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The map label for this gene is lepB [H]

Identifier: 16125806

GI number: 16125806

Start: 1723183

End: 1724028

Strand: Direct

Name: lepB [H]

Synonym: CC_1559

Alternate gene names: 16125806

Gene position: 1723183-1724028 (Clockwise)

Preceding gene: 16125805

Following gene: 16125807

Centisome position: 42.9

GC content: 63.59

Gene sequence:

>846_bases
ATGACTGACGCCGCCGACGACTTCACGCCGCCCGAAGAGAAGGGCGTCGTCGCCGAGCTTATCGAGATCGTCAAAACCGT
CGCCTATGCGCTGGGTATCGCCCTGGTGCTGCGCGTGTTGCTGTTCCAGCCCTTTACGATCCCGTCGGCCTCGATGGAGC
CGAACCTCTACCAGGGCGACTACATCATCGTGTCGAAGTTCAGCTACGGTTGGAGCAAGCACTCGATCCCGTTCAGCCCG
CCGATCATCAAGGGGCGAATCTTCGATCGCGCGCCCAAGCGCGGCGACATCGTCGTGTTCAAGCTGCCGCGCGACAATCG
CACCGACTACATCAAGCGCCTGATCGGCATGCCCGGCGACAAGGTCCAGATCCGCGGCGGCGAGGTCTACATCAACGGCA
AGGCCCTGCCCCGCAAGGCCCAGGCCCCGGCCCTCGTTGACACCGGCTATGGCTTCACCCAGCAGGTCCAGCGCTTCCAG
GAGACCAGCCCCGAGGGTCGTCCGTACAACATCCAGGACTTCGGCCCCGACAGCCGTGGCGACAACACCGGCATCTATAC
GGTTCCGGCCGGCTGCTACTTCTTCATGGGCGACAACCGCGACAACTCGGCCGACAGCCGCTTTGATCCGGGCGTCTCGC
CCTACAAGGAAAGCGCTTGCAAGTGGGACTATGAGCTGGACCAGTATATCGGCGACGAGATCGGCGTCGGCTTCGTGCCG
GCCGAGAATCTGGTCGGCCGCGCCCAGATCATCCTCTTGTCGTGGAACGCCGAGGCGAGCCTCTTCAAGCCGTGGACCTG
GTTCCTGGACGCGCGTCCCAGCCGCTTCTTCCACGTGCTGAAGTGA

Upstream 100 bases:

>100_bases
GAAGCTTGGCTACGCGCCGCTCTTGCCCGTCCGGCCAAGCCCGTCTAGCAAAGCCGAACCGGTTCGCCGGCCATCCCATT
TCGTAGAGCTCCGCGCCCGC

Downstream 100 bases:

>100_bases
CTTTGTTGGGTCTTGGGCCTCATGGATAGACGGGTCGCCGCCGTCGGCGACCTGGAGCGCCGGATCGGCCACAGGTTCGA
AGACCGCGAACTGCTCGAAC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTDAADDFTPPEEKGVVAELIEIVKTVAYALGIALVLRVLLFQPFTIPSASMEPNLYQGDYIIVSKFSYGWSKHSIPFSP
PIIKGRIFDRAPKRGDIVVFKLPRDNRTDYIKRLIGMPGDKVQIRGGEVYINGKALPRKAQAPALVDTGYGFTQQVQRFQ
ETSPEGRPYNIQDFGPDSRGDNTGIYTVPAGCYFFMGDNRDNSADSRFDPGVSPYKESACKWDYELDQYIGDEIGVGFVP
AENLVGRAQIILLSWNAEASLFKPWTWFLDARPSRFFHVLK

Sequences:

>Translated_281_residues
MTDAADDFTPPEEKGVVAELIEIVKTVAYALGIALVLRVLLFQPFTIPSASMEPNLYQGDYIIVSKFSYGWSKHSIPFSP
PIIKGRIFDRAPKRGDIVVFKLPRDNRTDYIKRLIGMPGDKVQIRGGEVYINGKALPRKAQAPALVDTGYGFTQQVQRFQ
ETSPEGRPYNIQDFGPDSRGDNTGIYTVPAGCYFFMGDNRDNSADSRFDPGVSPYKESACKWDYELDQYIGDEIGVGFVP
AENLVGRAQIILLSWNAEASLFKPWTWFLDARPSRFFHVLK
>Mature_280_residues
TDAADDFTPPEEKGVVAELIEIVKTVAYALGIALVLRVLLFQPFTIPSASMEPNLYQGDYIIVSKFSYGWSKHSIPFSPP
IIKGRIFDRAPKRGDIVVFKLPRDNRTDYIKRLIGMPGDKVQIRGGEVYINGKALPRKAQAPALVDTGYGFTQQVQRFQE
TSPEGRPYNIQDFGPDSRGDNTGIYTVPAGCYFFMGDNRDNSADSRFDPGVSPYKESACKWDYELDQYIGDEIGVGFVPA
ENLVGRAQIILLSWNAEASLFKPWTWFLDARPSRFFHVLK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=281, Percent_Identity=33.8078291814947, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 31564; Mature: 31433

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAADDFTPPEEKGVVAELIEIVKTVAYALGIALVLRVLLFQPFTIPSASMEPNLYQGD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
YIIVSKFSYGWSKHSIPFSPPIIKGRIFDRAPKRGDIVVFKLPRDNRTDYIKRLIGMPGD
EEEEEECCCCCCCCCCCCCCCEEECEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
KVQIRGGEVYINGKALPRKAQAPALVDTGYGFTQQVQRFQETSPEGRPYNIQDFGPDSRG
EEEEECCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DNTGIYTVPAGCYFFMGDNRDNSADSRFDPGVSPYKESACKWDYELDQYIGDEIGVGFVP
CCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHCCHHCCCCEEC
AENLVGRAQIILLSWNAEASLFKPWTWFLDARPSRFFHVLK
HHHCCCCEEEEEEEECCCCCEECCEEEEEECCCCCEEEECC
>Mature Secondary Structure 
TDAADDFTPPEEKGVVAELIEIVKTVAYALGIALVLRVLLFQPFTIPSASMEPNLYQGD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECC
YIIVSKFSYGWSKHSIPFSPPIIKGRIFDRAPKRGDIVVFKLPRDNRTDYIKRLIGMPGD
EEEEEECCCCCCCCCCCCCCCEEECEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
KVQIRGGEVYINGKALPRKAQAPALVDTGYGFTQQVQRFQETSPEGRPYNIQDFGPDSRG
EEEEECCEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DNTGIYTVPAGCYFFMGDNRDNSADSRFDPGVSPYKESACKWDYELDQYIGDEIGVGFVP
CCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHCCHHCCCCEEC
AENLVGRAQIILLSWNAEASLFKPWTWFLDARPSRFFHVLK
HHHCCCCEEEEEEEECCCCCEECCEEEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA