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The map label for this gene is rnhA

Identifier: 16127595

GI number: 16127595

Start: 3614808

End: 3615257

Strand: Direct

Name: rnhA

Synonym: CC_3365

Alternate gene names: 16127595

Gene position: 3614808-3615257 (Clockwise)

Preceding gene: 16127594

Following gene: 16127597

Centisome position: 89.99

GC content: 66.67

Gene sequence:

>450_bases
ATGACGCCGAAGGTCACGATCTATACCGACGGCGCCTGCAAGGGGAATCCGGGCCCCGGCGGCTGGGGCGCCATCCTGTT
CTATGGCGACAAGAAAAAGGAAATCTGCGGCGGCGAGCCGGGGACGACCAACAACCGCATGGAGCTGATGGCCGCCATCC
AGGCGCTGGAGCTCCTGAACCGTCCCTGCGTGGTCGAGCTGCACACCGACAGCCAGTACGTGATGAAGGGCATCCAGGAG
TGGATCCGCGGCTGGAAGGCGCGCGGCTGGAAGACGGCCGACAAGAGCCCCGTGAAGAACGACGACCTCTGGAAGCGGCT
CGATGCGGCCCGCGCGCGCCACGACGTCGACTGGCGCTGGGTCAAGGGCCATGCCGGCCATCCCCTGAACGAACGGGCCG
ACGCCCTGGCCAATGAAGGCCTGCGTCAGGCCAATCCGCGCGTCATCTAG

Upstream 100 bases:

>100_bases
ACTGGGGTTCGACCCCGGCCGGCGCGCTGGTCAGGCCCAAGGACCCGCTAGAGTACGAGCGCAAGCTGGCCGTCCACCGC
GAGGGTCTCGTGCTGTTCGC

Downstream 100 bases:

>100_bases
AGACTCCCCGGCTCCGCCCCTTCGGCGAACGGCAGGCCCTCATCGGCCCAGCCGGTGATGCCGCCGATCATCAGCTTCAC
CGGTCGCCCCAGGCGCGCCA

Product: ribonuclease HI

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MTPKVTIYTDGACKGNPGPGGWGAILFYGDKKKEICGGEPGTTNNRMELMAAIQALELLNRPCVVELHTDSQYVMKGIQE
WIRGWKARGWKTADKSPVKNDDLWKRLDAARARHDVDWRWVKGHAGHPLNERADALANEGLRQANPRVI

Sequences:

>Translated_149_residues
MTPKVTIYTDGACKGNPGPGGWGAILFYGDKKKEICGGEPGTTNNRMELMAAIQALELLNRPCVVELHTDSQYVMKGIQE
WIRGWKARGWKTADKSPVKNDDLWKRLDAARARHDVDWRWVKGHAGHPLNERADALANEGLRQANPRVI
>Mature_148_residues
TPKVTIYTDGACKGNPGPGGWGAILFYGDKKKEICGGEPGTTNNRMELMAAIQALELLNRPCVVELHTDSQYVMKGIQEW
IRGWKARGWKTADKSPVKNDDLWKRLDAARARHDVDWRWVKGHAGHPLNERADALANEGLRQANPRVI

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=145, Percent_Identity=35.8620689655172, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=64.963503649635, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI115532542, Length=142, Percent_Identity=38.7323943661972, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=35.6164383561644, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=35.6164383561644, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_CAUCN (B8H4W7)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002518849.1
- ProteinModelPortal:   B8H4W7
- SMR:   B8H4W7
- GeneID:   7332473
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_03476
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16674; Mature: 16543

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKVTIYTDGACKGNPGPGGWGAILFYGDKKKEICGGEPGTTNNRMELMAAIQALELLN
CCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RPCVVELHTDSQYVMKGIQEWIRGWKARGWKTADKSPVKNDDLWKRLDAARARHDVDWRW
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
VKGHAGHPLNERADALANEGLRQANPRVI
ECCCCCCCCHHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure 
TPKVTIYTDGACKGNPGPGGWGAILFYGDKKKEICGGEPGTTNNRMELMAAIQALELLN
CCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RPCVVELHTDSQYVMKGIQEWIRGWKARGWKTADKSPVKNDDLWKRLDAARARHDVDWRW
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
VKGHAGHPLNERADALANEGLRQANPRVI
ECCCCCCCCHHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA