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The map label for this gene is envZ [H]

Identifier: 161524069

GI number: 161524069

Start: 974708

End: 976024

Strand: Direct

Name: envZ [H]

Synonym: Bmul_0890

Alternate gene names: 161524069

Gene position: 974708-976024 (Clockwise)

Preceding gene: 161524068

Following gene: 161524071

Centisome position: 28.26

GC content: 72.67

Gene sequence:

>1317_bases
ATGCGCAAACCCATTGATTCGCTGTTCGGCCGGCTCGCGCTGCTTGTCGTCGGCGTGCTGCTGCTGTCGCACTTCGCGTG
GTATTTCGCGATGCGGCTCGAACGCAATCAGATGCAGACGCGTTACGCGGTCGAGGAGGCCGCGTTCCTCGTCGACGCCG
TGCGCCAGCACGTCGCGCGTTCGCCCGATCAGCCGCTGCCGTCGCGCGTGCGGCTCGTCGCGCCGGACAGCCCCGACGTG
CCGAAGGACGACGACCCGCCGCTGCCGGCGCCGCTCAAGCGCTTTCGCGACGACGTCGGCGAGCGGATGCCGCCCGGCAC
GCAGGTGCGGATCGGCGCGCCGGGCCGACCGCCCGTGCTATGGGTGAAGGAGCCGACCGACCGCAGCTGGATCGTCGTGC
CGGTGCAGCCGCTGCGGCCGCCGCGCTCGCTCGACCGGATGCTGCTGTGGCTCGGCACGATTTTCTCGGCCGGTGTGATC
GCCGCGCTGTTCGCGGCATGGCAGCTGCAGCAGCCGCTGCGCTCGCTCGCGCGTGCGGTCGCGCGCTTCGGCCGCGGGCA
GCCGGTGCCGCCGCTGCGCGAGCGCGGCCCGCGCGAGCTGCGCCAGCTTACGCACGGTTTCAATCAGATGGTCGAGCAGG
TGTCGCAGGCCGAGAACGACCGCGCGGTGATGCTGGCGGGCGTCGCGCACGACCTGCGTACGCCGCTTGCGCGGATGCGG
CTGCGCGCCGAAATGATGGACGATGCACGTCTGCGCGACGGCGTCGTGCGCGATGTCGACTCGATGACGCACATCGTCGA
CCAGTTCCTCGTGTTCGCGCACGGCGGCGCCGACCGCAGCGAGCCGGTGCCGGTCGACCAGGCGTGCGAGCGGATCGCGC
GCACCTATCGCGCGGTCGCGCCGAACGCGCCGACGGTGCAGACGCGGCTCGGCGCCGATCCCGGTTTCTGCCTGCCGACC
GCGACGCTCGACCGCATCCTGTCGAACCTGCTCGACAACGCGCATGCGTACGGCGCGCCGCCCGTGCTCGTCGAAACCGC
GCGCACGCCGGCCGGCTACGTGCTGGCCGTCAGCGATCACGGCAGCGGGATCGCGCCGCGCGATCTGGCGGCCGCGACGC
GGCCGTTCGTACGCCTCGATCCGGCGCGCGGCGGCAACGGGCATAGCGGGCTCGGGCTCGCGATCGTCGAGCGGCTGGTG
CTCAGGCTGGGCGGGACGTGCGACATCGGCAACCGTCCGGAAGGCGGGCTGCGCGTCGCGATGACGTTCCCGTTCGACGC
GGTGCCGAAGGGCGAGCCGCACGCGCAGGCGGCGTAA

Upstream 100 bases:

>100_bases
TGGCGCCTGCGCCGCATCCTCGAGACCGATCCGTCGACGCCGCGCTTCATCCAGACGGTCCGCGGGCGCGGCTACGTGTT
CGTGCCCGACGGCGAGGCCC

Downstream 100 bases:

>100_bases
GCGGCCGAAACGGCGCCCGGGCGGGCGCCGCGCCGCGCGGCGTCACTCGCCGAACAGCGTGCCGAGCGTCTCGGCGGCGT
TGCTGTCGATCGTGTTGTAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAMRLERNQMQTRYAVEEAAFLVDAVRQHVARSPDQPLPSRVRLVAPDSPDV
PKDDDPPLPAPLKRFRDDVGERMPPGTQVRIGAPGRPPVLWVKEPTDRSWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAENDRAVMLAGVAHDLRTPLARMR
LRAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGGADRSEPVPVDQACERIARTYRAVAPNAPTVQTRLGADPGFCLPT
ATLDRILSNLLDNAHAYGAPPVLVETARTPAGYVLAVSDHGSGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGTCDIGNRPEGGLRVAMTFPFDAVPKGEPHAQAA

Sequences:

>Translated_438_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAMRLERNQMQTRYAVEEAAFLVDAVRQHVARSPDQPLPSRVRLVAPDSPDV
PKDDDPPLPAPLKRFRDDVGERMPPGTQVRIGAPGRPPVLWVKEPTDRSWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAENDRAVMLAGVAHDLRTPLARMR
LRAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGGADRSEPVPVDQACERIARTYRAVAPNAPTVQTRLGADPGFCLPT
ATLDRILSNLLDNAHAYGAPPVLVETARTPAGYVLAVSDHGSGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGTCDIGNRPEGGLRVAMTFPFDAVPKGEPHAQAA
>Mature_438_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAMRLERNQMQTRYAVEEAAFLVDAVRQHVARSPDQPLPSRVRLVAPDSPDV
PKDDDPPLPAPLKRFRDDVGERMPPGTQVRIGAPGRPPVLWVKEPTDRSWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAENDRAVMLAGVAHDLRTPLARMR
LRAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGGADRSEPVPVDQACERIARTYRAVAPNAPTVQTRLGADPGFCLPT
ATLDRILSNLLDNAHAYGAPPVLVETARTPAGYVLAVSDHGSGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGTCDIGNRPEGGLRVAMTFPFDAVPKGEPHAQAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=339, Percent_Identity=32.1533923303835, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787894, Length=265, Percent_Identity=31.6981132075472, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790551, Length=326, Percent_Identity=26.6871165644172, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=29.1139240506329, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=320, Percent_Identity=25.3125, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082128, Length=270, Percent_Identity=25.1851851851852, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=286, Percent_Identity=25.8741258741259, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47967; Mature: 47967

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAMRLERNQMQTRYAVEEAAFLVDAVRQHVAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPDQPLPSRVRLVAPDSPDVPKDDDPPLPAPLKRFRDDVGERMPPGTQVRIGAPGRPPVL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEE
WVKEPTDRSWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVIAALFAAWQLQQPLRSLARAV
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAENDRAVMLAGVAHDLRTPLARMR
HHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
LRAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGGADRSEPVPVDQACERIARTYRAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC
PNAPTVQTRLGADPGFCLPTATLDRILSNLLDNAHAYGAPPVLVETARTPAGYVLAVSDH
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECC
GSGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLVLRLGGTCDIGNRPEGGLRVA
CCCCCCHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
MTFPFDAVPKGEPHAQAA
EECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWYFAMRLERNQMQTRYAVEEAAFLVDAVRQHVAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPDQPLPSRVRLVAPDSPDVPKDDDPPLPAPLKRFRDDVGERMPPGTQVRIGAPGRPPVL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCEE
WVKEPTDRSWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVIAALFAAWQLQQPLRSLARAV
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAENDRAVMLAGVAHDLRTPLARMR
HHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
LRAEMMDDARLRDGVVRDVDSMTHIVDQFLVFAHGGADRSEPVPVDQACERIARTYRAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHC
PNAPTVQTRLGADPGFCLPTATLDRILSNLLDNAHAYGAPPVLVETARTPAGYVLAVSDH
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECC
GSGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLVLRLGGTCDIGNRPEGGLRVA
CCCCCCHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
MTFPFDAVPKGEPHAQAA
EECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]