Click here to switch to the map view.

The map label for this gene is fadD [C]

Identifier: 16124646

GI number: 16124646

Start: 411052

End: 412842

Strand: Direct

Name: fadD [C]

Synonym: CC_0391

Alternate gene names: 16124646

Gene position: 411052-412842 (Clockwise)

Preceding gene: 16124643

Following gene: 16124648

Centisome position: 10.23

GC content: 70.97

Gene sequence:

>1791_bases
ATGGACGGATCGACCCTCGACACAGCCCCCTTCCGTGACGCTCGCTACGCGCCCCGCGCGCTGGAGGTCGAGCGACAGGG
GCAGACGCTGATCCTGCGCAATCCCATGCCCTATTCGGACGCGGTGCGGACCACGACTGCGCCGCTGGCCCGCTGGGCCG
CGCAGGCGCCGGACCGGGTCTGGCTGGCCGAGCGGGACGGCGAAGGCTGGCGGACGGTCACCTATGCGGACGCCAAGGCG
CAGGTCGAAGCGCTGGCGGGCGGACTGCAAGGTCTGGGTCTGCGCCGAGGCCAGCCGCTGCTGATCCTGGCCCGCAACGG
CGTCGATCACGCGCGGATCGCCTACGCGGCCATGAGCCTGGGCGCCCCGGCCGCGCCGGTGTCGCCGCAGTACGGGCTGA
AGGGCGCGGATCTCACCCGGCTGCAGCACGCCGTCGAACGGCTGAAGCCCGCCGCCGTCTACGCCGACGACGCAGAAGCC
TTCGGCGACGCCCTGGCCGCGCCGTTCCTGGCCGGACTGCCGGTGGTGGTCAGCCGAAATGCGCGACCCGGCGACGTCGC
CTTCGAGGCTTTGCTGAAGAGCCCGCCGCTGGCGCCCCAGGCCCAGCCGGACGATGTGGCCAAGCTGCTTTTGACCTCCG
GCTCGACCGGCAAGCCGAAAGCGGTGGTCTGCACCCATGCCAACATCGCGCTGAACGCGGCCCAGATCGAGGCCTGCTAC
GCCGACCCCGACCCGCCGGTGCTGGTCAATTCCGCGCCGTGGAGCCACAGCCTCGGCGCCAACGCCATCCTGCACATGGT
GCTGCACCGGGGCGGGACGCTCTATATCGACGCCGGCCAACCCGTGCCGGGGCGCTTTGGCGAGACGGTGCGTAACCTGT
CCGAGGTGGCGACGACCTATCACAACATGGTCCCGGCCGGCTGGGCGATGTTCGTCGGCGAACTGGAGCGCGACGAGGCC
CTGGCCGCCAGGTTCTTCGAGAAGGTCCGTGTGCTGCAGTACGGCGGCGCCTCGATGGCCCAGTCGATCCTCGACCGCGT
CCAGGCTGTCGCGGTGCGTACGGTGGGCGAACGGATCACCTTCGCCGCTGGCTATGGCGCGACCGAGACCGGCCCGACCG
CTTGTAACATCCACTGGCTGAACGCGCGCTCGGGTATGGTTGGCCTGCCCACGCCCGGCACCGCAGTGAAGCTGGTGCCT
GCGGGGGAGGGCGGCAAGTTCGAGATCCGCGTGAAGGGGCCGCAGGTCTCGCCGGGCTATCTGGATCAGCCCGAGGCCAC
GGCGCAGGCCTTCGACGAGGACGGTTTTTACCGCCTGGGCGACGCGGCGCGGTTGGCCGATCCGGAGGATCCCGCCGCAG
GGCTGGTGTTCGACGGGCGCCTGGTCGAGAACTTCAAGCTGGCCAGCGGCACCTTCGTCGCGGCCGGGGCCCTGCGGGTG
GCGGCGGTGTCGGCGATCGGCGGCGTGGTCTCCGATGCGGTGGTCTGCGGCGAGGGGCAGGAGGGCGTTGGCCTGATGCT
GTTCCTCGACGCCAAGGCGGTCGAGCGTCTCGGGAGCCCCGAGGCGGTGCGCGCGGCGATCGTCGAGGCTCTTTCGCGGA
TGAACGCGGCGGCCAAGGGCGGTGGCGGCCGCATCGCCCGCGCCCTGATCCTGGACGGCGCGCCCGACGCGGCCAGCGGC
GAGCTGACCGACAAGGGCTATATCAACCAGGCCCTGGCGCGGGATCGGCGGCCAAAAGAGCTTGAGCGGCTGTTTGCTGA
GACGCCGGATGAAGGGGTGATGGTGTTTTAA

