Click here to switch to the map view.

The map label for this gene is hexR [H]

Identifier: 161523738

GI number: 161523738

Start: 607951

End: 608892

Strand: Direct

Name: hexR [H]

Synonym: Bmul_0558

Alternate gene names: 161523738

Gene position: 607951-608892 (Clockwise)

Preceding gene: 161523735

Following gene: 161523739

Centisome position: 17.63

GC content: 70.06

Gene sequence:

>942_bases
ATGAATATGCGCGCTGTCCGTTCCGCGTCGCGTGCGGCCACGCCGGAATCGGCGTCGGTCGCGCAGCCCGTCCTCGACAT
CGTCGCGCGCATCGCCGAATGCGCGCCCGAGCTGCGCGATGCCGAGCGCAAGGTCGCCGAATTCATCCTCGCCGATCTCG
CGCGCGCCGCGCATGCGAGCATCGGCGCGCTTGCGCGCGACACCGGCGTGAGCGTCGCGACGGTCACGCGCTTCGCGAAG
GCGGTCGGCTGTCGCGACGTGCGCGAACTGAAGCTGCTCGTCGCGCAGGCGGCGGCCGTCGGCCGGCGCTTTCTCGTGCC
CGCCGAGCAGGTGCCTGCCGAAGAAGACGCGAACCCGGCGACGGTCGTCTACGACGAGATCCGCGTCGCGCTCGCGCACA
ATCATCAGCTGCTGCGCAACGCGTCGTTCGACGCGGCGGCCGACCGGCTCGTTGGCGCGAAGATGATCTACGTGTACGGG
CAGGGCGGCGGCTCGACTGCGCTGGCCGACGAGCTGCGCTTTCGGCTCGTGCGTTTCGGGCGACCGGTCGCGACGTATCA
GGACAGCCTGCTGCAGCGGATGGTGTCGGCCACGCTGTCGCGCGACGCGGTCGTCGTCGCGTTGTCGGTGAGCGGCCGCG
TGCCCGAGCTGCTCGAGAACTGCCGGCTCGCGAAACGCTACGGCGCGTCGCTGATTGCGATCACCGCGCCCGCGTCGCCG
CTCGCGAAGCTGGCCGACCACCTGATTCCGGTCGTCGCCTTCGAGACCGATTTCATTTACAAGCCGTCGACGTCGCGCTA
CGCGATGATGATGGCGATCGACGTGCTCGTGACGGGGGTCGCGCTGCGGCTCGGCGATGCGGGCCGGGAATCGCTGCGCC
GTATCAAGCATGCGCTCGACGCGCATCGCGGCGGCGGCGACCGTCAACCGGTAGGAGACTGA

Upstream 100 bases:

>100_bases
ACTATGCATTGCACTGAAGTTGACAGTCAGATGGTACAGAAAGTAGCATCGGCGCGGTGATGTTATTTAGTAACATGAAC
CCTTATCCCCGTTTCCGCAG

Downstream 100 bases:

>100_bases
CCATGCATTCGCATCCCGAAGCCGCCGATACGCTGATCGTCGGCGCGCAACTGTACGACGGGACCGGCGCGCCGCCCGTC
ACGCGCGACGTCGCGATCCG

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNMRAVRSASRAATPESASVAQPVLDIVARIAECAPELRDAERKVAEFILADLARAAHASIGALARDTGVSVATVTRFAK
AVGCRDVRELKLLVAQAAAVGRRFLVPAEQVPAEEDANPATVVYDEIRVALAHNHQLLRNASFDAAADRLVGAKMIYVYG
QGGGSTALADELRFRLVRFGRPVATYQDSLLQRMVSATLSRDAVVVALSVSGRVPELLENCRLAKRYGASLIAITAPASP
LAKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD

Sequences:

>Translated_313_residues
MNMRAVRSASRAATPESASVAQPVLDIVARIAECAPELRDAERKVAEFILADLARAAHASIGALARDTGVSVATVTRFAK
AVGCRDVRELKLLVAQAAAVGRRFLVPAEQVPAEEDANPATVVYDEIRVALAHNHQLLRNASFDAAADRLVGAKMIYVYG
QGGGSTALADELRFRLVRFGRPVATYQDSLLQRMVSATLSRDAVVVALSVSGRVPELLENCRLAKRYGASLIAITAPASP
LAKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD
>Mature_313_residues
MNMRAVRSASRAATPESASVAQPVLDIVARIAECAPELRDAERKVAEFILADLARAAHASIGALARDTGVSVATVTRFAK
AVGCRDVRELKLLVAQAAAVGRRFLVPAEQVPAEEDANPATVVYDEIRVALAHNHQLLRNASFDAAADRLVGAKMIYVYG
QGGGSTALADELRFRLVRFGRPVATYQDSLLQRMVSATLSRDAVVVALSVSGRVPELLENCRLAKRYGASLIAITAPASP
LAKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=280, Percent_Identity=35, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788767, Length=278, Percent_Identity=26.978417266187, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082369, Length=250, Percent_Identity=25.6, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 33489; Mature: 33489

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMRAVRSASRAATPESASVAQPVLDIVARIAECAPELRDAERKVAEFILADLARAAHAS
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALARDTGVSVATVTRFAKAVGCRDVRELKLLVAQAAAVGRRFLVPAEQVPAEEDANPA
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
TVVYDEIRVALAHNHQLLRNASFDAAADRLVGAKMIYVYGQGGGSTALADELRFRLVRFG
EEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHC
RPVATYQDSLLQRMVSATLSRDAVVVALSVSGRVPELLENCRLAKRYGASLIAITAPASP
CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCH
LAKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALD
HHHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AHRGGGDRQPVGD
HHCCCCCCCCCCC
>Mature Secondary Structure
MNMRAVRSASRAATPESASVAQPVLDIVARIAECAPELRDAERKVAEFILADLARAAHAS
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALARDTGVSVATVTRFAKAVGCRDVRELKLLVAQAAAVGRRFLVPAEQVPAEEDANPA
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
TVVYDEIRVALAHNHQLLRNASFDAAADRLVGAKMIYVYGQGGGSTALADELRFRLVRFG
EEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHC
RPVATYQDSLLQRMVSATLSRDAVVVALSVSGRVPELLENCRLAKRYGASLIAITAPASP
CCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCH
LAKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALD
HHHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AHRGGGDRQPVGD
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]