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The map label for this gene is pyrC [H]

Identifier: 16124643

GI number: 16124643

Start: 407848

End: 409182

Strand: Direct

Name: pyrC [H]

Synonym: CC_0388

Alternate gene names: 16124643

Gene position: 407848-409182 (Clockwise)

Preceding gene: 16124642

Following gene: 16124646

Centisome position: 10.15

GC content: 69.21

Gene sequence:

>1335_bases
ATGACCCAGACCTTCGACCTGATCGTGCGTGGCGGCGAGGTGGTGAACCACGCCGGCCGGGACTTCACCGACATCGGCGT
GCGCGGCGGCAAGATCGTCGCGATCGGCGACCTCTCCCAGGCCAGCGCCGGCGAGGTGTTCGACGCCACGGGCCTGACCG
TGCTGCCCGGCGTCATCGACAGCCAGGTGCACTTCCGCGAACCGGGCCTGGAGTGGAAGGAAGATCTCGAGAGCGGCTCG
CGCGGCGCGGCCCTGGGCGGCGTCACGGCCGTCTTCGAGATGCCCAACACCGAGCCGACCACCACGGACCCGGACGCCCT
GGCCGACAAGCTGGCGCGGGCCAAGAACCGGATGCACACCGACCACGCCTTCTATGTCGGCGGCACCCACGCGAACGCGA
CCTTCCTGGGCGAGCTGGAGCGCCTGCCGGGTTGCTGCGGCATCAAGGTGTTCATGGGCGCCTCGACAGGCTCGCTGTTG
GTGCATGACGACGAGGGCGTCGAGAACGTGCTGCGCCACGTCAACCGCCGCGCGGCCTTCCACTCCGAGGACGAGTACCG
CCTGGCCGAGCGCCGCGGCCTGGCCCGCCCCGGCGACTGGACCAGCCACCCGGAGGTGCGCGACGCCCAAGCCGCCCTGC
AGTCGACCCATCGCCTGGTCCGCATCGCAAAGGGCCTGGGCAAGCGCATCCACGTGCTGCACGTCACGACCAAGGAAGAA
ATCGACTTCCTGGCCCAGAACAAGGACGTCGCCAGCGTCGAGGTCACGCCCCAGCACCTGACCCTGGTCGCGCCCGAGGC
CTATGAGCGCCTGAAGGGTTTTGCGCAGATGAACCCGCCGATCCGCGAGGCCGACCATGTGGCCGGCATCTGGCGCGGGA
TCGACACCGGCGTCGCCGACGTGATCGGCTCCGACCACGCGCCGCACACCCGTGAGGAAAAGGCCCGTCCCTATCCGGCC
TCGCCCTCGGGCATGCCGGGCGTCCAGACCCTGGTGCCGATCATGCTGACCCACGTCGTCGACGGCAAGCTCACCCTTGA
GCGCTTTGTTGATCTGACCAGCCACGGCGTGAACCGCATCTTCGGCCTGGCCGATAAGGGCCGCATCGCCGAGGGCTTCG
ACGCCGACTTCACCATCGTCGACATGAAGGCCCGCCGGGTCATCACCCACGACTGGATGGCCACCCGCTCGGGCTGGACC
CCCTTCGACGGTTTCGAGGCCAAGGCCTGGCCGGTGGCCACCATCGTGCGCGGCATCGTGGTCATGCGCGACGACGAGAT
CATCGCCGAGGGCAAGGGCGAGCCGGTGCGGTTCCTGGAAACGCTGGCGGGATAG

Upstream 100 bases:

>100_bases
CGGCGCCCTCCGGGCCCTGAGGCGCGTCGGCCGTCACGAAACGGTTGCCTCTCGAACAGGTCGGCCCTAGATGCCTTGAA
CCCCTCCGAGGAGCCGTCCG

Downstream 100 bases:

>100_bases
GGGCTTTAGCGCCCCCTCCGTCGCGCTGCGTTCCGCATCGCGCCACCTCCCCCGTTTCAGGGGTGAGGATGCCACGATCG
CCCACCTCCCCCGCTTGCGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTQTFDLIVRGGEVVNHAGRDFTDIGVRGGKIVAIGDLSQASAGEVFDATGLTVLPGVIDSQVHFREPGLEWKEDLESGS
RGAALGGVTAVFEMPNTEPTTTDPDALADKLARAKNRMHTDHAFYVGGTHANATFLGELERLPGCCGIKVFMGASTGSLL
VHDDEGVENVLRHVNRRAAFHSEDEYRLAERRGLARPGDWTSHPEVRDAQAALQSTHRLVRIAKGLGKRIHVLHVTTKEE
IDFLAQNKDVASVEVTPQHLTLVAPEAYERLKGFAQMNPPIREADHVAGIWRGIDTGVADVIGSDHAPHTREEKARPYPA
SPSGMPGVQTLVPIMLTHVVDGKLTLERFVDLTSHGVNRIFGLADKGRIAEGFDADFTIVDMKARRVITHDWMATRSGWT
PFDGFEAKAWPVATIVRGIVVMRDDEIIAEGKGEPVRFLETLAG

Sequences:

>Translated_444_residues
MTQTFDLIVRGGEVVNHAGRDFTDIGVRGGKIVAIGDLSQASAGEVFDATGLTVLPGVIDSQVHFREPGLEWKEDLESGS
RGAALGGVTAVFEMPNTEPTTTDPDALADKLARAKNRMHTDHAFYVGGTHANATFLGELERLPGCCGIKVFMGASTGSLL
VHDDEGVENVLRHVNRRAAFHSEDEYRLAERRGLARPGDWTSHPEVRDAQAALQSTHRLVRIAKGLGKRIHVLHVTTKEE
IDFLAQNKDVASVEVTPQHLTLVAPEAYERLKGFAQMNPPIREADHVAGIWRGIDTGVADVIGSDHAPHTREEKARPYPA
SPSGMPGVQTLVPIMLTHVVDGKLTLERFVDLTSHGVNRIFGLADKGRIAEGFDADFTIVDMKARRVITHDWMATRSGWT
PFDGFEAKAWPVATIVRGIVVMRDDEIIAEGKGEPVRFLETLAG
>Mature_443_residues
TQTFDLIVRGGEVVNHAGRDFTDIGVRGGKIVAIGDLSQASAGEVFDATGLTVLPGVIDSQVHFREPGLEWKEDLESGSR
GAALGGVTAVFEMPNTEPTTTDPDALADKLARAKNRMHTDHAFYVGGTHANATFLGELERLPGCCGIKVFMGASTGSLLV
HDDEGVENVLRHVNRRAAFHSEDEYRLAERRGLARPGDWTSHPEVRDAQAALQSTHRLVRIAKGLGKRIHVLHVTTKEEI
DFLAQNKDVASVEVTPQHLTLVAPEAYERLKGFAQMNPPIREADHVAGIWRGIDTGVADVIGSDHAPHTREEKARPYPAS
PSGMPGVQTLVPIMLTHVVDGKLTLERFVDLTSHGVNRIFGLADKGRIAEGFDADFTIVDMKARRVITHDWMATRSGWTP
FDGFEAKAWPVATIVRGIVVMRDDEIIAEGKGEPVRFLETLAG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=400, Percent_Identity=30.75, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI19923821, Length=460, Percent_Identity=27.6086956521739, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4503379, Length=463, Percent_Identity=25.9179265658747, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI190194363, Length=452, Percent_Identity=27.212389380531, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4503377, Length=454, Percent_Identity=25.1101321585903, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=28.0623608017817, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI4503051, Length=464, Percent_Identity=25.2155172413793, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI62422571, Length=468, Percent_Identity=25.2136752136752, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786722, Length=442, Percent_Identity=33.4841628959276, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082175, Length=459, Percent_Identity=27.2331154684096, Blast_Score=145, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=402, Percent_Identity=28.8557213930348, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17539558, Length=460, Percent_Identity=26.5217391304348, Blast_Score=95, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=403, Percent_Identity=26.7990074441687, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24642586, Length=388, Percent_Identity=32.9896907216495, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137462, Length=466, Percent_Identity=27.0386266094421, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI18859883, Length=431, Percent_Identity=25.5220417633411, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221377917, Length=476, Percent_Identity=26.4705882352941, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48354; Mature: 48223

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTFDLIVRGGEVVNHAGRDFTDIGVRGGKIVAIGDLSQASAGEVFDATGLTVLPGVID
CCCCEEEEEECCHHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCCEECCCCCEEECCHHC
SQVHFREPGLEWKEDLESGSRGAALGGVTAVFEMPNTEPTTTDPDALADKLARAKNRMHT
CCEEECCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
DHAFYVGGTHANATFLGELERLPGCCGIKVFMGASTGSLLVHDDEGVENVLRHVNRRAAF
CCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCC
HSEDEYRLAERRGLARPGDWTSHPEVRDAQAALQSTHRLVRIAKGLGKRIHVLHVTTKEE
CCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
IDFLAQNKDVASVEVTPQHLTLVAPEAYERLKGFAQMNPPIREADHVAGIWRGIDTGVAD
HHHHHCCCCCEEEEECCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VIGSDHAPHTREEKARPYPASPSGMPGVQTLVPIMLTHVVDGKLTLERFVDLTSHGVNRI
HHCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FGLADKGRIAEGFDADFTIVDMKARRVITHDWMATRSGWTPFDGFEAKAWPVATIVRGIV
HCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCEE
VMRDDEIIAEGKGEPVRFLETLAG
EEECCCEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TQTFDLIVRGGEVVNHAGRDFTDIGVRGGKIVAIGDLSQASAGEVFDATGLTVLPGVID
CCCEEEEEECCHHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCCEECCCCCEEECCHHC
SQVHFREPGLEWKEDLESGSRGAALGGVTAVFEMPNTEPTTTDPDALADKLARAKNRMHT
CCEEECCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
DHAFYVGGTHANATFLGELERLPGCCGIKVFMGASTGSLLVHDDEGVENVLRHVNRRAAF
CCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCC
HSEDEYRLAERRGLARPGDWTSHPEVRDAQAALQSTHRLVRIAKGLGKRIHVLHVTTKEE
CCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
IDFLAQNKDVASVEVTPQHLTLVAPEAYERLKGFAQMNPPIREADHVAGIWRGIDTGVAD
HHHHHCCCCCEEEEECCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VIGSDHAPHTREEKARPYPASPSGMPGVQTLVPIMLTHVVDGKLTLERFVDLTSHGVNRI
HHCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FGLADKGRIAEGFDADFTIVDMKARRVITHDWMATRSGWTPFDGFEAKAWPVATIVRGIV
HCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCEE
VMRDDEIIAEGKGEPVRFLETLAG
EEECCCEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]