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The map label for this gene is hemC [H]

Identifier: 161486849

GI number: 161486849

Start: 752878

End: 753750

Strand: Direct

Name: hemC [H]

Synonym: CTC00727

Alternate gene names: 161486849

Gene position: 752878-753750 (Clockwise)

Preceding gene: 28210447

Following gene: 28210449

Centisome position: 26.9

GC content: 32.19

Gene sequence:

>873_bases
TTGAAGTTAATAGTAGCCACAAGAAGGAGTATTTTAGCACAAACTCAAACAGATTTAGTAATAAAGAAAATAGAGGAAGA
TAATGAGGTAAAATGTGAAAAACTTTTAATTCAAACTCTAGGGGATAAAATATTAGATAGAACCCTAGATAAAATAGGAG
GGAAGGGACTATTTATAAAAGAAATAGAGAAGGCCTTATTAGATGGAAAAGCTCATATGGCAGTACATAGCATGAAGGAT
GTTCCCTATGAAGTACCTTCTATGTTTTATATAGGAGCAATTCCTAGAAGAGAAGATGTAAGAGATGCATTTGTATCAAG
AGATGGTACAAAATTTATGGAGCTACCATCAGGTTCTAAAATAGGAACAAGTAGCAGAAGAAGATCAAGTCAGATTAAAA
TTCTAAGACCTGACGTGGAAGTTGTACCTATAAGGGGTAATGTTCAGACTAGATTAAGAAAAATAGAGGAAATGAATTTA
GCAGGCACTATTTTAGCGGTAGCTGGACTAAAGAGACTAAATATGGAAGAAGTTATTACAGATTATTTTAGTCCAGAGGA
AATGGTACCAGCTATAGGACAAGGAGCTTTAGGAATAGAAATAAAAAAATACGAGGATGTTATTGATTATATAAAAGGTA
TAGATCATGAAGAAACTAGAATATGTGTAGAGGGCGAAAGAAGTTTTATGGAAGCTTTAAAGGGAGACTGTCATTCAACT
ATAGGAGCTCATGCTATAGTTGAGAATGATTTAATGTATATGACAGGAATATTTGAAGTTAATGGAAAAATTGTAAAGAA
AGATATTGAAGGTAAGAAAGAAAATTATAAACAACTAGGAAAAACATTAGCAGATAGAATAATGAAGGCTTAA

Upstream 100 bases:

>100_bases
GCTACTATAATGGATTTTGTAGCCACAGAGGATTTTTACTTTTTTTACAATAAAAATAAGCACAAAATTATATTAGAAAT
GTTTTTTGGAGGTAATTATT

Downstream 100 bases:

>100_bases
GGAGGTAAAAGTATGGGTAAGGTATATCTAATAGGGGCAGGACCAGGAGATGAAGAACTTATAACATTAAAAGCCACTAG
AATGTTGCAAAAGTGCACTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKLIVATRRSILAQTQTDLVIKKIEEDNEVKCEKLLIQTLGDKILDRTLDKIGGKGLFIKEIEKALLDGKAHMAVHSMKD
VPYEVPSMFYIGAIPRREDVRDAFVSRDGTKFMELPSGSKIGTSSRRRSSQIKILRPDVEVVPIRGNVQTRLRKIEEMNL
AGTILAVAGLKRLNMEEVITDYFSPEEMVPAIGQGALGIEIKKYEDVIDYIKGIDHEETRICVEGERSFMEALKGDCHST
IGAHAIVENDLMYMTGIFEVNGKIVKKDIEGKKENYKQLGKTLADRIMKA

Sequences:

>Translated_290_residues
MKLIVATRRSILAQTQTDLVIKKIEEDNEVKCEKLLIQTLGDKILDRTLDKIGGKGLFIKEIEKALLDGKAHMAVHSMKD
VPYEVPSMFYIGAIPRREDVRDAFVSRDGTKFMELPSGSKIGTSSRRRSSQIKILRPDVEVVPIRGNVQTRLRKIEEMNL
AGTILAVAGLKRLNMEEVITDYFSPEEMVPAIGQGALGIEIKKYEDVIDYIKGIDHEETRICVEGERSFMEALKGDCHST
IGAHAIVENDLMYMTGIFEVNGKIVKKDIEGKKENYKQLGKTLADRIMKA
>Mature_290_residues
MKLIVATRRSILAQTQTDLVIKKIEEDNEVKCEKLLIQTLGDKILDRTLDKIGGKGLFIKEIEKALLDGKAHMAVHSMKD
VPYEVPSMFYIGAIPRREDVRDAFVSRDGTKFMELPSGSKIGTSSRRRSSQIKILRPDVEVVPIRGNVQTRLRKIEEMNL
AGTILAVAGLKRLNMEEVITDYFSPEEMVPAIGQGALGIEIKKYEDVIDYIKGIDHEETRICVEGERSFMEALKGDCHST
IGAHAIVENDLMYMTGIFEVNGKIVKKDIEGKKENYKQLGKTLADRIMKA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=270, Percent_Identity=39.2592592592593, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI20149500, Length=270, Percent_Identity=39.2592592592593, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI48994974, Length=291, Percent_Identity=40.2061855670103, Blast_Score=196, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319996, Length=308, Percent_Identity=36.038961038961, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI20130425, Length=244, Percent_Identity=38.9344262295082, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32596; Mature: 32596

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIVATRRSILAQTQTDLVIKKIEEDNEVKCEKLLIQTLGDKILDRTLDKIGGKGLFIK
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHH
EIEKALLDGKAHMAVHSMKDVPYEVPSMFYIGAIPRREDVRDAFVSRDGTKFMELPSGSK
HHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCC
IGTSSRRRSSQIKILRPDVEVVPIRGNVQTRLRKIEEMNLAGTILAVAGLKRLNMEEVIT
CCCCHHHCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DYFSPEEMVPAIGQGALGIEIKKYEDVIDYIKGIDHEETRICVEGERSFMEALKGDCHST
HHCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCHHHHH
IGAHAIVENDLMYMTGIFEVNGKIVKKDIEGKKENYKQLGKTLADRIMKA
HHHHHHHHCCCEEEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLIVATRRSILAQTQTDLVIKKIEEDNEVKCEKLLIQTLGDKILDRTLDKIGGKGLFIK
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHH
EIEKALLDGKAHMAVHSMKDVPYEVPSMFYIGAIPRREDVRDAFVSRDGTKFMELPSGSK
HHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCC
IGTSSRRRSSQIKILRPDVEVVPIRGNVQTRLRKIEEMNLAGTILAVAGLKRLNMEEVIT
CCCCHHHCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
DYFSPEEMVPAIGQGALGIEIKKYEDVIDYIKGIDHEETRICVEGERSFMEALKGDCHST
HHCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCHHHHH
IGAHAIVENDLMYMTGIFEVNGKIVKKDIEGKKENYKQLGKTLADRIMKA
HHHHHHHHCCCEEEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]