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The map label for this gene is dnaA [H]

Identifier: 161523181

GI number: 161523181

Start: 74

End: 1648

Strand: Direct

Name: dnaA [H]

Synonym: Bmul_0001

Alternate gene names: 161523181

Gene position: 74-1648 (Clockwise)

Preceding gene: NA

Following gene: 161523182

Centisome position: 0.0

GC content: 65.78

Gene sequence:

>1575_bases
ATGAACGATTTCTGGCAACACTGTTCCGCACTGCTGGAGCGCGAATTGACGCCCCAGCAGTACGTGACGTGGATCAAACC
CTTGGCCCCGGTGGCCTTCGATGCGTCGGCGAACACGCTGTCCATCGCTGCGCCGAACCGCTTCAAGCTGGACTGGGTCA
AGAGCCAGTTTTCGGGTCGGATCGCCGATCTGGCCCGCGATTTCTGGAACGCGCCGATCGAAGTCCAGTTCGTCCTCGAT
CCGAAGGCCGGCATGCGCAGCCCGGCGGCCGGCGCGGCGCCCGCTGCGCCGCGCGCGCCGCTCGCGAGCGGCCCGGCCGC
GACGGTGGCCGCGATCGCGGCGAATCTGACCGCGAACCAGTCGGCCACGCCCGCCGCGCCGGCCGACGTGCCGATGACGC
CGTCGGCCGCCGCGGCGCATCATCTGAACAACGACGACGCGGACATCGACCTGCCGAGCCTTCCCGCCCACGAGGCGGCG
GCCGGCCGGCGCACCTGGCGTCCGGGCCCCGGCGCCGCACCCGCGGCAGGCGGCGAGGCCGATTCGATGTACGAGCGCTC
GAAGCTGAACCCGGTGCTCACGTTCGACAACTTCGTGACCGGCAAGGCGAACCAGCTCGCGCGCGCGGCCGCGATCCAGG
TCGCGGACAACCCCGGCATCTCGTACAACCCGCTGTTCCTGTACGGCGGCGTCGGCCTCGGCAAGACGCACCTGATCCAC
GCGATCGGCAACCAGCTGCTGCTCGACAAGCCGGGCGCGCGGATCCGCTACATCCATGCGGAGCAATACGTGTCGGACGT
CGTGAAGGCGTACCAGCGCAAGGCGTTCGACGATTTCAAGCGCTACTACCACTCGCTCGACCTGCTGCTGATCGACGACA
TCCAGTTCTTCTCGGGCAAGTCGCGCACGCAGGAGGAATTCTTCTACGCGTTCGAGGCGCTCGTCGCGAACAAGGCGCAG
GTCATCATCACCAGCGATACGTATCCGAAGGAGATTTCGGGGATCGACGATCGCCTGATCTCGCGCTTCGATTCCGGGCT
GACCGTCGCGATCGAGCCGCCCGAGCTCGAGATGCGCGTCGCGATCCTGATGCGCAAGGCGCAGTCCGAAGGCGTGAACC
TGTCGGAGGACGTCGCGTTCTTCGTCGCGAAGCATCTGCGCTCGAACGTGCGCGAGCTCGAGGGCGCGCTGCGCAAGATC
CTCGCGTATTCGAAGTTCCACGGCCGCGAGATCTCGATCGAGCTGACCAAGGAAGCGCTGAAGGATCTGCTGACCGTGCA
GAACCGGCAGATTTCGGTCGAGAACATCCAGAAGACCGTCGCCGACTTCTACAACATCAAGGTCGCCGACATGTATTCGA
AGAAGCGTCCGGCGAACATCGCGCGGCCGCGGCAGATCGCGATGTATCTGGCGAAGGAACTGACGCAAAAGAGCCTGCCC
GAGATCGGCGAGCTGTTCGGCGGACGCGATCACACGACCGTGCTGCACGCGGTGCGCAAGATCGCCGACGAACGCAGCAA
GGACGCGCAGCTGAACCACGAACTGCACGTGCTGGAGCAGACGCTGAAGGGTTGA

Upstream 100 bases:

