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The map label for this gene is ispH1 [H]

Identifier: 161523975

GI number: 161523975

Start: 874143

End: 875633

Strand: Direct

Name: ispH1 [H]

Synonym: Bmul_0795

Alternate gene names: 161523975

Gene position: 874143-875633 (Clockwise)

Preceding gene: 161523970

Following gene: 161523976

Centisome position: 25.35

GC content: 65.19

Gene sequence:

>1491_bases
TTGGCTTTGCGCTGGGCCTCGCGGCCGTTTCGGGCGCCGACTGAACGAGTAATTCATGAGCCTCATCGATCTATCCGAAG
TGAAGCCCGGTTCCCATGTCACGCTGCATTACCGGCTTGCACTGGCCGACGGCGCCGACATCGTCAACACCTTCGCCGAC
AAACCCGCGACGCTGCTGCTGGGCGCCGGGCAACTGGCGCCGTCGCTGGAACAGATTCTGCTGGGGCTCAAGGTCGGAGA
CCATTCGACTTTTCAGCTAACGCCCGAGCAAGGGTTCGGTCCCCGCAATCCCGACATGCTGCAGCGCGTGACGCTCGCGA
CGCTGCGCGAGAACGGCATGGTCGACGAGGACTTCACGCCGGGCGAACTGATCGAGTTCAACGCACCGGACGGCGGCCGA
TATGCAGGCGTGCTGAAGGAAGTCGGCGAAACCTCCGCGCTGTTCGATTTCAATCATCCGCTCGCGGGCCAAGCGCTCAC
GTTCGAAGTGAAAATCATCGGAATCCTGTAATCATGAGCACCACCGATACGCTGTCCGGACAGACCGTCGCCGCCGACGC
CGAAATCCTGCTCGCGCAGCCGCGCGGGTTTTGCGCGGGCGTCGATCGCGCGATCGAGATCGTCGAACGCGCGATCGCGA
TGCATGGCGCACCGATCTACGTCCGTCACGAGATCGTCCACAACAAGTACGTGGTCGAGGATCTGAAGAAGAAAGGCGCG
ATCTTCGTCGAGGAGCTCGAGGAAGTGCCGGCCGGCAACACCGTGATCTTCAGCGCGCACGGCGTGTCGAAGGCCGTGCG
CGACGAAGCCGGCGTGCGCGGGCTGCGCATCTACGATGCGACCTGCCCGCTCGTCACGAAGGTGCACGTCGAAGTCGCGA
AGATGCGCCAGGACGGCGTCGACATCGTGATGATCGGCCACAAGGGCCATCCGGAAGTCGAAGGCACGATGGGGCAGGTC
GAGCGCGGGATGCATCTGGTCGAGAGCGTCGAGGACGTGCAGAAGCTCGAGCTCGCCGATCCGGAACGCATCGCGCTCGT
CACGCAAACCACGCTCTCCGTCGACGATGCGGCCGAGATCATCGCGGCGCTGAAGGCGAAGTACCCGAAGATCCGCGAAC
CGAAGAAGCAGGACATCTGCTACGCGACGCAGAACCGCCAGGACGCGGTGAAGTTCATGGCGCCGCAGTGCGACGTCGTG
ATCGTCGTCGGCAGCCCGAACAGTTCGAATTCGAGCCGTCTGCGCGAAGTGGCCGAGAAGCGCGGCGTTGCGGCCTACAT
GGTCGACGCGCCCGAGCAGATCGATCCGGCGTGGGTCGCCGGCAAGCGCCGCATCGGCGTAACGGCCGGCGCGTCGGCGC
CGGAAGTGCTGGCCCAGGCCGTGATCGCGCGGCTGCGCGAGCTCGGCGTGCGCAACGTGCGCGCGCTCGAGGGGATCGAG
GAAAACGTGTCGTTCCCGCTGCCGCGCGGGCTGAACCTGCCCGCCGCCTGA

Upstream 100 bases:

>100_bases
AAGAGGGCAGGATATGAGCATCGTCGAAACTCCATTGGCGGCGGCCGCACGTGCAACGTCGTCGCACTTTCAGCCTTGCG
CGCTCAGGTGACTTACAATA

Downstream 100 bases:

>100_bases
TTGCCGCATTGCAATCGCGATGCACCGAAGCGCGCCTGAGGGCGCGCTTTTTTTGTCCGTCGAATTCCCCATTCGCAACC
ATCGTTCCCCGGCATGGTGC

Product: hydroxymethylbutenyl pyrophosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MALRWASRPFRAPTERVIHEPHRSIRSEARFPCHAALPACTGRRRRHRQHLRRQTRDAAAGRRATGAVAGTDSAGAQGRR
PFDFSANARARVRSPQSRHAAARDARDAARERHGRRGLHAGRTDRVQRTGRRPICRRAEGSRRNLRAVRFQSSARGPSAH
VRSENHRNPVIMSTTDTLSGQTVAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGA
IFVEELEEVPAGNTVIFSAHGVSKAVRDEAGVRGLRIYDATCPLVTKVHVEVAKMRQDGVDIVMIGHKGHPEVEGTMGQV
ERGMHLVESVEDVQKLELADPERIALVTQTTLSVDDAAEIIAALKAKYPKIREPKKQDICYATQNRQDAVKFMAPQCDVV
IVVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVRNVRALEGIE
ENVSFPLPRGLNLPAA

Sequences:

>Translated_496_residues
MALRWASRPFRAPTERVIHEPHRSIRSEARFPCHAALPACTGRRRRHRQHLRRQTRDAAAGRRATGAVAGTDSAGAQGRR
PFDFSANARARVRSPQSRHAAARDARDAARERHGRRGLHAGRTDRVQRTGRRPICRRAEGSRRNLRAVRFQSSARGPSAH
VRSENHRNPVIMSTTDTLSGQTVAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGA
IFVEELEEVPAGNTVIFSAHGVSKAVRDEAGVRGLRIYDATCPLVTKVHVEVAKMRQDGVDIVMIGHKGHPEVEGTMGQV
ERGMHLVESVEDVQKLELADPERIALVTQTTLSVDDAAEIIAALKAKYPKIREPKKQDICYATQNRQDAVKFMAPQCDVV
IVVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVRNVRALEGIE
ENVSFPLPRGLNLPAA
>Mature_495_residues
ALRWASRPFRAPTERVIHEPHRSIRSEARFPCHAALPACTGRRRRHRQHLRRQTRDAAAGRRATGAVAGTDSAGAQGRRP
FDFSANARARVRSPQSRHAAARDARDAARERHGRRGLHAGRTDRVQRTGRRPICRRAEGSRRNLRAVRFQSSARGPSAHV
RSENHRNPVIMSTTDTLSGQTVAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGAI
FVEELEEVPAGNTVIFSAHGVSKAVRDEAGVRGLRIYDATCPLVTKVHVEVAKMRQDGVDIVMIGHKGHPEVEGTMGQVE
RGMHLVESVEDVQKLELADPERIALVTQTTLSVDDAAEIIAALKAKYPKIREPKKQDICYATQNRQDAVKFMAPQCDVVI
VVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVRNVRALEGIEE
NVSFPLPRGLNLPAA

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=307, Percent_Identity=58.3061889250814, Blast_Score=370, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 54483; Mature: 54352

Theoretical pI: Translated: 10.95; Mature: 10.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRWASRPFRAPTERVIHEPHRSIRSEARFPCHAALPACTGRRRRHRQHLRRQTRDAAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GRRATGAVAGTDSAGAQGRRPFDFSANARARVRSPQSRHAAARDARDAARERHGRRGLHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GRTDRVQRTGRRPICRRAEGSRRNLRAVRFQSSARGPSAHVRSENHRNPVIMSTTDTLSG
CCHHHHHHCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCC
QTVAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGA
CEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCC
IFVEELEEVPAGNTVIFSAHGVSKAVRDEAGVRGLRIYDATCPLVTKVHVEVAKMRQDGV
CHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
DIVMIGHKGHPEVEGTMGQVERGMHLVESVEDVQKLELADPERIALVTQTTLSVDDAAEI
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHH
IAALKAKYPKIREPKKQDICYATQNRQDAVKFMAPQCDVVIVVGSPNSSNSSRLREVAEK
HHHHHHCCCCCCCCCHHCCEEECCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
RGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVRNVRALEGIE
CCCEEEEECCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHCHH
ENVSFPLPRGLNLPAA
HCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALRWASRPFRAPTERVIHEPHRSIRSEARFPCHAALPACTGRRRRHRQHLRRQTRDAAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GRRATGAVAGTDSAGAQGRRPFDFSANARARVRSPQSRHAAARDARDAARERHGRRGLHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GRTDRVQRTGRRPICRRAEGSRRNLRAVRFQSSARGPSAHVRSENHRNPVIMSTTDTLSG
CCHHHHHHCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCC
QTVAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGA
CEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCC
IFVEELEEVPAGNTVIFSAHGVSKAVRDEAGVRGLRIYDATCPLVTKVHVEVAKMRQDGV
CHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
DIVMIGHKGHPEVEGTMGQVERGMHLVESVEDVQKLELADPERIALVTQTTLSVDDAAEI
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHH
IAALKAKYPKIREPKKQDICYATQNRQDAVKFMAPQCDVVIVVGSPNSSNSSRLREVAEK
HHHHHHCCCCCCCCCHHCCEEECCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
RGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVRNVRALEGIE
CCCEEEEECCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHCHH
ENVSFPLPRGLNLPAA
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA