Click here to switch to the map view.

The map label for this gene is gph

Identifier: 16126544

GI number: 16126544

Start: 2508322

End: 2509035

Strand: Direct

Name: gph

Synonym: CC_2305

Alternate gene names: 16126544

Gene position: 2508322-2509035 (Clockwise)

Preceding gene: 16126536

Following gene: 16126545

Centisome position: 62.44

GC content: 69.33

Gene sequence:

>714_bases
ATGAGCACGCTTCATGACCTGAACGGGGCGACCATCGCCTTCGACCTGGACGGCACCCTCGTCGACACCGCGCCCGACCT
GGTGGGCGCGCTGAACATCATCCTCGCCCAAGAATCGCTGCCGCCGCTGCCCTTCGACGATGTGCGCCTGATGGTGGGCC
GAGGCGCGCGGGCCCTCTTGGAGCGTGGCTTCGCCGCCGCCGGCGCGCCGCTCGACGCCGAGCAGGCGCCCGCCCTGGTC
CAGCGGTTCATCGACGTCTACCTCGCCCGCATCGCCGACGAGAGCGCGCCCTTCCCCGGCGTGGTCGAGGTGCTGAGCGA
CCTCAAGACGGCCGGCGCCAAGCTTGTGGTCTGCACCAACAAGCTCACCAACCTGTCGACCGCGCTGCTCGACGCCGTGG
CGCTTTCGCCCTTCTTCGAAGCGGTGATCGGCGCTGATCTGGCGCCCGCCGCCAAGCCGGACGGTCGCCACGTCGCCGCC
GCTGTCGCGGCTGTGGGCGGAGACGTTAGCCGCGCCGTGATGATCGGTGACAGCGTCAATGACGCGCTCGGCGCCCGCAA
CGCGGGGGTTCCCGGCGTGCTGGTCTCGTTCGGCTACACCGAGGAACCGGTCGAGACCCTGGGCGCGGATCTGGTCATCC
ACAGCTTTTTGGACGTGCCCAAGGCCTGCATCACGCTTTTGACCTCTTGCCCCGCGCCGAACACCGGGCTATAG

Upstream 100 bases:

>100_bases
GACGAACGGGCTTGGAAACGGACTCGGTCATGGTCCCGGCGACTCCCTGGAGGCGAACCAAAGTTGCATTAGCCGTGCAA
TTGGCCGAAAGGCCAGACCC

Downstream 100 bases:

>100_bases
CCCCCGTCCTCTCGCGGATCGGTCCCTTTCGGGGCCCTCCACACGGCGGATGCGTAGCTCAGCGGGAGAGCACCTCGTTC
ACACCGAGGGGGTCACAGGT

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP; PGPase

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSTLHDLNGATIAFDLDGTLVDTAPDLVGALNIILAQESLPPLPFDDVRLMVGRGARALLERGFAAAGAPLDAEQAPALV
QRFIDVYLARIADESAPFPGVVEVLSDLKTAGAKLVVCTNKLTNLSTALLDAVALSPFFEAVIGADLAPAAKPDGRHVAA
AVAAVGGDVSRAVMIGDSVNDALGARNAGVPGVLVSFGYTEEPVETLGADLVIHSFLDVPKACITLLTSCPAPNTGL

Sequences:

>Translated_237_residues
MSTLHDLNGATIAFDLDGTLVDTAPDLVGALNIILAQESLPPLPFDDVRLMVGRGARALLERGFAAAGAPLDAEQAPALV
QRFIDVYLARIADESAPFPGVVEVLSDLKTAGAKLVVCTNKLTNLSTALLDAVALSPFFEAVIGADLAPAAKPDGRHVAA
AVAAVGGDVSRAVMIGDSVNDALGARNAGVPGVLVSFGYTEEPVETLGADLVIHSFLDVPKACITLLTSCPAPNTGL
>Mature_236_residues
STLHDLNGATIAFDLDGTLVDTAPDLVGALNIILAQESLPPLPFDDVRLMVGRGARALLERGFAAAGAPLDAEQAPALVQ
RFIDVYLARIADESAPFPGVVEVLSDLKTAGAKLVVCTNKLTNLSTALLDAVALSPFFEAVIGADLAPAAKPDGRHVAAA
VAAVGGDVSRAVMIGDSVNDALGARNAGVPGVLVSFGYTEEPVETLGADLVIHSFLDVPKACITLLTSCPAPNTGL

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family

Homologues:

Organism=Escherichia coli, GI1789787, Length=237, Percent_Identity=31.2236286919831, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPH_CAUCR (Q9A5Z2)

Other databases:

- EMBL:   AE005673
- PIR:   H87534
- RefSeq:   NP_421108.1
- ProteinModelPortal:   Q9A5Z2
- SMR:   Q9A5Z2
- GeneID:   943469
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2305
- NMPDR:   fig|190650.1.peg.2288
- TIGR:   CC_2305
- HOGENOM:   HBG742904
- OMA:   PLLHACK
- ProtClustDB:   CLSK890910
- BRENDA:   3.1.3.18
- HAMAP:   MF_00495
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198
- Gene3D:   G3DSA:3.40.50.1000
- Gene3D:   G3DSA:1.10.150.240
- TIGRFAMs:   TIGR01549
- TIGRFAMs:   TIGR01509

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: =3.1.3.18

Molecular weight: Translated: 24219; Mature: 24088

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: NA

Important sites: ACT_SITE 15-15

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLHDLNGATIAFDLDGTLVDTAPDLVGALNIILAQESLPPLPFDDVRLMVGRGARALL
CCCCCCCCCCEEEEECCCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHH
ERGFAAAGAPLDAEQAPALVQRFIDVYLARIADESAPFPGVVEVLSDLKTAGAKLVVCTN
HCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECC
KLTNLSTALLDAVALSPFFEAVIGADLAPAAKPDGRHVAAAVAAVGGDVSRAVMIGDSVN
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHH
DALGARNAGVPGVLVSFGYTEEPVETLGADLVIHSFLDVPKACITLLTSCPAPNTGL
HHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STLHDLNGATIAFDLDGTLVDTAPDLVGALNIILAQESLPPLPFDDVRLMVGRGARALL
CCCCCCCCCEEEEECCCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHH
ERGFAAAGAPLDAEQAPALVQRFIDVYLARIADESAPFPGVVEVLSDLKTAGAKLVVCTN
HCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECC
KLTNLSTALLDAVALSPFFEAVIGADLAPAAKPDGRHVAAAVAAVGGDVSRAVMIGDSVN
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHH
DALGARNAGVPGVLVSFGYTEEPVETLGADLVIHSFLDVPKACITLLTSCPAPNTGL
HHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647