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The map label for this gene is acsA [H]

Identifier: 161486590

GI number: 161486590

Start: 3215950

End: 3217902

Strand: Direct

Name: acsA [H]

Synonym: VV3133

Alternate gene names: 161486590

Gene position: 3215950-3217902 (Clockwise)

Preceding gene: 37681316

Following gene: 37681318

Centisome position: 95.87

GC content: 52.12

Gene sequence:

>1953_bases
ATGAGTGAAGCCCACATTTATCCGGTAAAAGAGAACATCAAAGCCCATACCCATGCGGATAATGATACCTACCTAGCCAT
GTACCAGCAGTCAGTCACTGACCCAGAAGGTTTCTGGAGTGAACACGGCAAAATTGTTGACTGGATTAAGCCCTTCACCA
AAGTCAAACAAACGTCTTTTGATACTGGCCACGTTGATATTCGCTGGTTTGAAGATGGCACGCTCAACGTCTCAGCAAAC
TGTATTGACCGCCATCTAGCAGAGCGCGGCGATGATGTCGCCATCATTTGGGAAGGCGACAACCCAGCGGACGACAAAAC
TCTGACTTACAACGAGCTCTACACCGAAGTGTGTCGTTTCTCGAATGCACTCAAAGAGCAAGGCGTACGCAAAGGCGACG
TGGTGTGTCTCTACATGCCAATGGTCCCTGAAGCGGCGGTTGCGATGTTGGCCTGTACCCGTATTGGTGCGGTGCACACC
ATCGTCTTTGGTGGTTTTTCACCAGAAGCACTGGCTGGCCGCATCATCGACTCCGATGCCAAAGTCGTCATCACGGCCGA
CGAAGGCGTTCGTGGTGGTCGCGCGGTGCCACTGAAAAAGAACGTGGACGAAGCACTAACCAACCCAGAAGTGAAAACCA
TCAGCAAAGTGGTGGTGTTCAAGCGCACTGGCGGCAACATTGATTGGCACGAACATCGTGATGTTTGGTGGCACGAAGCG
ACAGCAAAAGTCTCTGACGTTTGCCCACCAGAAGAGATGAAAGCTGAAGATCCGCTGTTCATCCTCTACACGTCAGGCTC
AACCGGCAAACCGAAAGGCGTGCTGCACACCACGGGCGGCTATTTGGTCTACGCGACCATGACCTTTAAGTACGTGTTTG
ACTACCAGCCAGGCGAAACTTTCTGGTGTACGGCCGACGTGGGTTGGATCACTGGCCACACGTATCTGGTTTACGGTCCA
CTGGCAAACGGCGCGAAAACCATTCTCTTTGAAGGCGTGCCAAACTATCCAAACACCAGCCGCATGAGTGAAGTGGTCGA
TAAGCACCAAGTCAACATTCTTTACACCGCACCAACGGCCATTCGTGCGCTGATGGCAAAAGGCAACGAAGCGATTGAAG
GTACGGATCGTAGCAGCCTACGCATCATGGGCTCTGTGGGTGAACCTATTAACCCAGAGGCGTGGGAGTGGTACTACAAG
ACCATCGGCAACGAGAAATCACCGATTGTCGATACTTGGTGGCAAACCGAAACCGGCGGCATTTTGATCACACCACTGCC
AGGCGCCACCGCGCTGAAACCGGGTTCTGCAACGCGCCCATTCTTTGGTGTTCAGCCTGCACTGGTGGACAACATGGGTA
ATGTGATCGAAGACCAAGCCGCAGAAGGTAACCTCGTTATCCTCGATTCTTGGCCAGGTCAAATGCGCACGGTTTATGGT
GACCATGAACGTTTCGAACAAACCTACTTCTCAACCTTTAAAGGCATGTACTTTACCGGAGATGGTGCGCGCCGCGATGA
AGATGGTTACTACTGGATCACAGGCCGTGTGGATGACGTATTAAACGTTTCTGGCCACCGTATGGGTACAGCGGAAATTG
AATCCGCCCTAGTGGCACACCCGAAAATTGCTGAAGCGGCGATTGTTGGCATTCCACACGACATCAAAGGCCAAGCAATT
TACGCCTATGTCACCCTCAATGCGGGCGAGTATCCAACCGCCGAGCTGCATAAAGAAGTGAAAGATTGGGTACGTAAAGA
GATTGGCCCCATCGCAACACCAGATGTCCTGCATTGGACAGATGCACTACCGAAAACTCGTTCAGGTAAAATCATGCGCC
GCATTTTGCGCAAGATCGCCACGGGAGACACCAGCAACTTGGGTGACACCTCAACACTGGCCGACCCAAGCGTAGTTGAT
AAGCTGATCGCAGAAAAAGCCGAACTGGTTTAA

Upstream 100 bases:

>100_bases
TTGACAGTTAGAGGCATACGGATTCCCCCTTTCGTGATTGATGACTGTTTTAAACGTCATGGAACTCCATCACGAAGACA
AAGGCACAAGGAGAGAGACA

Downstream 100 bases:

>100_bases
TCCGTTTTAAACAAAACACCCTCAAAGCCACTCTACATAAGAGTGGCTTTTTTGTTTGCCGTTATCATTACCCATACTGT
AAGAAAGGTTAATCTTGTTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSEAHIYPVKENIKAHTHADNDTYLAMYQQSVTDPEGFWSEHGKIVDWIKPFTKVKQTSFDTGHVDIRWFEDGTLNVSAN
CIDRHLAERGDDVAIIWEGDNPADDKTLTYNELYTEVCRFSNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHT
IVFGGFSPEALAGRIIDSDAKVVITADEGVRGGRAVPLKKNVDEALTNPEVKTISKVVVFKRTGGNIDWHEHRDVWWHEA
TAKVSDVCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPGETFWCTADVGWITGHTYLVYGP
LANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTAIRALMAKGNEAIEGTDRSSLRIMGSVGEPINPEAWEWYYK
TIGNEKSPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGNVIEDQAAEGNLVILDSWPGQMRTVYG
DHERFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAHPKIAEAAIVGIPHDIKGQAI
YAYVTLNAGEYPTAELHKEVKDWVRKEIGPIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVD
KLIAEKAELV

Sequences:

>Translated_650_residues
MSEAHIYPVKENIKAHTHADNDTYLAMYQQSVTDPEGFWSEHGKIVDWIKPFTKVKQTSFDTGHVDIRWFEDGTLNVSAN
CIDRHLAERGDDVAIIWEGDNPADDKTLTYNELYTEVCRFSNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHT
IVFGGFSPEALAGRIIDSDAKVVITADEGVRGGRAVPLKKNVDEALTNPEVKTISKVVVFKRTGGNIDWHEHRDVWWHEA
TAKVSDVCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPGETFWCTADVGWITGHTYLVYGP
LANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTAIRALMAKGNEAIEGTDRSSLRIMGSVGEPINPEAWEWYYK
TIGNEKSPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGNVIEDQAAEGNLVILDSWPGQMRTVYG
DHERFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAHPKIAEAAIVGIPHDIKGQAI
YAYVTLNAGEYPTAELHKEVKDWVRKEIGPIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVD
KLIAEKAELV
>Mature_649_residues
SEAHIYPVKENIKAHTHADNDTYLAMYQQSVTDPEGFWSEHGKIVDWIKPFTKVKQTSFDTGHVDIRWFEDGTLNVSANC
IDRHLAERGDDVAIIWEGDNPADDKTLTYNELYTEVCRFSNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHTI
VFGGFSPEALAGRIIDSDAKVVITADEGVRGGRAVPLKKNVDEALTNPEVKTISKVVVFKRTGGNIDWHEHRDVWWHEAT
AKVSDVCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPGETFWCTADVGWITGHTYLVYGPL
ANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTAIRALMAKGNEAIEGTDRSSLRIMGSVGEPINPEAWEWYYKT
IGNEKSPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGNVIEDQAAEGNLVILDSWPGQMRTVYGD
HERFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAHPKIAEAAIVGIPHDIKGQAIY
AYVTLNAGEYPTAELHKEVKDWVRKEIGPIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDK
LIAEKAELV

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=653, Percent_Identity=52.0673813169985, Blast_Score=692, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=666, Percent_Identity=51.0510510510511, Blast_Score=687, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=626, Percent_Identity=50.6389776357827, Blast_Score=648, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=36.6929133858268, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI42544132, Length=543, Percent_Identity=29.4659300184162, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=27.7173913043478, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI38505220, Length=517, Percent_Identity=29.9806576402321, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI115511026, Length=546, Percent_Identity=27.8388278388278, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI31982927, Length=647, Percent_Identity=23.8021638330757, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI58082049, Length=530, Percent_Identity=24.7169811320755, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI157311624, Length=530, Percent_Identity=24.3396226415094, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI157311622, Length=530, Percent_Identity=24.3396226415094, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI187761345, Length=574, Percent_Identity=25.0871080139373, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI187761343, Length=574, Percent_Identity=25.0871080139373, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI195947378, Length=406, Percent_Identity=27.8325123152709, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI42544134, Length=361, Percent_Identity=26.0387811634349, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156151445, Length=388, Percent_Identity=24.4845360824742, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=649, Percent_Identity=74.5762711864407, Blast_Score=1037, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=35.4992076069731, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788107, Length=578, Percent_Identity=23.7024221453287, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI221142682, Length=561, Percent_Identity=22.9946524064171, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=23.062381852552, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786810, Length=570, Percent_Identity=20.7017543859649, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982997, Length=640, Percent_Identity=51.40625, Blast_Score=642, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=641, Percent_Identity=51.3260530421217, Blast_Score=642, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=591, Percent_Identity=23.1810490693739, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17559526, Length=555, Percent_Identity=24.6846846846847, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=576, Percent_Identity=23.0902777777778, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=518, Percent_Identity=23.3590733590734, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32563687, Length=516, Percent_Identity=23.6434108527132, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=32.1167883211679, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=376, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=48.59375, Blast_Score=629, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=635, Percent_Identity=48.0314960629921, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319699, Length=405, Percent_Identity=24.4444444444444, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667955, Length=665, Percent_Identity=53.0827067669173, Blast_Score=695, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=563, Percent_Identity=57.7264653641208, Blast_Score=652, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=521, Percent_Identity=57.9654510556622, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI21355225, Length=637, Percent_Identity=36.2637362637363, Blast_Score=391, Evalue=1e-108,
Organism=Drosophila melanogaster, GI18859661, Length=542, Percent_Identity=25.4612546125461, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355181, Length=518, Percent_Identity=23.7451737451737, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656500, Length=530, Percent_Identity=24.5283018867925, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24581924, Length=536, Percent_Identity=20.8955223880597, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71912; Mature: 71781

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAHIYPVKENIKAHTHADNDTYLAMYQQSVTDPEGFWSEHGKIVDWIKPFTKVKQTSF
CCCCEEEEHHHCCEEEECCCCCCEEEEEECCCCCCCHHHHHCCCEEHHHHHHHHHHHCCC
DTGHVDIRWFEDGTLNVSANCIDRHLAERGDDVAIIWEGDNPADDKTLTYNELYTEVCRF
CCCCEEEEEECCCEEEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHH
SNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSDA
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEECCCC
KVVITADEGVRGGRAVPLKKNVDEALTNPEVKTISKVVVFKRTGGNIDWHEHRDVWWHEA
EEEEECCCCCCCCEECCCCCCHHHHHCCCCHHEEEEEEEEEECCCCCCCCCCCCCEEECC
TAKVSDVCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPGET
CCHHHCCCCCHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEECCCCE
FWCTADVGWITGHTYLVYGPLANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTA
EEEEECCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAKGNEAIEGTDRSSLRIMGSVGEPINPEAWEWYYKTIGNEKSPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEECCCCC
ILITPLPGATALKPGSATRPFFGVQPALVDNMGNVIEDQAAEGNLVILDSWPGQMRTVYG
EEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECC
DHERFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAH
CHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCC
PKIAEAAIVGIPHDIKGQAIYAYVTLNAGEYPTAELHKEVKDWVRKEIGPIATPDVLHWT
CCHHCEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
DALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDKLIAEKAELV
HCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEAHIYPVKENIKAHTHADNDTYLAMYQQSVTDPEGFWSEHGKIVDWIKPFTKVKQTSF
CCCEEEEHHHCCEEEECCCCCCEEEEEECCCCCCCHHHHHCCCEEHHHHHHHHHHHCCC
DTGHVDIRWFEDGTLNVSANCIDRHLAERGDDVAIIWEGDNPADDKTLTYNELYTEVCRF
CCCCEEEEEECCCEEEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHH
SNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSDA
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEECCCC
KVVITADEGVRGGRAVPLKKNVDEALTNPEVKTISKVVVFKRTGGNIDWHEHRDVWWHEA
EEEEECCCCCCCCEECCCCCCHHHHHCCCCHHEEEEEEEEEECCCCCCCCCCCCCEEECC
TAKVSDVCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPGET
CCHHHCCCCCHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEECCCCE
FWCTADVGWITGHTYLVYGPLANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTA
EEEEECCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAKGNEAIEGTDRSSLRIMGSVGEPINPEAWEWYYKTIGNEKSPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEECCCCC
ILITPLPGATALKPGSATRPFFGVQPALVDNMGNVIEDQAAEGNLVILDSWPGQMRTVYG
EEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECC
DHERFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAH
CHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCC
PKIAEAAIVGIPHDIKGQAIYAYVTLNAGEYPTAELHKEVKDWVRKEIGPIATPDVLHWT
CCHHCEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
DALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDKLIAEKAELV
HCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]