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The map label for this gene is ppa

Identifier: 161485675

GI number: 161485675

Start: 1723759

End: 1724268

Strand: Direct

Name: ppa

Synonym: MM_1441

Alternate gene names: 161485675

Gene position: 1723759-1724268 (Clockwise)

Preceding gene: 21227542

Following gene: 21227548

Centisome position: 42.08

GC content: 39.61

Gene sequence:

>510_bases
ATGACTGAAAGACAGGTTGAATGTGTACTTATAGAAATTCCTCAAGGAAGTCGGAATAAGTATGAGTATGATAAGGAAAG
GAAAGTCATTAGATTCGACAGAATGCTTTTTTCGTCAATCGTATACCCATGTGATTACGGCTTTTTCCCGGATACCCTGG
CACTTGACGGTGACCCTCTGGATGCCATGGTATTGATGTGGGAGCCTACATTTCCTGGATGTGTAATAGATGTACATCCC
GTTGCAATGCTTGATATGGAAGATGATAAGGGAAGAGATGAAAAGATACTCTGTGTCCCTCAGAGAGACCCACTATGGAA
CTATATCAAAACAATTGAACAGGTTCCTCCACATTTACTGAAAGAAATTACACATTTCTTTGAAACTTATAAAAATTTGG
AACGAAAAGACGTGGTGGTTTACGGGTGGAGAGATCTGGAAACAGCACGCAAGGTAATCCAGGAAGCTAAGGATCGATAT
ACTGAACAAAAAAAATTATCTAATCAGTGA

Upstream 100 bases:

>100_bases
ACCCTCTCAAAATATTTATTAATCTTCAAGCGAAAAGTTTAGAGGCAAAAATAAAATTAAGTCGATTTTGGGATGCGTTC
AACAGGCAGGAAGTATTGAC

Downstream 100 bases:

>100_bases
AGAACTACAGTTTTTATTCCTGATTCGACGTTATTTCACACCACCAGTTCACAACAGAGGGGCGAGCTGCCCCCTGCTCT
GTGTTATTCTACATTTTTTT

Product: inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MTERQVECVLIEIPQGSRNKYEYDKERKVIRFDRMLFSSIVYPCDYGFFPDTLALDGDPLDAMVLMWEPTFPGCVIDVHP
VAMLDMEDDKGRDEKILCVPQRDPLWNYIKTIEQVPPHLLKEITHFFETYKNLERKDVVVYGWRDLETARKVIQEAKDRY
TEQKKLSNQ

Sequences:

>Translated_169_residues
MTERQVECVLIEIPQGSRNKYEYDKERKVIRFDRMLFSSIVYPCDYGFFPDTLALDGDPLDAMVLMWEPTFPGCVIDVHP
VAMLDMEDDKGRDEKILCVPQRDPLWNYIKTIEQVPPHLLKEITHFFETYKNLERKDVVVYGWRDLETARKVIQEAKDRY
TEQKKLSNQ
>Mature_168_residues
TERQVECVLIEIPQGSRNKYEYDKERKVIRFDRMLFSSIVYPCDYGFFPDTLALDGDPLDAMVLMWEPTFPGCVIDVHPV
AMLDMEDDKGRDEKILCVPQRDPLWNYIKTIEQVPPHLLKEITHFFETYKNLERKDVVVYGWRDLETARKVIQEAKDRYT
EQKKLSNQ

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family

Homologues:

Organism=Escherichia coli, GI1790673, Length=155, Percent_Identity=41.2903225806452, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): IPYR_METMA (Q8PWY5)

Other databases:

- EMBL:   AF312700
- EMBL:   AE008384
- RefSeq:   NP_633465.2
- ProteinModelPortal:   Q8PWY5
- GeneID:   1479783
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1441
- NMPDR:   fig|192952.1.peg.1441
- HOGENOM:   HBG529150
- OMA:   PVALMKM
- ProtClustDB:   CLSK538096
- BioCyc:   MMAZ192952:MM1441-MONOMER
- BRENDA:   3.6.1.1
- GO:   GO:0005737
- HAMAP:   MF_00209
- InterPro:   IPR008162
- Gene3D:   G3DSA:3.90.80.10
- PANTHER:   PTHR10286

Pfam domain/function: PF00719 Pyrophosphatase; SSF50324 Pyrophosphatase

EC number: =3.6.1.1

Molecular weight: Translated: 20066; Mature: 19935

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERQVECVLIEIPQGSRNKYEYDKERKVIRFDRMLFSSIVYPCDYGFFPDTLALDGDPL
CCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCC
DAMVLMWEPTFPGCVIDVHPVAMLDMEDDKGRDEKILCVPQRDPLWNYIKTIEQVPPHLL
CEEEEEECCCCCCEEEEECCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHH
KEITHFFETYKNLERKDVVVYGWRDLETARKVIQEAKDRYTEQKKLSNQ
HHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TERQVECVLIEIPQGSRNKYEYDKERKVIRFDRMLFSSIVYPCDYGFFPDTLALDGDPL
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCC
DAMVLMWEPTFPGCVIDVHPVAMLDMEDDKGRDEKILCVPQRDPLWNYIKTIEQVPPHLL
CEEEEEECCCCCCEEEEECCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHH
KEITHFFETYKNLERKDVVVYGWRDLETARKVIQEAKDRYTEQKKLSNQ
HHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824