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The map label for this gene is fabH

Identifier: 16125618

GI number: 16125618

Start: 1521404

End: 1522372

Strand: Direct

Name: fabH

Synonym: CC_1369

Alternate gene names: 16125618

Gene position: 1521404-1522372 (Clockwise)

Preceding gene: 16125617

Following gene: 16125619

Centisome position: 37.87

GC content: 66.77

Gene sequence:

>969_bases
GTGCGAAGCGTTGTAACGGGCGTCGGCGCCTATCTGCCGTCCAAGGTCGTGACCAATGACGACCTGGCGAAGTTTGTCGA
CACCAGCGACGAGTGGATCGTCGAGCGCACCGGGATCCGTCAGCGCCATCAGGCGGCGGACGATCAGCCTGTTTCGGATC
TTGCGTTCGAGGCGGCCAAGGAAGCCCTGGCGGCGGCGGGCAAGACGGCCGCAGACGTCGATCTGATCATCGTGGCGACG
ACGACCGGGGATCTTACCTTCCCCGCGACCGCTACGATCGTACAGCGCAAGCTGGGCGCGCCGGTCGGCGTCGCCTTCGA
CGTCCAGGCCGTCTGCTCTGGCTTCGTCTACGCCATGAGCGTCGCCGACGGCTTCGTCGCGCGCGGCCATTCCAAATGCG
CGCTGGTGATCGGCGCTGAAGCCATGACCCGCCTGATGGACTGGAGCGATCGCGGCACTTGCGTTCTCTTCGGCGACGGC
GCCGGCGCGATCGTGCTCGAGCCGGGGGAAGGCGAGGGGACCACCGATGACCGGGGCATGCTGGGCTTCGCCCTGCGCGC
CGACGGGACCAAGCAGGATCTGCTGTATGTCGACGGCGGCCCGTCGACGACCGGAACGGTCGGCAAGCTCCGGATGCTGG
GCAATCAGGTCTTCAAGCACGCGGTCGTCAATATCTCCGAAGCGATTCACGCCGCCGCCGGCAAGGCGGGCGTTGCGGTC
GCCGATGTCGACTGGTTCATTCCGCACCAGGCCAATCAGCGCATCCTCCAAGGCGTGGCGCATCGCTGCGGCATTGACGA
GGAAAAGGTCATCTCGACCGTGGCCATCCACGCCAACACCTCGGCCGCCTCGATCCCGCTGGCGTTCGCGCACGGGATCA
AGGACGGCCGGATCAAGAAGGGCGACTTGCTGCTTCTGGAGGCGATGGGCGGTGGGCTGACCTGGGGCGCCTGCGTCGTC
CGTCTCTAG

Upstream 100 bases:

>100_bases
ACAGAAATCTCAAGCGCCTGACCGCTACGGCGGCGGCCATCAAGTCCGGCGACGGGCAGGGTCCCGGCGAAGACGCCCAA
GGAGTGGCCGAGTGAGCGTT

Downstream 100 bases:

>100_bases
TTTCAGGGCACTGGCGCTGCGCGCTGCGCGATCCTGCGCCAAGGCATGAACTCTTGGCGTTGAGTCTTTGACTTCATGCG
GTAATCGCGGCATGAGGTCG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRSVVTGVGAYLPSKVVTNDDLAKFVDTSDEWIVERTGIRQRHQAADDQPVSDLAFEAAKEALAAAGKTAADVDLIIVAT
TTGDLTFPATATIVQRKLGAPVGVAFDVQAVCSGFVYAMSVADGFVARGHSKCALVIGAEAMTRLMDWSDRGTCVLFGDG
AGAIVLEPGEGEGTTDDRGMLGFALRADGTKQDLLYVDGGPSTTGTVGKLRMLGNQVFKHAVVNISEAIHAAAGKAGVAV
ADVDWFIPHQANQRILQGVAHRCGIDEEKVISTVAIHANTSAASIPLAFAHGIKDGRIKKGDLLLLEAMGGGLTWGACVV
RL

Sequences:

>Translated_322_residues
MRSVVTGVGAYLPSKVVTNDDLAKFVDTSDEWIVERTGIRQRHQAADDQPVSDLAFEAAKEALAAAGKTAADVDLIIVAT
TTGDLTFPATATIVQRKLGAPVGVAFDVQAVCSGFVYAMSVADGFVARGHSKCALVIGAEAMTRLMDWSDRGTCVLFGDG
AGAIVLEPGEGEGTTDDRGMLGFALRADGTKQDLLYVDGGPSTTGTVGKLRMLGNQVFKHAVVNISEAIHAAAGKAGVAV
ADVDWFIPHQANQRILQGVAHRCGIDEEKVISTVAIHANTSAASIPLAFAHGIKDGRIKKGDLLLLEAMGGGLTWGACVV
RL
>Mature_322_residues
MRSVVTGVGAYLPSKVVTNDDLAKFVDTSDEWIVERTGIRQRHQAADDQPVSDLAFEAAKEALAAAGKTAADVDLIIVAT
TTGDLTFPATATIVQRKLGAPVGVAFDVQAVCSGFVYAMSVADGFVARGHSKCALVIGAEAMTRLMDWSDRGTCVLFGDG
AGAIVLEPGEGEGTTDDRGMLGFALRADGTKQDLLYVDGGPSTTGTVGKLRMLGNQVFKHAVVNISEAIHAAAGKAGVAV
ADVDWFIPHQANQRILQGVAHRCGIDEEKVISTVAIHANTSAASIPLAFAHGIKDGRIKKGDLLLLEAMGGGLTWGACVV
RL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=44.8916408668731, Blast_Score=271, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CAUCR (Q9A8I4)

Other databases:

- EMBL:   AE005673
- PIR:   B87419
- RefSeq:   NP_420182.1
- ProteinModelPortal:   Q9A8I4
- SMR:   Q9A8I4
- GeneID:   941702
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1369
- NMPDR:   fig|190650.1.peg.1362
- TIGR:   CC_1369
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- ProtClustDB:   PRK09352
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33527; Mature: 33527

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 249-249 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVVTGVGAYLPSKVVTNDDLAKFVDTSDEWIVERTGIRQRHQAADDQPVSDLAFEAAK
CCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHH
EALAAAGKTAADVDLIIVATTTGDLTFPATATIVQRKLGAPVGVAFDVQAVCSGFVYAMS
HHHHHCCCCCCCEEEEEEEECCCCEECCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
VADGFVARGHSKCALVIGAEAMTRLMDWSDRGTCVLFGDGAGAIVLEPGEGEGTTDDRGM
HHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCC
LGFALRADGTKQDLLYVDGGPSTTGTVGKLRMLGNQVFKHAVVNISEAIHAAAGKAGVAV
EEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
ADVDWFIPHQANQRILQGVAHRCGIDEEKVISTVAIHANTSAASIPLAFAHGIKDGRIKK
EEEEEECCCCCHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCCCCHHHCCCCCCCEEC
GDLLLLEAMGGGLTWGACVVRL
CCEEEEEECCCCCEEHEEEEEC
>Mature Secondary Structure
MRSVVTGVGAYLPSKVVTNDDLAKFVDTSDEWIVERTGIRQRHQAADDQPVSDLAFEAAK
CCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHH
EALAAAGKTAADVDLIIVATTTGDLTFPATATIVQRKLGAPVGVAFDVQAVCSGFVYAMS
HHHHHCCCCCCCEEEEEEEECCCCEECCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHH
VADGFVARGHSKCALVIGAEAMTRLMDWSDRGTCVLFGDGAGAIVLEPGEGEGTTDDRGM
HHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCC
LGFALRADGTKQDLLYVDGGPSTTGTVGKLRMLGNQVFKHAVVNISEAIHAAAGKAGVAV
EEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
ADVDWFIPHQANQRILQGVAHRCGIDEEKVISTVAIHANTSAASIPLAFAHGIKDGRIKK
EEEEEECCCCCHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCCCCHHHCCCCCCCEEC
GDLLLLEAMGGGLTWGACVVRL
CCEEEEEECCCCCEEHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647