Upstream 100 bases:

>100_bases
GCCGGTTCGGACGGATTCGACAGCGGGCGCTGAAAAATGTCGAGGGCCGCCGTCGCGCCGCATGGATTGAACAGCCGTAT
GACCCGCGACATAACAGGTC

Downstream 100 bases:

>100_bases
CCCGACCTCCCCGGCGAAGGCCGGGGTCCAGATCGAACCCGTGAACATCTCGGGCTTGGTCAGGGCGGTAGGCGCGTCAT
CCCCAAAGTCTCAGGCTGAA

Product: feruloyl-CoA synthase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MDGSTLDTAPFRDARYAPRALEVERQGQTLILRNPMPYSDAVRTTTAPLARWAAQAPDRVWLAERDGEGWRTVTYADAKA
QVEALAGGLQGLGLRRGQPLLILARNGVDHARIAYAAMSLGAPAAPVSPQYGLKGADLTRLQHAVERLKPAAVYADDAEA
FGDALAAPFLAGLPVVVSRNARPGDVAFEALLKSPPLAPQAQPDDVAKLLLTSGSTGKPKAVVCTHANIALNAAQIEACY
ADPDPPVLVNSAPWSHSLGANAILHMVLHRGGTLYIDAGQPVPGRFGETVRNLSEVATTYHNMVPAGWAMFVGELERDEA
LAARFFEKVRVLQYGGASMAQSILDRVQAVAVRTVGERITFAAGYGATETGPTACNIHWLNARSGMVGLPTPGTAVKLVP
AGEGGKFEIRVKGPQVSPGYLDQPEATAQAFDEDGFYRLGDAARLADPEDPAAGLVFDGRLVENFKLASGTFVAAGALRV
AAVSAIGGVVSDAVVCGEGQEGVGLMLFLDAKAVERLGSPEAVRAAIVEALSRMNAAAKGGGGRIARALILDGAPDAASG
ELTDKGYINQALARDRRPKELERLFAETPDEGVMVF

Sequences:

>Translated_596_residues
MDGSTLDTAPFRDARYAPRALEVERQGQTLILRNPMPYSDAVRTTTAPLARWAAQAPDRVWLAERDGEGWRTVTYADAKA
QVEALAGGLQGLGLRRGQPLLILARNGVDHARIAYAAMSLGAPAAPVSPQYGLKGADLTRLQHAVERLKPAAVYADDAEA
FGDALAAPFLAGLPVVVSRNARPGDVAFEALLKSPPLAPQAQPDDVAKLLLTSGSTGKPKAVVCTHANIALNAAQIEACY
ADPDPPVLVNSAPWSHSLGANAILHMVLHRGGTLYIDAGQPVPGRFGETVRNLSEVATTYHNMVPAGWAMFVGELERDEA
LAARFFEKVRVLQYGGASMAQSILDRVQAVAVRTVGERITFAAGYGATETGPTACNIHWLNARSGMVGLPTPGTAVKLVP
AGEGGKFEIRVKGPQVSPGYLDQPEATAQAFDEDGFYRLGDAARLADPEDPAAGLVFDGRLVENFKLASGTFVAAGALRV
AAVSAIGGVVSDAVVCGEGQEGVGLMLFLDAKAVERLGSPEAVRAAIVEALSRMNAAAKGGGGRIARALILDGAPDAASG
ELTDKGYINQALARDRRPKELERLFAETPDEGVMVF
>Mature_596_residues
MDGSTLDTAPFRDARYAPRALEVERQGQTLILRNPMPYSDAVRTTTAPLARWAAQAPDRVWLAERDGEGWRTVTYADAKA
QVEALAGGLQGLGLRRGQPLLILARNGVDHARIAYAAMSLGAPAAPVSPQYGLKGADLTRLQHAVERLKPAAVYADDAEA
FGDALAAPFLAGLPVVVSRNARPGDVAFEALLKSPPLAPQAQPDDVAKLLLTSGSTGKPKAVVCTHANIALNAAQIEACY
ADPDPPVLVNSAPWSHSLGANAILHMVLHRGGTLYIDAGQPVPGRFGETVRNLSEVATTYHNMVPAGWAMFVGELERDEA
LAARFFEKVRVLQYGGASMAQSILDRVQAVAVRTVGERITFAAGYGATETGPTACNIHWLNARSGMVGLPTPGTAVKLVP
AGEGGKFEIRVKGPQVSPGYLDQPEATAQAFDEDGFYRLGDAARLADPEDPAAGLVFDGRLVENFKLASGTFVAAGALRV
AAVSAIGGVVSDAVVCGEGQEGVGLMLFLDAKAVERLGSPEAVRAAIVEALSRMNAAAKGGGGRIARALILDGAPDAASG
ELTDKGYINQALARDRRPKELERLFAETPDEGVMVF

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=313, Percent_Identity=27.7955271565495, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI187761345, Length=288, Percent_Identity=26.0416666666667, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI187761343, Length=288, Percent_Identity=26.0416666666667, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788107, Length=463, Percent_Identity=25.4859611231102, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17556552, Length=321, Percent_Identity=28.6604361370716, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17558820, Length=387, Percent_Identity=24.2894056847545, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563687, Length=380, Percent_Identity=23.6842105263158, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193204819, Length=179, Percent_Identity=32.9608938547486, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859661, Length=454, Percent_Identity=25.7709251101322, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 62574; Mature: 62574

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSTLDTAPFRDARYAPRALEVERQGQTLILRNPMPYSDAVRTTTAPLARWAAQAPDRV
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEE
WLAERDGEGWRTVTYADAKAQVEALAGGLQGLGLRRGQPLLILARNGVDHARIAYAAMSL
EEEECCCCCCEEEEECCHHHHHHHHHCCHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
GAPAAPVSPQYGLKGADLTRLQHAVERLKPAAVYADDAEAFGDALAAPFLAGLPVVVSRN
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCEEEECC
ARPGDVAFEALLKSPPLAPQAQPDDVAKLLLTSGSTGKPKAVVCTHANIALNAAQIEACY
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEHHHEEEEE
ADPDPPVLVNSAPWSHSLGANAILHMVLHRGGTLYIDAGQPVPGRFGETVRNLSEVATTY
CCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
HNMVPAGWAMFVGELERDEALAARFFEKVRVLQYGGASMAQSILDRVQAVAVRTVGERIT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEE
FAAGYGATETGPTACNIHWLNARSGMVGLPTPGTAVKLVPAGEGGKFEIRVKGPQVSPGY
EEECCCCCCCCCCEEEEEEEECCCCEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCC
LDQPEATAQAFDEDGFYRLGDAARLADPEDPAAGLVFDGRLVENFKLASGTFVAAGALRV
CCCCCHHHHHCCCCCCEEECCCHHCCCCCCCCCCEEECCEEEECEEECCCCEEEHHHHHH
AAVSAIGGVVSDAVVCGEGQEGVGLMLFLDAKAVERLGSPEAVRAAIVEALSRMNAAAKG
HHHHHHHHHHHCCEEECCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
GGGRIARALILDGAPDAASGELTDKGYINQALARDRRPKELERLFAETPDEGVMVF
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEC
>Mature Secondary Structure
MDGSTLDTAPFRDARYAPRALEVERQGQTLILRNPMPYSDAVRTTTAPLARWAAQAPDRV
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEE
WLAERDGEGWRTVTYADAKAQVEALAGGLQGLGLRRGQPLLILARNGVDHARIAYAAMSL
EEEECCCCCCEEEEECCHHHHHHHHHCCHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
GAPAAPVSPQYGLKGADLTRLQHAVERLKPAAVYADDAEAFGDALAAPFLAGLPVVVSRN
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCEEEECC
ARPGDVAFEALLKSPPLAPQAQPDDVAKLLLTSGSTGKPKAVVCTHANIALNAAQIEACY
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEEHHHEEEEE
ADPDPPVLVNSAPWSHSLGANAILHMVLHRGGTLYIDAGQPVPGRFGETVRNLSEVATTY
CCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
HNMVPAGWAMFVGELERDEALAARFFEKVRVLQYGGASMAQSILDRVQAVAVRTVGERIT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEE
FAAGYGATETGPTACNIHWLNARSGMVGLPTPGTAVKLVPAGEGGKFEIRVKGPQVSPGY
EEECCCCCCCCCCEEEEEEEECCCCEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCC
LDQPEATAQAFDEDGFYRLGDAARLADPEDPAAGLVFDGRLVENFKLASGTFVAAGALRV
CCCCCHHHHHCCCCCCEEECCCHHCCCCCCCCCCEEECCEEEECEEECCCCEEEHHHHHH
AAVSAIGGVVSDAVVCGEGQEGVGLMLFLDAKAVERLGSPEAVRAAIVEALSRMNAAAKG
HHHHHHHHHHHCCEEECCCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
GGGRIARALILDGAPDAASGELTDKGYINQALARDRRPKELERLFAETPDEGVMVF
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]