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The map label for this gene is parC

Identifier: 16125813

GI number: 16125813

Start: 1729890

End: 1732169

Strand: Direct

Name: parC

Synonym: CC_1566

Alternate gene names: 16125813

Gene position: 1729890-1732169 (Clockwise)

Preceding gene: 16125812

Following gene: 16125814

Centisome position: 43.06

GC content: 66.18

Gene sequence:

>2280_bases
ATGAACAAGCCTGTCCTTCCTCCCCCCGGCGGCCCCGACGACGGCGACCGCATTCTCGACGAGCCGCTGACCGAGGCGCT
GTCGCGGCGCTATCTGGCCTATGCGCTGTCGACGATCGGCTCGCGAGCGCTGCCTGACGTGCGCGATGGCTTGAAGCCCG
TGCACCGCCGCGTGCTCTACGCGATGAGCAATATGCGGCTGAACCCCGACGCCGCCGCGCGCAAGTGCGCCAAGGTGGTC
GGCGAGGTGATGGGTAACTTCCACCCGCACGGCGACGCCTCGATCTATGACGCCCTGGTGCGTCTGGCCCAGGAGTTCAG
CCAACGCATCCCGCTGGTCGAAGGGCAGGGGAACTTCGGCAATATCGACGGCGATAGCGCCGCGGCGATGCGCTACACCG
AGTGCAAGATGACGGAAGCGGCGATGCTTCTGTTGGACGGCATCGACGAGGACGCGGTCGACTTCCGCCCAACCTATGAC
GGCCAGGACGAAGAGCCGGTCGTGCTGCCGTCGGGCTTCCCGAACCTGTTGGCCAACGGCTCGTCGGGCATCGCGGTCGG
CATGGCCACCTCGATCCCGCCCCACAACGCCGCCGAGCTGATCGACGCCTGCCAGCTGTTGCTGGCCAATCCCGACGCGA
CGACGGCGGACCTGCTGGAAAAGGTCCCGGGGCCGGACTTCCCGACCGGCGGCGTGATCGTCGAGTCCCGCGCCTCGTTG
CTGGAAACCTACGAGACCGGACGTGGCGGCGTGCGGATGCGCGCCAAGTGGGAGAAGGAAGACACCGGTCGCGGCACCTA
CCAGATCGTCGTCACCGAGATTCCGTATCAGGTGAAGAAGTCGGATCTGGTCGAGCAGCTGGCCGACCTGATCGACAGCA
AGAAGGCCGCCCTGCTGGGCGACGTCCGCGACGAGAGCGCCGAGGACATCCGTCTGGTCCTCGAGCCCAAGTCCAAGAAC
GTCGAGCCCGAAGTGCTGATGGAGAGCCTGTTCAAGCTCTCGGCGCTGGAGAGCCGGTTCCCGGTCAATATCAACGTGCT
GGATGCGCGCGGCACGCCGGGCGTGATGGGAATCAAGCAGGCGCTGATGGCCTTCCTGGCTCACCGCCGCGAAGTGCTGA
CCCGCCGGGCTCGCCACCGCCTGGCCAAGATCGAAGCCCGTCTGCACATCCTGGACGGCCTGCTGATCGCCTATCTGAAC
CTCGACGAGGTCATTCGGATCGTCCGCTATGAGGACAAGCCGAAGGAAAAGCTGATCGAGACCTTCGGGCTCACGGACAT
CCAGGCCGACGCCATCCTCAACACCCGCCTGCGCCAACTGGCCAAGCTGGAGGAGATGGAGATCCGGCGTGAGCACGCCG
AACTGGTGGAAGAGCGCGACGGCATTCTGGCCATGCTGGCCAGCGAGGCCAAGCAGTGGAAGCTGGTCGGCGTGGGTCTC
TCCGAGGTCCGCGCGGCGCTGCTCAAGATCAAGCATCCGCTCGACAAGCCGCGCCCCACGGGCGTGACCGGCCGTTCGGT
GTTCGGCGAGGCTCCGCAGGTCGACGCCGACGCCGCCATCGAGGCGATGATCGTGCGCGAGCCGATCACGATCATCCTGT
CCGAGCGCGGCTGGATCCGCGCCGCCAAGGGCAAGATCGATGATCCCTCGGAACTGAAGTTCAAGGAAGGCGACAAGCTG
GGCTTCCTGGTCCCGGCCGAGACCACCGACAAGCTGCTGATCTTCTCCAGCGACGGGCGCTTCTTCACGCTGGGCTGTGA
CAAGCTGCCCAGCGCGCGCGGTCACGGCGAGCCGGTGCGGATGATGATCGAGCTGGACGACAAGGTGAAGATCATCGACG
TCTTCCCGTTCAAGGCCGGCCGCAAACGCATTCTGGCCTCGAAGGGCGGCTATGGCTTCCTGATGCCCGAGGAAGAAGCC
CTGGCCAACCGCAAGGCCGGCAAGCAGGTCCTGAATGTCGGCAATGAAGGCGCGGCCTTCTGCCTGGAGGCCGTCGGCGA
CCAGCTGGCGGTGATCGGCGACAATGGCAAGATCCTGATCTTCCCGCTGGAAGAGCTGCCGGAAATGCCGCGCGGCAAGG
GCGTCAAGCTGCAGGCCTACCGCGAAGGCGGCCTGCGCGACGGTCTGTCGTTCAACGCCGAGACCGGAGCCTACTGGATC
GACACCGCCGGCCGGCGTCGTGACTGGGCCGAGTGGAAGGAATGGGTGGGCCGCCGCGCGGGCGCCGGGAAGCTGGTTCC
CAAGGGCTTCGCCACCAACAAGCGGTTCCGTCCCAAATGA

