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The map label for this gene is gppA

Identifier: 161486587

GI number: 161486587

Start: 3272096

End: 3273589

Strand: Direct

Name: gppA

Synonym: VV3184

Alternate gene names: 161486587

Gene position: 3272096-3273589 (Clockwise)

Preceding gene: 37681367

Following gene: 37681372

Centisome position: 97.54

GC content: 51.14

Gene sequence:

>1494_bases
ATGAGTCAGGCAGGCAATTCTCCGCTTTATGCAGCCATCGATCTCGGGTCGAATAGTTTTCATATGCTCGTAGTGCGTCA
TATCGATGGCAGCGTTCAAACTATGGCTAAAATCAAACGCAAAGTGCGTCTTGCCGCCGGGCTTGATGAACACAATGCGC
TCAGTAAAGAAGCGATGCAGCGAGGATGGGATTGCCTGAGCTTATTTGCGGAACGGTTGCAAGATATTCCCGCAGAGCAC
ATTCGTATTGTTGGCACAGCCACACTGCGCACCGCCACTAATGTCGATCTGTTTCTGCAAAAGGCCAATCAAATCCTTGG
CCACCCGATTGAAGTCATTTCTGGGGAAGAAGAAGCCGCGACGATTTACAAAGGCGTGGCGCACACCTCTGGGGGAAGCG
GCCGACGCTTAGTGGTGGATATTGGTGGTGCGAGCACCGAGCTGATCATCGGTGAGGGGTTTGAAGCCAAAGCGCTGACG
AGCCTCAAGATGGGTTGCGTAACTTGGCTGGAAAACTTTTTCAAAGATCGCCAACTCAGTGCACGCAACTTTGAGGCCGC
CATTGAAGGGGCCAAGCAAACCTTATTGCCGATCCTGGAGCAATACAAATCACTCGGTTGGGATGTTTGTGTGGGCGCTT
CCGGTACCGTACAAGCGCTGCAGGAAATCATGTTGGCGCAGGGCATGGACGAGGTCATTACCCACGCTAAGCTTAAGCGC
TTACAAAAACAGGCCATGCTTGCGGATCATCTCGAAGAACTTGAAATTGAAGGATTAACCCTCGAAAGAGCACTGGTCTT
CCCTAGTGGTTTATCGATTTTGATCGCTATTTTCGAACTGCTGGAAATCGACGCAATGACGCTTGCTGGCGGCGCTTTGC
GTGAAGGCTTGGCATACGAGATGATGAGTGAGTTACGCCAAGATGATATCCGAGCACGCACGATTGGTAGCATCCAGAGT
CGCTACCAACTCGACAGTCAATATGGTCAGCAAGTCGCGAATTTGGCCTTAAAGCTGCTGCAACAAGTGGGCGACGTGAT
GTGGATCCCTGAACCACAAGGGGCCATGTTGCTAGAGACCACAGCCAAACTGCATGAAATTGGGTTGACCATTGATTTCA
AAAAAGGTGGCGAGCACAGTGCGTATCTGATGCAGCATCTGGATCTTCCAGGGTTTACTCGCGCACAGAAATTCTTAATG
GGTGAAATTGCCCGTCGTTATCGTGAAGGCTTAACCTCGCTCCCAGAACAGCATGCACTGTCTGGCAACAGCGGCAAGCG
CCTGCTGCGTTTATTACGCTTGGCCGTAATATTGTCGCATCGCCGTCAGCCATCCTTAGAGCCTGAGGTGACCCTGAGTG
CTGAGGGTGACAAACTCACTTTAGCGATTGATGCGCAATGGTTGGAAAACAATCCACTCACTGCAGCAGAACTGGAACTG
GAAGCCAACCGCCAAACCGATATTGGCTGGCCTTTGGTTATAGAAAGTCGCTAG

Upstream 100 bases:

>100_bases
CAGCGCCGCACGAACACTGGCGGTGCACGTTCAGGTGATCGTAAGTCAAACAACCGTCGTCCACGACAACCGCGTCAACA
CAAGGAAGCGTAAACCGTTT

Downstream 100 bases:

>100_bases
CTTACAGAGAATAAAAAATCCCGAACCATGATGATTCGGGATTTTTTGTTTGTGCCACTCGAAATCAGAGCAACTGGCCA
TTAATGTGATGCGGAAGCAA

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSQAGNSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSKEAMQRGWDCLSLFAERLQDIPAEH
IRIVGTATLRTATNVDLFLQKANQILGHPIEVISGEEEAATIYKGVAHTSGGSGRRLVVDIGGASTELIIGEGFEAKALT
SLKMGCVTWLENFFKDRQLSARNFEAAIEGAKQTLLPILEQYKSLGWDVCVGASGTVQALQEIMLAQGMDEVITHAKLKR
LQKQAMLADHLEELEIEGLTLERALVFPSGLSILIAIFELLEIDAMTLAGGALREGLAYEMMSELRQDDIRARTIGSIQS
RYQLDSQYGQQVANLALKLLQQVGDVMWIPEPQGAMLLETTAKLHEIGLTIDFKKGGEHSAYLMQHLDLPGFTRAQKFLM
GEIARRYREGLTSLPEQHALSGNSGKRLLRLLRLAVILSHRRQPSLEPEVTLSAEGDKLTLAIDAQWLENNPLTAAELEL
EANRQTDIGWPLVIESR

Sequences:

>Translated_497_residues
MSQAGNSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSKEAMQRGWDCLSLFAERLQDIPAEH
IRIVGTATLRTATNVDLFLQKANQILGHPIEVISGEEEAATIYKGVAHTSGGSGRRLVVDIGGASTELIIGEGFEAKALT
SLKMGCVTWLENFFKDRQLSARNFEAAIEGAKQTLLPILEQYKSLGWDVCVGASGTVQALQEIMLAQGMDEVITHAKLKR
LQKQAMLADHLEELEIEGLTLERALVFPSGLSILIAIFELLEIDAMTLAGGALREGLAYEMMSELRQDDIRARTIGSIQS
RYQLDSQYGQQVANLALKLLQQVGDVMWIPEPQGAMLLETTAKLHEIGLTIDFKKGGEHSAYLMQHLDLPGFTRAQKFLM
GEIARRYREGLTSLPEQHALSGNSGKRLLRLLRLAVILSHRRQPSLEPEVTLSAEGDKLTLAIDAQWLENNPLTAAELEL
EANRQTDIGWPLVIESR
>Mature_496_residues
SQAGNSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSKEAMQRGWDCLSLFAERLQDIPAEHI
RIVGTATLRTATNVDLFLQKANQILGHPIEVISGEEEAATIYKGVAHTSGGSGRRLVVDIGGASTELIIGEGFEAKALTS
LKMGCVTWLENFFKDRQLSARNFEAAIEGAKQTLLPILEQYKSLGWDVCVGASGTVQALQEIMLAQGMDEVITHAKLKRL
QKQAMLADHLEELEIEGLTLERALVFPSGLSILIAIFELLEIDAMTLAGGALREGLAYEMMSELRQDDIRARTIGSIQSR
YQLDSQYGQQVANLALKLLQQVGDVMWIPEPQGAMLLETTAKLHEIGLTIDFKKGGEHSAYLMQHLDLPGFTRAQKFLMG
EIARRYREGLTSLPEQHALSGNSGKRLLRLLRLAVILSHRRQPSLEPEVTLSAEGDKLTLAIDAQWLENNPLTAAELELE
ANRQTDIGWPLVIESR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily

Homologues:

Organism=Escherichia coli, GI48994966, Length=489, Percent_Identity=56.2372188139059, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1788848, Length=497, Percent_Identity=40.2414486921529, Blast_Score=357, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPPA_VIBVU (Q8DDN5)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_759910.1
- ProteinModelPortal:   Q8DDN5
- SMR:   Q8DDN5
- GeneID:   1177880
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_0940
- HOGENOM:   HBG451789
- OMA:   AMQRGWQ
- ProtClustDB:   PRK11031
- BioCyc:   VVUL216895:VV1_0940-MONOMER
- BRENDA:   3.6.1.40
- HAMAP:   MF_01550
- InterPro:   IPR003695

Pfam domain/function: PF02541 Ppx-GppA

EC number: =3.6.1.40

Molecular weight: Translated: 54756; Mature: 54625

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAGNSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSKEAMQ
CCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RGWDCLSLFAERLQDIPAEHIRIVGTATLRTATNVDLFLQKANQILGHPIEVISGEEEAA
CCHHHHHHHHHHHHHCCHHHEEEEEEEHHHHHCCHHHHHHHHHHHHCCCHHHCCCCHHHH
TIYKGVAHTSGGSGRRLVVDIGGASTELIIGEGFEAKALTSLKMGCVTWLENFFKDRQLS
HHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
ARNFEAAIEGAKQTLLPILEQYKSLGWDVCVGASGTVQALQEIMLAQGMDEVITHAKLKR
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHH
LQKQAMLADHLEELEIEGLTLERALVFPSGLSILIAIFELLEIDAMTLAGGALREGLAYE
HHHHHHHHHHHHHHHCCCEEEEHHEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MMSELRQDDIRARTIGSIQSRYQLDSQYGQQVANLALKLLQQVGDVMWIPEPQGAMLLET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEHHH
TAKLHEIGLTIDFKKGGEHSAYLMQHLDLPGFTRAQKFLMGEIARRYREGLTSLPEQHAL
HHHHHHHCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
SGNSGKRLLRLLRLAVILSHRRQPSLEPEVTLSAEGDKLTLAIDAQWLENNPLTAAELEL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEEECCCCCCEEEEEEE
EANRQTDIGWPLVIESR
ECCCCCCCCCCEEEECC
>Mature Secondary Structure 
SQAGNSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSKEAMQ
CCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RGWDCLSLFAERLQDIPAEHIRIVGTATLRTATNVDLFLQKANQILGHPIEVISGEEEAA
CCHHHHHHHHHHHHHCCHHHEEEEEEEHHHHHCCHHHHHHHHHHHHCCCHHHCCCCHHHH
TIYKGVAHTSGGSGRRLVVDIGGASTELIIGEGFEAKALTSLKMGCVTWLENFFKDRQLS
HHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
ARNFEAAIEGAKQTLLPILEQYKSLGWDVCVGASGTVQALQEIMLAQGMDEVITHAKLKR
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHH
LQKQAMLADHLEELEIEGLTLERALVFPSGLSILIAIFELLEIDAMTLAGGALREGLAYE
HHHHHHHHHHHHHHHCCCEEEEHHEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MMSELRQDDIRARTIGSIQSRYQLDSQYGQQVANLALKLLQQVGDVMWIPEPQGAMLLET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEHHH
TAKLHEIGLTIDFKKGGEHSAYLMQHLDLPGFTRAQKFLMGEIARRYREGLTSLPEQHAL
HHHHHHHCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
SGNSGKRLLRLLRLAVILSHRRQPSLEPEVTLSAEGDKLTLAIDAQWLENNPLTAAELEL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEEECCCCCCEEEEEEE
EANRQTDIGWPLVIESR
ECCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA