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The map label for this gene is serC

Identifier: 161349961

GI number: 161349961

Start: 2599641

End: 2600720

Strand: Reverse

Name: serC

Synonym: ACIAD2647

Alternate gene names: 161349961

Gene position: 2600720-2599641 (Counterclockwise)

Preceding gene: 50085721

Following gene: 50085714

Centisome position: 72.27

GC content: 39.35

Gene sequence:

>1080_bases
ATGCGTGCGTACAATTTCTGTGCTGGCCCAGCTGCTTTACCCACTGCTGTTTTAGAAAAAGCTCAACAAGAATTGTTGGA
CTGGCAGGGTAAGGGGCTTTCCATCATGGAAATGAGCCATCGTAGTAAAGACTATGTTGCAGTTGCTGAAAAAGCTGAAG
CTGATCTCAGAAAGTTAATGAATATTCCTGAAAACTATCAGGTACTATTTTTACAAGGCGGGGCTTCTTTACAATTCTCA
GCAATCCCTATGAATTTACTGGGAAAAAATAGCAAGGCTGATTATATTCATACTGGAATTTGGTCAGAAAAAGCGCTGAA
AGAAGCGCAGCGCTATGGCGATATCAATGTCATTGAAGCAGGTACCAGTATTGATGGCAAACTGGCCATTAAGAATCAAA
GCGAATGGAATTTATCCCAAGATGCCGCTTATGTTCATTATGCAGAAAATGAAACAATTGGTGGTATTCAGTTTGCAGAT
ATTCCTGATGTCAATGTACCACTAGTTTCTGATTTGTCTTCAAGCATTTTATCTGCGCCTTTAGATGTCTCTAAGTTTGG
TTTGATTTATGCAGGCGCTCAAAAAAATATTGGTCCAGCAGGTTTAACGATTGTCATTGTACGTGATGATCTCCTTGATC
AGTCCCGTTCAGATATTCCGAGCATTTTAAAATACTCGGCTCAAGCTAAAAATGGTTCGATGGTAAATACACCAGCAACT
TATGCTTGGTATTTATCTGGTCTGGTATTTGAGTGGTTGCTTGAGCAAGGTGGAGTAGATGCTATTCATCAAGTCAATTT
GGAAAAAGCTAAATTGCTTTATGGCTATATTGATTCTAGCGATTTTTATAATAACCCGATTGCTGTGCCTAACCGTTCCA
TCATGAACGTGCCATTTACCTTGGCAGATGAAGCTTTGGAAAAATTATTTTTGCAAGAAGCAGAAGAGAATCATTTGCTT
AATCTTGCAGGTCACCGTTCCGTAGGTGGTATGCGTGCCAGTATTTATAATGCTGTTCCTTTAGAAGGCGTACAAGCATT
GGTTAACTTTATGGATACTTTTGTTCAAAAACACGGATAA

Upstream 100 bases:

>100_bases
TGTGAATATTGAAATTTTTGTTGGAGTAACTACTGCATGACCAGAAAAGATGTGGTTAAATGCCAACTCTAGTTTTGTTT
CACTCAACAAAGGAACGATC

Downstream 100 bases:

>100_bases
TTTTCCAGCAAAAAGCCCTCATCCAATCTAATTGATGAGGGCTTTTTGACATGTGCAGTTTAGACTGGAAAAAAACCAAG
ATGATGAATAATCATCGCGG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MRAYNFCAGPAALPTAVLEKAQQELLDWQGKGLSIMEMSHRSKDYVAVAEKAEADLRKLMNIPENYQVLFLQGGASLQFS
AIPMNLLGKNSKADYIHTGIWSEKALKEAQRYGDINVIEAGTSIDGKLAIKNQSEWNLSQDAAYVHYAENETIGGIQFAD
IPDVNVPLVSDLSSSILSAPLDVSKFGLIYAGAQKNIGPAGLTIVIVRDDLLDQSRSDIPSILKYSAQAKNGSMVNTPAT
YAWYLSGLVFEWLLEQGGVDAIHQVNLEKAKLLYGYIDSSDFYNNPIAVPNRSIMNVPFTLADEALEKLFLQEAEENHLL
NLAGHRSVGGMRASIYNAVPLEGVQALVNFMDTFVQKHG

Sequences:

>Translated_359_residues
MRAYNFCAGPAALPTAVLEKAQQELLDWQGKGLSIMEMSHRSKDYVAVAEKAEADLRKLMNIPENYQVLFLQGGASLQFS
AIPMNLLGKNSKADYIHTGIWSEKALKEAQRYGDINVIEAGTSIDGKLAIKNQSEWNLSQDAAYVHYAENETIGGIQFAD
IPDVNVPLVSDLSSSILSAPLDVSKFGLIYAGAQKNIGPAGLTIVIVRDDLLDQSRSDIPSILKYSAQAKNGSMVNTPAT
YAWYLSGLVFEWLLEQGGVDAIHQVNLEKAKLLYGYIDSSDFYNNPIAVPNRSIMNVPFTLADEALEKLFLQEAEENHLL
NLAGHRSVGGMRASIYNAVPLEGVQALVNFMDTFVQKHG
>Mature_359_residues
MRAYNFCAGPAALPTAVLEKAQQELLDWQGKGLSIMEMSHRSKDYVAVAEKAEADLRKLMNIPENYQVLFLQGGASLQFS
AIPMNLLGKNSKADYIHTGIWSEKALKEAQRYGDINVIEAGTSIDGKLAIKNQSEWNLSQDAAYVHYAENETIGGIQFAD
IPDVNVPLVSDLSSSILSAPLDVSKFGLIYAGAQKNIGPAGLTIVIVRDDLLDQSRSDIPSILKYSAQAKNGSMVNTPAT
YAWYLSGLVFEWLLEQGGVDAIHQVNLEKAKLLYGYIDSSDFYNNPIAVPNRSIMNVPFTLADEALEKLFLQEAEENHLL
NLAGHRSVGGMRASIYNAVPLEGVQALVNFMDTFVQKHG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=362, Percent_Identity=49.171270718232, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=43.1372549019608, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1787136, Length=358, Percent_Identity=57.8212290502793, Blast_Score=433, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506897, Length=364, Percent_Identity=43.6813186813187, Blast_Score=311, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324758, Length=386, Percent_Identity=41.4507772020725, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI21356589, Length=361, Percent_Identity=48.1994459833795, Blast_Score=353, Evalue=9e-98,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_ACIAD (Q6F961)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047226.2
- ProteinModelPortal:   Q6F961
- SMR:   Q6F961
- STRING:   Q6F961
- GeneID:   2879293
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2647
- NMPDR:   fig|62977.3.peg.2419
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   Q6F961
- ProtClustDB:   PRK05355
- BioCyc:   ASP62977:ACIAD2647-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39329; Mature: 39329

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 101-101 BINDING 152-152 BINDING 171-171 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYNFCAGPAALPTAVLEKAQQELLDWQGKGLSIMEMSHRSKDYVAVAEKAEADLRKLM
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHH
NIPENYQVLFLQGGASLQFSAIPMNLLGKNSKADYIHTGIWSEKALKEAQRYGDINVIEA
CCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEC
GTSIDGKLAIKNQSEWNLSQDAAYVHYAENETIGGIQFADIPDVNVPLVSDLSSSILSAP
CCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHCC
LDVSKFGLIYAGAQKNIGPAGLTIVIVRDDLLDQSRSDIPSILKYSAQAKNGSMVNTPAT
CCHHHCCEEEECCCCCCCCCCEEEEEEECCHHCCHHCCHHHHHHHHCCCCCCCEECCCHH
YAWYLSGLVFEWLLEQGGVDAIHQVNLEKAKLLYGYIDSSDFYNNPIAVPNRSIMNVPFT
HHHHHHHHHHHHHHHHCCCCHHHHCCHHHEEEEEEEECCCCCCCCCCCCCCCCEEECCHH
LADEALEKLFLQEAEENHLLNLAGHRSVGGMRASIYNAVPLEGVQALVNFMDTFVQKHG
HHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAYNFCAGPAALPTAVLEKAQQELLDWQGKGLSIMEMSHRSKDYVAVAEKAEADLRKLM
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHH
NIPENYQVLFLQGGASLQFSAIPMNLLGKNSKADYIHTGIWSEKALKEAQRYGDINVIEA
CCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEC
GTSIDGKLAIKNQSEWNLSQDAAYVHYAENETIGGIQFADIPDVNVPLVSDLSSSILSAP
CCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHCC
LDVSKFGLIYAGAQKNIGPAGLTIVIVRDDLLDQSRSDIPSILKYSAQAKNGSMVNTPAT
CCHHHCCEEEECCCCCCCCCCEEEEEEECCHHCCHHCCHHHHHHHHCCCCCCCEECCCHH
YAWYLSGLVFEWLLEQGGVDAIHQVNLEKAKLLYGYIDSSDFYNNPIAVPNRSIMNVPFT
HHHHHHHHHHHHHHHHCCCCHHHHCCHHHEEEEEEEECCCCCCCCCCCCCCCCEEECCHH
LADEALEKLFLQEAEENHLLNLAGHRSVGGMRASIYNAVPLEGVQALVNFMDTFVQKHG
HHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA