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The map label for this gene is yngJ [H]

Identifier: 16124682

GI number: 16124682

Start: 441717

End: 442865

Strand: Direct

Name: yngJ [H]

Synonym: CC_0427

Alternate gene names: 16124682

Gene position: 441717-442865 (Clockwise)

Preceding gene: 16124681

Following gene: 16124683

Centisome position: 11.0

GC content: 67.71

Gene sequence:

>1149_bases
ATGGCCCTCGATCTGGAAACCCGTGAACAACTGATCGACACGGTCGCCCGCTTCGTGGCCGAACGTCTGCGGCCCATCGA
GGCGCAGGTCGCCGAGAATGACGCCGTCCCCGACGATGTGATCGAGGAGATGAAGGGCCTTGGCCTCTTTGGCCTGACGA
TCCCGGAAGAGTTCGGCGGGCTTGGCCTGACCATGGAGGAAGAGGCGCTGGTGGCCATCGAGCTGGGCCGCGCCTCGCCG
GCCTTTCGCTCGGTGTTCGGCACCAATGTCGGCATCGGCAGCCAGGGCCTCGTCATGTTCGGCAATGACGAGCAGAAGGC
CAAGTGGCTGCCGGGGATCGCGTCCGGCGCGGTGATCACCTCGTTCGCCTTGACCGAGCCGGAGGCGGGCTCCGACAGCG
CCGCCGTGCAGACCCGCGCCACCCGGGACGGCGACGACTACATCCTGAACGGCTCCAAGCGCTACATCACCAATGCCGGC
AAGGCCTCGCTGTTCACGGTGATGGCCCGTACCAATCCCGACGCCAAGGGCGGGGCGGGGGTCTCGGCCTTCCTGGTGCC
GCGCGACCTGCCGGGCCTGACGGTCGGCAAGCCCGAAAAGAAGATGGGCCAGCAGGGCGCCCACATCCACGACGTGACCT
TCGATAACGTCCGCGTGCCGGCCTGGAACCGGCTGGGCGCCGAGGGCGAAGGCTTCAAGGTCGCCATGCAGGTGCTGGAT
CGCGGGCGGCTGCACATCGCCGCCGTCTGCGTCGGTGTGGCCGAGCGCCTGATCGCCGACTGCGTGGCCTACGCCTCCGA
ACGCAAGCAGTTCGGCCAGCCGATCGCCAGCTTCCAGCTGATCCAGGCGATGATCGCCGACAGCAAGACCGAAGCCCTGG
CGGCCAAGGCGCTGGTGCTGGAGACCGCCCGCAAGCGCGACGCCGGCGTGAATGTCACGCTGGAGGCCGCCTCGTCCAAG
CTGTTCGCCTCGGAAATGGTCGGCCGCGTGGCGGACCGCGCGGTGCAGGTGTTCGGCGGCGCCGGCTATGTCGCCGACTA
CGGGATCGAACGCCTCTACCGCGATGTTCGTATTTTCCGGATCTACGAGGGCACCAGCCAGGTCCAGCAGCTGATCATTG
CGCGTGAAACGCTGAAGCGCGGCGGGTGA

Upstream 100 bases:

>100_bases
TCCATTCTCGAGGGCCGTCGCTACAGTTCCCGGCAAAACAAGCGTTTGACGCCACCCTCGCGGTTTCCGCGAGGGGCTGG
GAAACTGGGAGACGAAGCGA

Downstream 100 bases:

>100_bases
GTGCGACACCCTGTCGCCCCCTCCGCCCGTCGGCCGTATGCAATCGATAAACCATCCCCTCGTTCCCACGATATTGACCG
TTCAGTCTGTGCAAACGGTT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MALDLETREQLIDTVARFVAERLRPIEAQVAENDAVPDDVIEEMKGLGLFGLTIPEEFGGLGLTMEEEALVAIELGRASP
AFRSVFGTNVGIGSQGLVMFGNDEQKAKWLPGIASGAVITSFALTEPEAGSDSAAVQTRATRDGDDYILNGSKRYITNAG
KASLFTVMARTNPDAKGGAGVSAFLVPRDLPGLTVGKPEKKMGQQGAHIHDVTFDNVRVPAWNRLGAEGEGFKVAMQVLD
RGRLHIAAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVLETARKRDAGVNVTLEAASSK
LFASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRIYEGTSQVQQLIIARETLKRGG

Sequences:

>Translated_382_residues
MALDLETREQLIDTVARFVAERLRPIEAQVAENDAVPDDVIEEMKGLGLFGLTIPEEFGGLGLTMEEEALVAIELGRASP
AFRSVFGTNVGIGSQGLVMFGNDEQKAKWLPGIASGAVITSFALTEPEAGSDSAAVQTRATRDGDDYILNGSKRYITNAG
KASLFTVMARTNPDAKGGAGVSAFLVPRDLPGLTVGKPEKKMGQQGAHIHDVTFDNVRVPAWNRLGAEGEGFKVAMQVLD
RGRLHIAAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVLETARKRDAGVNVTLEAASSK
LFASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRIYEGTSQVQQLIIARETLKRGG
>Mature_381_residues
ALDLETREQLIDTVARFVAERLRPIEAQVAENDAVPDDVIEEMKGLGLFGLTIPEEFGGLGLTMEEEALVAIELGRASPA
FRSVFGTNVGIGSQGLVMFGNDEQKAKWLPGIASGAVITSFALTEPEAGSDSAAVQTRATRDGDDYILNGSKRYITNAGK
ASLFTVMARTNPDAKGGAGVSAFLVPRDLPGLTVGKPEKKMGQQGAHIHDVTFDNVRVPAWNRLGAEGEGFKVAMQVLDR
GRLHIAAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVLETARKRDAGVNVTLEAASSKL
FASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRIYEGTSQVQQLIIARETLKRGG

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=391, Percent_Identity=38.8746803069054, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=40.1069518716578, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI4557235, Length=378, Percent_Identity=39.9470899470899, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI76496475, Length=378, Percent_Identity=39.9470899470899, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=36.3395225464191, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=36.3395225464191, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=37.3655913978495, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=34.5844504021448, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI226958414, Length=376, Percent_Identity=34.5744680851064, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI7656849, Length=387, Percent_Identity=34.3669250645995, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=33.6927223719677, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI48976061, Length=395, Percent_Identity=31.1392405063291, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI211971008, Length=395, Percent_Identity=31.1392405063291, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI38505218, Length=404, Percent_Identity=29.4554455445545, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=31.7460317460317, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=31.4207650273224, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1786223, Length=359, Percent_Identity=32.5905292479109, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=30.3430079155673, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87082384, Length=294, Percent_Identity=25.8503401360544, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081702, Length=293, Percent_Identity=27.3037542662116, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=39.5287958115183, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17570075, Length=369, Percent_Identity=39.8373983739837, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=37.5, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=40.3269754768392, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=37.2972972972973, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=36, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17538396, Length=368, Percent_Identity=32.8804347826087, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=38.5350318471338, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=30.5039787798408, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=38.2671480144404, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=378, Percent_Identity=31.4814814814815, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=370, Percent_Identity=30.8108108108108, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=30.3763440860215, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=34.0659340659341, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17562446, Length=366, Percent_Identity=31.9672131147541, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=34.1666666666667, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17531913, Length=174, Percent_Identity=29.8850574712644, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=274, Percent_Identity=28.4671532846715, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=274, Percent_Identity=28.4671532846715, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24660351, Length=372, Percent_Identity=38.7096774193548, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI281363737, Length=387, Percent_Identity=38.7596899224806, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=39.0374331550802, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24666513, Length=363, Percent_Identity=39.3939393939394, Blast_Score=250, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=36.7724867724868, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=32.8912466843501, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI19920834, Length=343, Percent_Identity=33.5276967930029, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24652780, Length=347, Percent_Identity=23.6311239193084, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45550141, Length=340, Percent_Identity=24.1176470588235, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221473076, Length=340, Percent_Identity=24.1176470588235, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281365206, Length=386, Percent_Identity=23.8341968911917, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585193, Length=386, Percent_Identity=23.8341968911917, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585195, Length=386, Percent_Identity=23.8341968911917, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24585191, Length=386, Percent_Identity=23.8341968911917, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40905; Mature: 40774

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDLETREQLIDTVARFVAERLRPIEAQVAENDAVPDDVIEEMKGLGLFGLTIPEEFGG
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCCCEEEEECCHHHCC
LGLTMEEEALVAIELGRASPAFRSVFGTNVGIGSQGLVMFGNDEQKAKWLPGIASGAVIT
CCCEECCCEEEEEEECCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHHH
SFALTEPEAGSDSAAVQTRATRDGDDYILNGSKRYITNAGKASLFTVMARTNPDAKGGAG
EEEECCCCCCCCCCCEEECCCCCCCCEEECCCCEEEECCCCCEEEEEEECCCCCCCCCCC
VSAFLVPRDLPGLTVGKPEKKMGQQGAHIHDVTFDNVRVPAWNRLGAEGEGFKVAMQVLD
CEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCCEECCCHHHCCCCCCCHHHHHHHHH
RGRLHIAAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
ETARKRDAGVNVTLEAASSKLFASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFR
HHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEE
IYEGTSQVQQLIIARETLKRGG
EECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALDLETREQLIDTVARFVAERLRPIEAQVAENDAVPDDVIEEMKGLGLFGLTIPEEFGG
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCCCEEEEECCHHHCC
LGLTMEEEALVAIELGRASPAFRSVFGTNVGIGSQGLVMFGNDEQKAKWLPGIASGAVIT
CCCEECCCEEEEEEECCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHCCCCCCCHHHH
SFALTEPEAGSDSAAVQTRATRDGDDYILNGSKRYITNAGKASLFTVMARTNPDAKGGAG
EEEECCCCCCCCCCCEEECCCCCCCCEEECCCCEEEECCCCCEEEEEEECCCCCCCCCCC
VSAFLVPRDLPGLTVGKPEKKMGQQGAHIHDVTFDNVRVPAWNRLGAEGEGFKVAMQVLD
CEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCCEECCCHHHCCCCCCCHHHHHHHHH
RGRLHIAAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
ETARKRDAGVNVTLEAASSKLFASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFR
HHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEE
IYEGTSQVQQLIIARETLKRGG
EECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]