>100_bases
GGCGCCCGAAGCACGCTCGCACGCCGCTTCGGGCCTTGTTGCGCGACCGCGACAAGGGCGCCGGCGAGTCGCTGTGCACG
CATAAAACGACAGTCATTTG

Downstream 100 bases:

>100_bases
GCGCGCCGCGCACTTGAGAATCATGAGTCCGCCCCAATTTAGGAGGGGCGATTCGGTTTTGAGGCACAATACAGGTTTGA
CCGCCCCGGCGTCGGCGGGC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDASANTLSIAAPNRFKLDWVKSQFSGRIADLARDFWNAPIEVQFVLD
PKAGMRSPAAGAAPAAPRAPLASGPAATVAAIAANLTANQSATPAAPADVPMTPSAAAAHHLNNDDADIDLPSLPAHEAA
AGRRTWRPGPGAAPAAGGEADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIH
AIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQ
VIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVNLSEDVAFFVAKHLRSNVRELEGALRKI
LAYSKFHGREISIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLP
EIGELFGGRDHTTVLHAVRKIADERSKDAQLNHELHVLEQTLKG

Sequences:

>Translated_524_residues
MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDASANTLSIAAPNRFKLDWVKSQFSGRIADLARDFWNAPIEVQFVLD
PKAGMRSPAAGAAPAAPRAPLASGPAATVAAIAANLTANQSATPAAPADVPMTPSAAAAHHLNNDDADIDLPSLPAHEAA
AGRRTWRPGPGAAPAAGGEADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIH
AIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQ
VIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVNLSEDVAFFVAKHLRSNVRELEGALRKI
LAYSKFHGREISIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLP
EIGELFGGRDHTTVLHAVRKIADERSKDAQLNHELHVLEQTLKG
>Mature_524_residues
MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDASANTLSIAAPNRFKLDWVKSQFSGRIADLARDFWNAPIEVQFVLD
PKAGMRSPAAGAAPAAPRAPLASGPAATVAAIAANLTANQSATPAAPADVPMTPSAAAAHHLNNDDADIDLPSLPAHEAA
AGRRTWRPGPGAAPAAGGEADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIH
AIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQ
VIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVNLSEDVAFFVAKHLRSNVRELEGALRKI
LAYSKFHGREISIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLP
EIGELFGGRDHTTVLHAVRKIADERSKDAQLNHELHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=520, Percent_Identity=49.4230769230769, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI226510964, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 57627; Mature: 57627

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDASANTLSIAAPNRFKLDWVKSQFSGR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEHHHHHHHHCCH
IADLARDFWNAPIEVQFVLDPKAGMRSPAAGAAPAAPRAPLASGPAATVAAIAANLTANQ
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SATPAAPADVPMTPSAAAAHHLNNDDADIDLPSLPAHEAAAGRRTWRPGPGAAPAAGGEA
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCH
DSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIH
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHEEEECCCCCCCCCEEEECCCCCCHHHHHH
AIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGK
HHCCCEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCC
SRTQEEFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRV
CCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHHHHHCCCCEEEECCCCHHHHH
AILMRKAQSEGVNLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREISIELTKEAL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
KDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLP
HHHHHHCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCH
EIGELFGGRDHTTVLHAVRKIADERSKDAQLNHELHVLEQTLKG
HHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDASANTLSIAAPNRFKLDWVKSQFSGR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEHHHHHHHHCCH
IADLARDFWNAPIEVQFVLDPKAGMRSPAAGAAPAAPRAPLASGPAATVAAIAANLTANQ
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SATPAAPADVPMTPSAAAAHHLNNDDADIDLPSLPAHEAAAGRRTWRPGPGAAPAAGGEA
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCH
DSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIH
HHHHHHHCCCEEEEECCCCCCCHHHHHHHHHEEEECCCCCCCCCEEEECCCCCCHHHHHH
AIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGK
HHCCCEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCC
SRTQEEFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRV
CCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHHHHHCCCCEEEECCCCHHHHH
AILMRKAQSEGVNLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREISIELTKEAL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHH
KDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLP
HHHHHHCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCH
EIGELFGGRDHTTVLHAVRKIADERSKDAQLNHELHVLEQTLKG
HHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA