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The map label for this gene is srpA [H]

Identifier: 161523186

GI number: 161523186

Start: 7995

End: 9086

Strand: Reverse

Name: srpA [H]

Synonym: Bmul_0006

Alternate gene names: 161523186

Gene position: 9086-7995 (Counterclockwise)

Preceding gene: 161523189

Following gene: 161523185

Centisome position: 0.26

GC content: 70.79

Gene sequence:

>1092_bases
ATGGAACGATCTTCCTCTTCTTCGCCGCCGCCGCGCGAGCCCGGCCGCAGAGGGTGGCGGTGGGCCGCGATCGGCGGCGC
CGTCGCGGGCGCCGCGCTGGCGTTCGGCTATGTCGGTGGCTGGCTTGCGCCGGCCCGCCTGACCCCGCACCGGCTCGTCG
ATGCGCTGCAGACTGCCGGCGGCCTGCATCCCGGCTTCCGGCGCAATCACGCGAAGGGCGTCTGCGTGACGGGCTACTTC
GAAGGCAACGGCACGGCGAGCCAGTATTCCGTCGCGCCATTCTTCAAACCCGTGCGCACGCCGGTGGTCGGGCGGTTCGC
GTTGCCGGGCGGGAATCCATATGCGCCCGACAGCAGCGTGCCGATCCGCAGCCTGGCGCTAAAGCTGACGGCGCCCGATG
GCGAGCAATGGCGCACCGGGATGAACGCGATGCCCGTGTTTCCGGTCGCGACGCCGCAGGCGTTCTACGCGCAATTGCTC
GCGACGCGGCCCGACCCGGCGACCGGCAAGCCCGATCCGGCGAAGGTGAAGGCGTTTTTTGCCGCGCATCCGGAGACGGC
CGCGTTCCGCGAATGGGTGAAGGGTGCGAAGCCGAGCGCGAGTTACGTCACCGAGCGCTACGACGCGCTGAACGCGTTCT
ACTTCATCGACGCGGCCGGGCAGCGGCACGCGGTGCGATGGCGCGTCGTGCCGGAGCAGACGGCCGGCGCCGGCGATGTC
GCGACGGCCGCGGATCCGAACGTGCTGGAGCAGGATCTGACGCGGCGCATCGCGGACGGTGCGCAGAAGTGGAAGTTGCT
CGTCACGCTCGCCGAGCCCGGCGATCCGGTGGACGACGCGACGAAGGTCTGGCCCGCGCAGCGCACGACGATCGACGCGG
GGACGCTCGTGCTCGATCACGTGGAGCCGCAGGACAGCGGGCCGTGCCGCGACGTCAATTACGACCCGACGGTGCTGCCG
CGCGGGATTCAGGTGTCGGGCGATCCGTTGCTGGCGGCGCGGTCCGCGGCGTATGCGGATTCGTATCTGCGCAGGACAAG
CGAAGAGGCCGGCGTGGCCGACGCGGCGCGGTTGAGTGCGGAGGGACGATGA

Upstream 100 bases:

>100_bases
GTTATTCCATCAGCATACGAAAAATTTCTTCATGGAATAAAGGCGGGCGGCCGGCGTCCTACGCGCGTTCGACAATGATC
TGACGATCGGGAGTGCATTC

Downstream 100 bases:

>100_bases
TGAAGGCTTCTACGACTTTCAGTTTGCCGGCGCGCGTGCTGCATTGGGTGATGGCTGCGATGGTGCTCACGATGCTGTTC
GTCGGCGTGGGGATGGTGGC

Product: catalase domain-containing protein

Products: O2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MERSSSSSPPPREPGRRGWRWAAIGGAVAGAALAFGYVGGWLAPARLTPHRLVDALQTAGGLHPGFRRNHAKGVCVTGYF
EGNGTASQYSVAPFFKPVRTPVVGRFALPGGNPYAPDSSVPIRSLALKLTAPDGEQWRTGMNAMPVFPVATPQAFYAQLL
ATRPDPATGKPDPAKVKAFFAAHPETAAFREWVKGAKPSASYVTERYDALNAFYFIDAAGQRHAVRWRVVPEQTAGAGDV
ATAADPNVLEQDLTRRIADGAQKWKLLVTLAEPGDPVDDATKVWPAQRTTIDAGTLVLDHVEPQDSGPCRDVNYDPTVLP
RGIQVSGDPLLAARSAAYADSYLRRTSEEAGVADAARLSAEGR

Sequences:

>Translated_363_residues
MERSSSSSPPPREPGRRGWRWAAIGGAVAGAALAFGYVGGWLAPARLTPHRLVDALQTAGGLHPGFRRNHAKGVCVTGYF
EGNGTASQYSVAPFFKPVRTPVVGRFALPGGNPYAPDSSVPIRSLALKLTAPDGEQWRTGMNAMPVFPVATPQAFYAQLL
ATRPDPATGKPDPAKVKAFFAAHPETAAFREWVKGAKPSASYVTERYDALNAFYFIDAAGQRHAVRWRVVPEQTAGAGDV
ATAADPNVLEQDLTRRIADGAQKWKLLVTLAEPGDPVDDATKVWPAQRTTIDAGTLVLDHVEPQDSGPCRDVNYDPTVLP
RGIQVSGDPLLAARSAAYADSYLRRTSEEAGVADAARLSAEGR
>Mature_363_residues
MERSSSSSPPPREPGRRGWRWAAIGGAVAGAALAFGYVGGWLAPARLTPHRLVDALQTAGGLHPGFRRNHAKGVCVTGYF
EGNGTASQYSVAPFFKPVRTPVVGRFALPGGNPYAPDSSVPIRSLALKLTAPDGEQWRTGMNAMPVFPVATPQAFYAQLL
ATRPDPATGKPDPAKVKAFFAAHPETAAFREWVKGAKPSASYVTERYDALNAFYFIDAAGQRHAVRWRVVPEQTAGAGDV
ATAADPNVLEQDLTRRIADGAQKWKLLVTLAEPGDPVDDATKVWPAQRTTIDAGTLVLDHVEPQDSGPCRDVNYDPTVLP
RGIQVSGDPLLAARSAAYADSYLRRTSEEAGVADAARLSAEGR

Specific function: Decomposes Hydrogen Peroxide Into Water And Oxygen; Serves To Protect Cells From The Toxic Effects Of Hydrogen Peroxide. [C]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=294, Percent_Identity=27.2108843537415, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71998444, Length=294, Percent_Identity=25.8503401360544, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147792, Length=294, Percent_Identity=24.8299319727891, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25151141, Length=294, Percent_Identity=24.8299319727891, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17981717, Length=294, Percent_Identity=27.2108843537415, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19920968, Length=319, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020835
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase [H]

EC number: 1.11.1.6

Molecular weight: Translated: 38736; Mature: 38736

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERSSSSSPPPREPGRRGWRWAAIGGAVAGAALAFGYVGGWLAPARLTPHRLVDALQTAG
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GLHPGFRRNHAKGVCVTGYFEGNGTASQYSVAPFFKPVRTPVVGRFALPGGNPYAPDSSV
CCCCCHHCCCCCCEEEEEEECCCCCCCCEECCHHHHHHCCCCEEEEECCCCCCCCCCCCC
PIRSLALKLTAPDGEQWRTGMNAMPVFPVATPQAFYAQLLATRPDPATGKPDPAKVKAFF
CHHHEEEEEECCCCHHHHCCCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCHHHEEEEE
AAHPETAAFREWVKGAKPSASYVTERYDALNAFYFIDAAGQRHAVRWRVVPEQTAGAGDV
ECCCCHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEECCCCCCEEEEEECCCCCCCCCCC
ATAADPNVLEQDLTRRIADGAQKWKLLVTLAEPGDPVDDATKVWPAQRTTIDAGTLVLDH
CCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHCCCCCCEEECCCEEEEEC
VEPQDSGPCRDVNYDPTVLPRGIQVSGDPLLAARSAAYADSYLRRTSEEAGVADAARLSA
CCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHCCCHHHHHHCC
EGR
CCC
>Mature Secondary Structure
MERSSSSSPPPREPGRRGWRWAAIGGAVAGAALAFGYVGGWLAPARLTPHRLVDALQTAG
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GLHPGFRRNHAKGVCVTGYFEGNGTASQYSVAPFFKPVRTPVVGRFALPGGNPYAPDSSV
CCCCCHHCCCCCCEEEEEEECCCCCCCCEECCHHHHHHCCCCEEEEECCCCCCCCCCCCC
PIRSLALKLTAPDGEQWRTGMNAMPVFPVATPQAFYAQLLATRPDPATGKPDPAKVKAFF
CHHHEEEEEECCCCHHHHCCCCCCCEECCCCHHHHHHHHHHCCCCCCCCCCCHHHEEEEE
AAHPETAAFREWVKGAKPSASYVTERYDALNAFYFIDAAGQRHAVRWRVVPEQTAGAGDV
ECCCCHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEECCCCCCEEEEEECCCCCCCCCCC
ATAADPNVLEQDLTRRIADGAQKWKLLVTLAEPGDPVDDATKVWPAQRTTIDAGTLVLDH
CCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHCCCCCCEEECCCEEEEEC
VEPQDSGPCRDVNYDPTVLPRGIQVSGDPLLAARSAAYADSYLRRTSEEAGVADAARLSA
CCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHCCCHHHHHHCC
EGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Heme Group. [C]

Metal ions: NA

Kcat value (1/min): 980000 [C]

Specific activity: NA

Km value (mM): 18.2 {H2O2}} 10 {H2O2}} 3.7 {H2O2}} [C]

Substrates: H2O2

Specific reaction: 2 H2O2 = O2 + 2 H2O

General reaction: Redox reaction [C]

Inhibitor: 3-Amino-1-H-1, 2, 4-triazolecoli, Rhodopseudomonascapsulata; Dianisidine; H2O2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7536734 [H]