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The map label for this gene is hemE [H]

Identifier: 161523292

GI number: 161523292

Start: 117080

End: 118258

Strand: Direct

Name: hemE [H]

Synonym: Bmul_0112

Alternate gene names: 161523292

Gene position: 117080-118258 (Clockwise)

Preceding gene: 161523289

Following gene: 161523293

Centisome position: 3.4

GC content: 69.47

Gene sequence:

>1179_bases
ATGGCCGCCATCGCACGGGCACGCGCAGTCGGAGCGCGGCTGTCCGGTAAAATGCCGGTTTGCCTACGCACCGTCGCTCA
CACCGTGGCCCATACCCTGCTCAACGACACCTTCCTGCGTGCGCTTCTGCGCGAGCCGACCGACTACACGCCGATCTGGC
TCATGCGCCAGGCGGGCCGCTATCTGCCGGAATACAACGCGACGCGCGCGCGGGCCGGCAGCTTCCTCGGCCTCGCGAAG
AATCCCGATTACGCGACCGAAGTGACGCTGCAGCCGCTCGAGCGCTTTCCGCTCGACGCCGCGATCCTGTTCTCCGACAT
CCTGACGATTCCCGACGCCATGGGCCTCGGCCTCGACTTCCAGGTCGGCGAAGGGCCGAAGTTCGCGCATCCGGTGCGCA
CCGAGGCCGACGTCGCGAAGCTCGCGGTGCCCGACATCGGCGCGACGCTCGGCTACGTGACCGATGCGGTACGCGAGATC
CGGCGCGCGCTCACCGACGGCCAGGGCCGCCAGCGCGTGCCGCTGATCGGCTTCTCCGGCAGCCCGTGGACGCTCGCCTG
CTATATGGTCGAGGGCGGCGGCTCGGACGATTTCCGCACCGTGAAGTCGATGGCGTATGCACGTCCCGACCTGATGCACC
GGATTCTCGACGTGAACGCGCAGGCCGTGGCCGCGTATCTGAACGCGCAGATCGAGGCGGGCGCGCAGGCGGTGATGATT
TTCGACACGTGGGGCGGCGCGCTCGCCGACGGCGCGTATCAGCGCTATTCGCTCGACTACATTCGGCGCGTCGTCGCGCA
GCTCAAGCGCGAGCATGACGGCCAGCGCGTGCCGGTCATCACGTTCACGAAGGGCGGCGGGCTGTGGCTCGAGGAAATCG
CGGCGACCGGCGTCGACGCGGTCGGGCTCGACTGGACGGTCAACGTCGGCGCCGCGCGCGAGCGTGTCGGCGGCCGCGTC
GCGCTGCAGGGCAACCTCGATCCGACGATCCTGTTTGCGCCGCCGGCCGTCGTGCGCGAGCAGGCGCGTGCGGTGCTCGA
CAGCTACGGCAACCATCCGGGCCACGTGTTCAACCTCGGCCACGGCATCTCGCAGTTCACGCCGCCCGAGCACGTCGCCG
AACTCGTCGACGAAGTGCATCGCCACAGCCGCGCGATCCGTAGCGGAGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CATCGCGGCCGCGGCGATCGTGGCGAGTGTCTTCATCTGTCTCCTCCTGGTTCGGTTCGATATGAGCGTCCGATCATAAC
GGAGCCATCGCGCGCGTCAT

Downstream 100 bases:

>100_bases
ACGCAAGCGCCGTCATGCTGCAGTGCGGCGCGACGGCGTTGCGCAGCCGGCGCTAAACAGGGCGCAACCCCGCACCGGCT
GCCGATTCGATGCTTGTCAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAAIARARAVGARLSGKMPVCLRTVAHTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAK
NPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREI
RRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
FDTWGGALADGAYQRYSLDYIRRVVAQLKREHDGQRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNVGAARERVGGRV
ALQGNLDPTILFAPPAVVREQARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAAR

Sequences:

>Translated_392_residues
MAAIARARAVGARLSGKMPVCLRTVAHTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAK
NPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREI
RRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
FDTWGGALADGAYQRYSLDYIRRVVAQLKREHDGQRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNVGAARERVGGRV
ALQGNLDPTILFAPPAVVREQARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAAR
>Mature_391_residues
AAIARARAVGARLSGKMPVCLRTVAHTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKN
PDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIR
RALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIF
DTWGGALADGAYQRYSLDYIRRVVAQLKREHDGQRVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNVGAARERVGGRVA
LQGNLDPTILFAPPAVVREQARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAAR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=47.6454293628809, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=62.2159090909091, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320252, Length=363, Percent_Identity=35.5371900826446, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI19921920, Length=352, Percent_Identity=38.6363636363636, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=38.5269121813031, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 42524; Mature: 42393

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIARARAVGARLSGKMPVCLRTVAHTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGR
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YLPEYNATRARAGSFLGLAKNPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDF
CCCCCCCHHHHCCCEEECCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEE
QVGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGQGRQRVPLIGFSG
EECCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
SPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
CCCEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEE
FDTWGGALADGAYQRYSLDYIRRVVAQLKREHDGQRVPVITFTKGGGLWLEEIAATGVDA
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCE
VGLDWTVNVGAARERVGGRVALQGNLDPTILFAPPAVVREQARAVLDSYGNHPGHVFNLG
ECCCEEEECCHHHHHHCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEECC
HGISQFTPPEHVAELVDEVHRHSRAIRSGAAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAIARARAVGARLSGKMPVCLRTVAHTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YLPEYNATRARAGSFLGLAKNPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDF
CCCCCCCHHHHCCCEEECCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEE
QVGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGQGRQRVPLIGFSG
EECCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
SPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
CCCEEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEE
FDTWGGALADGAYQRYSLDYIRRVVAQLKREHDGQRVPVITFTKGGGLWLEEIAATGVDA
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCE
VGLDWTVNVGAARERVGGRVALQGNLDPTILFAPPAVVREQARAVLDSYGNHPGHVFNLG
ECCCEEEECCHHHHHHCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEECC
HGISQFTPPEHVAELVDEVHRHSRAIRSGAAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA