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The map label for this gene is mhpT [H]

Identifier: 16126651

GI number: 16126651

Start: 2616752

End: 2617969

Strand: Direct

Name: mhpT [H]

Synonym: CC_2412

Alternate gene names: 16126651

Gene position: 2616752-2617969 (Clockwise)

Preceding gene: 16126650

Following gene: 16126655

Centisome position: 65.14

GC content: 69.38

Gene sequence:

>1218_bases
ATGACCACCAAAGGCCGATCCGCAGCCGGAACCCATGGTGGCTTAGTCGCCGTCGCGATTTGCTGCCTCCTGGCGGTCTT
CGAGGGGTTCGACCTCCAGGCCGCCGGCGTCGCCGCGCCTCGCCTGGCCCCTGACCTTGGCCTGAAGCCGGAGGATCTTG
GCTGGTTCTTCAGCATCAGCACGTTCGGCCTGATGGTCGGCGCCGCGCTGGGCGGGCGTCTTTCCGATCGCTTCGGCCGC
AAGGTCACGCTGCTGGTCTCCGTTGCGGCGTTTGGTTTGCTGTCGATCGCCACGGGCCTGGCCCAGGATCTAAACGGCCT
GCTGGTCGCTCGCTTTCTAACCGGGGTTGGGCTGGGCGGCGCCTTGCCTAACCTGATCGCCATCGTGGCCGAGAGCGTCT
CGCCCAAGCTTCGTGGTCGCGCCGTGGGCTTCCTCTATGCCGGCTTGCCCTGTGGCGGCGCCCTGGCCAGCCTCGTCAGC
CTAGCGGGGGCCGATCCCTCAGACTGGCGCATCGTCTTCTTCGTCGGAGGCGTCGGACCGCTGCTGGCCATGCTGCTTGC
GATGGTCCTGCTGCCCGATACTCCCATGGCCCAGGTCGGCCCGGTCGGCGACCAGAAGTCAGGTTTCGTCGAAGCGCTGG
CCGGCGAGGGTCGAGGCCTGACCACCCTGCTGCTATGGATCGCCTTCTTCCTGGCGCTGCTGATCATGTACCTGCTGCTC
AGCTGGCTGCCGTCGCTGATGATCGGGCGGGGCCTCAGCCGCTCCGACGCTGGACTGATCCAGATGGCGTTCAATCTGGC
CGGAGCGGCCGGCAGCGTCGCCACAGGCTGGCTGATGGATCACCGTCGCTGGCGCACCCTGACGATCCTGGGCGCGTTCG
GCGCTTCTGCGGCAGCTATGGCGACAGCCGCCGCCGCGCCGGCGTCGCTGGCCGTGTTCCTGATCGTCGGCGCGGCGTTG
GGCGCCACGGTGTCAGGCGTCCAGTCGGTGGTCTACGGCCTGGCGCCGGGCTTCTACCCGGCCCGGCTGCGCGGCACCGG
CGTGGGCGCGGCGGTGGTCGTCGGACGGCTCGGCTCGGCGGCCGGCCCATTGCTAGCCGCCACCCTGATCGGGGCCGGAG
GATCCTCCAACCAGGTGCTGCTGGCGCTGATGCCGGTCATCGCCCTGGGCGGCCTAGTCAGCCTGCTGCTGGCGACACGC
CCGCATTCGGGAGACTGA

Upstream 100 bases:

>100_bases
CCTTCACCGAGGCCGCGGACGTGATGTCCGAACTCGGCTGAACGGCGCGCCATCAGATCGAACCGCAGAGTTCGACATCG
AGGAAACGCCAGGAGCACCC

Downstream 100 bases:

>100_bases
CGACCCAGCCAGGGTCGCCCCGGCGTGCGGCCAGAGCGACATCTCTAAGCGGCCTAGACATGGGGCGTAAGAGCCGGCCG
TAGGCCCAACTCCCACAGGC

Product: putative 3-hydroxyphenylpropionic transporter MhpT

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTTKGRSAAGTHGGLVAVAICCLLAVFEGFDLQAAGVAAPRLAPDLGLKPEDLGWFFSISTFGLMVGAALGGRLSDRFGR
KVTLLVSVAAFGLLSIATGLAQDLNGLLVARFLTGVGLGGALPNLIAIVAESVSPKLRGRAVGFLYAGLPCGGALASLVS
LAGADPSDWRIVFFVGGVGPLLAMLLAMVLLPDTPMAQVGPVGDQKSGFVEALAGEGRGLTTLLLWIAFFLALLIMYLLL
SWLPSLMIGRGLSRSDAGLIQMAFNLAGAAGSVATGWLMDHRRWRTLTILGAFGASAAAMATAAAAPASLAVFLIVGAAL
GATVSGVQSVVYGLAPGFYPARLRGTGVGAAVVVGRLGSAAGPLLAATLIGAGGSSNQVLLALMPVIALGGLVSLLLATR
PHSGD

Sequences:

>Translated_405_residues
MTTKGRSAAGTHGGLVAVAICCLLAVFEGFDLQAAGVAAPRLAPDLGLKPEDLGWFFSISTFGLMVGAALGGRLSDRFGR
KVTLLVSVAAFGLLSIATGLAQDLNGLLVARFLTGVGLGGALPNLIAIVAESVSPKLRGRAVGFLYAGLPCGGALASLVS
LAGADPSDWRIVFFVGGVGPLLAMLLAMVLLPDTPMAQVGPVGDQKSGFVEALAGEGRGLTTLLLWIAFFLALLIMYLLL
SWLPSLMIGRGLSRSDAGLIQMAFNLAGAAGSVATGWLMDHRRWRTLTILGAFGASAAAMATAAAAPASLAVFLIVGAAL
GATVSGVQSVVYGLAPGFYPARLRGTGVGAAVVVGRLGSAAGPLLAATLIGAGGSSNQVLLALMPVIALGGLVSLLLATR
PHSGD
>Mature_404_residues
TTKGRSAAGTHGGLVAVAICCLLAVFEGFDLQAAGVAAPRLAPDLGLKPEDLGWFFSISTFGLMVGAALGGRLSDRFGRK
VTLLVSVAAFGLLSIATGLAQDLNGLLVARFLTGVGLGGALPNLIAIVAESVSPKLRGRAVGFLYAGLPCGGALASLVSL
AGADPSDWRIVFFVGGVGPLLAMLLAMVLLPDTPMAQVGPVGDQKSGFVEALAGEGRGLTTLLLWIAFFLALLIMYLLLS
WLPSLMIGRGLSRSDAGLIQMAFNLAGAAGSVATGWLMDHRRWRTLTILGAFGASAAAMATAAAAPASLAVFLIVGAALG
ATVSGVQSVVYGLAPGFYPARLRGTGVGAAVVVGRLGSAAGPLLAATLIGAGGSSNQVLLALMPVIALGGLVSLLLATRP
HSGD

Specific function: Could be a transporter for 3-phenylpropionate (hydrocinnamic acid) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI73695465, Length=169, Percent_Identity=28.4023668639053, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87081723, Length=387, Percent_Identity=41.8604651162791, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082404, Length=365, Percent_Identity=22.7397260273973, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786229, Length=382, Percent_Identity=25.9162303664921, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082231, Length=171, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082159, Length=362, Percent_Identity=26.2430939226519, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082320, Length=415, Percent_Identity=23.3734939759036, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24640198, Length=191, Percent_Identity=30.3664921465969, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640196, Length=191, Percent_Identity=30.3664921465969, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640200, Length=191, Percent_Identity=30.3664921465969, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40625; Mature: 40493

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKGRSAAGTHGGLVAVAICCLLAVFEGFDLQAAGVAAPRLAPDLGLKPEDLGWFFSIS
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
TFGLMVGAALGGRLSDRFGRKVTLLVSVAAFGLLSIATGLAQDLNGLLVARFLTGVGLGG
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ALPNLIAIVAESVSPKLRGRAVGFLYAGLPCGGALASLVSLAGADPSDWRIVFFVGGVGP
HHHHHHHHHHHHCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHH
LLAMLLAMVLLPDTPMAQVGPVGDQKSGFVEALAGEGRGLTTLLLWIAFFLALLIMYLLL
HHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SWLPSLMIGRGLSRSDAGLIQMAFNLAGAAGSVATGWLMDHRRWRTLTILGAFGASAAAM
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHH
ATAAAAPASLAVFLIVGAALGATVSGVQSVVYGLAPGFYPARLRGTGVGAAVVVGRLGSA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHCCCC
AGPLLAATLIGAGGSSNQVLLALMPVIALGGLVSLLLATRPHSGD
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTKGRSAAGTHGGLVAVAICCLLAVFEGFDLQAAGVAAPRLAPDLGLKPEDLGWFFSIS
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
TFGLMVGAALGGRLSDRFGRKVTLLVSVAAFGLLSIATGLAQDLNGLLVARFLTGVGLGG
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ALPNLIAIVAESVSPKLRGRAVGFLYAGLPCGGALASLVSLAGADPSDWRIVFFVGGVGP
HHHHHHHHHHHHCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHH
LLAMLLAMVLLPDTPMAQVGPVGDQKSGFVEALAGEGRGLTTLLLWIAFFLALLIMYLLL
HHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SWLPSLMIGRGLSRSDAGLIQMAFNLAGAAGSVATGWLMDHRRWRTLTILGAFGASAAAM
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHH
ATAAAAPASLAVFLIVGAALGATVSGVQSVVYGLAPGFYPARLRGTGVGAAVVVGRLGSA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHCCCC
AGPLLAATLIGAGGSSNQVLLALMPVIALGGLVSLLLATRPHSGD
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]