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The map label for this gene is rnr [H]

Identifier: 16126692

GI number: 16126692

Start: 2658641

End: 2660923

Strand: Direct

Name: rnr [H]

Synonym: CC_2453

Alternate gene names: 16126692

Gene position: 2658641-2660923 (Clockwise)

Preceding gene: 16126690

Following gene: 16126694

Centisome position: 66.19

GC content: 69.16

Gene sequence:

>2283_bases
ATGGCCAAACTTCGCCCCACCAAGACCTTCAAGCCCAAGCCTCCGGCCGGCCTGCCCGACCGCGAGACGCTGCTGGCGTT
CCTGCGTGACGCGGGTGAGACGGGGAAGGCCGATATCGCCCGCCACTTTGGCCTCAAGGGCGCCGATCGCCGGGCCCTGC
GCGAGATGATCCGCGAACTGGAAGCCCAAGGCGCTCTGGCCAAGCGCGGCCGCAAGGGTTTTGCGGAAGCCGGCTCCCTG
CCCCCGGTCGGCGTGGCCGACGTGGTCGAGCGCGACGGCGACGGCGAGCTCTATGTGAAGCTGACCAAGTCCGACGACGA
CGTGCCCAATGTCCGCCTCGCGCCCGGCAAGGGCGAGGCCGCCGCCGGCGCGCCGGGGCTGGGCGACCGCCTTCTGGTCC
GCTTCGAGCGTCTGGAGACCGGCGAGTTCGAGGCCAAGCTGATCAAGAAGCTGGGCCAGAGCGCGCACAAGATCCTGGGC
GTCATCCGCAAGCATCGGCGCGAGGTCCGCGTCGAGCCGGTCGACCGCAAATCCAAGGAAAGCCTAGTCTTGGACCCCAG
CGTCGCCCACGACTTCAAGGAGGGCGACCTTGTCCTGGCCCAGGTCGGCACGCACGGCGGCCGCTATGGTCCAAAGCCCG
GCAAGGTGCTGGAGGTGGTCGGGACCGAGAACGACCCGCGCGCCGCTTCGCTGATCGCCATCCACAGCCACGGCATCCCC
ACGGGCTTCTCCGAGGCCGCAGAAGCCGAGGCCAAGACCGCCGTCGAGCCGACCCTGGCGGGCCGCGAGGACCTGCGCGA
TCTGCCGTTCGTGACCATCGACCCGGTGGACGCCCGCGACCACGACGACGCTGTCTACGCCCATCCCGACGAGGACGAGA
CCAACAAGGGCGGCTTCGTCGTCTGGGTGGCCATCGCCGACGTCGCGGCTTACGTCCGCCCGGGCTCGGCCCTGGACCGC
GATGCTCGCGAGAAGGGCAACAGCGTCTATTTCCCCGACCGGGTGGAGCCGATGCTGCCGGAAACCCTATCGAACGGCCT
GTGCTCGCTGCGCGAAAGCGAGAACCGCGCGACGCTGGCCGTGCGGATGGTGTTCGACAAGTCGGGTCGCAAGAAAGGCC
ACAGGTTCGTGCGCGGCCTGATGCGCTCGGCCGCCAAGCTCTCCTACGAGCAGGCCCAGGCGGCGATCGACGGCCAGCCG
GATGACAAGGCGGGTCCGCTGCTCGACCCGATCCTCAAGCCGCTGTGGGACGCCTACCGGACGATGAAGATCGGCCGCGA
CGCCCGCTCGCCCCTAGCGATCGAAAGCGACGAGCGCCGGATCATCATCAAGGGCGGCGAGATCACCTCGATCACCAAGC
GCGCCTCCCTCGAAGCCCACAAGCTGATCGAGGAGATGATGGTGCAGGCCAATGTCTGCGCCGCCGAAAGCCTGGAGGCC
AAGCGCTCGCCCCTGATCTACCGGGTGCACGATACGCCGAGCCTGGAGAAGGTGCAGAACCTCGCCGACTTCCTGCAGAC
CCTGGAGATTCGCTGGAGCAAGGGCGAGGCCCCGCAGACCGCGCGGTTCAACAAGCTGCTGGAAGAGACGCGAGAGAGCC
CCAATGCGGCGATCATCAACGAGGTGGTGCTGCGCACCCAGATGCAGGCTCACTACAGCGCCGACAACATCGGCCACTTC
GGTCTGAATCTCGCCAAGTACGCCCACTTCACCAGCCCGATCCGCCGCTACGCCGACCTGATCGTCCACCGGGGGCTGAT
CCGGGCCCTGGGCCTGGGGACCGACGGCCTGACCGACCAGGACATCGCCCAGATCAAGGACACCGCCGAGGTCATCACCC
ACGCCGAGCGCCGGGCCATGGCCGCCGAGCGCGACGCCACCGACCGCTACATCGCCGCCTTCCTGGCCGACCGCGTGGGC
GCGACCTTTGAGGGCCGGATCACCGGCGTCACCCGGTTTGGCCTGTTCATCAAGCTGGCCGACACCGGCGCCGACGGCCT
CGTGCCCGTCTCAAGCCTGGGCCAGGAGTTCTTCGTCCACGACGACAAGATGCATGCCCTGGTCGGCGAGCGGACCGGCA
AGCGCTGGCCGCTGGGCCTCTCCGTCGAGGTCAAGCTGGTCGAGGCCACGCCGGTGACCGGCGGCCTCTTGTTCGAGATG
CTCAGCGAGCCGCTGCCGCCCGATCCCAAGATGCCCCGCCCTCGGCTCGGGGCGCGGCGGCAGGCGGCGGTGAAGCCGCG
CGGCGGCCTGCCCAAGGGCGTGCGGCGTGGGAAGCGGCGGTAG

Upstream 100 bases:

>100_bases
TTGAATCTGGGCCCCGGCATTCGCCGGGGAAATCGGTTCAAGGTTTGCGCAGCCCCCACCCCGCGTTTCCCTAAGGCCGC
CGAACGCGTTAAGGCAGGAC

Downstream 100 bases:

>100_bases
GCATCGCCAAGATCCTCCCCCCAGCGGGGGAGGTGTCCGCGCAGCGGACGGAGGGGGAAGTCCTGCTCCCCCTGCCCCTT
CCCCCTCCGTCGTCTCTTCG

Product: VacB and RNase II family exoribonuclease

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MAKLRPTKTFKPKPPAGLPDRETLLAFLRDAGETGKADIARHFGLKGADRRALREMIRELEAQGALAKRGRKGFAEAGSL
PPVGVADVVERDGDGELYVKLTKSDDDVPNVRLAPGKGEAAAGAPGLGDRLLVRFERLETGEFEAKLIKKLGQSAHKILG
VIRKHRREVRVEPVDRKSKESLVLDPSVAHDFKEGDLVLAQVGTHGGRYGPKPGKVLEVVGTENDPRAASLIAIHSHGIP
TGFSEAAEAEAKTAVEPTLAGREDLRDLPFVTIDPVDARDHDDAVYAHPDEDETNKGGFVVWVAIADVAAYVRPGSALDR
DAREKGNSVYFPDRVEPMLPETLSNGLCSLRESENRATLAVRMVFDKSGRKKGHRFVRGLMRSAAKLSYEQAQAAIDGQP
DDKAGPLLDPILKPLWDAYRTMKIGRDARSPLAIESDERRIIIKGGEITSITKRASLEAHKLIEEMMVQANVCAAESLEA
KRSPLIYRVHDTPSLEKVQNLADFLQTLEIRWSKGEAPQTARFNKLLEETRESPNAAIINEVVLRTQMQAHYSADNIGHF
GLNLAKYAHFTSPIRRYADLIVHRGLIRALGLGTDGLTDQDIAQIKDTAEVITHAERRAMAAERDATDRYIAAFLADRVG
ATFEGRITGVTRFGLFIKLADTGADGLVPVSSLGQEFFVHDDKMHALVGERTGKRWPLGLSVEVKLVEATPVTGGLLFEM
LSEPLPPDPKMPRPRLGARRQAAVKPRGGLPKGVRRGKRR

Sequences:

>Translated_760_residues
MAKLRPTKTFKPKPPAGLPDRETLLAFLRDAGETGKADIARHFGLKGADRRALREMIRELEAQGALAKRGRKGFAEAGSL
PPVGVADVVERDGDGELYVKLTKSDDDVPNVRLAPGKGEAAAGAPGLGDRLLVRFERLETGEFEAKLIKKLGQSAHKILG
VIRKHRREVRVEPVDRKSKESLVLDPSVAHDFKEGDLVLAQVGTHGGRYGPKPGKVLEVVGTENDPRAASLIAIHSHGIP
TGFSEAAEAEAKTAVEPTLAGREDLRDLPFVTIDPVDARDHDDAVYAHPDEDETNKGGFVVWVAIADVAAYVRPGSALDR
DAREKGNSVYFPDRVEPMLPETLSNGLCSLRESENRATLAVRMVFDKSGRKKGHRFVRGLMRSAAKLSYEQAQAAIDGQP
DDKAGPLLDPILKPLWDAYRTMKIGRDARSPLAIESDERRIIIKGGEITSITKRASLEAHKLIEEMMVQANVCAAESLEA
KRSPLIYRVHDTPSLEKVQNLADFLQTLEIRWSKGEAPQTARFNKLLEETRESPNAAIINEVVLRTQMQAHYSADNIGHF
GLNLAKYAHFTSPIRRYADLIVHRGLIRALGLGTDGLTDQDIAQIKDTAEVITHAERRAMAAERDATDRYIAAFLADRVG
ATFEGRITGVTRFGLFIKLADTGADGLVPVSSLGQEFFVHDDKMHALVGERTGKRWPLGLSVEVKLVEATPVTGGLLFEM
LSEPLPPDPKMPRPRLGARRQAAVKPRGGLPKGVRRGKRR
>Mature_759_residues
AKLRPTKTFKPKPPAGLPDRETLLAFLRDAGETGKADIARHFGLKGADRRALREMIRELEAQGALAKRGRKGFAEAGSLP
PVGVADVVERDGDGELYVKLTKSDDDVPNVRLAPGKGEAAAGAPGLGDRLLVRFERLETGEFEAKLIKKLGQSAHKILGV
IRKHRREVRVEPVDRKSKESLVLDPSVAHDFKEGDLVLAQVGTHGGRYGPKPGKVLEVVGTENDPRAASLIAIHSHGIPT
GFSEAAEAEAKTAVEPTLAGREDLRDLPFVTIDPVDARDHDDAVYAHPDEDETNKGGFVVWVAIADVAAYVRPGSALDRD
AREKGNSVYFPDRVEPMLPETLSNGLCSLRESENRATLAVRMVFDKSGRKKGHRFVRGLMRSAAKLSYEQAQAAIDGQPD
DKAGPLLDPILKPLWDAYRTMKIGRDARSPLAIESDERRIIIKGGEITSITKRASLEAHKLIEEMMVQANVCAAESLEAK
RSPLIYRVHDTPSLEKVQNLADFLQTLEIRWSKGEAPQTARFNKLLEETRESPNAAIINEVVLRTQMQAHYSADNIGHFG
LNLAKYAHFTSPIRRYADLIVHRGLIRALGLGTDGLTDQDIAQIKDTAEVITHAERRAMAAERDATDRYIAAFLADRVGA
TFEGRITGVTRFGLFIKLADTGADGLVPVSSLGQEFFVHDDKMHALVGERTGKRWPLGLSVEVKLVEATPVTGGLLFEML
SEPLPPDPKMPRPRLGARRQAAVKPRGGLPKGVRRGKRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=446, Percent_Identity=27.5784753363229, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI190014623, Length=444, Percent_Identity=27.2522522522523, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI134288890, Length=504, Percent_Identity=27.7777777777778, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI219521928, Length=476, Percent_Identity=28.781512605042, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI19115966, Length=476, Percent_Identity=28.781512605042, Blast_Score=136, Evalue=9e-32,
Organism=Escherichia coli, GI87082383, Length=728, Percent_Identity=33.9285714285714, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1787542, Length=496, Percent_Identity=31.6532258064516, Blast_Score=172, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI212645896, Length=565, Percent_Identity=28.3185840707965, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17553506, Length=460, Percent_Identity=27.6086956521739, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324552, Length=494, Percent_Identity=28.5425101214575, Blast_Score=157, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24649634, Length=370, Percent_Identity=28.9189189189189, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24654592, Length=488, Percent_Identity=24.7950819672131, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922976, Length=488, Percent_Identity=24.7950819672131, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24654597, Length=488, Percent_Identity=24.7950819672131, Blast_Score=130, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 83241; Mature: 83110

