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The map label for this gene is hisE

Identifier: 16127968

GI number: 16127968

Start: 3992725

End: 3993048

Strand: Direct

Name: hisE

Synonym: CC_3738

Alternate gene names: 16127968

Gene position: 3992725-3993048 (Clockwise)

Preceding gene: 16127967

Following gene: 16127972

Centisome position: 99.4

GC content: 68.83

Gene sequence:

>324_bases
ATGAGCCAGCGCCTGACCGATGTCCTGCAGCGGCTGGCCGCGACCATCGAAGCCCGCAAGGGCGGCGATCCGTCGGTGTC
CTATACGGCCAAGCTGTTGAACGACCCGGCCCTCGCCGCCAAGAAGCTCGGCGAAGAAGCCGTCGAGACGGTGATCGCCG
CCGTGGCGCAGGGTTCGGACGCGTTGGCGGCGGAAAGCGCCGACCTGCTCTACCACTGGCTGGCCCTGATGGCGGCCTCG
GGCGTCTCGCTGGACGCCGTGGCCGAGAAGCTGGAAGCCCGCGAGGGAACGTCGGGCATTGCTGAGAAGGCGTCGCGCGC
TTAA

Upstream 100 bases:

>100_bases
CCTCGATCTTCCACTTCGGCGAGATTTCGATCGGCGAGGCCAAGCAGGCCATGGCCGACGCCGGCATCCCCGTGCGCCTA
GACGCGCTGAAGGGAGCCGC

Downstream 100 bases:

>100_bases
AATCCCTCTCTCATGGAGAGAGGGAGGGGCCCGCCGCGAAGCGGTGGGAGGGTGAGTGGGTACGCCGCCGAACCCTTGAT
GCGCCCATTCCCTGGATTGT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSQRLTDVLQRLAATIEARKGGDPSVSYTAKLLNDPALAAKKLGEEAVETVIAAVAQGSDALAAESADLLYHWLALMAAS
GVSLDAVAEKLEAREGTSGIAEKASRA

Sequences:

>Translated_107_residues
MSQRLTDVLQRLAATIEARKGGDPSVSYTAKLLNDPALAAKKLGEEAVETVIAAVAQGSDALAAESADLLYHWLALMAAS
GVSLDAVAEKLEAREGTSGIAEKASRA
>Mature_106_residues
SQRLTDVLQRLAATIEARKGGDPSVSYTAKLLNDPALAAKKLGEEAVETVIAAVAQGSDALAAESADLLYHWLALMAASG
VSLDAVAEKLEAREGTSGIAEKASRA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=40.4494382022472, Blast_Score=63, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_CAUCN (B8GW16)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002519227.1
- ProteinModelPortal:   B8GW16
- SMR:   B8GW16
- GeneID:   7332702
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03854
- OMA:   VCKELER
- ProtClustDB:   PRK00400
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11038; Mature: 10906

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRLTDVLQRLAATIEARKGGDPSVSYTAKLLNDPALAAKKLGEEAVETVIAAVAQGSD
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCH
ALAAESADLLYHWLALMAASGVSLDAVAEKLEAREGTSGIAEKASRA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
SQRLTDVLQRLAATIEARKGGDPSVSYTAKLLNDPALAAKKLGEEAVETVIAAVAQGSD
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCH
ALAAESADLLYHWLALMAASGVSLDAVAEKLEAREGTSGIAEKASRA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA