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The map label for this gene is ilvD1 [H]

Identifier: 161353766

GI number: 161353766

Start: 3298403

End: 3300226

Strand: Reverse

Name: ilvD1 [H]

Synonym: BRADO3103

Alternate gene names: 161353766

Gene position: 3300226-3298403 (Counterclockwise)

Preceding gene: 146340095

Following gene: 146340093

Centisome position: 44.26

GC content: 66.39

Gene sequence:

>1824_bases
ATGACAAAATCCAACGGACATGCCGGCAACGACGCTGACAAGAGCCGCAAGCTGCGGTCGCAGGCGTGGTTCAACGATCC
GCACAACCCGGGCATGACCGCGCTCTATCTCGAGCGCTATCTGAATTTCGGCCTCACCCGCGCCGAGTTGCAGTCAGGCA
AGCCGATCATCGGCATCGCGCAGACCGGAAACGACCTGTCGCCGTGCAACCGCCACCACCTCGAGCTGGCGCATCGCGTG
CGCGAGGGCATCCGCGAGGCCGGCGGCATCGCGATGGAGTTTCCGACCCATCCGATCCAGGAGACCGGCAAGCGGCCGAC
GGCGGCGCTCGACCGCAACCTTGCTTATCTCGGCCTGGTGGAAATCCTGTTCGGCTATCCGCTCGACGGCGTGGTGCTGA
CCACCGGCTGCGACAAGACGACGCCGGCCTGCCTGATGGCGGCGGCTACCGTCAACATTCCCGCCATCGTGCTCTCGGGT
GGACCGATGCTGAACGGCTGGCACGAAGGCCAGCGCACCGGCTCCGGCACCGTGGTGTGGAAGTCGCGCGAGCGGCTGGC
CGCCGGCGAGATCGACTATGAGGAATTCATGCAGATCGTGGCGTCGTCGGCGCCATCGGTCGGGCATTGCAACACCATGG
GCACGGCCTCGACCATGAACGCGCTGGCCGAAGCGCTCGGCATGTCCCTGCCCGGCTGCGCCGCGATCCCTGCGCCCTAC
CGCGAGCGCGGCCAGATCGCCTACGAGACCGGCAAGCGCATCGTCGACATGGTGTGGGAGGACCTGAAGCCGTCGGACAT
CCTCACCCGCAAGGCGTTCGAGAACTGCATCGTCGCGAACTCCGCGATCGGCGGCTCGACCAATGCGCCGATCCACATCA
ATGCGCTGGCGCGCCATGTCGGCGTCGAGCTGAACATCGATGATTGGCAGAAGGTCGGCCACGATGTGCCGCTCTTGGTC
AACATGCAGCCGGCCGGCTTCTATCTCGGCGAGGAATTCCATCGCGCCGGCGGCGTGCCGGCGGTGATCGGCGAATTGAT
GCGGCACAAGCGCATCCACGAGGACGTCATCACCGCCAACGGCCGCAGCATGGGCGACAATTGCCGCGCCGCGCCGAAGC
CCGACAACGACGTGATCTGGTCGTACGACAAGCCGCTGGTGAAGGACGCCGGCTTCCTCGTGCTGCGCGGCAATCTGTTC
GATTCCGCGATCATGAAGACCAGCGTGATCTCCAAGGAATTCCGCGACCGCTATCTGAACAACCCGAAGGACCCCAACGC
CTTCGAAGGCCGCGCCATCGTGTTCGAGGGTCCGGAGGACTATCACGACCGCATCGACGATCCGGCGCTCACGATCGACG
AGCACTGCGTGCTGTTCATCCGCGGCGCCGGCCCGATCGGCTATCCCGGCGGCGCCGAGGTCGTGAACATGCAGCCGCCG
GCGGCGCTGATCAAGCGCGGCATCCTGTCCCTGCCCTGCATCGGCGACGGCCGCCAGTCCGGCACCTCGGGCTCGCCGTC
GATCCTCAACGCCTCGCCGGAAGCCGCCGCCGACGGCGGGCTCGCGATCCTCAGGGCCGGCGACAAGGTCCGGATCGACC
TCAACAAGGGCTCGGCCAACATCCTGATCTCCGACGAGGAGGTTGCGAACCGGCATGCCGAGCTGAAGGCCAAGGGGGGC
TTCCCGCACCCGGCCAACCAGACGCCCTGGCAGGAGCTCTATCGCAACACCGTCGGCCAGCAATCCACCGGCGCCTGCAT
GGAGCTCGCGACACGGTACCAGAACATCGCTGGCACTGTCGGCGTGGCCAGGCATAACCACTAG

Upstream 100 bases:

>100_bases
GGCGGCATCTGACTGCGGCGCCTCATCCCGCGTGATCCCCACGCGGGATGAGACATCCCGATGGGCCGGTGTCGCCACGT
TTGCACTGCGGGAGGAACGA

Downstream 100 bases:

>100_bases
ACACACGGCACAAAGCCAGCCACCGTCATTGCGACGAGCGAAGCGACGAAGCAATCCAGAGCCGCACACGCAGCCCTGGA
TTGCTTCGCTGCGCTCGCAA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTKSNGHAGNDADKSRKLRSQAWFNDPHNPGMTALYLERYLNFGLTRAELQSGKPIIGIAQTGNDLSPCNRHHLELAHRV
REGIREAGGIAMEFPTHPIQETGKRPTAALDRNLAYLGLVEILFGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSG
GPMLNGWHEGQRTGSGTVVWKSRERLAAGEIDYEEFMQIVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPY
RERGQIAYETGKRIVDMVWEDLKPSDILTRKAFENCIVANSAIGGSTNAPIHINALARHVGVELNIDDWQKVGHDVPLLV
NMQPAGFYLGEEFHRAGGVPAVIGELMRHKRIHEDVITANGRSMGDNCRAAPKPDNDVIWSYDKPLVKDAGFLVLRGNLF
DSAIMKTSVISKEFRDRYLNNPKDPNAFEGRAIVFEGPEDYHDRIDDPALTIDEHCVLFIRGAGPIGYPGGAEVVNMQPP
AALIKRGILSLPCIGDGRQSGTSGSPSILNASPEAAADGGLAILRAGDKVRIDLNKGSANILISDEEVANRHAELKAKGG
FPHPANQTPWQELYRNTVGQQSTGACMELATRYQNIAGTVGVARHNH

Sequences:

>Translated_607_residues
MTKSNGHAGNDADKSRKLRSQAWFNDPHNPGMTALYLERYLNFGLTRAELQSGKPIIGIAQTGNDLSPCNRHHLELAHRV
REGIREAGGIAMEFPTHPIQETGKRPTAALDRNLAYLGLVEILFGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSG
GPMLNGWHEGQRTGSGTVVWKSRERLAAGEIDYEEFMQIVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPY
RERGQIAYETGKRIVDMVWEDLKPSDILTRKAFENCIVANSAIGGSTNAPIHINALARHVGVELNIDDWQKVGHDVPLLV
NMQPAGFYLGEEFHRAGGVPAVIGELMRHKRIHEDVITANGRSMGDNCRAAPKPDNDVIWSYDKPLVKDAGFLVLRGNLF
DSAIMKTSVISKEFRDRYLNNPKDPNAFEGRAIVFEGPEDYHDRIDDPALTIDEHCVLFIRGAGPIGYPGGAEVVNMQPP
AALIKRGILSLPCIGDGRQSGTSGSPSILNASPEAAADGGLAILRAGDKVRIDLNKGSANILISDEEVANRHAELKAKGG
FPHPANQTPWQELYRNTVGQQSTGACMELATRYQNIAGTVGVARHNH
>Mature_606_residues
TKSNGHAGNDADKSRKLRSQAWFNDPHNPGMTALYLERYLNFGLTRAELQSGKPIIGIAQTGNDLSPCNRHHLELAHRVR
EGIREAGGIAMEFPTHPIQETGKRPTAALDRNLAYLGLVEILFGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGG
PMLNGWHEGQRTGSGTVVWKSRERLAAGEIDYEEFMQIVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYR
ERGQIAYETGKRIVDMVWEDLKPSDILTRKAFENCIVANSAIGGSTNAPIHINALARHVGVELNIDDWQKVGHDVPLLVN
MQPAGFYLGEEFHRAGGVPAVIGELMRHKRIHEDVITANGRSMGDNCRAAPKPDNDVIWSYDKPLVKDAGFLVLRGNLFD
SAIMKTSVISKEFRDRYLNNPKDPNAFEGRAIVFEGPEDYHDRIDDPALTIDEHCVLFIRGAGPIGYPGGAEVVNMQPPA
ALIKRGILSLPCIGDGRQSGTSGSPSILNASPEAAADGGLAILRAGDKVRIDLNKGSANILISDEEVANRHAELKAKGGF
PHPANQTPWQELYRNTVGQQSTGACMELATRYQNIAGTVGVARHNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=569, Percent_Identity=30.2284710017575, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1788157, Length=456, Percent_Identity=30.4824561403509, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI2367371, Length=500, Percent_Identity=27.2, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786464, Length=441, Percent_Identity=28.1179138321995, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322476, Length=552, Percent_Identity=28.804347826087, Blast_Score=211, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65455; Mature: 65324

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSNGHAGNDADKSRKLRSQAWFNDPHNPGMTALYLERYLNFGLTRAELQSGKPIIGIA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEE
QTGNDLSPCNRHHLELAHRVREGIREAGGIAMEFPTHPIQETGKRPTAALDRNLAYLGLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHCCCCCCHHHHCCHHHHHHH
EILFGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGWHEGQRTGSGTVVW
HHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
KSRERLAAGEIDYEEFMQIVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
RERGQIAYETGKRIVDMVWEDLKPSDILTRKAFENCIVANSAIGGSTNAPIHINALARHV
HHCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEHHHHH
GVELNIDDWQKVGHDVPLLVNMQPAGFYLGEEFHRAGGVPAVIGELMRHKRIHEDVITAN
CCEECCHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GRSMGDNCRAAPKPDNDVIWSYDKPLVKDAGFLVLRGNLFDSAIMKTSVISKEFRDRYLN
CCCCCCCCCCCCCCCCCEEEECCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
NPKDPNAFEGRAIVFEGPEDYHDRIDDPALTIDEHCVLFIRGAGPIGYPGGAEVVNMQPP
CCCCCCCCCCCEEEECCCHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEECCCC
AALIKRGILSLPCIGDGRQSGTSGSPSILNASPEAAADGGLAILRAGDKVRIDLNKGSAN
HHHHHCCCEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEEECCCEE
ILISDEEVANRHAELKAKGGFPHPANQTPWQELYRNTVGQQSTGACMELATRYQNIAGTV
EEECCHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
GVARHNH
CCCCCCC
>Mature Secondary Structure 
TKSNGHAGNDADKSRKLRSQAWFNDPHNPGMTALYLERYLNFGLTRAELQSGKPIIGIA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEE
QTGNDLSPCNRHHLELAHRVREGIREAGGIAMEFPTHPIQETGKRPTAALDRNLAYLGLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHCCCCCCHHHHCCHHHHHHH
EILFGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGWHEGQRTGSGTVVW
HHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
KSRERLAAGEIDYEEFMQIVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
RERGQIAYETGKRIVDMVWEDLKPSDILTRKAFENCIVANSAIGGSTNAPIHINALARHV
HHCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEHHHHH
GVELNIDDWQKVGHDVPLLVNMQPAGFYLGEEFHRAGGVPAVIGELMRHKRIHEDVITAN
CCEECCHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GRSMGDNCRAAPKPDNDVIWSYDKPLVKDAGFLVLRGNLFDSAIMKTSVISKEFRDRYLN
CCCCCCCCCCCCCCCCCEEEECCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
NPKDPNAFEGRAIVFEGPEDYHDRIDDPALTIDEHCVLFIRGAGPIGYPGGAEVVNMQPP
CCCCCCCCCCCEEEECCCHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEECCCC
AALIKRGILSLPCIGDGRQSGTSGSPSILNASPEAAADGGLAILRAGDKVRIDLNKGSAN
HHHHHCCCEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEEECCCEE
ILISDEEVANRHAELKAKGGFPHPANQTPWQELYRNTVGQQSTGACMELATRYQNIAGTV
EEECCHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
GVARHNH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA