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The map label for this gene is lig [H]

Identifier: 16127840

GI number: 16127840

Start: 3866750

End: 3868375

Strand: Direct

Name: lig [H]

Synonym: CC_3610

Alternate gene names: 16127840

Gene position: 3866750-3868375 (Clockwise)

Preceding gene: 16127839

Following gene: 16127842

Centisome position: 96.26

GC content: 68.2

Gene sequence:

>1626_bases
ATGTCCATGCGCGCCTTCGCCCATCTGCTCGATCGGCTGTCCCTGACCAGTTCGCGCAACGCCAAGCTGATCTTGATCCA
GGATCATTTGCGCCAGACGCCCGATCCCGATCGGGGCTATGCGCTTGCGGCCCTGACCGGCGCGCTGTCGTTCAACGCCG
CCAAGCCGGCCTTCATCCGCAAGGCCATTGAGGCGCGGATGGACCCCCAGCTGTTCGCCTGGTCGTACGACTTCGTCGGC
GACCTGGCCGAGACGGTCTCGCTGGTCTGGCCCGCCCCCTCCTCCAGAAAATGGCTGGGCGCCAACCGCCCACCGGAACT
GTCCGAGGTCATCGACGCCCTGCATTCGGCCTCGCGCCCCGAGGTGCAGCGGCTGATCGAGGGCTGGCTGGACGCGCTGG
ATCCCGACGGTCGCTGGGCGTTGCTGAAGCTGATGACCGGCGGACTGCGGGTCGGCGTCTCCTCGCGCCTGGCCAAGCAG
GCCTGCGCCAACCTCGGCGGCGTCGACATCGGCGAGATCGAGGAGATCTGGCATGCGCTGGCGCCGCCCTATGGCGACCT
CTTCGCCTGGCTGGAGGGGCGCTCCGAACGCCCGTCGCCCGACGCGCCGGGCCGCTTCCGCCCGGTGATGCTGGCCCAGC
CGCTGGACGAGGAGGTCGACTTCCAAAAGCTCGACCCGGCCGACTACCTCGCCGAATGGAAGTGGGACGGCATCCGCGTG
CAGGCAGTTTCCGAACGCGGCGAGCGCCGGCTCTACACCCGCACCGGCGACGACATCTCGGCCAGCTTTCCCGATGTGGT
GGAGGCGCTCGACTTCGAGGGCGCGATCGACGGCGAACTGCTGGTGCTGCGCGACGGCGCCCTGGCCTCGTTCGGCGATC
TCCAGCAACGCCTGAACCGCAAGACGGTCGACGCCAAACTGCTAGCCGCGTTCCCGGCCGGGATCCGGGCCTATGATCTG
CTGATGGACGGCGAGACCGACCTGCGGGCCCTGCCGTTCGAGACGCGCCGCGCCCGGCTGGAAGCGTTCGTCGCCAGCCT
CAAGACCTCGCGCATCGACCTCTCGCCCCTGCAGCCCTTTTCGACCTGGAAGGCGCTCGCCGCGCTTCGACTTGAACCGC
CCGAGGGTGATGCGCGCCTGTCCGAAGGTCTGATGCTGAAGCGCCGCGACAGCGTCTACGAACCCGGCCGCCCCAAGGGC
CCCTGGTTCAAGTGGAAACGCGATCCGCGCCTGATCGACGCGGTGCTGATGTACGCCCAGCGCGGTCACGGCAAGCGATC
GAGCTTCTATTCCGACTACACCTTCGGCGTCTGGCGCGAGGATGAGGACGGCCGGCGCACCCTGACCCCCGTCGGCAAGG
CCTATTTCGGCTTCACCGACGAGGAGCTGAAGCAGATCGACAAGTTCGTCCGCGACCACACGATCGAACGCTTCGGCCCC
GTGCGCTCGGTGCGCGCCGACGCGGACGTCGGTCTGATCTTCGAGGTCGCCTTCGAAGGCCTGCAGCGGTCCAGCCGCCA
CAAGTCCGGCGTCGCCATGCGGTTTCCCCGCATCAACCGCATCCGCTGGGACAAGCCCGCGCGCGAGGCTGATGAGCTAG
CGACGTTGGAAGCGATGCTGGACTGA

