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The map label for this gene is guaA

Identifier: 16125867

GI number: 16125867

Start: 1793148

End: 1794710

Strand: Direct

Name: guaA

Synonym: CC_1620

Alternate gene names: 16125867

Gene position: 1793148-1794710 (Clockwise)

Preceding gene: 16125866

Following gene: 16125872

Centisome position: 44.64

GC content: 66.22

Gene sequence:

>1563_bases
ATGACTCAGAAAACCGACCACCAGCGCGTCCTGATCGTCGACTTCGGCAGCCAGGTCACCCAACTGATCGCCCGCCGAGT
GCGCGAGGCGGGGGTCTATTGCGAGATCCATCCGTTCGACAAGGCCGAGGCCATTGTCGACGAGTACGCGCCCTCGGCGA
TCATCCTGTCGGGCGGTCCGGCCAGTGTGCTGGAGGCGGACAGCCCGCGCATCGGTCGCAAGCTGTTCGATCTGGGCCTG
CCGCTGCTGGCCATCTGCTACGGCCAGCAACTGCTGTGCGACGTCTTGAGCGGCAAGGTCGAGGGTGGTCACGCGGGCGA
ATTCGGCCGCGCCGAGCTGACCATCGGCAAGGATAGCCCGATGTTCCAAGGCCTGGCCGGTGTCGGCGGCGTCGAGACGG
TGTGGATGAGCCACGGCGATCGCGTCACGGCGATCCCGGAAGGCTTCGAGGTGATCGGTACGTCGACCGGCGCGCCGTTC
GCGGCGATCGCCAATGACGCCAAGAAGATCTACGCCCTGCAGTTCCATCCTGAGGTCTATCACACGGTCAACGGACCGGC
GATGTACCGCAATTTCCTGTTCAATATCGCGGGGCTGAAGGGCGACTGGACGATGGCGGCGTTCCGCCAGGAGATGGTCC
AGAAGATCCGCGACCAGGTCGGAGACGGCAAGGTGATCTGCGGCCTGTCGGGCGGCGTCGACAGCTCGGTGGCCGCCGTG
CTGATCCACGAGGCGATCGGCGACCAGCTGACCTGCGTGTTCGTCGACACGGGCCTCTTGCGCAAGAACGAGGCCGACCA
GGTCGTGACCCTGTTCCGCGACCACTACAACATCCCGCTGGTCCACGTGGACGCCGGCGACCTGTTCCTGGGCGAGCTGG
CCGGCGTCAGCGATCCCGAAACCAAGCGCAAGACCATCGGCCGCCTGTTCATCGACGTGTTCGACAAGGAAGCCGCCAAG
ATCGAGGGCGCGACGTTCCTGGCCCAGGGCACGCTCTATCCGGACGTCGTCGAGAGCGTCTCGGCCCGCGGCGGCCCCTC
GGCGGTGATCAAGAGCCACCACAACGTCGGCGGCTTGCCCGACTACATGAAGCTGAAGCTGGTCGAGCCGCTGCGCGAGC
TGTTCAAGGACGAGGTTCGCGCCCTGGGTGTCGAGCTGGGCCTGGCCCCGGCCTTCGTCGGCCGCCATCCGTTCCCCGGA
CCGGGCCTCGCCATCCGTATCCCGGGCGAGATCACGCCCGAGAAGGTCAAGGTCCTGCAGGACGCCGACGCCATCTATCT
GGAAGAGATCCGCAACGCCGGCCTCTATGACCAGATCTGGCAGGCCTTCGCGGTGCTGCTGCCCGTGAAGACGGTGGGCG
TGATGGGCGATGCGCGGACCTACGAGAACGTTCTGGCCCTGCGCGCGGTGACCTCGACCGACGGCATGACCGCCGACTTC
TTCGAGTTCCCGTGGCCGGTTCTGGGCAAGACCGCCACGCGCATCATCAACGAGGTGCGCGGCGTCAACCGCGTCGTCTA
TGACGTGACCAGCAAGCCGCCGGGCACGATTGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
CCCCTCATCGCGCGGGCACTGACGGCTTCTTCGCCGCGGTGCTGCAACGCGCATCCTACACGCCCTGACCGATCACGTCC
GACCGCTGGAGACCTCGCCC

Downstream 100 bases:

>100_bases
CGCGGCGGCGCGGTTAGAGCCTGTCTGGTTTAGATGGAACTATCTAAACCAGATAAACAGGCTCTAAAATCAAACACTTA
GAGCCCTTTCAAACGCTTTG

Product: bifunctional GMP synthase/glutamine amidotransferase protein

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTQKTDHQRVLIVDFGSQVTQLIARRVREAGVYCEIHPFDKAEAIVDEYAPSAIILSGGPASVLEADSPRIGRKLFDLGL
PLLAICYGQQLLCDVLSGKVEGGHAGEFGRAELTIGKDSPMFQGLAGVGGVETVWMSHGDRVTAIPEGFEVIGTSTGAPF
AAIANDAKKIYALQFHPEVYHTVNGPAMYRNFLFNIAGLKGDWTMAAFRQEMVQKIRDQVGDGKVICGLSGGVDSSVAAV
LIHEAIGDQLTCVFVDTGLLRKNEADQVVTLFRDHYNIPLVHVDAGDLFLGELAGVSDPETKRKTIGRLFIDVFDKEAAK
IEGATFLAQGTLYPDVVESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLAPAFVGRHPFPG
PGLAIRIPGEITPEKVKVLQDADAIYLEEIRNAGLYDQIWQAFAVLLPVKTVGVMGDARTYENVLALRAVTSTDGMTADF
FEFPWPVLGKTATRIINEVRGVNRVVYDVTSKPPGTIEWE

Sequences:

>Translated_520_residues
MTQKTDHQRVLIVDFGSQVTQLIARRVREAGVYCEIHPFDKAEAIVDEYAPSAIILSGGPASVLEADSPRIGRKLFDLGL
PLLAICYGQQLLCDVLSGKVEGGHAGEFGRAELTIGKDSPMFQGLAGVGGVETVWMSHGDRVTAIPEGFEVIGTSTGAPF
AAIANDAKKIYALQFHPEVYHTVNGPAMYRNFLFNIAGLKGDWTMAAFRQEMVQKIRDQVGDGKVICGLSGGVDSSVAAV
LIHEAIGDQLTCVFVDTGLLRKNEADQVVTLFRDHYNIPLVHVDAGDLFLGELAGVSDPETKRKTIGRLFIDVFDKEAAK
IEGATFLAQGTLYPDVVESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLAPAFVGRHPFPG
PGLAIRIPGEITPEKVKVLQDADAIYLEEIRNAGLYDQIWQAFAVLLPVKTVGVMGDARTYENVLALRAVTSTDGMTADF
FEFPWPVLGKTATRIINEVRGVNRVVYDVTSKPPGTIEWE
>Mature_519_residues
TQKTDHQRVLIVDFGSQVTQLIARRVREAGVYCEIHPFDKAEAIVDEYAPSAIILSGGPASVLEADSPRIGRKLFDLGLP
LLAICYGQQLLCDVLSGKVEGGHAGEFGRAELTIGKDSPMFQGLAGVGGVETVWMSHGDRVTAIPEGFEVIGTSTGAPFA
AIANDAKKIYALQFHPEVYHTVNGPAMYRNFLFNIAGLKGDWTMAAFRQEMVQKIRDQVGDGKVICGLSGGVDSSVAAVL
IHEAIGDQLTCVFVDTGLLRKNEADQVVTLFRDHYNIPLVHVDAGDLFLGELAGVSDPETKRKTIGRLFIDVFDKEAAKI
EGATFLAQGTLYPDVVESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLAPAFVGRHPFPGP
GLAIRIPGEITPEKVKVLQDADAIYLEEIRNAGLYDQIWQAFAVLLPVKTVGVMGDARTYENVLALRAVTSTDGMTADFF
EFPWPVLGKTATRIINEVRGVNRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=35.5191256830601, Blast_Score=288, Evalue=7e-78,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=53.7142857142857, Blast_Score=581, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=37.521815008726, Blast_Score=312, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=37.521815008726, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=37.521815008726, Blast_Score=311, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=51.1583011583012, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=35.8181818181818, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CAUCN (B8GVI7)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002517065.1
- ProteinModelPortal:   B8GVI7
- SMR:   B8GVI7
- GeneID:   7331752
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01692
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56338; Mature: 56207

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKTDHQRVLIVDFGSQVTQLIARRVREAGVYCEIHPFDKAEAIVDEYAPSAIILSGGP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEECCCC
ASVLEADSPRIGRKLFDLGLPLLAICYGQQLLCDVLSGKVEGGHAGEFGRAELTIGKDSP
CHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
MFQGLAGVGGVETVWMSHGDRVTAIPEGFEVIGTSTGAPFAAIANDAKKIYALQFHPEVY
HHHHHCCCCCCEEEEECCCCEEEECCCCCEEEECCCCCCHHHHHCCCCEEEEEEECCHHE
HTVNGPAMYRNFLFNIAGLKGDWTMAAFRQEMVQKIRDQVGDGKVICGLSGGVDSSVAAV
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LIHEAIGDQLTCVFVDTGLLRKNEADQVVTLFRDHYNIPLVHVDAGDLFLGELAGVSDPE
HHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCCCCH
TKRKTIGRLFIDVFDKEAAKIEGATFLAQGTLYPDVVESVSARGGPSAVIKSHHNVGGLP
HHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCC
DYMKLKLVEPLRELFKDEVRALGVELGLAPAFVGRHPFPGPGLAIRIPGEITPEKVKVLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
DADAIYLEEIRNAGLYDQIWQAFAVLLPVKTVGVMGDARTYENVLALRAVTSTDGMTADF
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCHH
FEFPWPVLGKTATRIINEVRGVNRVVYDVTSKPPGTIEWE
HHCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TQKTDHQRVLIVDFGSQVTQLIARRVREAGVYCEIHPFDKAEAIVDEYAPSAIILSGGP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEECCCC
ASVLEADSPRIGRKLFDLGLPLLAICYGQQLLCDVLSGKVEGGHAGEFGRAELTIGKDSP
CHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
MFQGLAGVGGVETVWMSHGDRVTAIPEGFEVIGTSTGAPFAAIANDAKKIYALQFHPEVY
HHHHHCCCCCCEEEEECCCCEEEECCCCCEEEECCCCCCHHHHHCCCCEEEEEEECCHHE
HTVNGPAMYRNFLFNIAGLKGDWTMAAFRQEMVQKIRDQVGDGKVICGLSGGVDSSVAAV
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LIHEAIGDQLTCVFVDTGLLRKNEADQVVTLFRDHYNIPLVHVDAGDLFLGELAGVSDPE
HHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCCCCH
TKRKTIGRLFIDVFDKEAAKIEGATFLAQGTLYPDVVESVSARGGPSAVIKSHHNVGGLP
HHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCC
DYMKLKLVEPLRELFKDEVRALGVELGLAPAFVGRHPFPGPGLAIRIPGEITPEKVKVLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
DADAIYLEEIRNAGLYDQIWQAFAVLLPVKTVGVMGDARTYENVLALRAVTSTDGMTADF
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCCCCHH
FEFPWPVLGKTATRIINEVRGVNRVVYDVTSKPPGTIEWE
HHCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA