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The map label for this gene is nadC [H]

Identifier: 161523970

GI number: 161523970

Start: 869922

End: 870803

Strand: Direct

Name: nadC [H]

Synonym: Bmul_0790

Alternate gene names: 161523970

Gene position: 869922-870803 (Clockwise)

Preceding gene: 161523969

Following gene: 161523975

Centisome position: 25.23

GC content: 68.71

Gene sequence:

>882_bases
ATGACGAGCGCCGTTTCTCCGCTTTACGACGCGATCCGCGCGCAATACGGCGCGGCCTTCGACGACGCAATCGCGCGCAA
CGTCGCCGATGCCATTGCCGAGGACGTCGGCCCCGGCGATCAGACCGGGCGACTCGTGCCGGCCGACGAGCGGCGCCGTG
CGCGCATCATCGTGCGCGAGGAGGCCGTGCTGTGCGGCGTGCCGTGGTTCGACGCGGTGGTCGCGCGGATCGATCCGTCG
ATCGCCGTGCAGTGGCGCTACCGCGAAGGCGAGCGGATGACGGCCGATTCGGTCGTCTGCGAACTCGAAGGGCCGGCGCG
CGCGCTGCTGACCGCCGAGCGCAACGCGCTGAATTTCCTGCAGCTGCTGTCCGGTGTCGCAACGGCGACGCGCCGCTACG
TCGATCGCATCGAAGGCACGCGCGCGAAGATTCTCGATACGCGCAAGACCTTGCCGGGGCTGCGGCTTGCGCAGAAATAC
GCGGTGCGCGTCGGCGGCGGCGAGAACCAGCGTCTTGCGCTGTACGACGGCATTCTGATCAAGGAAAACCACATTGCGGC
CGCAGGCGGCGTCGGCGAGGCGCTCGATGCGGCGTTCGCGCTGAACGCGGGCGTGCCCGTGCAGATCGAGGTCGAGACGC
TCGCGCAGCTCGACACGGCGCTCGCGCACGGCGCGCAGTCGGTGCTGCTCGACAACTTCACGCTCGACATGATGCGCGAA
GCGGTGCGCGTCGCGGCCGGCAAGGCGGTGCTCGAAGTGTCGGGCGGCGTCAATTTCGATACGGTGCGCACGTTCGCCGA
AACGGGCGTCGACCGCATCTCGATCGGCGCGCTGACGAAGGACGTGCGCGCGACCGATTATTCGATGCGCATCGTCGCCT
GA

Upstream 100 bases:

>100_bases
TCGACCGCATGCTCGCGTTCGCGGCCGCGCACAAGAAGCGCGTGCAGGCGAGCGGCGATCTGCAGCGCGACCAGCCGCTG
TTCGCGAACGTGGGGGCGGC

Downstream 100 bases:

>100_bases
TCGCACGACGCGCGGCAACGCAATGAAAAGGCCGCCGGTGCGTATGCGCCGGCGGCCTTTCTCGTTCCGGTCAGCGCGTG
CGTCGCTCAGCGACGCGAAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTSAVSPLYDAIRAQYGAAFDDAIARNVADAIAEDVGPGDQTGRLVPADERRRARIIVREEAVLCGVPWFDAVVARIDPS
IAVQWRYREGERMTADSVVCELEGPARALLTAERNALNFLQLLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKY
AVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALNAGVPVQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE
AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMRIVA

Sequences:

>Translated_293_residues
MTSAVSPLYDAIRAQYGAAFDDAIARNVADAIAEDVGPGDQTGRLVPADERRRARIIVREEAVLCGVPWFDAVVARIDPS
IAVQWRYREGERMTADSVVCELEGPARALLTAERNALNFLQLLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKY
AVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALNAGVPVQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE
AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMRIVA
>Mature_292_residues
TSAVSPLYDAIRAQYGAAFDDAIARNVADAIAEDVGPGDQTGRLVPADERRRARIIVREEAVLCGVPWFDAVVARIDPSI
AVQWRYREGERMTADSVVCELEGPARALLTAERNALNFLQLLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKYA
VRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALNAGVPVQIEVETLAQLDTALAHGAQSVLLDNFTLDMMREA
VRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMRIVA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=266, Percent_Identity=34.9624060150376, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=51.4814814814815, Blast_Score=246, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6321162, Length=301, Percent_Identity=32.890365448505, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31478; Mature: 31347

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAVSPLYDAIRAQYGAAFDDAIARNVADAIAEDVGPGDQTGRLVPADERRRARIIVRE
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
EAVLCGVPWFDAVVARIDPSIAVQWRYREGERMTADSVVCELEGPARALLTAERNALNFL
CEEEECCCHHHHHHHHCCCCEEEEEEECCCCCEECCCEEEEECCCHHHHHHHHHHHHHHH
QLLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEE
KENHIAAAGGVGEALDAAFALNAGVPVQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE
ECCCEEECCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMRIVA
HHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
TSAVSPLYDAIRAQYGAAFDDAIARNVADAIAEDVGPGDQTGRLVPADERRRARIIVRE
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
EAVLCGVPWFDAVVARIDPSIAVQWRYREGERMTADSVVCELEGPARALLTAERNALNFL
CEEEECCCHHHHHHHHCCCCEEEEEEECCCCCEECCCEEEEECCCHHHHHHHHHHHHHHH
QLLSGVATATRRYVDRIEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGILI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEE
KENHIAAAGGVGEALDAAFALNAGVPVQIEVETLAQLDTALAHGAQSVLLDNFTLDMMRE
ECCCEEECCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
AVRVAAGKAVLEVSGGVNFDTVRTFAETGVDRISIGALTKDVRATDYSMRIVA
HHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]