Upstream 100 bases:

>100_bases
GCCGCACAGGCCTGATCGCGCGGAGGATGGCCCTTGATCCCGGTCGATTTGGCCGGTCTGATCGTCCGGTCACGATCGCA
AGGGCCTTGCTTCGCGTTCC

Downstream 100 bases:

>100_bases
TCAGCCGCCGAAGCTGCGGATCGCGTCGATGATCTTCTGCTGGTCCTCAGCGCCCAGATACGGGTGCATCGGCAAGGCCA
GAACCGTCTCGGCCTTGGCT

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MSMRAFAHLLDRLSLTSSRNAKLILIQDHLRQTPDPDRGYALAALTGALSFNAAKPAFIRKAIEARMDPQLFAWSYDFVG
DLAETVSLVWPAPSSRKWLGANRPPELSEVIDALHSASRPEVQRLIEGWLDALDPDGRWALLKLMTGGLRVGVSSRLAKQ
ACANLGGVDIGEIEEIWHALAPPYGDLFAWLEGRSERPSPDAPGRFRPVMLAQPLDEEVDFQKLDPADYLAEWKWDGIRV
QAVSERGERRLYTRTGDDISASFPDVVEALDFEGAIDGELLVLRDGALASFGDLQQRLNRKTVDAKLLAAFPAGIRAYDL
LMDGETDLRALPFETRRARLEAFVASLKTSRIDLSPLQPFSTWKALAALRLEPPEGDARLSEGLMLKRRDSVYEPGRPKG
PWFKWKRDPRLIDAVLMYAQRGHGKRSSFYSDYTFGVWREDEDGRRTLTPVGKAYFGFTDEELKQIDKFVRDHTIERFGP
VRSVRADADVGLIFEVAFEGLQRSSRHKSGVAMRFPRINRIRWDKPAREADELATLEAMLD

Sequences:

>Translated_541_residues
MSMRAFAHLLDRLSLTSSRNAKLILIQDHLRQTPDPDRGYALAALTGALSFNAAKPAFIRKAIEARMDPQLFAWSYDFVG
DLAETVSLVWPAPSSRKWLGANRPPELSEVIDALHSASRPEVQRLIEGWLDALDPDGRWALLKLMTGGLRVGVSSRLAKQ
ACANLGGVDIGEIEEIWHALAPPYGDLFAWLEGRSERPSPDAPGRFRPVMLAQPLDEEVDFQKLDPADYLAEWKWDGIRV
QAVSERGERRLYTRTGDDISASFPDVVEALDFEGAIDGELLVLRDGALASFGDLQQRLNRKTVDAKLLAAFPAGIRAYDL
LMDGETDLRALPFETRRARLEAFVASLKTSRIDLSPLQPFSTWKALAALRLEPPEGDARLSEGLMLKRRDSVYEPGRPKG
PWFKWKRDPRLIDAVLMYAQRGHGKRSSFYSDYTFGVWREDEDGRRTLTPVGKAYFGFTDEELKQIDKFVRDHTIERFGP
VRSVRADADVGLIFEVAFEGLQRSSRHKSGVAMRFPRINRIRWDKPAREADELATLEAMLD
>Mature_540_residues
SMRAFAHLLDRLSLTSSRNAKLILIQDHLRQTPDPDRGYALAALTGALSFNAAKPAFIRKAIEARMDPQLFAWSYDFVGD
LAETVSLVWPAPSSRKWLGANRPPELSEVIDALHSASRPEVQRLIEGWLDALDPDGRWALLKLMTGGLRVGVSSRLAKQA
CANLGGVDIGEIEEIWHALAPPYGDLFAWLEGRSERPSPDAPGRFRPVMLAQPLDEEVDFQKLDPADYLAEWKWDGIRVQ
AVSERGERRLYTRTGDDISASFPDVVEALDFEGAIDGELLVLRDGALASFGDLQQRLNRKTVDAKLLAAFPAGIRAYDLL
MDGETDLRALPFETRRARLEAFVASLKTSRIDLSPLQPFSTWKALAALRLEPPEGDARLSEGLMLKRRDSVYEPGRPKGP
WFKWKRDPRLIDAVLMYAQRGHGKRSSFYSDYTFGVWREDEDGRRTLTPVGKAYFGFTDEELKQIDKFVRDHTIERFGPV
RSVRADADVGLIFEVAFEGLQRSSRHKSGVAMRFPRINRIRWDKPAREADELATLEAMLD

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=380, Percent_Identity=26.0526315789474, Blast_Score=77, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71985269, Length=377, Percent_Identity=27.0557029177719, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320038, Length=364, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85815841, Length=386, Percent_Identity=27.979274611399, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 60932; Mature: 60801

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMRAFAHLLDRLSLTSSRNAKLILIQDHLRQTPDPDRGYALAALTGALSFNAAKPAFIR
CCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCEEHHHHHHHHHCCCCCHHHHH
KAIEARMDPQLFAWSYDFVGDLAETVSLVWPAPSSRKWLGANRPPELSEVIDALHSASRP
HHHHHHCCCCEEEECHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCH
EVQRLIEGWLDALDPDGRWALLKLMTGGLRVGVSSRLAKQACANLGGVDIGEIEEIWHAL
HHHHHHHHHHHHCCCCCCEEHHHHHHCCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
APPYGDLFAWLEGRSERPSPDAPGRFRPVMLAQPLDEEVDFQKLDPADYLAEWKWDGIRV
CCCHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCHHHHHHCCCCCEEE
QAVSERGERRLYTRTGDDISASFPDVVEALDFEGAIDGELLVLRDGALASFGDLQQRLNR
EEECCCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
KTVDAKLLAAFPAGIRAYDLLMDGETDLRALPFETRRARLEAFVASLKTSRIDLSPLQPF
HHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
STWKALAALRLEPPEGDARLSEGLMLKRRDSVYEPGRPKGPWFKWKRDPRLIDAVLMYAQ
HHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RGHGKRSSFYSDYTFGVWREDEDGRRTLTPVGKAYFGFTDEELKQIDKFVRDHTIERFGP
HCCCCCCCCCCCCCEEEEECCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCC
VRSVRADADVGLIFEVAFEGLQRSSRHKSGVAMRFPRINRIRWDKPAREADELATLEAML
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHC
D
C
>Mature Secondary Structure 
SMRAFAHLLDRLSLTSSRNAKLILIQDHLRQTPDPDRGYALAALTGALSFNAAKPAFIR
CHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCCCEEHHHHHHHHHCCCCCHHHHH
KAIEARMDPQLFAWSYDFVGDLAETVSLVWPAPSSRKWLGANRPPELSEVIDALHSASRP
HHHHHHCCCCEEEECHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCH
EVQRLIEGWLDALDPDGRWALLKLMTGGLRVGVSSRLAKQACANLGGVDIGEIEEIWHAL
HHHHHHHHHHHHCCCCCCEEHHHHHHCCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
APPYGDLFAWLEGRSERPSPDAPGRFRPVMLAQPLDEEVDFQKLDPADYLAEWKWDGIRV
CCCHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCHHHHHHCCCCCEEE
QAVSERGERRLYTRTGDDISASFPDVVEALDFEGAIDGELLVLRDGALASFGDLQQRLNR
EEECCCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
KTVDAKLLAAFPAGIRAYDLLMDGETDLRALPFETRRARLEAFVASLKTSRIDLSPLQPF
HHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
STWKALAALRLEPPEGDARLSEGLMLKRRDSVYEPGRPKGPWFKWKRDPRLIDAVLMYAQ
HHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RGHGKRSSFYSDYTFGVWREDEDGRRTLTPVGKAYFGFTDEELKQIDKFVRDHTIERFGP
HCCCCCCCCCCCCCEEEEECCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCC
VRSVRADADVGLIFEVAFEGLQRSSRHKSGVAMRFPRINRIRWDKPAREADELATLEAML
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA