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The map label for this gene is nuoL [H]

Identifier: 161524215

GI number: 161524215

Start: 1134505

End: 1136559

Strand: Direct

Name: nuoL [H]

Synonym: Bmul_1039

Alternate gene names: 161524215

Gene position: 1134505-1136559 (Clockwise)

Preceding gene: 161524214

Following gene: 161524216

Centisome position: 32.9

GC content: 62.77

Gene sequence:

>2055_bases
ATGTCAACGACACTCAATGAAAACCTGCTGCTGGCGATTCCGCTCGCTCCGCTGGCCGGCTCGCTGATTGCGGGGCTGTT
CGGGAACGCAGTCGGGCGCAAGGGCGCACACCGGATCACGATCCTCGGCGTATTGATCGCGTTCCTGCTGTCGGCGAAAG
TCTTCGTCGACGTGATGGGCGGCGCAAGCTTCAACGCGACCGTCTACGAATGGATGCACGTCGGCTCGCTGAAGCTCGAA
GTCGGCTTCCTCGTCGATTCGCTGACGGCGATGATGATGGTCGTCGTGACCTTCGTGTCGCTGATGGTGCACATCTACAC
GATCGGCTACATGTCGGAAGAGGACGGCTACCAGCGCTTCTTCTCGTACATCTCGCTGTTCACGTTCTCGATGCTGATGC
TCGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTGGTGTCGTACCTGCTGATCGGCTTC
TACTTCACGCGTGAGAGCGCGATCTACGCGAACATGAAGGCGTTCCTCGTGAACCGCGTGGGCGACTTCGGCTTCCTGCT
CGGCATCGGCCTGCTGCTCGCGTTCGCCGGCTCGATGAACTACGGCGAAGTGTTCGCGAAGCGCGCGGAACTCGCGAGCC
TGCATTTCCCGGGCACCGACTGGGGCCTGCTGACGGTCGCCTGCATCTGCCTGTTCATCGGCGCGATGGGCAAGTCGGCG
CAGTTCCCGCTGCACGTCTGGCTGCCTGACTCGATGGAAGGCCCGACGCCGATCTCCGCGCTGATTCACGCGGCGACGAT
GGTGACGGCCGGCATCTTCATGGTGTCGCGCATGTCGCCGCTGTTCGAGCTGTCGGATACCGCACTGTCGTTCATCACGG
TGATCGGCGCGATCACGGCGCTGTTCATGGGCTTCCTCGGGATCGTCCAGAACGACATCAAGCGTGTCGTCGCTTACTCG
ACGCTGTCGCAACTCGGCTACATGACGGTCGCGCTCGGCGTGTCCGCGTACCCGGTCGCGGTGTTCCACCTGATGACGCA
CGCGTTCTTCAAGGCGCTGCTGTTCCTCGGCGCCGGCTCGGTGATCATCGGCATGCACCACGATCAGGACATGCGCAACA
TGGGCGGCCTGCGCAAGTACATGCCGATCACCTGGATCACGTCGCTGATCGGTTCGCTCGCGCTGATCGGTACGCCGTTC
TTCTCGGGCTTCTACTCGAAGGACTCGATCATCGACGCGGTGAAGCTGTCGCACCTGCCGGGTTCGGGCTTCGCGTACTT
CGCGGTCGTCGCGAGCGTGTTCGTCACGGCGCTGTACTCGTTCCGCATGTACTTCCTCGTGTTCCACGGCGAAGAGCGCT
TCCGCCATCCGAAGCATCCGGAATCGCCGATGGGCATGGCGGCCGCGCACGGTCACGACGATCACGGCCATGGCCACGGC
CATGACGACCACGCGCACGAGCCGCACGAGACCCCGTGGGTCGTGTGGGTGCCGCTGGTCCTGCTCGCAATTCCGTCGGT
GATCATCGGTGCGATCGCGATCGGCCCGATGCTGTTCGGCGATTTCTTCCAGCACGGCGTCGCGTTCGACAAGGTGATCT
TCGTCGGCGAAAACCATCCGGCGCTGGCCGAGATGGCCGAGGAGTTCCACGGTTGGGTCGGCATGGGCCTGCATTCGGTG
TCGGGCCTGCCGGTGTGGCTCGCGCTGGCCGGTGTCGTCGTCGCCTGGTTCCTGTATCTGAAGCGTCCGGATCTGCCGGC
GTCGATCCGCCGCGCGTTCGGTCCGATCTACACGCTGCTGGATAACAAGTACTACATGGACAAGATCAACGAAGTGGTGT
TCGCCCGCGGTTCGGTGGCGATCGGCCGCGGCCTGTGGAAGGAGGGCGACGTCGTGGTGATCGACGGCCTCGTCAACGGC
AGCGCCAAGTTCATCGCCTGGTTCGCCAGCGTGATCCGCTTCCTCCAATCCGGTTACATCTATCACTACGCGTTCGCCAT
GATCATCGGCATGCTGGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCAAATAA

Upstream 100 bases:

>100_bases
CGATCGGTCTCGCGATTCTGGTGACCCTGTTCCGTAAGCTCGACACGATCAATGTCGAGGATCTCGATCAGCTCAAAGGT
TAATTTCAGGCAACGCTGTT

Downstream 100 bases:

>100_bases
GGCGGGGGGACAACTAATGCACGCTTTTCCGATTCTCAGTACCGCGATCTGGCTGCCGATCGTTTTCGGCCTCCTCGTGC
TCGCGGTCGGTAACGACAAG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFVDVMGGASFNATVYEWMHVGSLKLE
VGFLVDSLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKHPESPMGMAAAHGHDDHGHGHG
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLFGDFFQHGVAFDKVIFVGENHPALAEMAEEFHGWVGMGLHSV
SGLPVWLALAGVVVAWFLYLKRPDLPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNG
SAKFIAWFASVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Sequences:

>Translated_684_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFVDVMGGASFNATVYEWMHVGSLKLE
VGFLVDSLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKHPESPMGMAAAHGHDDHGHGHG
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLFGDFFQHGVAFDKVIFVGENHPALAEMAEEFHGWVGMGLHSV
SGLPVWLALAGVVVAWFLYLKRPDLPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNG
SAKFIAWFASVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK
>Mature_683_residues
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFVDVMGGASFNATVYEWMHVGSLKLEV
GFLVDSLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFY
FTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSAQ
FPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYST
LSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPFF
SGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKHPESPMGMAAAHGHDDHGHGHGH
DDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLFGDFFQHGVAFDKVIFVGENHPALAEMAEEFHGWVGMGLHSVS
GLPVWLALAGVVVAWFLYLKRPDLPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGS
AKFIAWFASVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=386, Percent_Identity=40.6735751295337, Blast_Score=288, Evalue=1e-77,
Organism=Escherichia coli, GI1788614, Length=672, Percent_Identity=36.9047619047619, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1788829, Length=416, Percent_Identity=29.0865384615385, Blast_Score=152, Evalue=1e-37,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=30.3977272727273, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788827, Length=416, Percent_Identity=29.0865384615385, Blast_Score=126, Evalue=6e-30,
Organism=Escherichia coli, GI2367154, Length=125, Percent_Identity=35.2, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788613, Length=325, Percent_Identity=26.4615384615385, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693160, Length=318, Percent_Identity=24.2138364779874, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74812; Mature: 74681

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFVDVMG
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMHVGSLKLEVGFLVDSLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRF
CCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKHPESPMGMAAAHGHDDHGHGHG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCHHCCCCCCCCCCCC
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLFGDFFQHGVAFDKVIFVGENHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
ALAEMAEEFHGWVGMGLHSVSGLPVWLALAGVVVAWFLYLKRPDLPASIRRAFGPIYTLL
HHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGSAKFIAWFASVIRFLQSGYI
CCCHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
YHYAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFVDVMG
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMHVGSLKLEVGFLVDSLTAMMMVVVTFVSLMVHIYTIGYMSEEDGYQRF
CCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VIIGMHHDQDMRNMGGLRKYMPITWITSLIGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
EEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRHPKHPESPMGMAAAHGHDDHGHGHG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCHHCCCCCCCCCCCC
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAIGPMLFGDFFQHGVAFDKVIFVGENHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
ALAEMAEEFHGWVGMGLHSVSGLPVWLALAGVVVAWFLYLKRPDLPASIRRAFGPIYTLL
HHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGSAKFIAWFASVIRFLQSGYI
CCCHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
YHYAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]