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The map label for this gene is sdaA [H]

Identifier: 161523319

GI number: 161523319

Start: 153743

End: 155131

Strand: Reverse

Name: sdaA [H]

Synonym: Bmul_0139

Alternate gene names: 161523319

Gene position: 155131-153743 (Counterclockwise)

Preceding gene: 161523320

Following gene: 161523316

Centisome position: 4.5

GC content: 68.47

Gene sequence:

>1389_bases
ATGGCAGTCAGCGTGTTTGACCTTTTCAAGATCGGCATCGGGCCGTCCAGTTCGCATACGGTCGGACCGATGCGCGCGGC
GCTGATGTTCGTCCAGGGCCTTGAGCGCGACGGGCTGCTCGACGCGACTGCGCACGTGAAGGTCGAGCTGTACGGCTCGC
TCGGCGCGACCGGCAAGGGTCACGGCACCGACCGCGGTGTGATGCTCGGCCTGCTCGGCGACGCGCCCGACACCGTCGAT
CCCGACACGATCGGTGCACGGCTCGAGCAGGTGCGCACGTCGAAGCAGCTCGCGCTGCTCGGCAAGCACGCGGTGCCGTT
CGTGCTGAAGGAAAACATCGCGTTCTACCGGCAGGCGCTGCCCGAGCACCCGAACGGGATGAAGCTGCGCGCGTCCGACG
CGAACGGCGCGGTGCTCGCCGAGCGCACGTATCTGTCGGTCGGCGGCGGCTTCGTCGTGACGGCCGGCGCACCGAACACG
AAGGTGCTGAGCGCGGCCGAACAGATGACGCATCCGTTCCGCACCGGCGCCGAGTTGCTCGCGCTGACCGAGTCGACCGG
CAAGTCGATCGCGCAGCTGATGTGGGAAAACGAGCGTGCGTGGCATACCGAGCAGGAGACGCGCGACGGCCTGCTGAAGA
TCTGGGCCGTGATGCAGTCGTGCGTGTCGCGCGGCTGCGGCGTCGGCAACCCGGATGCCGAAGGCAACCTGCCGGGCCCG
TTCCAGGTGAAGCGCCGCGCGCCGCAGCTGTACCGCGCGCTGACGGGCAACCCCGAGCGTGCGCTGCAGGATCCGCTGTC
GATGGTCGACTGGATCAACCTGTATGCGATCGCGGTGAACGAGGAAAACGCGGCAGGCGGGCGCGTCGTCACCGCGCCGA
CCAACGGCGCGGCCGGCATCATCCCCGCCGTGCTGCATTACTACACGCGCTTCACGCCGGGCGCGAACGAACAGGGCGTG
ATCGACTTCCTGCTGACGGCCGCCGCGATCGGCATTCTGTACAAGCTCAACGCGTCGATTTCGGGCGCGGAAGTCGGCTG
TCAGGGCGAAGTCGGCGTCGCCTGCTCGATGGCGGCCGGCGCGCTCGCGGCGGTGCTCGGCGGCACGCCGCGCCAGGTCG
AGAATGCGGCCGAGATCGGCATGGAGCACAACCTCGGCCTCACGTGCGACCCGGTCGGCGGGATGGTGCAGATTCCGTGC
ATCGAGCGCAACGCGATGGCGTCGGTGAAGGCCGTCAACGCGGCGCGCATGGCGCTGCGCGGCGACGGCTCGCACTACGT
GTCGCTCGACTCGGTGATCAAGACGATGCGCGAAACCGGCGCCGACATGAAGACCAAGTACAAGGAAACGTCGCGCGGCG
GGCTGGCCGTGAACATCGTCGAGTGCTGA

Upstream 100 bases:

>100_bases
CCCGCGTCGCGCAGCAGCTTTCTCCAACGCCGCCCGCATGGCTCGCCGCGTGCCTGCCGTTGCAGGCGCGCTAGTTTTTT
ATCGCAAGGCAGGAATTCAA

Downstream 100 bases:

>100_bases
GCGGCGGCCGTCACGGCCGCTCGCCCCGACCGCGCGATACGTGCCCCCCTTCCATCGGCGGGCCGTCGCGCCCCGGCCGC
CCTCGCGGCCGTTCGAACCG

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFVQGLERDGLLDATAHVKVELYGSLGATGKGHGTDRGVMLGLLGDAPDTVD
PDTIGARLEQVRTSKQLALLGKHAVPFVLKENIAFYRQALPEHPNGMKLRASDANGAVLAERTYLSVGGGFVVTAGAPNT
KVLSAAEQMTHPFRTGAELLALTESTGKSIAQLMWENERAWHTEQETRDGLLKIWAVMQSCVSRGCGVGNPDAEGNLPGP
FQVKRRAPQLYRALTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFTPGANEQGV
IDFLLTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPRQVENAAEIGMEHNLGLTCDPVGGMVQIPC
IERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC

Sequences:

>Translated_462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFVQGLERDGLLDATAHVKVELYGSLGATGKGHGTDRGVMLGLLGDAPDTVD
PDTIGARLEQVRTSKQLALLGKHAVPFVLKENIAFYRQALPEHPNGMKLRASDANGAVLAERTYLSVGGGFVVTAGAPNT
KVLSAAEQMTHPFRTGAELLALTESTGKSIAQLMWENERAWHTEQETRDGLLKIWAVMQSCVSRGCGVGNPDAEGNLPGP
FQVKRRAPQLYRALTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFTPGANEQGV
IDFLLTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPRQVENAAEIGMEHNLGLTCDPVGGMVQIPC
IERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC
>Mature_461_residues
AVSVFDLFKIGIGPSSSHTVGPMRAALMFVQGLERDGLLDATAHVKVELYGSLGATGKGHGTDRGVMLGLLGDAPDTVDP
DTIGARLEQVRTSKQLALLGKHAVPFVLKENIAFYRQALPEHPNGMKLRASDANGAVLAERTYLSVGGGFVVTAGAPNTK
VLSAAEQMTHPFRTGAELLALTESTGKSIAQLMWENERAWHTEQETRDGLLKIWAVMQSCVSRGCGVGNPDAEGNLPGPF
QVKRRAPQLYRALTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFTPGANEQGVI
DFLLTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPRQVENAAEIGMEHNLGLTCDPVGGMVQIPCI
ERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=463, Percent_Identity=53.1317494600432, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI48994925, Length=461, Percent_Identity=54.880694143167, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1789161, Length=461, Percent_Identity=53.7960954446855, Blast_Score=467, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48633; Mature: 48502

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFVQGLERDGLLDATAHVKVELYGSLGATGKG
CEEEHEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCC
HGTDRGVMLGLLGDAPDTVDPDTIGARLEQVRTSKQLALLGKHAVPFVLKENIAFYRQAL
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
PEHPNGMKLRASDANGAVLAERTYLSVGGGFVVTAGAPNTKVLSAAEQMTHPFRTGAELL
CCCCCCCEEEECCCCCEEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCHHCCCCEE
ALTESTGKSIAQLMWENERAWHTEQETRDGLLKIWAVMQSCVSRGCGVGNPDAEGNLPGP
EEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
FQVKRRAPQLYRALTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHH
IPAVLHYYTRFTPGANEQGVIDFLLTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHH
ALAAVLGGTPRQVENAAEIGMEHNLGLTCDPVGGMVQIPCIERNAMASVKAVNAARMALR
HHHHHHCCCHHHHHHHHHCCCCCCCCEEECCCCCEEEECEECCCHHHHHHHHHHHHHEEE
GDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC
CCCCCEEEHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure 
AVSVFDLFKIGIGPSSSHTVGPMRAALMFVQGLERDGLLDATAHVKVELYGSLGATGKG
EEEHEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCC
HGTDRGVMLGLLGDAPDTVDPDTIGARLEQVRTSKQLALLGKHAVPFVLKENIAFYRQAL
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
PEHPNGMKLRASDANGAVLAERTYLSVGGGFVVTAGAPNTKVLSAAEQMTHPFRTGAELL
CCCCCCCEEEECCCCCEEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCHHCCCCEE
ALTESTGKSIAQLMWENERAWHTEQETRDGLLKIWAVMQSCVSRGCGVGNPDAEGNLPGP
EEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
FQVKRRAPQLYRALTGNPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHH
IPAVLHYYTRFTPGANEQGVIDFLLTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHH
ALAAVLGGTPRQVENAAEIGMEHNLGLTCDPVGGMVQIPCIERNAMASVKAVNAARMALR
HHHHHHCCCHHHHHHHHHCCCCCCCCEEECCCCCEEEECEECCCHHHHHHHHHHHHHEEE
GDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC
CCCCCEEEHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]