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The map label for this gene is rnc

Identifier: 16125807

GI number: 16125807

Start: 1724050

End: 1724745

Strand: Direct

Name: rnc

Synonym: CC_1560

Alternate gene names: 16125807

Gene position: 1724050-1724745 (Clockwise)

Preceding gene: 16125806

Following gene: 16125808

Centisome position: 42.92

GC content: 71.55

Gene sequence:

>696_bases
ATGGATAGACGGGTCGCCGCCGTCGGCGACCTGGAGCGCCGGATCGGCCACAGGTTCGAAGACCGCGAACTGCTCGAACG
CGCCCTGACGCACGCCAGCGTCGGGGACGGGGCCAAGAAGGTCCGCGACAACGAGGTGCTGGAGTTCATCGGCGACCGCG
TGCTGGGCCTTCTGGCCGCCGAAGCGCTGGCGCAGCGCTTCCCCAAGGCCAAGGAGGGCGAGCTTGCGCCGCGCCTCAAC
GCCCTGGTCAGCCGCGAGACCTGCGCCCGCGTCGCGCGCAAGGCCGAACTCGGCCCCGCCCTGCGGCTGTCGGCCTCGTC
CAGCAAGATCGGCGGCCGCGAAACCGACTCGATCCTGGCCGGCGCCACCGAGGCCCTGATGGCCGCCCTCTATCAGGACG
GCGGGCTGGAGGCGGCGCGCAAGGTGTTCCTCGATCTGTGGAACGACGAGTTCGACCGCGCTGGCGAAGGCCGTCCGCGC
GATCCCAAAACCGCGCTGCAGGAGTGGGCGCAGGGCCAGGGTCGCCCGCTGCCGACCTACCGCGTGCTGGACCGCACGGG
TCCCGACCACGCGCCGGTGTTCACCGTGGAAGTCAGCGTGACTGGCGTCGATCCCGCCATCGCCAAGGGCAAGTCGCGCC
AGGAGGCCGAAAAAGCGGCGGCCAAGGCGCTGCTGGAGCGTGAAGGGGCGGGCTAG

Upstream 100 bases:

>100_bases
CGCCGAGGCGAGCCTCTTCAAGCCGTGGACCTGGTTCCTGGACGCGCGTCCCAGCCGCTTCTTCCACGTGCTGAAGTGAC
TTTGTTGGGTCTTGGGCCTC

Downstream 100 bases:

>100_bases
GTTCGCGCTGCGGTGAGGCGGGGGGGGGCCGATTCAAACGGGGACGCTCAAGGCGACTTTCGACCCTGAGGCTGAGTTCA
AATAGTCAGCTTCAAGTCCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAAEALAQRFPKAKEGELAPRLN
ALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILAGATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPR
DPKTALQEWAQGQGRPLPTYRVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG

Sequences:

>Translated_231_residues
MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAAEALAQRFPKAKEGELAPRLN
ALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILAGATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPR
DPKTALQEWAQGQGRPLPTYRVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG
>Mature_231_residues
MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAAEALAQRFPKAKEGELAPRLN
ALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILAGATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPR
DPKTALQEWAQGQGRPLPTYRVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1788920, Length=223, Percent_Identity=38.5650224215247, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI193202651, Length=223, Percent_Identity=29.5964125560538, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506883, Length=223, Percent_Identity=29.5964125560538, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137682, Length=239, Percent_Identity=30.9623430962343, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CAUCN (B8H627)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002517003.1
- ProteinModelPortal:   B8H627
- SMR:   B8H627
- GeneID:   7331608
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01630
- OMA:   THASART
- ProtClustDB:   CLSK890476
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 24972; Mature: 24972

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAA
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EALAQRFPKAKEGELAPRLNALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHH
GATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPRDPKTALQEWAQGQGRPLPTY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHH
RVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG
HHHHCCCCCCCCEEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDRRVAAVGDLERRIGHRFEDRELLERALTHASVGDGAKKVRDNEVLEFIGDRVLGLLAA
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EALAQRFPKAKEGELAPRLNALVSRETCARVARKAELGPALRLSASSSKIGGRETDSILA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHH
GATEALMAALYQDGGLEAARKVFLDLWNDEFDRAGEGRPRDPKTALQEWAQGQGRPLPTY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHH
RVLDRTGPDHAPVFTVEVSVTGVDPAIAKGKSRQEAEKAAAKALLEREGAG
HHHHCCCCCCCCEEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA