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The map label for this gene is mscS [H]

Identifier: 16127842

GI number: 16127842

Start: 3869674

End: 3870660

Strand: Direct

Name: mscS [H]

Synonym: CC_3612

Alternate gene names: 16127842

Gene position: 3869674-3870660 (Clockwise)

Preceding gene: 16127840

Following gene: 16127847

Centisome position: 96.33

GC content: 66.67

Gene sequence:

>987_bases
ATGACGACAAAGCCCAGCATCATCCCGGCGGACGCCGCGCTGCCCTCGCTCGCCAACGTGAAGGCCGACGAGACCATGCT
CAGCCATTTCATCGACTGGCTGGGCAAGTTGGCCGTGAATCTGGTGGTCGCCGCCCTGATCCTGGCGGTCACCTTCTGGG
CCGCCGGCTGGGCCGCGCGGTTCATGCGCCGGACCCTGACGCGTGTGCATCGCAGCAACCCAGACCCGACTCTGGAGAGT
TTCGCCGCGTCCCTGGCCCGCTACGCCATCGTGGCCGTTGGCCTGGTGGCCGTGCTCCAGCAACTGGGCGTGCAGGCGAC
CTCGATCATCGCGGTCCTCGGCGCGGCGTCCCTGGCCATCGGCCTTGCGCTGCAAGGCGCGCTGTCGAACGTCGCCGCCG
GCGTGATGATCCTGCTGTTCCGCCCCTACAAGGTCGGCGACTTCATCGAGACGGCGACCCGTCAGGGTACGGTCAAGTCG
CTGGACCTGCTGTTCACCGAAATCGCCACCCCCGACAACGTCAAGGTGATGATCCCCAACAGCAAGGTGTTCGGGGATGT
GATCCTGAACTACTCGACCCACCGCAATCGCCGGGTGGACGTGCTGTTCAAGGTTCCCCTGAAGACGGATCTGGTGGCGG
TGCTCAAGCGTCTGCGCGAGCGGGCCGAGAACGACGCGCGCATCCGCCAGGACCCCGCCCCGATGATCGAGGTCACCGAC
CTGTCCGAGGCCTACGCCCAGGCGGCGATCCGGGTCTGGACGGCGGCGGCCGACTTCGGTCCGGTCAAGACCGACCTGAT
GCTGTCGGCTCATTTGCTGTCAGAGGACTCGGCCCGAACCGACCTGCCACCGCCACGCCCGTCCAAGGCGACGGATCCTT
CGCCCGCCATGCCGGGCGAGGGCGAACACCATAACCTGCTGGCGCTGATCAAGCCCAGGCGGTCTCGGAAGGCGACGGCC
AAGCCAACGGGCGTTGAGAAAAAATAG

Upstream 100 bases:

>100_bases
GCCAATTGATGTAACCGACTGTTTCCCGGCCCAGGCAAGCGGAACCCTGATCGCGTCGTGTCGTTGACCTCGGCCCACGG
GGGCGCCTATCGAGACATCC

Downstream 100 bases:

>100_bases
GCTCTCGAGCGTGACAGCCGAAAGTGGCTACCGGTTTCGGCGCCTGTCACGCTCTAAACGTTTGAATTAGAGCCTGTTTT
ACCCGTTTCAAATGGGTCCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTTKPSIIPADAALPSLANVKADETMLSHFIDWLGKLAVNLVVAALILAVTFWAAGWAARFMRRTLTRVHRSNPDPTLES
FAASLARYAIVAVGLVAVLQQLGVQATSIIAVLGAASLAIGLALQGALSNVAAGVMILLFRPYKVGDFIETATRQGTVKS
LDLLFTEIATPDNVKVMIPNSKVFGDVILNYSTHRNRRVDVLFKVPLKTDLVAVLKRLRERAENDARIRQDPAPMIEVTD
LSEAYAQAAIRVWTAAADFGPVKTDLMLSAHLLSEDSARTDLPPPRPSKATDPSPAMPGEGEHHNLLALIKPRRSRKATA
KPTGVEKK

Sequences:

>Translated_328_residues
MTTKPSIIPADAALPSLANVKADETMLSHFIDWLGKLAVNLVVAALILAVTFWAAGWAARFMRRTLTRVHRSNPDPTLES
FAASLARYAIVAVGLVAVLQQLGVQATSIIAVLGAASLAIGLALQGALSNVAAGVMILLFRPYKVGDFIETATRQGTVKS
LDLLFTEIATPDNVKVMIPNSKVFGDVILNYSTHRNRRVDVLFKVPLKTDLVAVLKRLRERAENDARIRQDPAPMIEVTD
LSEAYAQAAIRVWTAAADFGPVKTDLMLSAHLLSEDSARTDLPPPRPSKATDPSPAMPGEGEHHNLLALIKPRRSRKATA
KPTGVEKK
>Mature_327_residues
TTKPSIIPADAALPSLANVKADETMLSHFIDWLGKLAVNLVVAALILAVTFWAAGWAARFMRRTLTRVHRSNPDPTLESF
AASLARYAIVAVGLVAVLQQLGVQATSIIAVLGAASLAIGLALQGALSNVAAGVMILLFRPYKVGDFIETATRQGTVKSL
DLLFTEIATPDNVKVMIPNSKVFGDVILNYSTHRNRRVDVLFKVPLKTDLVAVLKRLRERAENDARIRQDPAPMIEVTDL
SEAYAQAAIRVWTAAADFGPVKTDLMLSAHLLSEDSARTDLPPPRPSKATDPSPAMPGEGEHHNLLALIKPRRSRKATAK
PTGVEKK

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=251, Percent_Identity=34.6613545816733, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786670, Length=157, Percent_Identity=29.9363057324841, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 35432; Mature: 35300

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS01246 UPF0003

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKPSIIPADAALPSLANVKADETMLSHFIDWLGKLAVNLVVAALILAVTFWAAGWAAR
CCCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMRRTLTRVHRSNPDPTLESFAASLARYAIVAVGLVAVLQQLGVQATSIIAVLGAASLAI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GLALQGALSNVAAGVMILLFRPYKVGDFIETATRQGTVKSLDLLFTEIATPDNVKVMIPN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECC
SKVFGDVILNYSTHRNRRVDVLFKVPLKTDLVAVLKRLRERAENDARIRQDPAPMIEVTD
CHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECH
LSEAYAQAAIRVWTAAADFGPVKTDLMLSAHLLSEDSARTDLPPPRPSKATDPSPAMPGE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GEHHNLLALIKPRRSRKATAKPTGVEKK
CCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTKPSIIPADAALPSLANVKADETMLSHFIDWLGKLAVNLVVAALILAVTFWAAGWAAR
CCCCCCCCCHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMRRTLTRVHRSNPDPTLESFAASLARYAIVAVGLVAVLQQLGVQATSIIAVLGAASLAI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GLALQGALSNVAAGVMILLFRPYKVGDFIETATRQGTVKSLDLLFTEIATPDNVKVMIPN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECC
SKVFGDVILNYSTHRNRRVDVLFKVPLKTDLVAVLKRLRERAENDARIRQDPAPMIEVTD
CHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECH
LSEAYAQAAIRVWTAAADFGPVKTDLMLSAHLLSEDSARTDLPPPRPSKATDPSPAMPGE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GEHHNLLALIKPRRSRKATAKPTGVEKK
CCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]