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLRPTKTFKPKPPAGLPDRETLLAFLRDAGETGKADIARHFGLKGADRRALREMIREL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
EAQGALAKRGRKGFAEAGSLPPVGVADVVERDGDGELYVKLTKSDDDVPNVRLAPGKGEA
HHCCHHHHHCCCCCHHCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCEEECCCCCCC
AAGAPGLGDRLLVRFERLETGEFEAKLIKKLGQSAHKILGVIRKHRREVRVEPVDRKSKE
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SLVLDPSVAHDFKEGDLVLAQVGTHGGRYGPKPGKVLEVVGTENDPRAASLIAIHSHGIP
CEEECCHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCC
TGFSEAAEAEAKTAVEPTLAGREDLRDLPFVTIDPVDARDHDDAVYAHPDEDETNKGGFV
CCCHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCCCCCCCEEECCCCCCCCCCCEE
VWVAIADVAAYVRPGSALDRDAREKGNSVYFPDRVEPMLPETLSNGLCSLRESENRATLA
EEEEHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
VRMVFDKSGRKKGHRFVRGLMRSAAKLSYEQAQAAIDGQPDDKAGPLLDPILKPLWDAYR
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
TMKIGRDARSPLAIESDERRIIIKGGEITSITKRASLEAHKLIEEMMVQANVCAAESLEA
HHHHCCCCCCCCEEECCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRSPLIYRVHDTPSLEKVQNLADFLQTLEIRWSKGEAPQTARFNKLLEETRESPNAAIIN
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCHHHHH
EVVLRTQMQAHYSADNIGHFGLNLAKYAHFTSPIRRYADLIVHRGLIRALGLGTDGLTDQ
HHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DIAQIKDTAEVITHAERRAMAAERDATDRYIAAFLADRVGATFEGRITGVTRFGLFIKLA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEE
DTGADGLVPVSSLGQEFFVHDDKMHALVGERTGKRWPLGLSVEVKLVEATPVTGGLLFEM
CCCCCCCCCHHHCCHHHEECCCHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHH
LSEPLPPDPKMPRPRLGARRQAAVKPRGGLPKGVRRGKRR
HHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
AKLRPTKTFKPKPPAGLPDRETLLAFLRDAGETGKADIARHFGLKGADRRALREMIREL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
EAQGALAKRGRKGFAEAGSLPPVGVADVVERDGDGELYVKLTKSDDDVPNVRLAPGKGEA
HHCCHHHHHCCCCCHHCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCEEECCCCCCC
AAGAPGLGDRLLVRFERLETGEFEAKLIKKLGQSAHKILGVIRKHRREVRVEPVDRKSKE
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SLVLDPSVAHDFKEGDLVLAQVGTHGGRYGPKPGKVLEVVGTENDPRAASLIAIHSHGIP
CEEECCHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCC
TGFSEAAEAEAKTAVEPTLAGREDLRDLPFVTIDPVDARDHDDAVYAHPDEDETNKGGFV
CCCHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCCCCCCCEEECCCCCCCCCCCEE
VWVAIADVAAYVRPGSALDRDAREKGNSVYFPDRVEPMLPETLSNGLCSLRESENRATLA
EEEEHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
VRMVFDKSGRKKGHRFVRGLMRSAAKLSYEQAQAAIDGQPDDKAGPLLDPILKPLWDAYR
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
TMKIGRDARSPLAIESDERRIIIKGGEITSITKRASLEAHKLIEEMMVQANVCAAESLEA
HHHHCCCCCCCCEEECCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRSPLIYRVHDTPSLEKVQNLADFLQTLEIRWSKGEAPQTARFNKLLEETRESPNAAIIN
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCHHHHH
EVVLRTQMQAHYSADNIGHFGLNLAKYAHFTSPIRRYADLIVHRGLIRALGLGTDGLTDQ
HHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DIAQIKDTAEVITHAERRAMAAERDATDRYIAAFLADRVGATFEGRITGVTRFGLFIKLA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEE
DTGADGLVPVSSLGQEFFVHDDKMHALVGERTGKRWPLGLSVEVKLVEATPVTGGLLFEM
CCCCCCCCCHHHCCHHHEECCCHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHH
LSEPLPPDPKMPRPRLGARRQAAVKPRGGLPKGVRRGKRR
HHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]