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The map label for this gene is fbp

Identifier: 16125634

GI number: 16125634

Start: 1535872

End: 1536882

Strand: Direct

Name: fbp

Synonym: CC_1385

Alternate gene names: 16125634

Gene position: 1535872-1536882 (Clockwise)

Preceding gene: 16125633

Following gene: 16125635

Centisome position: 38.23

GC content: 66.67

Gene sequence:

>1011_bases
ATGGGCCGCTCTGCTTTCGGTTCGAGGACGAGAATGACTGCTTTTGTCGACCTGGCCGCCCGGCTCGCGGCCGAGCCGGC
GGACGCCGCCCTGAAGGACGTGGTCCTGACCATCGCCGAGACGTGCGCGCAGATCAGCCGCGTCGTGGCCTCGGGCGCCC
TGTCGGGAAGCCTGGGCGCGGCGGGCAGCACCAACGTGCAGGACGAAGAGCAGAAGAAGCTCGACGTCATCACCAATGAC
ATGCTGAGCGACGCCCTGAAGGCCTGCGGTCCCGTGGCGGGTCTGGCTTCTGAAGAGCTGGAAGAGGTCGAGCCCACGGG
TCGTGTCGGCGGCTATCTCGTCACCTTCGATCCGCTGGACGGCTCCAGCAATATCGACGTCAACGTCTCGGTTGGAACGA
TCTTCTCGGTCTTGCCCGCGCCGGCCGGCCATGCGCCGACCGAAGGTGACTTCCTGCAGCCGGGCCGCAACCAGGTGGCG
GCGGGTTATGCCGTCTACGGGCCCCAGACGATGCTGGTCGTCACGCTGTCGGGCGGCGTCAACGGTTTCACGCTCAGCGC
CGACGGCCGCTGGTTGCTGACCCACCCGGACCTGGCCATCAAGCCGGACACCGCTGAGTTCGCGATCAATATGTCCAATC
AGCGCCACTGGGCGCCAGCTGTGCGCCGCTATATCGACGGCTGCCTGCAGGGCAAGGACGGCGCGCGGGGCAAGAACTTC
AACATGCGCTGGGTCGCCTCGATGGTGGCAGACGTCCACCGCATCATGATGCGCGGCGGGGTCTTCATGTACCCCTGGGA
TGCGCGCGAGCCGGACAAGCCCGGCAAGCTGCGCCTAATGTACGAGGCCAATCCGATGAGCCTTCTCGCCGAGCGGGCGG
GCGGCAAGTCGATCGAAGGCCTGAACGAAATCCTGGATATCAACCCGGCCAAGCTGCACCAGCGCGTGCCCGTCGTCCTG
GGCTCGGCCAATGAGGTCGAGGTCATCCGGGCCGAGATGCGCGCCGGCTGA

Upstream 100 bases:

>100_bases
GCACACCCACACGCTGGTGATGAACTCCTCGACGGGCACGGTCCGCGAGGTCCGCATGAAGCGGAAGGTCTGAAACCTTC
CTGTCACGCCCATCGCCTAG

Downstream 100 bases:

>100_bases
CGCACGTCCGACCCTGTCGTGTGGGCGCCGCATGGTTCGAATCCTTGCGACAAGCTAGGCTCGCCCGATGCCCGCCGATG
GTGTCACCGATATTTCCTCC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MGRSAFGSRTRMTAFVDLAARLAAEPADAALKDVVLTIAETCAQISRVVASGALSGSLGAAGSTNVQDEEQKKLDVITND
MLSDALKACGPVAGLASEELEEVEPTGRVGGYLVTFDPLDGSSNIDVNVSVGTIFSVLPAPAGHAPTEGDFLQPGRNQVA
AGYAVYGPQTMLVVTLSGGVNGFTLSADGRWLLTHPDLAIKPDTAEFAINMSNQRHWAPAVRRYIDGCLQGKDGARGKNF
NMRWVASMVADVHRIMMRGGVFMYPWDAREPDKPGKLRLMYEANPMSLLAERAGGKSIEGLNEILDINPAKLHQRVPVVL
GSANEVEVIRAEMRAG

Sequences:

>Translated_336_residues
MGRSAFGSRTRMTAFVDLAARLAAEPADAALKDVVLTIAETCAQISRVVASGALSGSLGAAGSTNVQDEEQKKLDVITND
MLSDALKACGPVAGLASEELEEVEPTGRVGGYLVTFDPLDGSSNIDVNVSVGTIFSVLPAPAGHAPTEGDFLQPGRNQVA
AGYAVYGPQTMLVVTLSGGVNGFTLSADGRWLLTHPDLAIKPDTAEFAINMSNQRHWAPAVRRYIDGCLQGKDGARGKNF
NMRWVASMVADVHRIMMRGGVFMYPWDAREPDKPGKLRLMYEANPMSLLAERAGGKSIEGLNEILDINPAKLHQRVPVVL
GSANEVEVIRAEMRAG
>Mature_335_residues
GRSAFGSRTRMTAFVDLAARLAAEPADAALKDVVLTIAETCAQISRVVASGALSGSLGAAGSTNVQDEEQKKLDVITNDM
LSDALKACGPVAGLASEELEEVEPTGRVGGYLVTFDPLDGSSNIDVNVSVGTIFSVLPAPAGHAPTEGDFLQPGRNQVAA
GYAVYGPQTMLVVTLSGGVNGFTLSADGRWLLTHPDLAIKPDTAEFAINMSNQRHWAPAVRRYIDGCLQGKDGARGKNFN
MRWVASMVADVHRIMMRGGVFMYPWDAREPDKPGKLRLMYEANPMSLLAERAGGKSIEGLNEILDINPAKLHQRVPVVLG
SANEVEVIRAEMRAG

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=300, Percent_Identity=44, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI16579888, Length=300, Percent_Identity=44, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI22907028, Length=286, Percent_Identity=40.2097902097902, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI1790679, Length=295, Percent_Identity=46.1016949152542, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17508131, Length=330, Percent_Identity=41.5151515151515, Blast_Score=237, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6323409, Length=290, Percent_Identity=43.7931034482759, Blast_Score=229, Evalue=7e-61,
Organism=Drosophila melanogaster, GI19921562, Length=329, Percent_Identity=41.6413373860182, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45550998, Length=329, Percent_Identity=41.6413373860182, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_CAUCR (Q9A8G9)

Other databases:

- EMBL:   AE005673
- PIR:   B87421
- RefSeq:   NP_420198.1
- HSSP:   P0A993
- ProteinModelPortal:   Q9A8G9
- SMR:   Q9A8G9
- GeneID:   941724
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1385
- NMPDR:   fig|190650.1.peg.1378
- TIGR:   CC_1385
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- ProtClustDB:   PRK09293
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 35734; Mature: 35603

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00124 FBPASE

Important sites: BINDING 210-210 BINDING 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRSAFGSRTRMTAFVDLAARLAAEPADAALKDVVLTIAETCAQISRVVASGALSGSLGA
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AGSTNVQDEEQKKLDVITNDMLSDALKACGPVAGLASEELEEVEPTGRVGGYLVTFDPLD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCC
GSSNIDVNVSVGTIFSVLPAPAGHAPTEGDFLQPGRNQVAAGYAVYGPQTMLVVTLSGGV
CCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCEEEECCCEEEEEEEECCC
NGFTLSADGRWLLTHPDLAIKPDTAEFAINMSNQRHWAPAVRRYIDGCLQGKDGARGKNF
CEEEEECCCEEEEECCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
NMRWVASMVADVHRIMMRGGVFMYPWDAREPDKPGKLRLMYEANPMSLLAERAGGKSIEG
CHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCHHH
LNEILDINPAKLHQRVPVVLGSANEVEVIRAEMRAG
HHHHHCCCHHHHHCCCCEEECCCCCHHHHHHHHCCC
>Mature Secondary Structure 
GRSAFGSRTRMTAFVDLAARLAAEPADAALKDVVLTIAETCAQISRVVASGALSGSLGA
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AGSTNVQDEEQKKLDVITNDMLSDALKACGPVAGLASEELEEVEPTGRVGGYLVTFDPLD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCC
GSSNIDVNVSVGTIFSVLPAPAGHAPTEGDFLQPGRNQVAAGYAVYGPQTMLVVTLSGGV
CCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCEEEECCCEEEEEEEECCC
NGFTLSADGRWLLTHPDLAIKPDTAEFAINMSNQRHWAPAVRRYIDGCLQGKDGARGKNF
CEEEEECCCEEEEECCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
NMRWVASMVADVHRIMMRGGVFMYPWDAREPDKPGKLRLMYEANPMSLLAERAGGKSIEG
CHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCHHH
LNEILDINPAKLHQRVPVVLGSANEVEVIRAEMRAG
HHHHHCCCHHHHHCCCCEEECCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647