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The map label for this gene is gyrB [H]

Identifier: 161523183

GI number: 161523183

Start: 3115

End: 5589

Strand: Direct

Name: gyrB [H]

Synonym: Bmul_0003

Alternate gene names: 161523183

Gene position: 3115-5589 (Clockwise)

Preceding gene: 161523182

Following gene: 161523187

Centisome position: 0.09

GC content: 63.35

Gene sequence:

>2475_bases
ATGAGTGAACAGCACAATTCGCAGCCCGATAACAGCAGCTACGGCGCCTCGTCGATCCAGATCCTCGAGGGTCTGGAGGC
GGTGCGCAAGCGCCCCGGGATGTACATCGGCGACACGTCGGACGGCACCGGTCTGCACCACCTCGTCTTCGAGGTGCTCG
ACAACTCGATCGACGAAGCGTTGGCCGGGTACTGCAACGACATCCACGTGACGATTCACGCCGACAACTCGATTTCCGTC
GTCGACAACGGCCGCGGAATTCCGACCGACGTGAAGATGAACGACAAGCACGAACCGAAGCGCAGCGCCGCCGAGATCGT
GATGACCGAGCTGCATGCGGGCGGCAAGTTCGATCAGAACAGCTACAAGGTGTCGGGCGGGTTGCACGGCGTCGGCGTGT
CGTGCGTGAACGCGCTGTCGAGCTGGCTGCGCCTCACCGTGCGCCGCAACGGCAAGAAGCACTTCATGGAGTTCCATCGC
GGCGTCGCGCAGGATCGCGTGATCGAAGTCGTCGACGGCGAGGAAGTGTCGCCGATGCAGGTGATCGGCGATACCGAGAA
CCGCGGCACCGAAGTCCACTTCATGGCCGATCCGACGATCTTCGGCACCGTCGAGTACCACTACGACATCCTCGCGAAGC
GGATGCGCGAGCTCTCGTTCCTGAACAACGGCGTGCGGATCCGCCTGACCGACCTGCGTTCGGGCAAGGAAGACGATTTC
GCGTTCGCCGGCGGCGTGAAGGGCTTCGTCGAGTACATCAACAAGACGAAGAGCAACCTGCACCCGACGATCTTCCACGT
GATCGGCGAGAAGGACGGCGTGGGCGTCGAAGTCGCGATGCAGTGGAACGACAGCTACAACGAGAACGTGCTCTGCTTCA
CGAACAACATTCCGCAGCGCGACGGCGGCACGCACCTCACCGGTCTGCGCGCGGCAATGACGCGCGTGATCAACAAGTAC
ATCGCCGATAACGAAATCGCGAAGAAGGCGAAGGTCGAGACGACCGGCGACGACATGCGCGAAGGTCTGTCGTGCGTGCT
GTCCGTGAAGGTGCCGGAGCCGAAGTTCAGCTCGCAGACGAAGGACAAGCTCGTGTCGTCGGAAGTGCGTGCGCCGGTCG
AGGAAGTCGTCGCGAAGGCGCTCGAGGAATTCCTGCTCGAAACGCCGAACGACGCGAAGATCATCTGCGGGAAGATCGTC
GAGGCTGCGCGCGCGCGCGATGCCGCGCGCAAGGCGCGCGAGATGACGCGCCGCAAGGGCGTGCTCGACGGCGTCGGCCT
GCCCGGCAAGCTCGCGGACTGCCAGGAGAAGGATCCGGCGAAGTCGGAAATCTACATCGTCGAGGGCGACTCGGCGGGCG
GTTCGGCGAAGCAAGGGCGCGACCGCAAGTTCCAGGCGATCCTGCCGCTGCGCGGCAAGGTGCTGAACGTCGAGAAGGCG
CGCTACGACAAGCTGCTGTCGTCGGAGCAGATCGTCACGCTCGTGACCGCGCTCGGCTGCGGCATCGGCAAGGACGATTA
CAACCTCGACAAGCTGCGCTATCACCGGATCATCATCATGACCGACGCGGACGTCGACGGTGCGCACATCCGGACGCTGC
TGCTCACGTTCTTCTACCGTCAGATGCCGGAGATGATCGAGCGCGGGTATGTGTATATCGCGCAGCCGCCGCTGTACAAG
GTGAAGGCCGGCAAGGACGAGCGCTATCTGAAGGACGACGCGGAACTGAACGCGCACATGCTGCGGCTCGCGCTGCAGGG
CTCGGAGCTGCTGCCGAGCGAGAACGCGACGCCGATCACCGGCGATGCGCTCGGCGAGCTCGCGCGGTCGTATCTGATGT
CGCAGAGCGTGATCGAGCGGCTGAGCCGCCTGTACGACCCGGCGGCGCTCGAGGCGATCATGGATGGCGTTTCGATCGAT
CTGTCGAGCGAGGCGTCGACGGAGGCGTCGGCGAAGGCGCTGCACGCGGCGCTGCATGACGACACGCTGAAGAACGAAGT
GCGCGTGGTGCCGGCGTACGATCCGGTGCGCGAACTGCGATCGCTGCGCGTCGAGCGTGCGCATCATGGCAACGTGCGCG
TTTCAGTGATCGACGAGGAGTTCCAGCACACGGCGGATTATCAGCAGCTCGTGAATACGGCCAAGACGTTCGAAGGGCTG
ATTCAGGCCGGTGCGGTGATCAAGCGCGGCGAGCGCAGCATGGCCGTGACGGACTTCAAGAACGCGATGAAGTGGCTGCT
CGCGGATGCGGAGCGGAACGTTTCGAAGCAGCGGTATAAGGGGTTGGGCGAGATGAACCCCGAGCAGCTGTGGGAAACGA
CGATGGATCCGAATGTGCGACGGTTGCTGCGTGTGCAGATCGAGGACGCGATCGCGGCAGATGGGATCTTTACGACGCTG
ATGGGGGATGAGGTGGAGCCTCGGCGGGCGTTTATCGAGTCTAATGCGTTGAGGGCGGGGAATATTGATGTTTGA

Upstream 100 bases:

>100_bases
GCGCCCTGGAGGGGCCAGGAAAACTGGAGCGGCCCGGCGTTTCCTCGCGGAAACGCACAGCGCCGCCGCTTGAGTGGCCT
CGCAGAACCGGAAGATATCC

Downstream 100 bases:

>100_bases
TGGCGTTGTCGGGCAACGCATAACGCCATACGCTTTCGACGTATAAGACGAGAGCTTTTTAAAGGGAACGCAATTGCGTT
CCCTTTTTTATGCTCAGCGT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MSEQHNSQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISV
VDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRNGKKHFMEFHR
GVAQDRVIEVVDGEEVSPMQVIGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
AFAGGVKGFVEYINKTKSNLHPTIFHVIGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKY
IADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIV
EAARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
RYDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYK
VKAGKDERYLKDDAELNAHMLRLALQGSELLPSENATPITGDALGELARSYLMSQSVIERLSRLYDPAALEAIMDGVSID
LSSEASTEASAKALHAALHDDTLKNEVRVVPAYDPVRELRSLRVERAHHGNVRVSVIDEEFQHTADYQQLVNTAKTFEGL
IQAGAVIKRGERSMAVTDFKNAMKWLLADAERNVSKQRYKGLGEMNPEQLWETTMDPNVRRLLRVQIEDAIAADGIFTTL
MGDEVEPRRAFIESNALRAGNIDV

Sequences:

>Translated_824_residues
MSEQHNSQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISV
VDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRNGKKHFMEFHR
GVAQDRVIEVVDGEEVSPMQVIGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
AFAGGVKGFVEYINKTKSNLHPTIFHVIGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKY
IADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIV
EAARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
RYDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYK
VKAGKDERYLKDDAELNAHMLRLALQGSELLPSENATPITGDALGELARSYLMSQSVIERLSRLYDPAALEAIMDGVSID
LSSEASTEASAKALHAALHDDTLKNEVRVVPAYDPVRELRSLRVERAHHGNVRVSVIDEEFQHTADYQQLVNTAKTFEGL
IQAGAVIKRGERSMAVTDFKNAMKWLLADAERNVSKQRYKGLGEMNPEQLWETTMDPNVRRLLRVQIEDAIAADGIFTTL
MGDEVEPRRAFIESNALRAGNIDV
>Mature_823_residues
SEQHNSQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEALAGYCNDIHVTIHADNSISVV
DNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLRLTVRRNGKKHFMEFHRG
VAQDRVIEVVDGEEVSPMQVIGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDFA
FAGGVKGFVEYINKTKSNLHPTIFHVIGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQRDGGTHLTGLRAAMTRVINKYI
ADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQTKDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVE
AARARDAARKAREMTRRKGVLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKAR
YDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPEMIERGYVYIAQPPLYKV
KAGKDERYLKDDAELNAHMLRLALQGSELLPSENATPITGDALGELARSYLMSQSVIERLSRLYDPAALEAIMDGVSIDL
SSEASTEASAKALHAALHDDTLKNEVRVVPAYDPVRELRSLRVERAHHGNVRVSVIDEEFQHTADYQQLVNTAKTFEGLI
QAGAVIKRGERSMAVTDFKNAMKWLLADAERNVSKQRYKGLGEMNPEQLWETTMDPNVRRLLRVQIEDAIAADGIFTTLM
GDEVEPRRAFIESNALRAGNIDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=550, Percent_Identity=25.0909090909091, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI19913408, Length=561, Percent_Identity=24.777183600713, Blast_Score=117, Evalue=4e-26,
Organism=Escherichia coli, GI48994957, Length=826, Percent_Identity=59.2009685230024, Blast_Score=954, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=562, Percent_Identity=37.5444839857651, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17535065, Length=600, Percent_Identity=24.5, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI212645845, Length=521, Percent_Identity=23.6084452975048, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=161, Percent_Identity=29.8136645962733, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=606, Percent_Identity=24.4224422442244, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136538, Length=546, Percent_Identity=25.0915750915751, Blast_Score=114, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91366; Mature: 91235

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQHNSQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LAGYCNDIHVTIHADNSISVVDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQN
HHHCCCEEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SYKVSGGLHGVGVSCVNALSSWLRLTVRRNGKKHFMEFHRGVAQDRVIEVVDGEEVSPMQ
CEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEECCCCCCCCE
VIGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
EECCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
AFAGGVKGFVEYINKTKSNLHPTIFHVIGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQR
CHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCC
DGGTHLTGLRAAMTRVINKYIADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQT
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCCCCHH
KDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEAARARDAARKAREMTRRKG
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEECHHH
RYDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYR
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
QMPEMIERGYVYIAQPPLYKVKAGKDERYLKDDAELNAHMLRLALQGSELLPSENATPIT
HHHHHHHCCEEEEECCCCEEEECCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GDALGELARSYLMSQSVIERLSRLYDPAALEAIMDGVSIDLSSEASTEASAKALHAALHD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHH
DTLKNEVRVVPAYDPVRELRSLRVERAHHGNVRVSVIDEEFQHTADYQQLVNTAKTFEGL
HHHCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
IQAGAVIKRGERSMAVTDFKNAMKWLLADAERNVSKQRYKGLGEMNPEQLWETTMDPNVR
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHH
RLLRVQIEDAIAADGIFTTLMGDEVEPRRAFIESNALRAGNIDV
HHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SEQHNSQPDNSSYGASSIQILEGLEAVRKRPGMYIGDTSDGTGLHHLVFEVLDNSIDEA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LAGYCNDIHVTIHADNSISVVDNGRGIPTDVKMNDKHEPKRSAAEIVMTELHAGGKFDQN
HHHCCCEEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
SYKVSGGLHGVGVSCVNALSSWLRLTVRRNGKKHFMEFHRGVAQDRVIEVVDGEEVSPMQ
CEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEECCCCCCCCE
VIGDTENRGTEVHFMADPTIFGTVEYHYDILAKRMRELSFLNNGVRIRLTDLRSGKEDDF
EECCCCCCCCEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
AFAGGVKGFVEYINKTKSNLHPTIFHVIGEKDGVGVEVAMQWNDSYNENVLCFTNNIPQR
CHHCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCC
DGGTHLTGLRAAMTRVINKYIADNEIAKKAKVETTGDDMREGLSCVLSVKVPEPKFSSQT
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCCCCHH
KDKLVSSEVRAPVEEVVAKALEEFLLETPNDAKIICGKIVEAARARDAARKAREMTRRKG
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLDGVGLPGKLADCQEKDPAKSEIYIVEGDSAGGSAKQGRDRKFQAILPLRGKVLNVEKA
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCEEECHHH
RYDKLLSSEQIVTLVTALGCGIGKDDYNLDKLRYHRIIIMTDADVDGAHIRTLLLTFFYR
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
QMPEMIERGYVYIAQPPLYKVKAGKDERYLKDDAELNAHMLRLALQGSELLPSENATPIT
HHHHHHHCCEEEEECCCCEEEECCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GDALGELARSYLMSQSVIERLSRLYDPAALEAIMDGVSIDLSSEASTEASAKALHAALHD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHH
DTLKNEVRVVPAYDPVRELRSLRVERAHHGNVRVSVIDEEFQHTADYQQLVNTAKTFEGL
HHHCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
IQAGAVIKRGERSMAVTDFKNAMKWLLADAERNVSKQRYKGLGEMNPEQLWETTMDPNVR
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHH
RLLRVQIEDAIAADGIFTTLMGDEVEPRRAFIESNALRAGNIDV
HHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1906260 [H]