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The map label for this gene is phbA [H]

Identifier: 161523723

GI number: 161523723

Start: 593367

End: 594548

Strand: Direct

Name: phbA [H]

Synonym: Bmul_0543

Alternate gene names: 161523723

Gene position: 593367-594548 (Clockwise)

Preceding gene: 161523722

Following gene: 161523724

Centisome position: 17.21

GC content: 69.2

Gene sequence:

>1182_bases
ATGACGGACGTAGTGATCGTATCGGCCGCGCGGACCGCGGTCGGCAAATTCGGCGGCTCGCTGGCGAAGGTGGCGGCGCC
CGAACTGGGCGCGACGGTGATCCGCGCGGCGCTGGAGCGCGCGGGCGTGAAGCCGGACCAGGTCAGCGAAGTGATCATGG
GGCAGGTGTTGACCGCGGGTTCGGGCCAGAACCCGGCACGCCAGTCGCTGATCAAGGCCGGACTGCCGAGCGCGGTGCCG
GGGATGACGATCAACAAGGTGTGTGGCTCGGGGCTGAAGGCCGTGATGCTGGCCGCGAACGCGATCGTCGCGGGCGACGC
GGAGATCGTCGTGGCGGGCGGGCAGGAGAACATGAGCGCGGCGCCGCACGTGCTGCCGGGCTCGCGCGACGGGTTCCGGA
TGGGCGACGCGAAGCTGGTCGACACGATGATCGTCGACGGCCTCTGGGACGTGTACAACCAGTACCACATGGGCATCACG
GCGGAGAACGTCGCGAAGGAATACGGCATCACGCGCGAAGAGCAGGATGCATTCGCGGCGCTGTCGCAGAACAAGGCCGA
AGCGGCGCAGAAGGCGGGGCGCTTCAATGACGAGATCGTGCCGGTGTCGATTCCGCAGCGCAAGGGCGAGCCGCTGCAGT
TCGCGACCGACGAGTTCGTGCGTCATGGCGTGACGGCGGAGTCGCTAGCGGGCCTGAAGCCGGCGTTCGCGAAGGACGGC
ACGGTGACGGCGGCCAACGCGTCGGGTATCAACGACGGCGCGGCGGCGGTGCTCGTGATGTCGGCGCAGAAGGCCCAGGC
GCTGGGCCTGACGCCGCTCGCGCGGATCAAGGCCTATGCGAACGCGGGCGTGGATCCGCGCGTGATGGGGATGGGCCCGG
TGCCGGCGTCGCGTCGATGCCTGGAGCGCGCGGGCTGGACGCCAGGCGATCTGGATCTGATGGAGATCAACGAGGCGTTT
GCGGCGCAGGCGCTGGCGGTGCACAAGCAGATGGGCTGGGACACGTCGAAGGTGAACGTGAACGGCGGGGCGATCGCGAT
CGGTCACCCGATCGGCGCATCGGGCTGCCGGATCCTGGTGACGCTGCTGCACGAGATGGTCAAGCGCGATGCGAAGCGCG
GGCTCGCGTCGCTCTGCATCGGCGGCGGGATGGGCGTCGCGCTGGCGGTCGAACGAGATTAG

Upstream 100 bases:

>100_bases
TGGCGTATCGCGACGCGAGGCGGCGAGCGTGTGCAGTCTGCATCGTTCGTCGATCGCTCGCGCAGGCGCCGGACCAACCG
ATTTGATGCAGGGATTGAAC

Downstream 100 bases:

>100_bases
CAGGAGACCAGGCGCCGTCTTGCGTGCGCGGCGCGATAGCGCGTCGCGAATGCAGGCAACGGCTTTGCGCGTCTGACCAA
TACAGAACAACAGGCGCGCA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKVAAPELGATVIRAALERAGVKPDQVSEVIMGQVLTAGSGQNPARQSLIKAGLPSAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPRVMGMGPVPASRRCLERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMVKRDAKRGLASLCIGGGMGVALAVERD

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKVAAPELGATVIRAALERAGVKPDQVSEVIMGQVLTAGSGQNPARQSLIKAGLPSAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPRVMGMGPVPASRRCLERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMVKRDAKRGLASLCIGGGMGVALAVERD
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKVAAPELGATVIRAALERAGVKPDQVSEVIMGQVLTAGSGQNPARQSLIKAGLPSAVPG
MTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITA
ENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDGT
VTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPRVMGMGPVPASRRCLERAGWTPGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMVKRDAKRGLASLCIGGGMGVALAVERD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=56.1224489795918, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.7837150127226, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.6153846153846, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=42.4242424242424, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.1320754716981, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.2977099236641, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=63.1043256997455, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=61.5776081424936, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.7920792079208, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.3558897243108, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=33.4963325183374, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=47.1794871794872, Blast_Score=337, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.8940568475452, Blast_Score=304, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.6666666666667, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.1632653061224, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.5420560747664, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=42.5692695214106, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=40.6565656565657, Blast_Score=237, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=56.8877551020408, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.5648854961832, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.1282051282051, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.2941176470588, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40508; Mature: 40377

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKVAAPELGATVIRAALERAGVKPDQVSEVIMGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPSAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPRVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMVKRDAKRGLASLCIGGGMGVALAVERD
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKVAAPELGATVIRAALERAGVKPDQVSEVIMGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPSAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPRVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMVKRDAKRGLASLCIGGGMGVALAVERD
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]