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The map label for this gene is hslU

Identifier: 16127958

GI number: 16127958

Start: 3984224

End: 3985516

Strand: Direct

Name: hslU

Synonym: CC_3728

Alternate gene names: 16127958

Gene position: 3984224-3985516 (Clockwise)

Preceding gene: 16127957

Following gene: 16127961

Centisome position: 99.19

GC content: 67.9

Gene sequence:

>1293_bases
ATGACCGAGTTTTCGCCCCGCGAGATCGTTTCCGAACTGGACCGCTACATCGTCGGTCACGCCGAGGCCAAGAAGGCCGT
CGCCGTGGCCCTGCGCAACCGCTGGCGTCGCCGCCGGGTCCCCGCCGACCTGCGCGATGAGGTGACCCCGAAGAACATCC
TGCTGATCGGCCCCACCGGCGTCGGCAAGACCGAGATCGCCCGCCGCCTGGCCAAGCTGGCCCAGGCGCCGTTCCTGAAG
GTGGAAGCCACCAAGTTCACCGAGGTCGGCTATGTCGGCCGCGACGTCGACCAGATCGTGCGTGACCTCGTCGAAAGCGC
CCTGGCCATGGTGCGGGAAAAGCGCCGCGCCGCCGTGAAGGCCAAGGCCGAGGGCGGCGCCGAGGAGCGCATCCTCGACG
CGCTCACCGGTCCAGGCTCGACAGCCGCACGCGAGTCGTTCCGCAAGAAGCTGCGCGCCGGCGAGCTGGACGACAAGGAG
GTCGAACTGCAACTGGCCGACACCGGCGGTCCCAGCTTCGACATCCCCGGCCAGCCCGGCGCGGCGGTGTTCAACCTGTC
GGACATGATGAAGTCGCTGGGCGGCGGCCGCACCAAGACCCACAAGACCACTGTCTCAGGCGCCTGGGCGCCCCTGATCG
CCGAGGAAAGCGACAAGCTGCTGGACCAGGAGGCCCTGACCCAGGAGGCGCTGGAACTGGCCGAGAACCACGGCATCGTG
TTCCTGGACGAAATCGACAAGGTCGCCAGCTCCTCGCAGCGTTCGGGGGCCGATGTCAGCCGCGAGGGCGTGCAGCGGGA
TCTCTTGCCGCTGATCGAGGGCACGACGGTCTCGACCAAGTACGGGCCGGTCAAGACCGACCACATCCTGTTCATCGCCT
CGGGCGCCTTCCACGTCGCCAAGCCCTCGGACCTTTTGCCGGAACTGCAGGGCCGCCTGCCGATCCGCGTGGAGCTGAAG
GGCCTGTCGCGCGATGACATGCGCCGCATCCTCACCGAGCCCGAAGCCAACCTCATCCGCCAGCACCAGGCGCTGATGGC
GACCGAAGAGGTCACGCTGGTCTTCACTGACGAGGCGATCGACGCCCTGGCCGACGCGGCGGTGGCCGTGAACGGCTCGG
TCGAGAACATCGGCGCCCGCCGGCTGCAGACGGTCATGGAAAAGGTGGTCGAGGAGATCAGCTTCACCGCCGCCGATCGT
GGCGGCGAGACCGTGACGATCGATGCGGCCTATGTGCAGGAGCGGGTGGGCGCGCTGGCGGCCAATGCGGATCTGAGCCG
GTTTATTTTGTAG

Upstream 100 bases:

>100_bases
ATCTGGACCTCTCGGCCGAGGACATCGCCCGCAAGGCGATGGGCATCGCCGCCGAGATCTGCGTCTACACCAACGGCAAC
CTGACCGTCGAAAGCCTGTA

Downstream 100 bases:

>100_bases
CTGTGGGAGAAACCCTCTCCCCAAGGGAGAGGTGTCGGCGAAGCCGACGGAGAGGGAAGCCGCAAGCTCAACAGCCCTTC
CCCCTCCGGTCGCTTCGCGA

Product: ATP-dependent protease ATP-binding subunit

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTEFSPREIVSELDRYIVGHAEAKKAVAVALRNRWRRRRVPADLRDEVTPKNILLIGPTGVGKTEIARRLAKLAQAPFLK
VEATKFTEVGYVGRDVDQIVRDLVESALAMVREKRRAAVKAKAEGGAEERILDALTGPGSTAARESFRKKLRAGELDDKE
VELQLADTGGPSFDIPGQPGAAVFNLSDMMKSLGGGRTKTHKTTVSGAWAPLIAEESDKLLDQEALTQEALELAENHGIV
FLDEIDKVASSSQRSGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVAKPSDLLPELQGRLPIRVELK
GLSRDDMRRILTEPEANLIRQHQALMATEEVTLVFTDEAIDALADAAVAVNGSVENIGARRLQTVMEKVVEEISFTAADR
GGETVTIDAAYVQERVGALAANADLSRFIL

Sequences:

>Translated_430_residues
MTEFSPREIVSELDRYIVGHAEAKKAVAVALRNRWRRRRVPADLRDEVTPKNILLIGPTGVGKTEIARRLAKLAQAPFLK
VEATKFTEVGYVGRDVDQIVRDLVESALAMVREKRRAAVKAKAEGGAEERILDALTGPGSTAARESFRKKLRAGELDDKE
VELQLADTGGPSFDIPGQPGAAVFNLSDMMKSLGGGRTKTHKTTVSGAWAPLIAEESDKLLDQEALTQEALELAENHGIV
FLDEIDKVASSSQRSGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVAKPSDLLPELQGRLPIRVELK
GLSRDDMRRILTEPEANLIRQHQALMATEEVTLVFTDEAIDALADAAVAVNGSVENIGARRLQTVMEKVVEEISFTAADR
GGETVTIDAAYVQERVGALAANADLSRFIL
>Mature_429_residues
TEFSPREIVSELDRYIVGHAEAKKAVAVALRNRWRRRRVPADLRDEVTPKNILLIGPTGVGKTEIARRLAKLAQAPFLKV
EATKFTEVGYVGRDVDQIVRDLVESALAMVREKRRAAVKAKAEGGAEERILDALTGPGSTAARESFRKKLRAGELDDKEV
ELQLADTGGPSFDIPGQPGAAVFNLSDMMKSLGGGRTKTHKTTVSGAWAPLIAEESDKLLDQEALTQEALELAENHGIVF
LDEIDKVASSSQRSGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVAKPSDLLPELQGRLPIRVELKG
LSRDDMRRILTEPEANLIRQHQALMATEEVTLVFTDEAIDALADAAVAVNGSVENIGARRLQTVMEKVVEEISFTAADRG
GETVTIDAAYVQERVGALAANADLSRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=445, Percent_Identity=58.6516853932584, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1786642, Length=117, Percent_Identity=43.5897435897436, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 46701; Mature: 46570

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFSPREIVSELDRYIVGHAEAKKAVAVALRNRWRRRRVPADLRDEVTPKNILLIGPTG
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCC
VGKTEIARRLAKLAQAPFLKVEATKFTEVGYVGRDVDQIVRDLVESALAMVREKRRAAVK
CCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AKAEGGAEERILDALTGPGSTAARESFRKKLRAGELDDKEVELQLADTGGPSFDIPGQPG
HHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCC
AAVFNLSDMMKSLGGGRTKTHKTTVSGAWAPLIAEESDKLLDQEALTQEALELAENHGIV
CEEEEHHHHHHHHCCCCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEE
FLDEIDKVASSSQRSGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVA
EEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCEECC
KPSDLLPELQGRLPIRVELKGLSRDDMRRILTEPEANLIRQHQALMATEEVTLVFTDEAI
CCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEHHHH
DALADAAVAVNGSVENIGARRLQTVMEKVVEEISFTAADRGGETVTIDAAYVQERVGALA
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHH
ANADLSRFIL
CCCCHHHHCC
>Mature Secondary Structure 
TEFSPREIVSELDRYIVGHAEAKKAVAVALRNRWRRRRVPADLRDEVTPKNILLIGPTG
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCC
VGKTEIARRLAKLAQAPFLKVEATKFTEVGYVGRDVDQIVRDLVESALAMVREKRRAAVK
CCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AKAEGGAEERILDALTGPGSTAARESFRKKLRAGELDDKEVELQLADTGGPSFDIPGQPG
HHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCC
AAVFNLSDMMKSLGGGRTKTHKTTVSGAWAPLIAEESDKLLDQEALTQEALELAENHGIV
CEEEEHHHHHHHHCCCCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEE
FLDEIDKVASSSQRSGADVSREGVQRDLLPLIEGTTVSTKYGPVKTDHILFIASGAFHVA
EEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCEECC
KPSDLLPELQGRLPIRVELKGLSRDDMRRILTEPEANLIRQHQALMATEEVTLVFTDEAI
CCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEHHHH
DALADAAVAVNGSVENIGARRLQTVMEKVVEEISFTAADRGGETVTIDAAYVQERVGALA
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHH
ANADLSRFIL
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA