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The map label for this gene is ksgA [H]

Identifier: 161523771

GI number: 161523771

Start: 646876

End: 647703

Strand: Direct

Name: ksgA [H]

Synonym: Bmul_0591

Alternate gene names: 161523771

Gene position: 646876-647703 (Clockwise)

Preceding gene: 161523770

Following gene: 161523773

Centisome position: 18.76

GC content: 66.55

Gene sequence:

>828_bases
ATGTCGAACAGCAGACAGCATCAAGGCCATTTCGCGCGCAAGCGCTTCGGGCAGAACTTCCTCGTCGATCACGGCGTGAT
CGACTCGATCGTCGCGACGATCGCCCCCGCGCGCGGCCAGCGGATGGTCGAGATCGGCCCCGGGCTCGGCGCGCTGACCG
AGCCGCTGATCGCACGGCTCGCGACGCCCGAAACGCCGCTGCATGCAGTCGAGCTCGATCGCGACCTGATCGCGCGTCTG
AAGCAGCGCTTCGGCGCCTTGCTCGAACTGCATGCGGGCGACGCGCTCGCGTTCGACTTCCGCTCGCTCGCCGCGCCCGG
CGATGCGCCGTCGCTGCGGATCGTCGGCAACCTGCCGTACAACATCTCGAGCCCGCTGCTGTTTCATCTGATGACGTTCG
CGGACGTCGTCGTCGATCAGCACTTCATGCTGCAGAACGAAGTCGTCGAGCGGATGGTCGCGGAGCCCGGCACGAAGGCC
TTTTCGCGGCTGTCGGTGATGCTGCAGTATCGCTACGTGATGGACAAGCTGATCGACGTGCCGCCCGAGTCGTTCCAGCC
GCCGCCGAAGGTCGATTCGGCGATCGTCCGGATGATTCCGTACGCGCCGCACGAGCTGCCGGACGTCGATCCGGTGCTGC
TCGGCGAAATCGTGACGGCCGCGTTCTCGCAGCGCCGCAAGATGCTGCGCAATACGCTCGGCGATTATCGCGAGACGATC
GATTTCGACGCGCTCGGCTTCGATCTCGCGCGACGCGCGGAGGACGTCAGCGTTGCCGAATACGTCGGCGTCGCGCAGGC
GCTCGCGGCCACGCGCAACGCGCAGTGA

Upstream 100 bases:

>100_bases
CCTGACGCGGCATGCCTGACCCGGCCCGGCCTGACGCGGCCAGCGTCGCTCGCGGCCGCCGCTTCCTTACTCATCGCATT
TTTGGTTTTTTCTTCAGCCG

Downstream 100 bases:

>100_bases
TGCGGTGACGCCGTGACGCGCGGCGATGCGCGTGCGGTGTTCCCGCACCGCATCGAACGGCGCGCTTGCTTCGATCGCGG
CGTTGGGGCTGATTACACGC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSNSRQHQGHFARKRFGQNFLVDHGVIDSIVATIAPARGQRMVEIGPGLGALTEPLIARLATPETPLHAVELDRDLIARL
KQRFGALLELHAGDALAFDFRSLAAPGDAPSLRIVGNLPYNISSPLLFHLMTFADVVVDQHFMLQNEVVERMVAEPGTKA
FSRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPYAPHELPDVDPVLLGEIVTAAFSQRRKMLRNTLGDYRETI
DFDALGFDLARRAEDVSVAEYVGVAQALAATRNAQ

Sequences:

>Translated_275_residues
MSNSRQHQGHFARKRFGQNFLVDHGVIDSIVATIAPARGQRMVEIGPGLGALTEPLIARLATPETPLHAVELDRDLIARL
KQRFGALLELHAGDALAFDFRSLAAPGDAPSLRIVGNLPYNISSPLLFHLMTFADVVVDQHFMLQNEVVERMVAEPGTKA
FSRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPYAPHELPDVDPVLLGEIVTAAFSQRRKMLRNTLGDYRETI
DFDALGFDLARRAEDVSVAEYVGVAQALAATRNAQ
>Mature_274_residues
SNSRQHQGHFARKRFGQNFLVDHGVIDSIVATIAPARGQRMVEIGPGLGALTEPLIARLATPETPLHAVELDRDLIARLK
QRFGALLELHAGDALAFDFRSLAAPGDAPSLRIVGNLPYNISSPLLFHLMTFADVVVDQHFMLQNEVVERMVAEPGTKAF
SRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPYAPHELPDVDPVLLGEIVTAAFSQRRKMLRNTLGDYRETID
FDALGFDLARRAEDVSVAEYVGVAQALAATRNAQ

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=192, Percent_Identity=33.8541666666667, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI156415992, Length=242, Percent_Identity=30.9917355371901, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786236, Length=271, Percent_Identity=53.5055350553505, Blast_Score=274, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI25146882, Length=218, Percent_Identity=33.0275229357798, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25141369, Length=268, Percent_Identity=27.2388059701493, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324989, Length=199, Percent_Identity=31.6582914572864, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358017, Length=241, Percent_Identity=32.7800829875519, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21357273, Length=268, Percent_Identity=29.1044776119403, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30405; Mature: 30274

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSRQHQGHFARKRFGQNFLVDHGVIDSIVATIAPARGQRMVEIGPGLGALTEPLIARL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
ATPETPLHAVELDRDLIARLKQRFGALLELHAGDALAFDFRSLAAPGDAPSLRIVGNLPY
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEECCCC
NISSPLLFHLMTFADVVVDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMDKLIDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
PPESFQPPPKVDSAIVRMIPYAPHELPDVDPVLLGEIVTAAFSQRRKMLRNTLGDYRETI
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DFDALGFDLARRAEDVSVAEYVGVAQALAATRNAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSRQHQGHFARKRFGQNFLVDHGVIDSIVATIAPARGQRMVEIGPGLGALTEPLIARL
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
ATPETPLHAVELDRDLIARLKQRFGALLELHAGDALAFDFRSLAAPGDAPSLRIVGNLPY
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEECCCC
NISSPLLFHLMTFADVVVDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMDKLIDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
PPESFQPPPKVDSAIVRMIPYAPHELPDVDPVLLGEIVTAAFSQRRKMLRNTLGDYRETI
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DFDALGFDLARRAEDVSVAEYVGVAQALAATRNAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA