGCGTCGAGAATGCCTTCGACTT
CCCGGGCTTCGTGCCGGCCTATATCCGTCCGCTGTTCTGCGAAGGCAAGGGGCCGTTCCGCTGGGTCGCGCTGTCGGGCG
ATCCGGAAGACATCTACAAGACCGACCAGAAGGTGAAGGAGTTGATCCCCGACGATCCGCACCTGCACAACTGGCTCGAC
ATGGCGCGCGAGCGCATCGCGTTCCAGGGGCTGCCGGCGCGCATTTGCTGGGTCGGCGTGAAGGATCGCTACCGCCTCGG
CCAGGCGTTCAACGAGATGGTGAAGAACGGCGAACTGAAGGCGCCGATCGTGATCGGCCGCGACCACCTCGACACCGGCT
CGGTCGCGAGCCCGAACCGCGAGACGGAATCGATGAAGGACGGCTCGGACGCCGTCAGCGACTGGCCGCTGCTCAACGCG
CTGCTGAACACCGCGGGCGGTGCGTCGTGGGTGTCGCTGCATCACGGCGGCGGCGTCGGGATGGGCTTCTCGCAGCACTC
GGGCGTCGTGATCGTCGCCGACGGCACGGCTGACGCGCACGAGCGTCTCGGTCGCGTGCTGCTGAACGACCCGGCGACGG
GCGTGATGCGCCACGCGGATGCCGGCTACGAACTCGCGCAGCAGACGGCCCGCGAAGTCGGCCTGAAGCTGCCGATGCTC
GGTCGCTGA

Upstream 100 bases:

>100_bases
TCGCCTCGGTGGCGAATTTGTGGCATCCCGGCAGCCGTTATCGCTTCACCGGGCATTTCTGATTCCTATTGATATTTCCT
TTCCTTCGGGAGCAGTCGTC

Downstream 100 bases:

>100_bases
GCATGACGGCGCACGACCGCGCGCCGATGGCCGCCGCGCTGATCCGCGCGGCGGATCTCGTTGCGTCGCCGTGGAAGAAC
GGCGGCGGCGTGACGCGCGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRSGKP
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLTLQQ
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHADAGYELAQQTAREVGLKLPML
GR

Sequences:

>Translated_562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRSGKP
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLTLQQ
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHADAGYELAQQTAREVGLKLPML
GR
>Mature_562_residues
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWECYDQILASLKDL
EENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPSGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRSGKP
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSIVKVAKQSMAVQVRAMLTLQQ
RGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHADAGYELAQQTAREVGLKLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=33.8541666666667, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI260306182, Length=636, Percent_Identity=30.9748427672956, Blast_Score=280, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71997891, Length=566, Percent_Identity=34.982332155477, Blast_Score=318, Evalue=5e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61801; Mature: 61801

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWECYDQILASLKDLEENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCC
DHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPSGRWILTGGL
CHHHHHHHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRSGKP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKVAKQSMAVQVRAMLTLQQRGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREVGLKLPMLGR
CCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNHPKHIDPRLDPTRTIRAPRGSEKTCKTWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWECYDQILASLKDLEENETLLIQSGKPVGVFRTHKDAPRVLLANSNLVPHWANW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCC
DHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPSGRWILTGGL
CHHHHHHHCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKATTLDEALGMIEEAKRSGKP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFTELVERGITPDCVTDQTSAHDPINGYLPQGWTVAQWREAQKVDPQSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKVAKQSMAVQVRAMLTLQQRGAATLDYGNNIRQMALEMGVENAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTADAHERLGRVLLNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHCCEEECCCCHHHHHHCC
AGYELAQQTAREVGLKLPMLGR
CCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]