Upstream 100 bases:

>100_bases
GCGCTGGAAGCCGGAAAGACGGGGATCGTTCAGGCCTAACCGCTCGAATCATCGAGGGGGTTTCTGCTAGGCTCCTTCCC
CGGAGTAACGAATCCCCTCG

Downstream 100 bases:

>100_bases
GGATCGGACGGTCGCGTCGCCGCGCGTTGAGCCTGTTGGCCGGCGTTTTCGGCTGCGCGGCCGTCGCCGCGACTCCGGCG
CTGGCCCTGCCCAAGGGCAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MNKPVLPPPGGPDDGDRILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLYAMSNMRLNPDAAARKCAKVV
GEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFGNIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYD
GQDEEPVVLPSGFPNLLANGSSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVESRASL
LETYETGRGGVRMRAKWEKEDTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLGDVRDESAEDIRLVLEPKSKN
VEPEVLMESLFKLSALESRFPVNINVLDARGTPGVMGIKQALMAFLAHRREVLTRRARHRLAKIEARLHILDGLLIAYLN
LDEVIRIVRYEDKPKEKLIETFGLTDIQADAILNTRLRQLAKLEEMEIRREHAELVEERDGILAMLASEAKQWKLVGVGL
SEVRAALLKIKHPLDKPRPTGVTGRSVFGEAPQVDADAAIEAMIVREPITIILSERGWIRAAKGKIDDPSELKFKEGDKL
GFLVPAETTDKLLIFSSDGRFFTLGCDKLPSARGHGEPVRMMIELDDKVKIIDVFPFKAGRKRILASKGGYGFLMPEEEA
LANRKAGKQVLNVGNEGAAFCLEAVGDQLAVIGDNGKILIFPLEELPEMPRGKGVKLQAYREGGLRDGLSFNAETGAYWI
DTAGRRRDWAEWKEWVGRRAGAGKLVPKGFATNKRFRPK

Sequences:

>Translated_759_residues
MNKPVLPPPGGPDDGDRILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLYAMSNMRLNPDAAARKCAKVV
GEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFGNIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYD
GQDEEPVVLPSGFPNLLANGSSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVESRASL
LETYETGRGGVRMRAKWEKEDTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLGDVRDESAEDIRLVLEPKSKN
VEPEVLMESLFKLSALESRFPVNINVLDARGTPGVMGIKQALMAFLAHRREVLTRRARHRLAKIEARLHILDGLLIAYLN
LDEVIRIVRYEDKPKEKLIETFGLTDIQADAILNTRLRQLAKLEEMEIRREHAELVEERDGILAMLASEAKQWKLVGVGL
SEVRAALLKIKHPLDKPRPTGVTGRSVFGEAPQVDADAAIEAMIVREPITIILSERGWIRAAKGKIDDPSELKFKEGDKL
GFLVPAETTDKLLIFSSDGRFFTLGCDKLPSARGHGEPVRMMIELDDKVKIIDVFPFKAGRKRILASKGGYGFLMPEEEA
LANRKAGKQVLNVGNEGAAFCLEAVGDQLAVIGDNGKILIFPLEELPEMPRGKGVKLQAYREGGLRDGLSFNAETGAYWI
DTAGRRRDWAEWKEWVGRRAGAGKLVPKGFATNKRFRPK
>Mature_759_residues
MNKPVLPPPGGPDDGDRILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLYAMSNMRLNPDAAARKCAKVV
GEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFGNIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYD
GQDEEPVVLPSGFPNLLANGSSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVESRASL
LETYETGRGGVRMRAKWEKEDTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLGDVRDESAEDIRLVLEPKSKN
VEPEVLMESLFKLSALESRFPVNINVLDARGTPGVMGIKQALMAFLAHRREVLTRRARHRLAKIEARLHILDGLLIAYLN
LDEVIRIVRYEDKPKEKLIETFGLTDIQADAILNTRLRQLAKLEEMEIRREHAELVEERDGILAMLASEAKQWKLVGVGL
SEVRAALLKIKHPLDKPRPTGVTGRSVFGEAPQVDADAAIEAMIVREPITIILSERGWIRAAKGKIDDPSELKFKEGDKL
GFLVPAETTDKLLIFSSDGRFFTLGCDKLPSARGHGEPVRMMIELDDKVKIIDVFPFKAGRKRILASKGGYGFLMPEEEA
LANRKAGKQVLNVGNEGAAFCLEAVGDQLAVIGDNGKILIFPLEELPEMPRGKGVKLQAYREGGLRDGLSFNAETGAYWI
DTAGRRRDWAEWKEWVGRRAGAGKLVPKGFATNKRFRPK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family

Homologues:

Organism=Homo sapiens, GI19913408, Length=430, Percent_Identity=24.4186046511628, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=30.8571428571429, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=681, Percent_Identity=40.8223201174743, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1788562, Length=717, Percent_Identity=37.6569037656904, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI212645845, Length=450, Percent_Identity=23.7777777777778, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=447, Percent_Identity=25.0559284116331, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=444, Percent_Identity=24.5495495495495, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=196, Percent_Identity=30.1020408163265, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=166, Percent_Identity=33.1325301204819, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PARC_CAUCR (O54478)

Other databases:

- EMBL:   U94696
- EMBL:   U86302
- EMBL:   AE005673
- PIR:   E87443
- RefSeq:   NP_420377.1
- ProteinModelPortal:   O54478
- GeneID:   941333
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1566
- NMPDR:   fig|190650.1.peg.1557
- TIGR:   CC_1566
- HOGENOM:   HBG635183
- OMA:   VQKSKLI
- ProtClustDB:   PRK05561
- GO:   GO:0005694
- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742
- Gene3D:   G3DSA:3.30.1360.40
- Gene3D:   G3DSA:3.90.199.10
- Gene3D:   G3DSA:1.10.268.10
- SMART:   SM00434
- TIGRFAMs:   TIGR01062

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen

EC number: 5.99.1.-

Molecular weight: Translated: 83522; Mature: 83522

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPVLPPPGGPDDGDRILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AMSNMRLNPDAAARKCAKVVGEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFG
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCC
NIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYDGQDEEPVVLPSGFPNLLANG
CCCCCCHHHEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCC
SSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVESRASL
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEHHHHHH
LETYETGRGGVRMRAKWEKEDTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLG
HHHHHCCCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHC
DVRDESAEDIRLVLEPKSKNVEPEVLMESLFKLSALESRFPVNINVLDARGTPGVMGIKQ
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
ALMAFLAHRREVLTRRARHRLAKIEARLHILDGLLIAYLNLDEVIRIVRYEDKPKEKLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHH
TFGLTDIQADAILNTRLRQLAKLEEMEIRREHAELVEERDGILAMLASEAKQWKLVGVGL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCH
SEVRAALLKIKHPLDKPRPTGVTGRSVFGEAPQVDADAAIEAMIVREPITIILSERGWIR
HHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHEECCEEEEEECCCEEE
AAKGKIDDPSELKFKEGDKLGFLVPAETTDKLLIFSSDGRFFTLGCDKLPSARGHGEPVR
ECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCEE
MMIELDDKVKIIDVFPFKAGRKRILASKGGYGFLMPEEEALANRKAGKQVLNVGNEGAAF
EEEEECCCEEEEEEECCCCCCHHEEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHH
CLEAVGDQLAVIGDNGKILIFPLEELPEMPRGKGVKLQAYREGGLRDGLSFNAETGAYWI
HHHHCCCEEEEEECCCCEEEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEE
DTAGRRRDWAEWKEWVGRRAGAGKLVPKGFATNKRFRPK
ECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKPVLPPPGGPDDGDRILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AMSNMRLNPDAAARKCAKVVGEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFG
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCC
NIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYDGQDEEPVVLPSGFPNLLANG
CCCCCCHHHEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCC
SSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVESRASL
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEHHHHHH
LETYETGRGGVRMRAKWEKEDTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLG
HHHHHCCCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHC
DVRDESAEDIRLVLEPKSKNVEPEVLMESLFKLSALESRFPVNINVLDARGTPGVMGIKQ
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
ALMAFLAHRREVLTRRARHRLAKIEARLHILDGLLIAYLNLDEVIRIVRYEDKPKEKLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHH
TFGLTDIQADAILNTRLRQLAKLEEMEIRREHAELVEERDGILAMLASEAKQWKLVGVGL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCH
SEVRAALLKIKHPLDKPRPTGVTGRSVFGEAPQVDADAAIEAMIVREPITIILSERGWIR
HHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHEECCEEEEEECCCEEE
AAKGKIDDPSELKFKEGDKLGFLVPAETTDKLLIFSSDGRFFTLGCDKLPSARGHGEPVR
ECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCEE
MMIELDDKVKIIDVFPFKAGRKRILASKGGYGFLMPEEEALANRKAGKQVLNVGNEGAAF
EEEEECCCEEEEEEECCCCCCHHEEECCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHH
CLEAVGDQLAVIGDNGKILIFPLEELPEMPRGKGVKLQAYREGGLRDGLSFNAETGAYWI
HHHHCCCEEEEEECCCCEEEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEE
DTAGRRRDWAEWKEWVGRRAGAGKLVPKGFATNKRFRPK
ECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9426128; 11259647