Click here to switch to the map view.

The map label for this gene is thiL [H]

Identifier: 16125610

GI number: 16125610

Start: 1513475

End: 1514533

Strand: Direct

Name: thiL [H]

Synonym: CC_1361

Alternate gene names: 16125610

Gene position: 1513475-1514533 (Clockwise)

Preceding gene: 16125609

Following gene: 16125611

Centisome position: 37.68

GC content: 67.8

Gene sequence:

>1059_bases
ATGGCGCCCTCGACGCGATCGCCCGTGATGCACGAGACTGACGAAGAAGACTGGTTCGCTGAAGACGACGCTGCGGCCCC
CGCTGCGGCGCCGCCGACTGAATTCGATCATATCGCGCGGTTGCTGCGGCCGCTGACGCGCGGCGACCCTGTCGCTCTGG
ATCTTCTGGACGATGCGGCGGTGCTGCCGTCCAGGCCGGGATACGACCTGGTGATCACCAAGGACGCCATGGTCGCGGGC
GTTCACTTCCTGGCCGAAGAGGCCTTGGATGTCGTCGCACGCAAGCTGCTTCGCACCAATCTGTCCGACCTCGCCGCCAA
GGCGGCCGAGCCCTATGGCTATTTCCTCGCCGTGGGCTGGCCCTCCGGCTCCGACGTCGCTTCGCGAGAGACCTTCGCCC
GAGGGTTGGCCGAGGACGGTGCGTTGTTCGACATTTCCCTGCTGGGTGGGGATACGGTCACCACCTCCGGTCCGCTCGTC
GTGTCGGCGACCTTCCTGGGCTGGGCGCCGCAGGGCGAGACGATCCTTCGCCGGGGCGCCAAGCCTGGTGACCGCCTGAT
GGTCTCGGGTACGATCGGTGACGGATGGCTGGGTCTTCTGGCGCAGTGGGGCGAGGTCATGGACGCCGATGGAGCCATGC
TGCGCCGCTATCGCCAGCCGGAACCGCGCGTGACCCTCCGCGACGCCATGCGCGTTCACGCCAAGGCCGCCGCCGATGTT
TCCGACGGGCTTCTGGCCGACAGCAGCCATATCGCCAAGGCCAGCGGCTGCCGGGTGCGGGTCGATCTTGAGCGGTTGCC
GCTTTCGCCGGGTGCGCAAGCCTGGCTGGATCAACAGCCCGAGCAGGTCGAGGGACGGATCTCCCTGGCGTCCGGTGGCG
ATGACTACGAGATCGTCTGTGCGGTTGACCCCAATGAGGCCTGGGCCTTCCGCGTGGCGGCTGCCGCCGCCGGCGTGAAG
GTCAGCGAGATCGGCGAGTTTGTCGAAGGCGAGGGGGTCTCGGCCTACTACAAGGGGCGTGACGTCACGCCCTCTCGGCT
TGGCTGGCTTCACGGCTAG

Upstream 100 bases:

>100_bases
GAGCTGATGTACCGATCGGACGTTCCGACCGAGGTGGTCATCAATGAATATGTAGAGATCGCGAAATCCTTTTTTGAAGG
TCCCGAGTCAGGCTTCATCA

Downstream 100 bases:

>100_bases
AGCATTTGCCGATCCGTATGAAACGGTGATCGGATCGAGAAGCGCTCTGAATGTCTGAGATGGAGCCCTTTTTATCCGAT
CTGAGTGAGTCAATCGGATC

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MAPSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAAVLPSRPGYDLVITKDAMVAG
VHFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGWPSGSDVASRETFARGLAEDGALFDISLLGGDTVTTSGPLV
VSATFLGWAPQGETILRRGAKPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTLRDAMRVHAKAAADV
SDGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVCAVDPNEAWAFRVAAAAAGVK
VSEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG

Sequences:

>Translated_352_residues
MAPSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAAVLPSRPGYDLVITKDAMVAG
VHFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGWPSGSDVASRETFARGLAEDGALFDISLLGGDTVTTSGPLV
VSATFLGWAPQGETILRRGAKPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTLRDAMRVHAKAAADV
SDGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVCAVDPNEAWAFRVAAAAAGVK
VSEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG
>Mature_351_residues
APSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAAVLPSRPGYDLVITKDAMVAGV
HFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGWPSGSDVASRETFARGLAEDGALFDISLLGGDTVTTSGPLVV
SATFLGWAPQGETILRRGAKPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTLRDAMRVHAKAAADVS
DGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVCAVDPNEAWAFRVAAAAAGVKV
SEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=324, Percent_Identity=38.5802469135802, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 37486; Mature: 37355

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCH
VLPSRPGYDLVITKDAMVAGVHFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGW
HCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEC
PSGSDVASRETFARGLAEDGALFDISLLGGDTVTTSGPLVVSATFLGWAPQGETILRRGA
CCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEEECCCCEEEEEEEECCCCCCHHHHHCCC
KPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTLRDAMRVHAKAAADV
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHCCC
SDGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVC
CCCCCCCCCCHHHCCCCEEEEEHHHCCCCCCCHHHHCCCCCHHCCEEEEECCCCCEEEEE
AVDPNEAWAFRVAAAAAGVKVSEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG
EECCCCCCEEEEEHHHCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCC
>Mature Secondary Structure 
APSTRSPVMHETDEEDWFAEDDAAAPAAAPPTEFDHIARLLRPLTRGDPVALDLLDDAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCH
VLPSRPGYDLVITKDAMVAGVHFLAEEALDVVARKLLRTNLSDLAAKAAEPYGYFLAVGW
HCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEC
PSGSDVASRETFARGLAEDGALFDISLLGGDTVTTSGPLVVSATFLGWAPQGETILRRGA
CCCCCHHHHHHHHHHHCCCCCEEEEEEECCCEEECCCCEEEEEEEECCCCCCHHHHHCCC
KPGDRLMVSGTIGDGWLGLLAQWGEVMDADGAMLRRYRQPEPRVTLRDAMRVHAKAAADV
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHCCC
SDGLLADSSHIAKASGCRVRVDLERLPLSPGAQAWLDQQPEQVEGRISLASGGDDYEIVC
CCCCCCCCCCHHHCCCCEEEEEHHHCCCCCCCHHHHCCCCCHHCCEEEEECCCCCEEEEE
AVDPNEAWAFRVAAAAAGVKVSEIGEFVEGEGVSAYYKGRDVTPSRLGWLHG
EECCCCCCEEEEEHHHCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]